EKS-AIM-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.7E-97	1079	1343	265

Status

Unreviewed

Ensembl Protein

ENSAMEP00000003838

UniProt Accession

G1LAB5;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003644	ENSAMEP00000003838	ENSAMET00000003993

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1348

Protein Sequence
(FASTA)

SREMENKETL KGLHKMDDRP EERMIREKLK ATCMPAWKHE WLERRNRRGP VVVKPIPIKG 60

DGSEIHNLST ESQGEGQAST TSPAPKGRRS PSPSSSPSGR TVKSESPGVR RKRVSPVPFQ 120

SGRITPPRRA PSPDGFSPYS PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV 180

FIGPQNCSCG RGTFCIHLLF VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI 240

KAPSRNTIQK FVSRMSNSHT LSSSSTSTSS SENSIKDEEE QMCPICLLGM LDEESLTVCE 300

EGCRNKLHHH CMSIWAEECR RNREPLICPL CRSKWRSHDF YSHELSSPVD SPSSLRAAQQ 360

QTIQQQPLAG SQRRSQESSF NLTHYGAQQI PPAYKDLAEP WIQVFGMELV GCLFSRNWNV 420

REMALRRLSH DVSGALLLAN GESTGNSGSN GRSSPSAGAS SGSSQTSISG DVVEACCNVL 480

SMVCGDPVYK VYVAALKTLR AMLVYTPCHS LAERIKLQRL LRPVVDTILV KCADANSRTS 540

QLSISTLLEL CKGQAGELAV GREILKAGSI GIGGVDYVLS CILGNQTESN NWQELLGRLC 600

LIDRLLLEFP AEFYPHIVST DVSQAEPVEV RYKKLLSLLT FALQSIDNSH SMVGKLSRRI 660

YLSSARMVTA VPHVFSKLLE MLNVSSSTHF TRMRRRLMAI ADEVEIAEAI QLGVGDTLDG 720

RHDSFLQASV STSYPETTEN SSLERTDHLE KTGKGLCATK LSANLEDITD RLGSISVGLP 780

SSTTIEQPKP MVQTKGRPHS QCLNTSPLSH HSPLMFPPLS TPSSSAPSAP TGTGTDVSKH 840

RPQGFIPCKI PSPSPQTQRK FSLQFQRNCS ENRDSDKLSP IFTQSRPLPS SNIHRPKPSR 900

PTPGNTSQQG DASKNSLTLD LNCTAQCDDS FGRSSNSSNA VIPSDETVFT PVEEKCRLDV 960

NTELNSSIED LLEASMPSSD TTVTFKSEVA VLSPEKDEND DTYKDDVNHN QKCKEKMEAE 1020

EEAALAIAMA MSASQDALPI VPQLQVENGE DIIIIQQDTP ETLPGHTKAK QPYREDTEWL 1080

KGQQIGLGAF SSCYQAQDVG TGTLMAVKQV TYVRNTSSEQ EEVVEALREE IRMMSHLNHP 1140

NIIRMLGATC EKSNYNLFIE WMAGGSVAHL LSKYGAFKES VVINYTEQLL RGLSYLHENQ 1200

IIHRDVKGAN LLIDSTGQRL RIADFGAAAR LASKGTGAGE FQGQLLGTIA FMAPEVLRGQ 1260

QYGRSCDVWS VGCAIIEMAC AKPPWNAEKH SNHLALIFKI ASATTAPSIP SHLSPGLRDV 1320

ALRCLELQPQ DRPPSRELLK HPVFRTTW 1348

Nucleotide Sequence
(FASTA)

AGTCGTGAGA TGGAGAACAA AGAAACTCTC AAGGGGTTGC ACAAGATGGA CGATCGCCCA 60

GAAGAACGAA TGATCAGGGA GAAACTGAAG GCAACCTGTA TGCCAGCCTG GAAGCATGAG 120

TGGCTGGAAA GGAGAAATAG GAGAGGCCCT GTGGTGGTAA AACCAATCCC TATTAAAGGA 180

GATGGTTCTG AAATTCACAA CTTGTCAACT GAGTCTCAAG GAGAGGGCCA GGCGAGCACC 240

ACGTCACCCG CTCCCAAAGG CCGACGCAGT CCTTCTCCTA GCAGCTCCCC ATCAGGTCGC 300

ACAGTGAAGT CGGAATCTCC AGGAGTTCGG AGAAAAAGAG TTTCCCCAGT GCCTTTTCAG 360

AGTGGGCGAA TCACACCACC TCGAAGAGCC CCTTCACCGG ATGGCTTCTC ACCATACAGC 420

CCTGAGGAGA CAAACCGCCG TGTAAACAAA GTTATGCGGG CCAGGCTGTA CTTACTGCAA 480

CAAATAGGAC CCAACTCTTT CCTGATTGGA GGAGATAGCC CAGATAATAA ATACCGGGTG 540

TTTATTGGGC CTCAGAACTG CAGCTGTGGG CGTGGAACAT TCTGTATTCA TCTGTTGTTT 600

GTTATGCTCC GGGTGTTTCA ACTAGAACCT TCAGACCCAA TGTTATGGAG AAAAACTTTA 660

AAGAATTTTG AGGTTGAAAG TTTGTTCCAG AAATATCACA GTAGGCGTAG CTCAAGGATC 720

AAAGCTCCAT CTCGTAACAC CATCCAGAAG TTTGTTTCAC GCATGTCAAA TTCTCATACA 780

TTGTCATCAT CTAGTACTTC TACATCTAGT TCAGAAAACA GTATAAAAGA TGAGGAGGAA 840

CAGATGTGTC CTATTTGCTT GCTGGGCATG CTTGATGAAG AGAGTCTCAC CGTGTGCGAA 900

GAAGGCTGCA GGAACAAGCT GCATCACCAC TGCATGTCAA TCTGGGCAGA AGAATGTAGA 960

AGAAATAGAG AACCTTTAAT ATGTCCCCTT TGTAGGTCTA AGTGGAGATC TCATGATTTC 1020

TACAGCCATG AGTTGTCAAG CCCTGTGGAT TCCCCTTCTT CCCTGAGAGC TGCACAGCAA 1080

CAAACCATAC AGCAGCAGCC TTTGGCTGGA TCACAACGGA GGAGTCAGGA GAGCAGTTTT 1140

AACCTTACTC ATTATGGAGC TCAGCAGATT CCTCCTGCTT ACAAAGATTT AGCTGAGCCA 1200

TGGATTCAGG TATTTGGAAT GGAACTCGTC GGCTGCTTAT TTTCTAGAAA CTGGAATGTA 1260

AGAGAGATGG CTCTCAGGCG TCTTTCCCAC GATGTTAGTG GGGCTCTGCT ATTGGCAAAT 1320

GGGGAGAGCA CTGGAAATTC TGGGAGCAAC GGTAGAAGCA GCCCGAGTGC TGGAGCCAGC 1380

AGTGGGTCTT CCCAGACCAG TATCTCAGGA GACGTGGTAG AGGCATGCTG CAACGTTTTA 1440

TCAATGGTCT GTGGTGACCC TGTCTACAAA GTGTACGTTG CTGCTTTAAA AACGTTGAGA 1500

GCCATGCTAG TATATACTCC TTGCCATAGT TTGGCAGAAA GAATCAAACT GCAGAGACTT 1560

CTCCGGCCTG TTGTAGACAC CATCTTAGTG AAGTGTGCAG ATGCCAATAG TCGTACAAGT 1620

CAGCTGTCTA TATCAACACT GTTGGAATTA TGCAAAGGCC AAGCAGGAGA GTTGGCAGTT 1680

GGCAGAGAAA TACTTAAAGC TGGATCCATT GGTATTGGTG GTGTTGATTA TGTCTTAAGT 1740

TGTATTCTTG GAAACCAAAC TGAATCAAAC AACTGGCAAG AACTTCTGGG TCGCCTTTGT 1800

CTTATAGACA GACTGCTGTT GGAATTTCCT GCTGAATTTT ACCCTCATAT TGTCAGTACT 1860

GATGTTTCAC AAGCTGAGCC TGTTGAAGTC AGGTATAAAA AGCTGCTGTC CCTCTTAACC 1920

TTTGCTTTGC AGTCCATTGA TAATTCCCAC TCAATGGTTG GTAAACTCTC CCGGAGGATA 1980

TATTTGAGTT CTGCAAGAAT GGTTACTGCA GTACCCCACG TATTTTCAAA ACTATTAGAA 2040

ATGCTAAATG TTTCCAGTTC CACTCATTTT ACCAGGATGC GTCGTCGTCT GATGGCTATT 2100

GCAGATGAGG TGGAAATTGC TGAGGCCATC CAGCTGGGCG TAGGAGACAC TTTGGATGGT 2160

CGACATGACA GCTTTTTGCA GGCATCTGTC TCTACCAGCT ATCCAGAAAC CACAGAGAAC 2220

AGCTCCCTTG AGCGCACAGA CCATTTAGAG AAAACTGGAA AAGGACTGTG TGCTACAAAA 2280

CTGAGTGCCA ACTTGGAGGA CATTACTGAC AGACTGGGCA GCATTTCAGT AGGACTTCCT 2340

AGTTCAACAA CAATAGAGCA ACCAAAGCCA ATGGTTCAAA CAAAAGGCAG ACCCCACAGT 2400

CAGTGTTTGA ACACCTCTCC TTTATCTCAT CATTCCCCAT TAATGTTTCC ACCCTTGTCA 2460

ACTCCTTCTT CATCTGCTCC CTCTGCACCA ACTGGCACTG GAACAGATGT CTCTAAGCAT 2520

AGACCTCAGG GATTCATTCC CTGCAAAATA CCTTCGCCAT CTCCTCAAAC ACAGCGCAAG 2580

TTTTCTCTAC AGTTCCAGAG AAACTGTTCT GAAAACAGAG ACTCAGATAA ACTTTCCCCC 2640

ATCTTTACTC AGTCAAGACC CCTGCCCTCT AGTAATATAC ATAGGCCAAA GCCATCTCGA 2700

CCTACCCCAG GTAATACAAG TCAACAGGGA GATGCCTCAA AGAATAGCTT GACACTTGAT 2760

CTGAACTGTA CTGCCCAATG TGATGACAGC TTTGGCAGAA GCAGCAACAG CAGTAATGCT 2820

GTCATACCCA GTGATGAGAC AGTGTTCACC CCAGTAGAAG AGAAATGCAG ATTAGATGTC 2880

AATACAGAGC TCAACTCCAG TATTGAGGAC CTTCTTGAAG CATCTATGCC TTCAAGTGAC 2940

ACAACAGTAA CTTTTAAGTC AGAAGTTGCT GTACTCTCTC CTGAAAAGGA TGAAAATGAT 3000

GATACCTACA AAGATGATGT GAATCATAAT CAGAAATGCA AAGAAAAGAT GGAAGCTGAA 3060

GAAGAAGCAG CTTTAGCAAT TGCCATGGCA ATGTCAGCGT CTCAGGATGC CCTTCCCATA 3120

GTTCCTCAAC TACAAGTTGA AAATGGAGAA GATATCATCA TCATTCAACA GGATACACCA 3180

GAAACTCTAC CAGGACATAC CAAAGCAAAA CAACCTTACA GAGAAGACAC TGAATGGCTG 3240

AAAGGTCAGC AGATAGGCCT TGGAGCATTT TCTTCCTGTT ACCAGGCTCA AGATGTGGGA 3300

ACTGGAACTT TAATGGCTGT TAAACAGGTG ACATATGTCA GAAATACATC TTCTGAGCAA 3360

GAAGAAGTAG TGGAAGCATT AAGAGAAGAG ATCAGAATGA TGAGCCATTT GAATCATCCC 3420

AACATCATTA GGATGTTGGG AGCCACATGT GAGAAGAGCA ATTATAATCT CTTCATCGAA 3480

TGGATGGCAG GGGGATCTGT GGCTCATTTG CTCAGTAAAT ATGGAGCCTT CAAGGAATCA 3540

GTAGTTATTA ACTATACTGA ACAATTACTT CGTGGCCTTT CGTATCTCCA TGAAAACCAA 3600

ATCATTCATA GAGATGTCAA AGGTGCCAAT TTGCTAATTG ACAGCACAGG TCAGAGACTG 3660

AGAATTGCAG ATTTTGGAGC TGCAGCGAGG TTGGCATCAA AAGGAACTGG TGCTGGAGAG 3720

TTTCAGGGAC AGTTACTGGG GACAATTGCA TTTATGGCAC CTGAGGTACT AAGAGGTCAG 3780

CAGTATGGTA GGAGCTGTGA TGTATGGAGT GTTGGCTGTG CCATTATAGA AATGGCTTGT 3840

GCTAAACCAC CTTGGAATGC AGAAAAACAC TCCAATCATC TTGCTTTGAT ATTTAAGATT 3900

GCAAGTGCGA CTACTGCTCC ATCGATCCCT TCACATTTGT CTCCTGGTTT ACGAGATGTG 3960

GCTCTTCGGT GTTTAGAACT TCAGCCTCAG GACAGACCTC CATCAAGAGA GCTACTGAAG 4020

CATCCAGTCT TCCGTACTAC GTGG 4044

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1079  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1138

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1139  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1198

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1199  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1258

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1259  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1316

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1317  LRDVALRCLELQPQDRPPSRELLKHPV  1343

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013