EKS-AIM-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Trk	561.8	2.2E-169	554	821	268

Status

Unreviewed

Ensembl Protein

ENSAMEP00000004235

UniProt Accession

G1LBG1;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

NTRK2

Gene Synonyms/Alias

NTRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000003994	ENSAMEP00000004235	ENSAMET00000004405

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

838

Protein Sequence
(FASTA)

MSSWTRWHGP AMARLWGFCW LVVGFWRAAL ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP 60

NSADPENITE IYIANQKRLE IINEDDVEAY AGLKNLTIVD SGLKFVAHKA FLKNSNLQHI 120

NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQETKSSPE TQDLYCLNES 180

SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNLYW DVGNLVSKHM 240

NETSHMQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH 300

WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYK 360

LVAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST 420

DVADKSGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKDFSWF GFGKVKSRQG 480

VGPASVISND DDSASPLHHI SNGSNTPSSS EGGPDAVIIG MTKIPVIENP QYFGITNSQL 540

KPDTFVQHIK RHNIVLKREL GEGAFGKVFL AECYNLCPEQ DKILVAVKTL KDASDNARKD 600

FHREAELLTN LQHEHIVKFY GVCVEGDPLI MVFEYMKHGD LNKFLRAHGP DAVLMAEGNP 660

PTELTQSQML HIAQQIAAGM VYLASQHFVH RDLATRNCLV GENLLVKIGD FGMSRDVYST 720

DYYRVGGHTM LPIRWMPPES IMYRKFTTES DVWSLGVVLW EIFTYGKQPW YQLSNNEVIE 780

CITQGRVLQR PRTCPQEVYE LMLGCWQREP HMRKNIKGIH TLLQNLAKAS PVYLDILG 838

Nucleotide Sequence
(FASTA)

ATGTCGTCCT GGACGAGGTG GCATGGACCC GCCATGGCGC GGCTCTGGGG CTTCTGCTGG 60

CTGGTTGTGG GCTTCTGGAG GGCCGCTCTC GCCTGTCCCA CGTCCTGCAA ATGCAGTGCC 120

TCTCGGATCT GGTGCAGCGA CCCTTCTCCG GGCATCGTGG CGTTTCCGAG GTTGGAGCCT 180

AACAGTGCAG ACCCTGAGAA CATCACTGAA ATTTACATTG CCAATCAGAA AAGGTTGGAA 240

ATCATCAACG AAGATGACGT TGAAGCTTAT GCAGGACTGA AAAACCTGAC AATCGTGGAT 300

TCTGGATTAA AATTTGTGGC TCATAAAGCA TTTCTGAAAA ACAGCAACTT ACAGCACATC 360

AATTTTACCC GAAATAAACT GACGAGCTTG TCTAGGAAAC ATTTTCGTCA CCTTGATTTG 420

TCTGAGCTGA TCCTGGTGGG CAATCCATTT ACATGCTCCT GTGACATTAT GTGGATCAAG 480

ACTCTTCAGG AGACTAAATC CAGCCCAGAA ACTCAGGATT TGTACTGCCT AAATGAAAGC 540

AGCAAGAATA TTCCCCTGGC AAACCTGCAG ATACCCAATT GTGGTTTACC ATCAGCAAAT 600

CTGGCCGCAC CTAACCTCAC CGTGGAGGAG GGAAAGTCTA TCACATTATC TTGTAGTGTT 660

GCAGGCGATC CAGTTCCGAA TTTGTACTGG GATGTTGGTA ATCTGGTTTC CAAACATATG 720

AATGAAACAA GCCACATGCA GGGCTCCTTA AGGATAACTA ACATTTCATC TGATGACAGT 780

GGAAAGCAAA TCTCCTGTGT GGCAGAAAAT CTTGTAGGAG AAGACCAAGA TTCTGTCAAC 840

CTCACTGTAC ATTTTGCTCC AACTATCACA TTTCTCGAAT CTCCAACCTC AGACCACCAC 900

TGGTGCATTC CATTCACTGT GAAAGGCAAC CCCAAACCAG CGCTTCAGTG GTTCTATAAC 960

GGGGCCATAT TGAATGAGTC CAAATACATC TGTACTAAAA TCCATGTTAC CAATCACACG 1020

GAGTACCATG GCTGCCTCCA GCTGGATAAT CCCACTCACA TGAACAATGG CGACTACAAG 1080

TTAGTAGCCA AGAATGAGTA TGGGAAGGAT GAGAAACAGA TTTCTGCTCA CTTCATGGGC 1140

TGGCCCGGAA TCGACGATGG TGCCAACCCA AATTATCCTG ATGTAATTTA TGAAGATTAT 1200

GGGACTGCAG CAAATGACAT TGGGGACACC ACGAACAGAA GTAACGAAAT CCCTTCCACA 1260

GATGTTGCTG ACAAAAGCGG TCGGGAACAT CTCTCGGTCT ATGCTGTGGT GGTAATTGCG 1320

TCTGTGGTGG GATTTTGTCT GCTGGTGATG TTGTTTCTGC TGAAGTTGGC AAGACACTCC 1380

AAGTTTGGCA TGAAAGATTT CTCATGGTTT GGATTTGGGA AAGTAAAATC AAGACAAGGT 1440

GTTGGCCCAG CTTCAGTTAT CAGCAATGAC GATGACTCTG CCAGCCCACT CCACCACATC 1500

TCCAATGGGA GTAACACCCC ATCATCTTCA GAGGGCGGCC CCGATGCCGT CATTATTGGA 1560

ATGACCAAGA TCCCTGTCAT TGAAAATCCC CAGTACTTTG GCATCACTAA CAGTCAGCTC 1620

AAGCCAGACA CATTTGTTCA GCACATCAAG AGACATAACA TTGTTCTGAA AAGGGAGCTA 1680

GGCGAAGGAG CCTTTGGAAA AGTTTTCCTA GCTGAATGCT ATAACCTCTG TCCTGAGCAG 1740

GACAAGATCT TGGTGGCAGT GAAGACGCTG AAGGACGCCA GCGACAACGC ACGCAAGGAC 1800

TTCCATCGCG AGGCGGAGCT GCTGACCAAC CTCCAGCACG AGCACATCGT CAAATTCTAC 1860

GGAGTCTGCG TGGAGGGCGA CCCGCTCATC ATGGTCTTCG AGTACATGAA GCACGGGGAC 1920

CTCAACAAGT TCCTCAGGGC CCATGGGCCT GACGCCGTGC TGATGGCCGA AGGCAACCCG 1980

CCAACAGAGT TGACCCAGTC CCAGATGCTG CACATTGCCC AACAGATAGC TGCAGGCATG 2040

GTCTACCTGG CGTCCCAGCA CTTCGTGCAC CGAGATCTGG CCACTCGCAA CTGCCTGGTC 2100

GGCGAGAACC TCCTGGTGAA AATCGGGGAC TTCGGGATGT CCCGGGACGT GTACAGCACC 2160

GACTACTACA GGGTCGGTGG CCACACAATG CTGCCCATCC GCTGGATGCC GCCCGAGAGC 2220

ATCATGTACA GGAAGTTCAC CACAGAAAGC GATGTCTGGA GCCTGGGCGT CGTGCTGTGG 2280

GAGATCTTCA CGTACGGCAA GCAGCCCTGG TATCAGCTGT CCAACAACGA GGTGATAGAA 2340

TGCATCACTC AGGGCCGAGT CTTGCAGCGA CCTAGAACGT GCCCCCAGGA GGTCTACGAG 2400

TTGATGCTGG GGTGCTGGCA GCGAGAGCCC CATATGAGGA AGAACATCAA GGGCATCCAC 2460

ACCCTTCTCC AGAACTTGGC CAAGGCATCT CCGGTCTACC TGGATATTCT AGGC 2514

Domain Profile

S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60

         ivlkrelgegafgkvflaecynl+pe+dk+lvavk+lkdas++arkdf+reaelltnlqh

Q: 554   IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH  613

         89**********************************************************

S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegepkgelglsqllaia  120

         ehivk+yGvc+egdpl++vfeymkhGdlnkflrahgpda+l++eg+p++el++sq+l+ia

Q: 614   EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIA  673

         ************************************************************

S: 121   kqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtmlpi  180

         +qiaaG+vylasqhfvhrdlatrnclvge+llvkigdfgmsrdvystdyyrvgg+tmlpi

Q: 674   QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI  733

         ************************************************************

S: 181   rwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerpra  240

         rw+ppesi+yrkfttesdvwslGvvlwei+tyGkqp+yqlsn+eviecitqGrvl+rpr+

Q: 734   RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRT  793

         ************************************************************

S: 241   cpkevydlmlgcwqrepqkrlnikeiya  268

         cp+evy+lmlgcwqrep++r+nik i++

Q: 794   CPQEVYELMLGCWQREPHMRKNIKGIHT  821

         **************************97

Domain Sequence
(FASTA)

IVLKRELGEG AFGKVFLAEC YNLCPEQDKI LVAVKTLKDA SDNARKDFHR EAELLTNLQH 60

EHIVKFYGVC VEGDPLIMVF EYMKHGDLNK FLRAHGPDAV LMAEGNPPTE LTQSQMLHIA 120

QQIAAGMVYL ASQHFVHRDL ATRNCLVGEN LLVKIGDFGM SRDVYSTDYY RVGGHTMLPI 180

RWMPPESIMY RKFTTESDVW SLGVVLWEIF TYGKQPWYQL SNNEVIECIT QGRVLQRPRT 240

CPQEVYELML GCWQREPHMR KNIKGIHT 268

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005887	; C:integral to plasma membrane
GO:0043195	; C:terminal button
GO:0005524	; F:ATP binding
GO:0060175	; F:brain-derived neurotrophic factor-activated receptor activity
GO:0035584	; P:calcium-mediated signaling using intracellular calcium source
GO:0021954	; P:central nervous system neuron development
GO:0021987	; P:cerebral cortex development
GO:0007631	; P:feeding behavior
GO:0014047	; P:glutamate secretion
GO:0007612	; P:learning
GO:0060291	; P:long-term synaptic potentiation
GO:0042490	; P:mechanoreceptor differentiation
GO:2000811	; P:negative regulation of anoikis
GO:0001764	; P:neuron migration
GO:0048709	; P:oligodendrocyte differentiation
GO:0048935	; P:peripheral nervous system neuron development
GO:0010628	; P:positive regulation of gene expression
GO:0010976	; P:positive regulation of neuron projection development
GO:0051896	; P:regulation of protein kinase B signaling cascade
GO:0032314	; P:regulation of Rac GTPase activity
GO:0046548	; P:retinal rod cell development
GO:0001570	; P:vasculogenesis

KEGG

aml:100477127

;

InterPros

IPR000483	; Cys-rich_flank_reg_C.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000372	; LRR-contain_N.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020455	; Tyr_kin_neurotrophic_rcpt_2.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR020777	; Tyr_kinase_NGF_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF07679	; I-set; 2.
PF01462	; LRRNT; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 1.
SM00082	; LRRCT; 1.
SM00013	; LRRNT; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR01939	; NTKRECEPTOR.
PR01941	; NTKRECEPTOR2.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013