EKS-AIM-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	428.0	1.3E-128	82	334	253

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003870

UniProt Accession

D2H938;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2; PANDA_006811;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003614	ENSAMEP00000003870	ENSAMET00000004026

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

MELLRTITYQ PAASTKMCEQ ALGKACGGDS KKKRPQQPPE EPQPPQPQAQ GQPAAPHHHH 60

HHSHSGAEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HEFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKKAAAA LFGGKKDKAR YIDTHNRVSK EDEEIYKLRH DLKKTSITQQ PSKHRTDEEL 420

QPPTTTVARS GTPAVENKQQ IGDAIRMIVR GTLGSCSSSS ECLEDSTMGS VADTVARVLR 480

GCLENMPEAD CIPKEQLSTS FQWVTKWVDY SNKYGFGYQL SDHTVGVLFN NGAHMSLLPD 540

KKTVHYYAEL GQCSVFPATD APEQFISQVT VLKYFSHYME ENLMDGGDLP SVTDIRRPRL 600

YLLQWLKSDK ALMMLFNDGT FQVNFYHDHT KIIICSQNEE YLLTYINEDR ISTTFRLTTL 660

LMSGCSLELK HRMEYALNML LQRCN 685

Nucleotide Sequence
(FASTA)

ATGGAGCTCT TGCGGACTAT CACCTACCAG CCGGCCGCCA GCACCAAGAT GTGCGAGCAG 60

GCGCTGGGGA AGGCTTGTGG CGGGGACTCT AAGAAGAAGC GGCCGCAGCA ACCCCCCGAG 120

GAGCCGCAGC CGCCGCAGCC CCAGGCACAG GGGCAGCCTG CAGCCCCGCA CCACCATCAC 180

CACCACTCGC ACTCGGGGGC CGAGATCTCG CGGATTATCG TGGACCCCAC GACGGGGAAG 240

CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTTG CCAAATGTTA CGAGATGACA 300

GATTTGACGA ACAACAAAGT CTATGCTGCA AAAATTATTC CTCACAGCAG AGTAGCTAAA 360

CCTCATCAAA GGGAAAAGAT TGACAAAGAA ATAGAGCTTC ACAGAATCCT TCATCATAAG 420

CATGTAGTGC AGTTTTACCA CTACTTTGAG GACAAAGAAA ACATTTACAT TCTCTTGGAA 480

TACTGCAGTA GAAGGTCCAT GGCTCATATC TTGAAAGCAA GGAAGGTGTT GACAGAGCCA 540

GAAGTCCGAT ACTACCTCAG GCAGATTGTG TCTGGACTAA AGTACCTTCA CGAACAAGAA 600

ATCTTACACA GAGATCTCAA ACTAGGGAAC TTTTTTATTA ATGAAGCCAT GGAATTAAAA 660

GTCGGGGACT TCGGTTTGGC AGCCAGGCTG GAACCCTTGG AACACAGAAG GAGAACAATA 720

TGTGGTACCC CAAATTATCT CTCTCCTGAA GTCCTCAACA AGCAAGGACA TGGCTGTGAA 780

TCAGACATTT GGGCCTTAGG TTGTGTAATG TATACAATGT TACTAGGAAG ACCCCCCTTT 840

GAAACGACAA ATCTGAAAGA AACGTACAGG TGCATAAGAG AAGCAAGGTA TACAATGCCA 900

TCTTCATTGC TGGCTCCTGC TAAGCACTTA ATAGCTAGCA TGTTGTCCAA GAACCCAGAG 960

GATCGTCCCA GTTTGGATGA CATCATTCGA CATGAATTTT TTTTGCAGGG CTTCACTCCA 1020

GACAGACTCT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTGTC AAGCCCAGCT 1080

AAGAATTTCT TTAAGAAAGC AGCTGCTGCT CTTTTTGGTG GCAAAAAAGA CAAAGCAAGA 1140

TATATTGACA CACATAATAG AGTGTCTAAA GAAGATGAAG AAATTTACAA GCTTAGGCAT 1200

GATTTGAAAA AGACTTCAAT AACTCAACAA CCCAGCAAAC ACAGGACAGA TGAGGAGCTT 1260

CAGCCACCTA CCACTACAGT CGCCAGATCT GGAACACCTG CAGTAGAAAA TAAACAGCAG 1320

ATTGGAGATG CTATTCGCAT GATAGTCCGA GGGACTCTTG GCAGCTGCAG CAGTAGCAGT 1380

GAATGCCTTG AGGACAGTAC CATGGGCAGT GTTGCAGACA CAGTAGCAAG AGTCCTTCGA 1440

GGATGTCTAG AAAACATGCC AGAAGCTGAC TGCATTCCCA AAGAACAGCT GAGCACTTCC 1500

TTTCAGTGGG TCACCAAATG GGTCGATTAC TCTAACAAAT ATGGCTTTGG GTACCAGCTC 1560

TCAGACCACA CTGTAGGTGT CCTTTTCAAC AATGGTGCTC ACATGAGCCT CCTTCCAGAC 1620

AAAAAAACAG TTCACTATTA CGCAGAGCTT GGCCAGTGCT CTGTTTTCCC AGCAACAGAT 1680

GCCCCTGAAC AATTCATTAG TCAAGTGACG GTGCTCAAAT ACTTCTCTCA TTACATGGAG 1740

GAGAACCTCA TGGATGGTGG AGATCTGCCT AGTGTTACCG ATATTCGAAG ACCTCGGCTC 1800

TACCTCCTTC AATGGCTAAA ATCTGATAAG GCCTTAATGA TGCTCTTCAA TGATGGCACC 1860

TTTCAGGTGA ATTTCTACCA TGATCATACG AAAATAATCA TCTGTAGCCA AAATGAAGAA 1920

TATCTTCTCA CTTACATCAA TGAGGACAGG ATATCTACAA CCTTCAGACT GACAACTCTG 1980

CTGATGTCTG GCTGTTCGTT AGAATTAAAA CATCGAATGG AATATGCTCT GAACATGCTC 2040

TTACAGAGAT GTAACTAA 2058

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl++++++ef+

Q: 322   RPSLDDIIRHEFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPSLDDIIRH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007613	; P:memory
GO:0007093	; P:mitotic cell cycle checkpoint
GO:0007052	; P:mitotic spindle organization
GO:0043066	; P:negative regulation of apoptotic process
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599	; P:regulation of centriole replication
GO:0048167	; P:regulation of synaptic plasticity

KEGG

aml:100478979

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013