EKS-AIM-00167

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00167

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	433.2	4.0E-130	180	450	271

Status

Unreviewed

Ensembl Protein

ENSAMEP00000004924

UniProt Accession

G1LDE2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCI

Gene Synonyms/Alias

PRKCI;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004662	ENSAMEP00000004916	ENSAMET00000005113
ENSAMEG00000004662	ENSAMEP00000004924	ENSAMET00000005121

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

GDPCTVSSQL ELEEAFRLYE LNKDSELLIH VFPCVPERPG MPCPGEDKSI YRRGARRWRK 60

LYCANGHTFQ AKRFNRRAHC AICTDRIWGL GRQGYKCINC KLLVHKKCHK LVTIECGRHS 120

MPPEPMMPMD QSSMHSDHAQ TVIPYNPSSH ESLDQVGEEK EAMNTRESGK ASSSLGLQDF 180

DLLRVIGRGS YAKVLLVRLK KTDRIYAMKV VKKELVNDDE DIDWVQTEKH VFEQASNHPF 240

LVGLHSCFQT ESRLFFVIEY VNGGDLMFHM QRQRKLPEEH ARFYSAEISL ALNYLHERGI 300

IYRDLKLDNV LLDSEGHIKL TDYGMCKKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYEGF 360

SVDWWALGVL MFEMMAGRSP FDIVGSSDNP DQNTEDYLFQ VILEKQIRIP RSLSVKAASV 420

LKSFLNKDPK ERLGCHPQTG FADIQGHPFF RNVDWDMMEQ KQVVPPFKPN ISGEFGLDNF 480

DSQFTNEPVQ LTPDDDDIVR KIDQSEFEGF EYINPLLMSA EECV 524

Nucleotide Sequence
(FASTA)

GGAGACCCGT GTACAGTATC ATCTCAGTTG GAGTTAGAAG AAGCCTTTAG GCTTTATGAG 60

CTAAACAAGG ATTCTGAGCT CTTGATTCAT GTCTTCCCTT GTGTACCAGA ACGTCCTGGA 120

ATGCCATGTC CAGGAGAAGA CAAATCCATC TACCGCAGGG GCGCACGCCG CTGGAGAAAG 180

CTTTATTGTG CAAATGGCCA CACTTTTCAA GCTAAGCGTT TCAACAGGCG TGCCCACTGT 240

GCCATCTGTA CTGACCGGAT ATGGGGACTT GGACGTCAGG GATATAAGTG CATCAACTGC 300

AAACTCCTGG TTCATAAGAA GTGCCACAAA CTTGTCACAA TCGAATGTGG GCGGCATTCT 360

ATGCCACCGG AACCAATGAT GCCCATGGAC CAGTCATCCA TGCATTCAGA CCACGCACAG 420

ACAGTAATTC CATATAATCC TTCAAGTCAT GAGAGTTTGG ACCAAGTTGG TGAAGAAAAG 480

GAGGCAATGA ATACCAGGGA AAGTGGCAAA GCTTCATCCA GTTTAGGTCT TCAGGACTTT 540

GATTTGCTTC GGGTAATAGG CAGAGGAAGT TATGCCAAAG TACTATTGGT GCGATTAAAA 600

AAAACAGATC GTATTTATGC GATGAAAGTT GTGAAAAAAG AGCTGGTCAA TGATGATGAG 660

GATATTGATT GGGTACAGAC GGAGAAGCAT GTTTTTGAGC AGGCATCCAA TCATCCTTTT 720

CTTGTTGGGC TGCATTCTTG CTTTCAGACA GAAAGCAGGT TGTTCTTTGT CATAGAGTAT 780

GTAAATGGAG GAGATCTAAT GTTTCATATG CAGCGACAAA GAAAACTTCC TGAAGAACAT 840

GCCAGATTTT ACTCTGCAGA AATCAGTCTA GCGTTAAATT ATCTTCATGA AAGAGGGATA 900

ATTTATAGAG ATTTGAAATT GGACAATGTA TTGCTGGACT CAGAAGGACA CATTAAACTC 960

ACTGACTACG GCATGTGTAA GAAGGAAGGA TTACGGCCCG GAGATACAAC CAGCACTTTT 1020

TGTGGTACTC CCAATTACAT TGCTCCTGAA ATTTTAAGAG GAGAAGATTA TGAAGGTTTC 1080

AGTGTCGACT GGTGGGCCCT TGGAGTACTA ATGTTTGAGA TGATGGCAGG AAGATCTCCA 1140

TTTGATATTG TTGGAAGCTC TGATAACCCT GATCAAAACA CAGAGGATTA TCTCTTCCAA 1200

GTTATTTTGG AAAAACAAAT ACGCATACCA CGTTCTCTGT CTGTAAAAGC TGCAAGTGTC 1260

CTGAAGAGTT TTCTCAACAA GGACCCAAAG GAACGATTGG GCTGTCACCC TCAAACAGGA 1320

TTTGCTGATA TTCAGGGACA CCCATTCTTT CGAAATGTTG ATTGGGATAT GATGGAGCAA 1380

AAGCAGGTGG TACCTCCCTT TAAACCAAAT ATTTCTGGGG AATTTGGTTT GGACAACTTT 1440

GATTCTCAAT TTACTAATGA ACCTGTCCAG CTCACTCCAG ATGACGATGA CATCGTGAGG 1500

AAGATTGATC AGTCTGAATT CGAAGGTTTT GAGTACATCA ACCCTCTTCT GATGTCTGCA 1560

GAAGAATGTG TC 1572

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+ll+v+G+Gs++kvll++lkktd++ya+kv+kk++v++d+d++++++ek+v+++as++p

Q: 180   FDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  239

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g

Q: 240   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  299

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlck.eeilegkttstfcGtPdyiaPeilkeeey.g  178

         iiyrdlkldnvlld+eGhikl+d+G+ck e++  g+ttstfcGtP+yiaPeil++e+y g

Q: 300   IIYRDLKLDNVLLDSEGHIKLTDYGMCKkEGLRPGDTTSTFCGTPNYIAPEILRGEDYeG  359

         ***************************73689**************************66

S: 179   ksvdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeave  229

         +svdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a++

Q: 360   FSVDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAAS  419

         9******************************99***************************

S: 230   ilkglltkdpekrlGvk.eegeedikehaff  259

         +lk++l+kdp++rlG++ ++g +di+ h+ff

Q: 420   VLKSFLNKDPKERLGCHpQTGFADIQGHPFF  450

         ****************989***********9

Domain Sequence
(FASTA)

FDLLRVIGRG SYAKVLLVRL KKTDRIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60

FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120

IIYRDLKLDN VLLDSEGHIK LTDYGMCKKE GLRPGDTTST FCGTPNYIAP EILRGEDYEG 180

FSVDWWALGV LMFEMMAGRS PFDIVGSSDN PDQNTEDYLF QVILEKQIRI PRSLSVKAAS 240

VLKSFLNKDP KERLGCHPQT GFADIQGHPF F 271

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016324	; C:apical plasma membrane
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0043220	; C:Schmidt-Lanterman incisure
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004697	; F:protein kinase C activity
GO:0007015	; P:actin filament organization
GO:0045216	; P:cell-cell junction organization
GO:0035089	; P:establishment of apical/basal cell polarity
GO:0042462	; P:eye photoreceptor cell development
GO:0035556	; P:intracellular signal transduction
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0043524	; P:negative regulation of neuron apoptotic process
GO:2000353	; P:positive regulation of endothelial cell apoptotic process
GO:0090004	; P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252	; P:positive regulation of glial cell proliferation
GO:0046326	; P:positive regulation of glucose import
GO:0010976	; P:positive regulation of neuron projection development
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013