EKS-AIM-00323
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00323
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ack450.22.1E-135127385259
StatusUnreviewed
Ensembl ProteinENSAMEP00000004230
UniProt AccessionG1LBE7;
Protein Name
Protein Synonyms/Alias
Gene NameTNK2
Gene Synonyms/Alias TNK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000003981ENSAMEP00000004230ENSAMET00000004400
ENSAMEG00000003981ENSAMEP00000004221ENSAMET00000004390
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1036
Protein Sequence
(FASTA)
MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60
EAVKRRKAMC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPTPGGPAG EGPLQSLTCL 120
IGEKDLHLFE KLGDGSFGVV RRGEWDAPSG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 180
MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 240
GYLESKRFIH RDLAARNLLL AARDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 300
SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 360
YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGSR 420
AENYWWRGQN TRTLCVGPFP RNVVTSVAGL SAQDISQPLQ NSFIHTGHGD SDPRHCWGFP 480
DKIDELYLGN PMDPPDLLSV ELSTSRPTQH LGRVKREPPP RPPQPAIFTQ KPTYDPVSED 540
QDPLSSDFKR LGLRKPALTR GLWLAKPSAR VPGTKAGRGG GGEVTLIDFG EEPVVPAPRP 600
CALSLAQLAM DACSLLDKTP PQSPTRALPR PLHPTPVVDW DARPLPPPPA YDDVAQDEDD 660
FEVCSINSTL VGAGVCAGPS QGETNYAFVP EQAQLLPPLE DNLFLPPQGG SKPPSLAQTA 720
EIFQALQQEC MRQLQVPAGS LGPSPGPAPA GEDKPQVPPR VPIPPRPTRP RGELSPASSG 780
EEEMGRWPGP ASPPRVPPRE PLSPQGSRTP SPLVPPGSSP LPPRLSSSPG KTMPTTQSFA 840
SDPKYATPQV IQAPGPRAGP CILPIVRDGK KVSSTHYYLL PERPPYLERY QRFLREAQSP 900
EEPAPLPGPL LLPPPSTPAP AAPTATVRPM PQAAPDPKAN FSTNNSNPGA RPPALRATAR 960
LPDKIQMLQA MVHGVTTEEC QAALQSHSWS VQRAAQYLKV EQLFGLGLRP RSECHKVLEL 1020
CDWNLEQAGC GPAHHK 1036
Nucleotide Sequence
(FASTA)
ATGCAGCCGG AGGAGGGCAC GGGCTGGCTG CTGGAGCTGC TGTCCGAGGT GCAGCTGCAA 60
CAGTACTTCC TGCGGCTCCG GGATGACCTC AACGTTACCC GCCTGTCCCA CTTTGAGTAT 120
GTCAAGAATG AGGACCTGGA GAAGATTGGC ATGGGCCGGC CTGGCCAGCG GCGGTTGTGG 180
GAGGCTGTGA AGAGGAGAAA GGCCATGTGC AAACGCAAGT CTTGGATGAG CAAGGTGTTC 240
AGTGGAAAGC GACTGGAGGC TGAGTTCCCC CCTCATCACT CTCAGAGCAC CTTCCGGAAG 300
ACGTCACCCA CCCCAGGGGG CCCGGCAGGG GAAGGGCCTC TGCAGAGCCT CACCTGCCTC 360
ATTGGGGAGA AGGACCTGCA TCTATTCGAG AAGCTAGGAG ATGGCTCCTT TGGCGTGGTG 420
CGCAGGGGCG AGTGGGATGC CCCTTCGGGG AAGACGGTGA GTGTGGCTGT GAAGTGCCTG 480
AAGCCTGATG TGCTGAGCCA GCCGGAGGCC ATGGACGACT TCATCCGGGA AGTTAACGCC 540
ATGCACTCGC TTGACCATCG CAACCTCATT CGCCTGTACG GTGTGGTGCT CACGCCGCCC 600
ATGAAGATGG TGACAGAGCT GGCGCCGCTC GGATCGCTGC TGGATCGGCT GCGCAAGCAC 660
CAGGGCCACT TCCTCCTGGG CACCCTGAGC CGCTATGCTG TGCAGGTAGC AGAGGGCATG 720
GGCTACCTGG AGTCTAAGCG CTTCATTCAC CGTGACCTGG CTGCCCGAAA TCTGCTGTTG 780
GCCGCCCGAG ACCTGGTCAA GATCGGGGAC TTCGGGTTGA TGCGTGCACT TCCCCAGAAT 840
GACGACCACT ATGTCATGCA AGAGCATCGC AAGGTGCCCT TTGCCTGGTG TGCTCCTGAG 900
AGCCTGAAGA CACGCACCTT CTCCCATGCC AGTGACACCT GGATGTTTGG GGTCACACTG 960
TGGGAGATGT TCACCTATGG CCAGGAGCCC TGGATTGGCC TCAATGGCAG TCAGATTCTG 1020
CATAAGATTG ACAAGGAGGG AGAGCGTCTG CCACGGCCTG AGGACTGCCC CCAGGATATC 1080
TACAACGTCA TGGTTCAGTG CTGGGCCCAC AAGCCAGAGG ACAGACCCAC CTTTGTGGCC 1140
CTGCGGGACT TCCTGCTGGA GGCCCAGCCC ACGGACATGC GGGCCCTTCA GGACTTTGAG 1200
GAACCAGACA AGCTGCACAT CCAGATGAAC GATGTCATCA CCGTCATTGA GGGAAGCAGG 1260
GCTGAGAATT ACTGGTGGCG TGGGCAGAAC ACACGGACGC TGTGTGTGGG GCCCTTCCCG 1320
CGCAACGTGG TGACCTCCGT GGCTGGCCTG TCGGCCCAGG ACATCAGTCA ACCCCTGCAG 1380
AATAGCTTCA TCCACACGGG ACATGGCGAC AGTGACCCCC GCCACTGCTG GGGCTTCCCC 1440
GACAAGATCG ACGAACTGTA CCTGGGAAAC CCCATGGACC CTCCTGACCT GCTGAGCGTG 1500
GAACTGAGCA CCTCCCGACC CACCCAGCAT CTAGGAAGGG TGAAAAGGGA GCCTCCACCT 1560
CGCCCACCTC AGCCTGCCAT CTTCACTCAG AAGCCAACCT ATGACCCCGT GAGTGAGGAC 1620
CAGGACCCCC TGTCCAGCGA CTTCAAGAGG CTGGGCCTCC GGAAACCAGC CCTGACCCGT 1680
GGGCTGTGGC TAGCGAAGCC CTCGGCTCGG GTCCCGGGCA CCAAGGCGGG TCGCGGTGGT 1740
GGGGGCGAGG TCACACTCAT TGACTTTGGC GAGGAGCCTG TCGTCCCCGC CCCGCGACCC 1800
TGCGCGCTCT CGCTGGCGCA GCTGGCCATG GACGCCTGCT CCTTACTGGA CAAGACCCCG 1860
CCACAGAGCC CCACGCGGGC CCTGCCCCGG CCCCTGCACC CCACGCCTGT GGTGGACTGG 1920
GACGCGCGCC CACTGCCCCC GCCTCCTGCC TACGACGATG TGGCCCAGGA TGAGGATGAC 1980
TTTGAGGTCT GCTCCATCAA CAGCACCCTG GTGGGTGCAG GGGTCTGTGC TGGGCCCAGC 2040
CAGGGTGAAA CCAACTACGC CTTTGTGCCT GAGCAGGCGC AGTTGCTCCC TCCCCTGGAG 2100
GACAATCTGT TCCTCCCACC CCAGGGTGGG AGCAAGCCGC CCAGCTTGGC CCAGACGGCA 2160
GAGATCTTCC AGGCGCTGCA GCAGGAGTGC ATGCGGCAGC TGCAGGTCCC GGCGGGCTCC 2220
CTGGGCCCTT CTCCCGGCCC GGCCCCAGCG GGTGAGGACA AGCCCCAGGT GCCCCCCCGC 2280
GTGCCCATTC CCCCGAGGCC CACTCGCCCA CGTGGCGAGC TGTCGCCGGC CTCCTCAGGT 2340
GAGGAGGAGA TGGGGCGGTG GCCCGGACCG GCCTCCCCTC CCCGGGTGCC TCCCCGGGAG 2400
CCCCTGTCCC CTCAAGGCTC AAGGACCCCT AGCCCCCTGG TACCGCCCGG AAGCTCCCCG 2460
CTGCCGCCCC GGCTCTCCAG CTCACCGGGC AAGACCATGC CCACCACCCA AAGCTTTGCC 2520
TCAGACCCCA AGTATGCCAC ACCCCAAGTG ATTCAGGCGC CTGGCCCGCG GGCTGGTCCC 2580
TGCATCCTGC CCATTGTCCG CGACGGCAAG AAGGTCAGCA GCACCCACTA TTACCTGCTG 2640
CCTGAGCGCC CACCCTACCT GGAGCGCTAT CAGCGCTTCC TGCGTGAGGC GCAGAGCCCC 2700
GAAGAGCCGG CCCCCCTGCC TGGGCCCCTG CTGCTGCCCC CGCCCAGCAC CCCAGCCCCT 2760
GCCGCCCCCA CGGCCACTGT TCGACCGATG CCCCAGGCTG CCCCAGACCC CAAGGCCAAC 2820
TTCTCCACCA ACAACAGTAA CCCAGGGGCC CGGCCACCAG CCCTGAGGGC CACGGCGCGG 2880
CTGCCAGACA AGATCCAGAT GCTGCAGGCC ATGGTGCATG GGGTGACCAC AGAGGAGTGC 2940
CAGGCAGCCC TGCAGAGCCA CAGCTGGAGC GTGCAGAGGG CTGCCCAGTA TCTGAAGGTG 3000
GAGCAGCTCT TCGGGTTGGG CCTGCGGCCG CGAAGCGAGT GCCACAAAGT GCTGGAGCTG 3060
TGCGACTGGA ACCTGGAGCA AGCCGGCTGT GGCCCGGCCC ACCACAAGTG A 3111
Domain Profile
S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60
         +l eklG+Gsfgvv+rgeW+apsgk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h
Q: 127   HLFEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  186
         5789***************************************99***************
S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120
         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle
Q: 187   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  244
         ***********************************9..9*********************
S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180
         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t
Q: 245   SKRFIHRDLAARNLLLAARDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  304
         ************************************************************
S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240
         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++
Q: 305   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVM  364
         ************************************************************
S: 241   lkcWakkpadrpkfsalkekl  261
         ++cWa+kp+drp+f+al+++l
Q: 365   VQCWAHKPEDRPTFVALRDFL  385
         ******************986
Domain Sequence
(FASTA)
HLFEKLGDGS FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60
RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120
RFIHRDLAAR NLLLAARDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180
FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDIYNVMVQ 240
CWAHKPEDRP TFVALRDFL 259
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00334
EKS-BOT-00345
EKS-CAE-00280
EKS-CAJ-00351
EKS-CAF-00350
EKS-CAP-00379
EKS-CII-00192
EKS-CIS-00099
EKS-DAR-00712
EKS-DRM-00169
EKS-EQC-00337
EKS-FEC-00333
EKS-GAA-00426
EKS-GOG-00342
EKS-HOS-00352
EKS-ICT-00326
EKS-LAC-00357
EKS-LOA-00354
EKS-MAM-00346
EKS-MEG-00282
EKS-MOD-00338
EKS-MUM-00377
EKS-MUP-00340
EKS-MYL-00346
EKS-NOL-00315
EKS-OCP-00064
EKS-ORN-00449
EKS-ORC-00324
EKS-ORL-00414
EKS-OTG-00350
EKS-PES-00305
EKS-POA-00335
EKS-PTV-00086
EKS-RAN-00360
EKS-SUS-00305
EKS-TAG-00421
EKS-TAR-00449
EKS-TEN-00446
EKS-XET-00440
EKS-XIM-00439
Gene Ontology
GO:0030424; C:axon
GO:0030136; C:clathrin-coated vesicle
GO:0005905; C:coated pit
GO:0030425; C:dendrite
GO:0070436; C:Grb2-EGFR complex
GO:0030426; C:growth cone
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369; P:regulation of clathrin-mediated endocytosis
KEGG
InterPros
IPR015116; GTPase_binding.
IPR021619; Inhibitor_Mig-6.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF09027; GTPase_binding; 1.
PF11555; Inhibitor_Mig-6; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50002; SH3; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013