EKS-AIM-00235

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00235

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	250.9	1.2E-74	2	183	182

Status

Unreviewed

Ensembl Protein

ENSAMEP00000004533

UniProt Accession

G1LCA8;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004288	ENSAMEP00000004533	ENSAMET00000004716

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

791

Protein Sequence
(FASTA)

KTACYLNTHS YSFKELLDYL ANHGRLNESE ARRKFWQILS AVDYCHGRKI VHRDLKAENL 60

LLDSNMNIKL ADFGFGNFFK SGELLATWCG SPPYAAPEVF EGQQYEGPQL DIWSMGVVLY 120

VLVCGALPFD GPTLPILRQR VLEGRFRIPY FMSEDCEHLI RRMLVLDPSK RLTIAQIKEH 180

KWMLVEVPVQ RPVLYPQGQE NEPSIGEFNE QVLRLMHSLG IDQQKTIESL QNKSYNHFAA 240

IYYLLVERLK SHRSSFPVEQ RLDARQRRPS TVAEQTVAKA QTVGLPVTMH SPNMRLMRSA 300

LLPQASNVEA FSFPASGCQA EAAFMEEECV DTPKVNGCLL DPVPPVLVRK GCQSLPSNMM 360

ETSIDEGLET EGEAEEDPSQ AFDAFQSTRS GQRRHTLSEV TNQLVVVPGS GKIFSMSDNP 420

SLDSVDSEYD MGSVQRDLNF LEDNPSLKDI MLANQPSPRM TSPFISLRPA NPAMQALSSQ 480

KREAHNRSPV SFREGRRASD TSLTQGIVAF RQHLQNLART KGILELNKVQ LLYEQIGPEA 540

DPDVAPAAQL QDLAGSCPQE EVSQQQKTVS AVASSVRPQL SPRQSLEAQY LQHRLQKPSL 600

LSKAQNTCQL YCKEPPRSLE QQLQEHRLQQ KRLFLQKQSQ LQAYFNQMQI AESSYPPSQQ 660

LPLPRQETST PSPQPPPFSL PQPLQQPPPP PPPPPPPQQA GAAPAPLPFS YQTCELPGAA 720

SPEPDYPSPC QYPMDGAPQS GLAAQDCPRS SGLQEAPSSY DPLALAEFPG LFDCEMLEAV 780

DPQHSGYVLV N 791

Nucleotide Sequence
(FASTA)

AAAACAGCAT GTTACTTGAA CACTCACTCC TATTCATTTA AAGAGCTTTT AGACTACCTT 60

GCTAATCACG GCCGATTAAA TGAGTCTGAG GCCAGGCGCA AATTCTGGCA AATCCTGTCT 120

GCTGTTGATT ATTGTCATGG ACGGAAGATC GTGCACCGTG ATCTCAAGGC TGAAAATCTC 180

CTGCTGGATA GCAACATGAA CATCAAGCTA GCAGATTTCG GTTTTGGAAA TTTCTTTAAA 240

AGTGGTGAAC TGCTGGCAAC ATGGTGTGGC AGCCCCCCTT ATGCAGCCCC AGAAGTCTTT 300

GAAGGGCAGC AGTATGAAGG ACCACAGCTG GATATTTGGA GCATGGGAGT TGTTCTTTAT 360

GTCCTTGTCT GTGGAGCTCT GCCTTTTGAT GGACCGACTC TTCCAATTTT GAGGCAGAGA 420

GTTTTAGAAG GAAGATTCCG GATTCCATAT TTCATGTCAG AAGATTGTGA GCACCTTATT 480

CGAAGGATGT TGGTCCTAGA CCCGTCCAAA CGGCTAACGA TAGCTCAAAT CAAGGAGCAT 540

AAATGGATGC TCGTAGAAGT TCCTGTACAG AGACCTGTTC TTTATCCACA AGGGCAAGAA 600

AATGAGCCAT CCATTGGGGA ATTTAATGAA CAGGTTCTGC GGTTGATGCA CAGCCTTGGA 660

ATAGATCAGC AGAAAACCAT TGAGTCTTTG CAGAACAAGA GCTATAACCA CTTTGCTGCC 720

ATTTATTACT TGTTGGTGGA GCGCCTGAAA TCACATCGGA GCAGTTTTCC CGTGGAGCAG 780

AGACTCGATG CCCGCCAGCG GCGGCCTAGC ACCGTGGCTG AACAAACAGT TGCCAAGGCG 840

CAAACGGTGG GGCTCCCGGT GACCATGCAT TCACCAAACA TGCGGCTGAT GCGGTCTGCC 900

CTCCTCCCAC AGGCGTCCAA CGTGGAGGCC TTTTCATTCC CAGCATCCGG CTGCCAGGCG 960

GAAGCCGCAT TTATGGAAGA AGAGTGTGTC GACACGCCAA AGGTAAATGG CTGTCTTCTG 1020

GACCCCGTGC CTCCTGTCCT GGTGAGGAAG GGGTGCCAGT CGTTGCCCAG CAACATGATG 1080

GAGACCTCCA TCGATGAGGG GCTGGAGACA GAGGGAGAGG CTGAGGAAGA TCCCAGTCAG 1140

GCCTTCGATG CATTCCAGTC CACGCGCAGC GGGCAGAGAC GGCACACTCT GTCAGAAGTG 1200

ACCAATCAGC TGGTCGTGGT GCCTGGTTCA GGGAAAATTT TCTCCATGAG TGACAATCCC 1260

TCCCTTGACA GTGTGGACTC TGAGTATGAT ATGGGGTCTG TTCAGAGGGA CCTGAACTTT 1320

CTGGAGGACA ACCCTTCCCT TAAGGACATC ATGTTAGCCA ATCAGCCCTC CCCACGCATG 1380

ACGTCTCCCT TCATCAGCCT GAGACCTGCC AACCCAGCCA TGCAGGCTTT GAGCTCCCAG 1440

AAGCGAGAGG CCCACAACAG GTCGCCAGTG AGCTTCAGAG AGGGCCGCAG GGCGTCAGAT 1500

ACCTCCCTCA CCCAAGGAAT TGTGGCATTT AGACAACATC TTCAGAATCT GGCCAGAACC 1560

AAAGGAATCT TAGAGTTGAA CAAAGTGCAG CTGCTGTATG AACAAATAGG ACCCGAGGCA 1620

GACCCTGACG TGGCACCAGC GGCTCAGCTC CAGGACCTCG CCGGCAGTTG CCCTCAGGAG 1680

GAAGTCTCTC AGCAGCAGAA GACAGTCTCT GCTGTGGCCA GCAGCGTGCG TCCCCAGCTC 1740

TCCCCGCGCC AGAGCCTGGA GGCCCAGTAC CTACAGCATA GACTCCAGAA GCCCAGCCTT 1800

CTGTCAAAAG CCCAGAACAC CTGTCAGCTT TATTGTAAAG AACCACCACG GAGCCTCGAA 1860

CAGCAGCTGC AGGAACACAG ACTCCAACAG AAGCGACTCT TTCTCCAGAA ACAGTCTCAG 1920

CTGCAGGCGT ACTTTAATCA GATGCAGATA GCCGAGAGCT CGTACCCACC GAGTCAGCAG 1980

CTGCCCCTGC CCCGCCAGGA GACATCCACG CCGTCCCCGC AGCCCCCGCC CTTCAGCCTG 2040

CCCCAGCCCC TTCAGCAGCC GCCGCCACCG CCGCCACCGC CGCCCCCCCC GCAGCAGGCA 2100

GGAGCCGCCC CGGCCCCCTT ACCGTTCTCC TATCAGACTT GCGAGCTGCC AGGGGCCGCC 2160

TCCCCAGAGC CAGACTACCC CTCGCCGTGT CAGTACCCCA TGGATGGAGC CCCGCAGAGC 2220

GGCCTAGCAG CACAGGACTG TCCCCGGAGC TCGGGACTGC AGGAGGCCCC CTCCAGCTAC 2280

GACCCTCTTG CCCTCGCAGA GTTCCCCGGA CTCTTCGATT GTGAAATGCT GGAGGCTGTG 2340

GACCCACAGC ACAGTGGCTA CGTCCTGGTA AATTAA 2376

Domain Profile

S: 71    kklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNll  130

         + +yl +  +s +eL+dy+ ++grl+e+ear+ f q++sav+Y+h ++ivHrDlK+eNll

Q: 2     TACYLNTHSYSFKELLDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLL  61

         568899999999************************************************

S: 131   ldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLya  190

         ld+++nik+aDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D+Ws+GvvLy+

Q: 62    LDSNMNIKLADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYV  121

         ************************************************************

S: 191   lvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhe  250

         lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR+ti +i++h+

Q: 122   LVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHK  181

         ************************************************************

S: 251   wl  252

w+

Q: 182   WM  183

*8

Domain Sequence
(FASTA)

TACYLNTHSY SFKELLDYLA NHGRLNESEA RRKFWQILSA VDYCHGRKIV HRDLKAENLL 60

LDSNMNIKLA DFGFGNFFKS GELLATWCGS PPYAAPEVFE GQQYEGPQLD IWSMGVVLYV 120

LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR LTIAQIKEHK 180

WM 182

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013