EKS-AIM-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.4	1.8E-140	184	471	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000004618

UniProt Accession

G1LCI9;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004381	ENSAMEP00000004618	ENSAMET00000004805

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

FFLIESCSLF PALQCFCHLC TKDNFTCVTD GLCFVSVTET TDKVIHNSMC IAEIDLIPRD 60

RPFVCAPSSK TGSVTTTYCC NQDHCNKIEL PTVGKPSSGL GPVELAAVIA GPVCFVCISL 120

MLMVYICHNR TVIHHRVPNE EDPSLDRPFI SEGTTLKDLI YDMTTSGSGS GLPLLVQRTI 180

ARTIVLQESI GKGRFGEVWR GKWRGEEVAV KIFSSREERS WFREAEIYQT VMLRHENILG 240

FIAADNKDNG TWTQLWLVSD YHEHGSLFDY LNRYTVTVEG MIKLALSTAS GLAHLHMEIV 300

GTQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVRHDSA TDTIDIAPNH RVGTKRYMAP 360

EVLDDSINMK HFESFKRADI YAMGLVFWEI ARRCSIGGIH EDYQLPYYDL VPSDPSVEEM 420

RKVVCEQKLR PNIPNRWQSC EALRVMAKIM RECWYANGAA RLTALRIKKT LSQLSQQEGI 480

KM 482

Nucleotide Sequence
(FASTA)

TTTTTTCTAA TAGAATCTTG TTCTCTTTTT CCAGCATTAC AGTGTTTCTG CCACCTTTGT 60

ACAAAAGATA ATTTTACGTG TGTGACAGAT GGGCTCTGCT TTGTCTCTGT CACAGAGACC 120

ACAGACAAAG TTATACACAA TAGCATGTGT ATAGCTGAAA TTGACCTAAT TCCTCGAGAC 180

AGACCATTTG TATGTGCACC GTCTTCAAAA ACTGGGTCTG TTACTACAAC CTATTGCTGC 240

AACCAGGACC ATTGCAATAA AATAGAACTC CCAACTGTTG GAAAGCCATC ATCTGGCCTT 300

GGCCCCGTCG AATTGGCAGC TGTCATTGCT GGACCAGTCT GCTTTGTCTG CATCTCGCTC 360

ATGTTGATGG TTTATATCTG CCATAACCGT ACTGTCATTC ACCATCGAGT GCCAAATGAA 420

GAGGATCCTT CCTTAGATCG TCCTTTTATT TCAGAGGGCA CTACATTAAA AGATTTAATT 480

TATGATATGA CGACATCAGG TTCTGGATCA GGTTTACCAT TGCTTGTTCA GAGAACAATT 540

GCAAGAACTA TTGTGTTACA AGAAAGTATT GGCAAAGGTC GATTTGGAGA AGTTTGGCGA 600

GGAAAGTGGA GAGGAGAAGA AGTTGCTGTT AAAATATTCT CCTCTAGAGA AGAGCGCTCA 660

TGGTTCCGTG AGGCAGAGAT TTATCAGACC GTAATGTTAC GTCATGAAAA CATCTTGGGA 720

TTTATAGCAG CAGACAATAA AGACAATGGT ACATGGACTC AGCTCTGGTT GGTGTCAGAT 780

TATCATGAGC ATGGATCCCT TTTTGATTAT TTGAACAGAT ACACAGTTAC TGTGGAAGGA 840

ATGATAAAAC TCGCTTTGTC CACAGCAAGT GGACTTGCCC ATCTCCACAT GGAGATCGTT 900

GGTACCCAAG GGAAACCAGC CATTGCTCAT AGAGATTTGA AATCCAAGAA TATCTTGGTA 960

AAGAAGAATG GAACTTGCTG TATTGCAGAC TTAGGACTGG CAGTGAGACA CGATTCGGCC 1020

ACAGATACGA TTGATATTGC TCCAAATCAC AGAGTGGGAA CAAAAAGGTA CATGGCCCCT 1080

GAAGTTCTAG ATGATTCCAT AAATATGAAA CACTTTGAAT CCTTCAAACG TGCCGACATC 1140

TATGCAATGG GCTTAGTATT CTGGGAAATA GCTCGACGAT GTTCCATTGG TGGAATTCAT 1200

GAAGATTACC AGCTGCCTTA TTATGATCTT GTACCTTCTG ATCCGTCAGT TGAAGAAATG 1260

AGAAAAGTTG TTTGTGAACA GAAGTTAAGG CCAAATATTC CAAACAGATG GCAGAGTTGT 1320

GAAGCCCTGA GGGTAATGGC TAAAATTATG AGAGAATGTT GGTATGCCAA CGGAGCAGCG 1380

AGGCTTACGG CTTTGCGGAT TAAGAAAACA TTGTCACAAC TCAGTCAACA GGAAGGCATC 1440

AAAATGTAG 1449

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 184   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  243

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 244   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  303

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 304   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  361

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 362   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  420

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 421   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  471

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0001525	; P:angiogenesis
GO:0009952	; P:anterior/posterior pattern specification
GO:0048844	; P:artery morphogenesis
GO:0001824	; P:blastocyst development
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0043542	; P:endothelial cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0008354	; P:germ cell migration
GO:0007507	; P:heart development
GO:0006917	; P:induction of apoptosis
GO:0001822	; P:kidney development
GO:0002088	; P:lens development in camera-type eye
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0048663	; P:neuron fate commitment
GO:0060021	; P:palate development
GO:0060017	; P:parathyroid gland development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0009791	; P:post-embryonic development
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0048538	; P:thymus development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013