EKS-AIM-00427

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00427

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	502.5	3.0E-151	26	310	285

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005035

UniProt Accession

D2HY39;

Protein Name

Protein Synonyms/Alias

Gene Name

PIK3R4

Gene Synonyms/Alias

PIK3R4; PANDA_017602;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004733	ENSAMEP00000005035	ENSAMET00000005242

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLHS AQNCLPFQKA VEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGLFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG QFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLGAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDVNIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNSEEIDEVS HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLEPPN IPQALPKGSD QEVIQTGKPP RSESSAGICV 900

PLSTSPQLPE VTNVQNRKPT IQVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSTLTYNR IGGHVKTLTF CQGSHYLAIA SDNCAVQLLA IEASKLPKSP 1080

KIQPLQSRIL DQKDDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYVVA GSASSSSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGGAATC AGCTTGCTGG CATTGCTCCT TCCCAGATCC TTTCTGTGGA GAGTTATTTC 60

TCAGACATCC ATGACTTTGA ATATGATAAG AGCCTGGGAA GTACTAGGTT TTTTAAAGTC 120

GCTCGAGCGA AGCACCGAGA AGGCCTGGTG GTTGTGAAGG TCTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA TAAACAAGAG TTGGAGGAAC TGAAAATCAG GCTTCATTCT 240

GCACAGAACT GTCTCCCTTT TCAGAAAGCA GTAGAAAAAG CGTCTGAGAA AGCAGCCATG 300

CTCTTTAGGC AGTATGTACG AGACAACCTC TATGATCGCA TCAGTACCCG TCCATTCTTA 360

AATAACATTG AGAAGCGTTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCGCAC 420

AAATCTGGAG TCCGTCATGG GGACATCAAG ACTGAGAATG TAATGGTCAC CAGTTGGAAT 480

TGGGTCCTTC TGACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA GGACAACCCA 540

GCAGATTTCA ACTATTTCTT TGACACTTCG AGGAGGAGAA CTTGCTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGATT GTTTGCCACT GAGTTAGAAT ATATGAGGGA TCCTTCAACT 660

CCACTTGTAG ACTTAAATAG TAATCAGAGA ACAAGAGGAG AGTTGAAGAG GGCAATGGAT 720

ATCTTTTCAG CAGGTTGTGT TATAGCTGAG CTTTTTACAG AAGGTGTACC ACTGTTTGAT 780

CTCTCTCAAC TTCTGGCTTA TAGAAATGGA CAGTTTTTCC CGGAACAAGT GCTAAATAAA 840

ATTGAAGACC GCAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGGGG CAGAAGATTA CCTAAAGCAG CAGCGTGGCA ATGCTTTTCC TGAAATATTT 960

TACACATTCC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACATTTCT TTCTGCAGAT 1020

GAGCGCATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 1080

GATCTGCCAG AAAAAGCAGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTGTCT 1140

GTTATAACGT CCTGTCTGCA GACCCTTAAA TACTGTGATT CCAAACTTGC TGCTTTGGAA 1200

CTTATTCTCC ATTTGGCCCC AAGATTAAGT GTAGAAATTC TTTTGGATCG TATTACTCCA 1260

TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGAGTGA GGGCTGAAGC CTTGAGGACA 1320

TTGACCAAAG TTCTTGCTCT TGTCAAAGAG GTTCCTCGCA ATGATGTCAA TATCTATCCG 1380

GAATATATTC TTCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT TGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCT GAAACAGCTT TGAGATTCCT GGAATTGGTG 1500

CAGTTAAAAA ATCTCAATAT GGAAAATGAC CCAAATAGTG AAGAAATAGA TGAAGTTTCG 1560

CATCCCAATG GAAATTACGA CACAGAGCTG CAAGCCTTAC ATGAAATGGT CCAACAGAAA 1620

GTTGTCACTT TGCTAAGTGA CCCTGAAAAT ATTGTGAAAC AAACCTTAAT GGAAAATGGA 1680

ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ATGATGTTTT ATTGTCCCAC 1740

ATGATCACTT TCCTAAATGA TAAGAATGAT TGGCATCTGC GTGGAGCTTT TTTTGATAGT 1800

ATTGTTGGTG TTGCTGCGTA TGTTGGTTGG CAAAGCTCCT CAATTCTCAA ACCCCTGCTG 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTTATTGTTA AAGCTCTTAA TGCCCTTACC 1920

TGTATGTGCC AGTTAGGGCT GCTACAAAAA CCCCATGTCT ATGAATTTGC CAGTGATATT 1980

GCCCCATTTC TGTGTCATCC CAATCTATGG ATACGCTATG GTGCTGTAGG ATTTATCACA 2040

GTAGTAGCTC ATCAAATAAG TACAGCTGAT GTATACTGCA AACTGATGCC TTACCTTGAC 2100

CCATATATTA CTCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTACT CAGTGTTTTA 2160

AAAGAGCCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATCACTAGC 2220

TTGTTCAGAC ATCTTCACAT GCGCCAGAAG AAACGGAATG GGTCTCTTCC TGACTGCCCT 2280

CCACCGGAGG ACCCCGCCAT AGCACAGCTT CTGAAGAAAT TGCTCTCACA GGGAATGACA 2340

GAGGAAGAGG AAGACAAACT CTTGGCACTG AAAGACTTCA TGATGAAATC TAACAAAGCA 2400

AAGGCCAATA TAGTAGACCA GAGCCATCTC CATGATAGTA GTCAGAAAGG TGTAATTGAC 2460

TTAGCAGCAT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAGGAACCT 2520

GATGACAAGC GAGCTAGAAA ACACGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGTATGTTTG GGTCACTGGA ACCACCGAAC ATCCCACAGG CCCTACCTAA AGGGAGTGAC 2640

CAGGAGGTGA TTCAGACCGG GAAACCGCCT CGTTCTGAGT CCTCTGCTGG CATTTGTGTC 2700

CCTTTATCAA CTTCTCCACA GCTTCCAGAA GTGACAAATG TCCAAAATAG AAAACCAACA 2760

ATACAGGTTT TAAGTAGTAC AATTTTACCA TCTACCTACC AGATTCGGAT CACAACTTGT 2820

AAAACAGAAC TTCAGCAGCT CATCCAGCAG AAGCGGGAGC AGTGTAACGC TGAGAGGATA 2880

GCTAAACAGA TGATGGAAAA TGCCGAATGG GAGAGTAAAC CACCACCACC TGGGTGGCGT 2940

CCTAAAGGGC TACTAGTTGC ACATCTTCAT GAACACAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AGCATTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 3060

AACAGTCAAA AGATGGAAGG GAAGACCACC ACTACCAGAT CTACTCTTAC GTACAACCGA 3120

ATTGGAGGAC ATGTCAAGAC GCTTACATTC TGCCAGGGGT CCCACTACTT AGCCATTGCG 3180

TCTGACAACT GTGCTGTCCA GCTTCTTGCG ATTGAAGCTT CTAAGCTGCC CAAGTCTCCT 3240

AAGATTCAGC CTCTGCAAAG CAGAATTCTA GACCAGAAGG ATGATGGCTG TGTTGTGGAT 3300

ATGCATCACT TCAACTCCGG GGCACAGTCC GTTCTGGCCT ATGCCACTGT GAATGGCTCT 3360

CTAGTTGGTT GGGACCTCAG GTCTTCAAGC AATGCATGGA CACTAAAACA TGATCTGAAG 3420

TCAGGCCTCA TCACTTCCTT TGCTGTGGAT ATTCACCAGT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGTA CTATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC CAGTCACTGT 3540

CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 3600

ATTGCAGCTG TGCAGGGCAA CAATGAGGTA TCCATGTGGG ACATGGAGAC CGGTGACCGA 3660

AGATTCACTC TCTGGGCTAG CAGTGCACCA CCGCTCTCGG AGTTACAGCC CTCTCCTCAC 3720

AGTGTCCATG GTATCTACTG TAGTCCTGCG GATGGAAATC CTATCCTGCT AACAGCTGGC 3780

TCAGATATGA AAATAAGGTT TTGGGATTTG GCTTACCCAG AGAGGTCCTA TGTTGTTGCA 3840

GGAAGTGCTA GTTCTTCGTC TGTGTCCTAC TATAGGAAAA TAATTGAAGG CACTGAAGTG 3900

GTCCAGGAGA TCCAGAATAA GCAGAAGGTA GGACCGAGTG ATGACACCCC TCGGAGGGGC 3960

CCAGAATCTC TGCCTGTGGG ACACCACGAC ATCATCACAG ATGTGGCCAC ATTCCAGACA 4020

ACACAGGGCT TCATTGTAAC TGCATCTAGA GATGGGATTG TTAAGGTGTG GAAATGA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLHSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKAVEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         ******9999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         + ++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GLFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr+ aed+lk+

Q: 266   AYRNGQFFPEQVLNKIEDRSIRELVTQMIHREPDKRLGAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLHSAQNCL 60

PFQKAVEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GLFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGQFFPE QVLNKIEDRS IRELVTQMIH REPDKRLGAE DYLKQ 285

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005770	; C:late endosome
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

aml:100484642

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013