EKS-AIM-00356

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00356

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	314.4	6.0E-94	36	283	248

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003776

UniProt Accession

D2HRF5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K7

Gene Synonyms/Alias

MAP3K7; PANDA_014574;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003532	ENSAMEP00000003776	ENSAMET00000003927

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

606

Protein Sequence
(FASTA)

MSTASAASSS SSSSAGEMIE APSQVLNFEE IDYKEIEVEE VVGRGAFGVV CKAKWRAKDV 60

AIKQIESESE RKAFIVELRQ LSRVNHPNIV KLYGACLNPV CLVMEYAEGG SLYNVLHGAE 120

PLPYYTAAHA MSWCLQCSQG VAYLHSMQPK ALIHRDLKPP NLLLVAGGTV LKICDFGTAC 180

DIQTHMTNNK GSAAWMAPEV FEGSNYSEKC DVFSWGIILW EVITRRKPFD EIGGPAFRIM 240

WAVHNGTRPP LIKNLPKPIE SLMTRCWSKD PSQRPSMEEI VKIMTHLMRY FPGADEPLQY 300

PCQYSDEGQS NSATSTGSFM DIASTNTSNK SDTNMEQIPA TNDTIKRLES KLLKNQAKQQ 360

SESGRLSLGA SRGSSVESLP PTSEGKRMSA DMSEIEARIA ATTAYSKPKR GHRKTASFGN 420

ILDVPEIVIS GNGQPRRRSI QDLTVTGTEP GQVSSRSSSP SVRMITTSGP TSEKPTRSHP 480

WTPDDSTDTN GSDNSIPMAY LTLDHQLQPL APCPNSKESM AVFEQHCKMA QEYMKVQTEI 540

ALLLQRKQEL VAELDQDEKD QQNTSRLVQE HKKLLDENKS LSTYYQQCKK QLEVIRSQQQ 600

KRQGTS 606

Nucleotide Sequence
(FASTA)

ATGTCTACAG CCTCCGCCGC TTCCTCCTCT TCCTCGTCTT CGGCCGGTGA GATGATCGAA 60

GCCCCCTCCC AAGTCCTCAA CTTTGAAGAG ATCGACTACA AGGAGATCGA GGTAGAAGAG 120

GTTGTTGGAA GAGGAGCCTT TGGAGTGGTT TGCAAAGCTA AGTGGAGAGC AAAAGATGTT 180

GCTATTAAAC AAATAGAAAG TGAATCTGAG AGGAAAGCTT TTATTGTAGA GCTTCGACAG 240

TTATCCCGTG TGAACCATCC TAATATTGTA AAGCTATATG GAGCCTGCTT GAATCCAGTG 300

TGTCTTGTGA TGGAATATGC TGAAGGGGGC TCTTTATATA ATGTGCTGCA TGGTGCTGAA 360

CCATTGCCAT ATTACACTGC TGCCCATGCA ATGAGTTGGT GTTTACAGTG TTCCCAAGGA 420

GTGGCTTATC TTCACAGCAT GCAACCCAAA GCTCTAATTC ACAGGGACCT GAAACCACCA 480

AACTTGCTGC TGGTTGCAGG TGGGACAGTA TTAAAAATCT GTGACTTTGG TACAGCCTGT 540

GACATTCAGA CTCATATGAC CAATAACAAG GGGAGTGCTG CTTGGATGGC ACCTGAAGTT 600

TTTGAAGGTA GCAATTACAG TGAAAAATGT GATGTCTTCA GCTGGGGTAT CATCCTTTGG 660

GAAGTGATAA CACGTCGGAA ACCCTTTGAT GAGATTGGTG GCCCAGCTTT CCGTATCATG 720

TGGGCTGTTC ATAACGGTAC TCGACCACCA CTGATCAAAA ATTTACCTAA GCCCATTGAG 780

AGCCTGATGA CTCGTTGTTG GTCTAAAGAT CCTTCTCAGC GCCCTTCAAT GGAGGAAATT 840

GTGAAAATAA TGACTCACTT GATGCGGTAC TTTCCAGGAG CAGATGAGCC ATTACAGTAT 900

CCTTGTCAGT ATTCAGATGA AGGACAGAGC AACTCTGCCA CCAGTACAGG CTCATTCATG 960

GACATTGCCT CTACAAATAC CAGTAATAAA AGTGACACTA ATATGGAGCA AATTCCTGCC 1020

ACAAATGATA CTATTAAACG CTTAGAATCA AAATTGTTGA AAAATCAGGC AAAGCAACAG 1080

AGTGAATCAG GACGTTTAAG CTTGGGAGCT TCCCGTGGGA GCAGTGTGGA GAGCTTGCCT 1140

CCAACCTCCG AGGGCAAGAG GATGAGTGCT GACATGTCTG AAATAGAAGC CAGGATTGCT 1200

GCAACCACAG CCTATTCCAA GCCTAAACGG GGCCACCGTA AAACTGCTTC ATTTGGCAAC 1260

ATTCTGGATG TCCCTGAGAT CGTCATATCA GGCAACGGAC AACCAAGACG TAGATCCATC 1320

CAAGACTTGA CTGTTACTGG AACAGAACCT GGTCAGGTAA GCAGTAGGTC ATCCAGTCCT 1380

AGTGTCAGAA TGATCACTAC CTCAGGACCA ACCTCAGAAA AGCCAACTCG AAGTCATCCA 1440

TGGACTCCTG ATGATTCCAC AGATACCAAT GGATCAGATA ACTCTATCCC AATGGCTTAT 1500

CTTACACTGG ATCACCAACT ACAGCCTCTA GCACCGTGCC CAAACTCCAA AGAATCTATG 1560

GCAGTGTTTG AACAGCATTG TAAAATGGCA CAAGAATATA TGAAAGTTCA AACAGAAATT 1620

GCATTGTTAT TACAGAGAAA GCAAGAACTA GTTGCAGAAC TGGACCAGGA TGAAAAGGAC 1680

CAGCAAAATA CATCTCGTCT GGTACAGGAA CATAAAAAGC TTTTAGATGA AAACAAAAGC 1740

CTTTCTACTT ACTACCAGCA ATGCAAAAAA CAACTAGAGG TCATCAGAAG TCAGCAGCAA 1800

AAACGACAAG GCACTTCATG A 1821

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniie  60

         ie+ee++g+gafg v+kakwr+k+va+K++++e+e+    +++  e+++ls+++hpni++

Q: 36    IEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER----KAFIVELRQLSRVNHPNIVK  91

         5789****************************9888....********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhe.kskreidlevlvswalqiArGmaYLhseap  119

         l+G+cl++  ++lvmey+eggsL+nvlh+ +  + ++ ++++sw+lq+++G+aYLhs++p

Q: 92    LYGACLNP--VCLVMEYAEGGSLYNVLHGaEPLPYYTAAHAMSWCLQCSQGVAYLHSMQP  149

         *******9..89*****************778899*************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         k++ihrdLk++n+Ll +  ++lkicdFGta++++ +++++++g++awmaPEv++ +++se

Q: 150   KALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAPEVFEGSNYSE  208

         ********************************99.9************************

S: 180   ksDvwSygvvLWelltrevPykdlse..laiaykvalkglrlpipsscpeklkkLmkecw  237

         k+Dv+S+g++LWe++tr++P++++    ++i+++v ++g+r+p+++++p+++++Lm++cw

Q: 209   KCDVFSWGIILWEVITRRKPFDEIGGpaFRIMWAV-HNGTRPPLIKNLPKPIESLMTRCW  267

         **********************9987447889999.99**********************

S: 238   nedpekRpsfseivks  253

         ++dp++Rps++eivk+

Q: 268   SKDPSQRPSMEEIVKI  283

         *************986

Domain Sequence
(FASTA)

IEVEEVVGRG AFGVVCKAKW RAKDVAIKQI ESESERKAFI VELRQLSRVN HPNIVKLYGA 60

CLNPVCLVME YAEGGSLYNV LHGAEPLPYY TAAHAMSWCL QCSQGVAYLH SMQPKALIHR 120

DLKPPNLLLV AGGTVLKICD FGTACDIQTH MTNNKGSAAW MAPEVFEGSN YSEKCDVFSW 180

GIILWEVITR RKPFDEIGGP AFRIMWAVHN GTRPPLIKNL PKPIESLMTR CWSKDPSQRP 240

SMEEIVKI 248

Keyword

Complete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005671	; C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007250	; P:activation of NF-kappaB-inducing kinase activity
GO:0001525	; P:angiogenesis
GO:0043966	; P:histone H3 acetylation
GO:0007252	; P:I-kappaB phosphorylation
GO:0007254	; P:JNK cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:0001841	; P:neural tube formation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032743	; P:positive regulation of interleukin-2 production
GO:0046330	; P:positive regulation of JNK cascade
GO:0043507	; P:positive regulation of JUN kinase activity
GO:0002726	; P:positive regulation of T cell cytokine production
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

aml:100466506

;

InterPros

IPR011009	; Kinase-like_dom.
IPR017421	; MAPKKK7.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013