EKS-AIM-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	3.8E-188	435	714	280

Status

Unreviewed

Ensembl Protein

ENSAMEP00000004242

UniProt Accession

G1LBG8;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003986	ENSAMEP00000004242	ENSAMET00000004412

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

QGPLNSESSN QSLCSVGSLS DKEVETPEKK QNDQRNRKRK AEPYETSQGK GTPRGHKISD 60

YFEFAGGSGP GTSPGRSVPP VARSSPQHSL SNPLPRRVEQ PLYGLDGSAA KDVSEEQSAL 120

PTLMSVMLAK PRLDTEQLAQ RGAGLCFTFV SAQQNSPSST GSGNTEHSGS SQKQISIQHR 180

QTQSDLTIEK ISALENSKNS DLEKKEGRID DLLRANCDLR RQIDEQQKML EKYKERLNRC 240

VTMSKKLLIE KSKQEKMACR DKSMQDRLRL GHFTTVRHGA SFTEQWTDGY AFQNLIKQQE 300

RINSQREEIE RQRKMLAKRK PPAMGQAPPA TNEQKQRKSK TNGAENETPD LMHTTISNNL 360

LGFLPLSSRL TLAEYHEQEE IFKLRLGHLK KEEAEIQAEL ERLERVRNLH IRELKRIHNE 420

DNSQFKDHPT LNDRYLLLHL LGRGGFSEVY KAFDLTEQRY VAVKIHQLNK NWRDEKKENY 480

HKHACREYRI HKELDHPRIV KLYDYFSLDT DSFCTVLEYC EGNDLDFYLK QHKLMSEKEA 540

RSIIMQIVNA LKYLNEIKPP IIHYDLKPGN ILLVNGTACG EIKITDFGLS KIMDDDSYNS 600

VDGMELTSQG AGTYWYLPPE CFVVGKEPPK ISNKVDVWSV GVIFYQCLYG RKPFGHNQSQ 660

QDILQENTIL KATEVQFPPK PVVTPEAKAF IRRCLAYRKE DRIDVQQLAC DPYLLPHIRK 720

SVSTSSPAGA AIASTSGASN NSSSN 745

Nucleotide Sequence
(FASTA)

CAGGGGCCGC TCAATAGTGA GTCTTCCAAC CAGAGCTTGT GCAGCGTGGG GTCCTTGAGT 60

GATAAAGAAG TAGAGACTCC TGAGAAAAAA CAGAATGACC AGCGAAACCG GAAAAGAAAA 120

GCTGAACCAT ATGAAACTAG CCAAGGGAAA GGCACTCCTA GGGGACATAA AATTAGTGAT 180

TACTTTGAGT TTGCTGGGGG AAGCGGGCCA GGAACCAGCC CTGGCAGAAG TGTTCCACCA 240

GTTGCACGAT CCTCACCGCA ACATTCCTTA TCCAATCCCT TACCGCGGCG AGTAGAACAG 300

CCCCTCTATG GCTTAGATGG CAGCGCTGCA AAGGACGTGT CAGAGGAGCA GTCCGCTCTG 360

CCCACCCTGA TGTCCGTGAT GCTCGCAAAA CCTCGGCTGG ACACGGAGCA GCTGGCACAG 420

AGGGGAGCTG GCCTCTGCTT CACTTTCGTT TCGGCTCAGC AAAACAGTCC ATCCTCTACG 480

GGATCTGGCA ACACAGAGCA TTCCGGCAGC TCCCAAAAAC AGATCTCCAT CCAGCACAGA 540

CAGACCCAGT CTGACCTCAC AATAGAAAAA ATATCTGCAC TAGAAAACAG TAAGAATTCT 600

GACTTAGAAA AGAAGGAGGG AAGAATAGAT GATTTGTTAA GAGCCAACTG CGATTTGAGG 660

CGGCAGATTG ACGAACAGCA AAAGATGCTA GAGAAGTACA AAGAGCGATT AAATCGATGT 720

GTGACAATGA GCAAGAAACT CCTTATAGAA AAGTCAAAAC AAGAGAAGAT GGCGTGTAGA 780

GATAAGAGCA TGCAAGACCG CTTGAGATTG GGCCACTTTA CCACTGTTCG ACATGGAGCC 840

TCTTTTACTG AACAATGGAC AGATGGTTAT GCTTTCCAGA ACCTTATCAA GCAGCAGGAA 900

AGGATAAATT CACAGAGGGA AGAGATAGAA AGACAACGGA AAATGTTAGC GAAGCGGAAA 960

CCTCCTGCCA TGGGACAGGC CCCTCCAGCA ACCAATGAGC AGAAACAGAG GAAAAGCAAG 1020

ACCAACGGAG CTGAAAATGA AACTCCTGAT CTCATGCACA CTACGATTTC AAATAATTTA 1080

TTGGGATTTC TACCATTATC TTCCAGGTTA ACATTAGCAG AATACCATGA ACAAGAAGAA 1140

ATCTTCAAAC TCAGATTAGG TCATCTTAAA AAGGAAGAAG CAGAGATCCA GGCAGAGCTG 1200

GAAAGGCTAG AAAGGGTTAG AAATCTACAT ATCAGGGAAC TAAAAAGGAT ACATAATGAA 1260

GATAATTCAC AATTTAAAGA TCACCCAACG CTCAATGACA GATACTTGTT GTTACATCTG 1320

TTGGGTAGAG GCGGTTTCAG TGAAGTTTAC AAGGCATTTG ATCTAACAGA ACAAAGATAT 1380

GTAGCTGTGA AAATTCACCA GTTAAATAAA AACTGGAGAG ATGAGAAAAA GGAGAATTAC 1440

CACAAGCATG CATGTAGGGA ATACCGGATT CACAAAGAAC TGGATCATCC CAGGATAGTT 1500

AAGCTGTATG ATTACTTTTC ACTGGACACT GACTCGTTTT GTACAGTATT AGAATACTGT 1560

GAGGGAAATG ATCTGGACTT CTACCTGAAA CAGCACAAAT TAATGTCGGA GAAAGAGGCC 1620

CGGTCCATTA TCATGCAGAT TGTGAATGCT TTAAAGTACT TAAATGAAAT AAAACCTCCC 1680

ATCATACACT ATGACCTCAA ACCAGGTAAT ATTCTTTTAG TAAATGGTAC AGCATGTGGA 1740

GAGATAAAAA TCACGGATTT TGGTCTTTCC AAGATCATGG ATGACGATAG CTACAATTCA 1800

GTGGATGGCA TGGAGCTAAC GTCACAAGGT GCTGGTACTT ACTGGTATTT ACCACCAGAG 1860

TGTTTTGTGG TTGGGAAAGA GCCACCAAAG ATCTCAAATA AAGTTGACGT CTGGTCAGTG 1920

GGTGTGATCT TCTACCAGTG TCTTTATGGA AGGAAGCCTT TTGGCCACAA CCAATCCCAG 1980

CAAGACATTT TACAAGAAAA TACTATTCTT AAAGCTACTG AAGTGCAGTT CCCGCCAAAG 2040

CCAGTAGTAA CACCAGAAGC AAAGGCGTTT ATTCGACGAT GCTTAGCCTA CCGAAAGGAG 2100

GACCGCATCG ATGTCCAGCA GCTGGCCTGT GACCCCTACT TGCTGCCTCA CATCCGAAAG 2160

TCAGTCTCCA CGAGTAGCCC TGCTGGAGCT GCTATCGCGT CGACCTCGGG GGCGTCCAAT 2220

AACAGTTCTT CGAATTGA 2238

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 435   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  494

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 495   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  554

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 555   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  614

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 615   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  674

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 675   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  714

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013