EKS-AIM-00288

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00288

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	364.8	2.5E-109	25	289	265

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005256

UniProt Accession

G1LEC2;

Protein Name

Protein Synonyms/Alias

Gene Name

TNIK

Gene Synonyms/Alias

TNIK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004798	ENSAMEP00000005243	ENSAMET00000005459
ENSAMEG00000004798	ENSAMEP00000005256	ENSAMET00000005472

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1360

Protein Sequence
(FASTA)

MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60

DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120

KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180

TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240

ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 300

QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360

NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420

REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 480

EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER 540

SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 600

QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 660

WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPVLES 720

PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPSKVK 780

PEESRDVTRP SRPASYKKAI DEDLTALAKE LRELRIEETN RPLKKVTDYS SSSEESESSD 840

EEEEDGESET HDGTVAVSDI PRLIPTGAPG STEQYNVGMV GTHGLETSHA DTFSSSISRE 900

GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV STHSQEMESG 960

TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA LFTSELLRQE QAKLNEARKI 1020

SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI LCAALWGVNL LVGTENGLML LDRSGQGKVY 1080

NLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD 1140

LEGCIHYKVV KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE 1200

EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD GMEMLVCYED 1260

EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK AIEIRSVETG HLDGVFMHKR 1320

AQRLKFLCER NDKVFFASVR SGGSSQVFFM TLNRNSMMNW 1360

Nucleotide Sequence
(FASTA)

ATGGCGAGCG ACTCCCCGGC TCGCAGCCTG GATGAAATCG ATCTCTCGGC TCTGAGGGAC 60

CCTGCAGGGA TCTTTGAATT AGTGGAACTT GTTGGAAATG GAACATACGG ACAAGTTTAT 120

AAGGGTCGTC ATGTTAAAAC GGGCCAGCTC GCAGCCATTA AGGTTATGGA TGTCACAGGG 180

GATGAAGAGG AAGAAATCAA ACAAGAAATT AACATGTTGA AGAAATATTC TCATCACCGA 240

AATATTGCTA CATACTATGG TGCTTTTATC AAAAAGAACC CACCAGGCAT GGATGACCAA 300

CTTTGGTTGG TGATGGAGTT CTGTGGCGCT GGCTCTGTCA CTGACCTGAT CAAGAACACA 360

AAAGGTAACA CCTTGAAGGA GGAGTGGATC GCATACATCT GCAGGGAGAT CTTACGAGGG 420

CTGAGTCATC TGCACCAGCA TAAAGTGATT CATCGAGATA TTAAAGGGCA GAATGTCTTG 480

CTGACTGAGA ATGCAGAAGT TAAACTAGTG GACTTTGGCG TCAGTGCCCA GCTCGATCGA 540

ACAGTGGGCA GGAGAAATAC CTTCATCGGG ACCCCTTACT GGATGGCACC GGAAGTCATT 600

GCTTGTGACG AAAACCCAGA CGCCACCTAC GATTTCAAGA GTGACCTGTG GTCTTTGGGA 660

ATCACCGCTA TTGAGATGGC AGAAGGTGCC CCCCCTCTCT GTGACATGCA CCCCATGAGA 720

GCCCTCTTCC TCATCCCCCG GAACCCAGCG CCTCGCCTGA AGTCAAAGAA GTGGTCAAAG 780

AAATTCCAGT CATTTATTGA GAGCTGCTTG GTAAAGAATC ACAGCCAGCG GCCAGCAACA 840

GAACAATTGA TGAAGCATCC GTTTATACGA GACCAACCTA ATGAACGACA GGTCCGCATT 900

CAACTCAAGG ACCATATTGA CAGAACAAAG AAGAAGCGAG GAGAGAAAGA TGAGACCGAG 960

TATGAGTACA GCGGAAGTGA GGAAGAGGAG GAGGAGAATG ACTCAGGAGA GCCCAGCTCC 1020

ATTCTGAACC TGCCGGGGGA GTCCACGCTG CGGCGGGACT TCCTGAGGCT CCAGCTGGCC 1080

AACAAGGAGC GCTCGGAGGC CCTGCGGCGG CAGCAGCTGG AGCAGCAGCA GCGGGAGAAC 1140

GAGGAGCACA AGCGGCAGCT GCTGGCCGAA CGCCAGAAGC GCATAGAGGA GCAGAAGGAG 1200

CAGCGGCGGC GGCTAGAGGA GCAACAACGG CGGGAGAAGG AGCTGCGGAA GCAGCAGGAG 1260

CGAGAGCAGC GCCGGCACTA CGAGGAGCAG ATGCGCCGGG AGGAGGAGAG GCGGCGCGCG 1320

GAGCACGAGC AGGAGTACAT CAGGCGACAG CTAGAGGAGG AGCAGAGACA GTTAGAGATC 1380

TTGCAGCAGC AGCTACTGCA TGAACAAGCC CTACTTCTGG AATATAAGCG CAAACAGTTG 1440

GAAGAACAGA GACAAGCAGA AAGACTACAG AGACAGCTAA AGCAAGAGAG AGACTACTTG 1500

GTATCTCTCC AGCATCAGCG GCAGGAGCAG AGGCCTGTGG AGAAGAAGCC ACTGTACCAT 1560

TACAAAGAAG GGATGAGTCC TAGCGAGAAA CCAGCATGGG CCAAGGAGGT AGAAGAGCGG 1620

TCAAGGCTCA ACCGGCAGAG TTCGCCGGCC ATGCCTCACA AGGTTGCCAA CAGAATATCT 1680

GACCCCAACC TGCCCCCGAG GTCGGAGTCC TTCAGTATCA GTGGGGTTCA GCCTGCTCGG 1740

ACACCCCCCA TGCTCAGACC AGTCGATCCC CAGATTCCAC ACCTGGTAGC TGTAAAATCC 1800

CAGGGACCTG CCTTGACCGC TTCCCAGTCA GTGCACGAGC AGCCCACGAA GGGCCTCTCT 1860

GGGTTTCAGG AGGCTCTGAA TGTGACCTCT CACCGCGTTG AGATGCCGCG CCAGAACTCG 1920

GATCCCACAT CTGAAAACCC TCCTCTCCCC ACTCGCATTG AGAAGTTTGA CCGAAGCTCT 1980

TGGTTACGAC AGGAAGAAGA CATTCCACCA AAGGTGCCTC AAAGAACAAC TTCTATATCC 2040

CCAGCGTTAG CCAGAAAGAA TTCTCCTGGA AATGGTAGTG CTCTGGGACC CAGACTAGGA 2100

TCTCAGCCCA TCAGAGCAAG CAACCCTGAC CTGCGGAGAA CTGAGCCCGT CTTGGAGAGC 2160

CCCTTGCAGA GGACCAGCAG TGGCAGTTCC TCCAGCTCCA GCACCCCTAG CTCCCAGCCC 2220

AGCTCCCAAG GAGGGTCTCA GCCTGGATCG CAAGCGGGGT CCAGTGAACG GACCAGAGTT 2280

CGCGCCAACA GTAAGTCGGA AGGATCTCCT GTGCTCCCCC ACGAGCCTTC CAAGGTGAAG 2340

CCAGAAGAAT CCAGGGACGT TACCCGACCT AGTCGACCAG CTAGCTATAA GAAAGCGATA 2400

GATGAGGATC TGACGGCATT AGCCAAAGAA TTACGAGAAC TCCGAATTGA AGAAACAAAC 2460

CGCCCGCTGA AGAAGGTGAC TGATTACTCC TCCTCCAGTG AGGAGTCGGA AAGTAGTGAT 2520

GAAGAGGAGG AAGATGGAGA GAGTGAGACC CACGACGGGA CGGTGGCTGT CAGTGACATA 2580

CCCAGACTGA TACCAACAGG AGCCCCCGGG AGCACCGAGC AGTACAATGT GGGAATGGTC 2640

GGCACGCACG GGCTGGAGAC CTCTCATGCG GACACTTTCA GCAGCAGTAT TTCAAGAGAA 2700

GGAACCCTGA TGATAAGAGA GACATCTGGA GAAAAGAAGC GATCTGGCCA CAGTGACAGC 2760

AATGGCTTCG CTGGCCACAT CAATCTCCCA GACCTGGTAC AGCAGAGCCA TTCCCCAGCC 2820

GGCACACCAA CCGAGGGCCT GGGGCGCGTC TCCACCCATT CCCAGGAGAT GGAATCCGGG 2880

ACTGAATATG GCATGGGGAG CAGCACGAAG GCCTCCTTCA CCCCGTTTGT GGACCCCAGA 2940

GTATACCAGA CATCTCCCAC GGACGAAGAC GAAGAAGATG AAGAGTCCTC AGCTGCGGCT 3000

CTGTTTACTA GCGAACTTCT TAGGCAAGAA CAGGCCAAAC TGAATGAAGC AAGAAAGATT 3060

TCAGTGGTAA ACGTAAACCC AACCAACATT CGACCTCATA GTGACACACC AGAAATCAGA 3120

AAATATAAGA AACGATTCAA CTCAGAAATA CTTTGTGCAG CTCTCTGGGG TGTAAATCTC 3180

CTGGTGGGAA CCGAAAATGG CCTGATGCTT TTGGACCGAA GTGGGCAAGG CAAAGTCTAT 3240

AATCTGATCA ACCGGAGGCG ATTTCAGCAG ATGGACGTGC TGGAGGGACT GAATGTCCTG 3300

GTGACGATAT CAGGAAAGAA GAACAAACTA CGAGTTTACT ATCTTTCATG GTTAAGAAAC 3360

AGAATACTGC ACAATGACCC AGAAGTAGAA AAGAAACAAG GCTGGATCAC GGTTGGGGAC 3420

TTGGAAGGCT GCATACATTA CAAAGTTGTT AAATACGAAA GGATTAAATT CCTAGTGATT 3480

GCCTTAAAGA ATGCTGTGGA AATATATGCT TGGGCTCCTA AGCCGTATCA TAAGTTCATG 3540

GCATTTAAGT CTTTTGCAGA TCTCCAGCAC AAGCCACTGC TTGTGGATCT CACGGTAGAA 3600

GAAGGTCAAA GATTGAAGGT TATTTTTGGT TCACACACTG GTTTTCATGT AATTGATGTT 3660

GATTCAGGAA ACTCTTACGA TATCTACATA CCATCTCATA TTCAGGGCAA TATCACTCCT 3720

CATGCCATTG TCATCTTGCC TAAAACAGAT GGAATGGAAA TGCTTGTTTG CTATGAGGAT 3780

GAGGGGGTGT ATGTAAACAC CTACGGCCGG ATAACTAAGG ATGTGGTGCT CCAATGGGGA 3840

GAAATGCCCA CATCTGTGGC CTACATTCAT TCCAATCAGA TAATGGGCTG GGGCGAGAAA 3900

GCTATTGAGA TCCGGTCAGT GGAAACAGGA CATTTGGATG GAGTATTTAT GCATAAGCGA 3960

GCTCAAAGGT TAAAGTTTCT ATGTGAAAGA AATGATAAGG TATTTTTTGC ATCCGTGCGA 4020

TCTGGAGGAA GTAGCCAAGT GTTTTTCATG ACCCTCAACA GAAATTCCAT GATGAACTGG 4080

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +el+e +g+G++g+vy++r++ktg+l+aik+++++  +++ee+++ei++lkk++h +ni

Q: 25    FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-DEEEEIKQEINMLKKYSHhRNIA  83

         899********************************8.999*************998****

S: 60    eylesflk......eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLey  113

         +y+++f+k      +++lwlvme++ +Gs++dl+k+++ ++lkEe+iayi+re+l++L++

Q: 84    TYYGAFIKknppgmDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSH  143

         ************************************************************

S: 114   lHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe  173

         lH++kviHrdik++n+Llte++eVkL+dfgv+aql++t+ +r+t++gtpywmAPEvia++

Q: 144   LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACD  203

         ************************************************************

S: 174   ...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskef  230

            + +Yd k+D+wslGItaie+aeg+pP++d++p++al++i++n++p+lksk k+sk+f

Q: 204   enpDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSK-KWSKKF  262

         999999********************************************888.******

S: 231   kefvekclqknpekRpsasellkhkFl  257

         ++f+e+cl kn ++Rp++++l+kh+F+

Q: 263   QSFIESCLVKNHSQRPATEQLMKHPFI  289

         **************************7

Domain Sequence
(FASTA)

FELVELVGNG TYGQVYKGRH VKTGQLAAIK VMDVTGDEEE EIKQEINMLK KYSHHRNIAT 60

YYGAFIKKNP PGMDDQLWLV MEFCGAGSVT DLIKNTKGNT LKEEWIAYIC REILRGLSHL 120

HQHKVIHRDI KGQNVLLTEN AEVKLVDFGV SAQLDRTVGR RNTFIGTPYW MAPEVIACDE 180

NPDATYDFKS DLWSLGITAI EMAEGAPPLC DMHPMRALFL IPRNPAPRLK SKKWSKKFQS 240

FIESCLVKNH SQRPATEQLM KHPFI 265

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0007256	; P:activation of JNKK activity
GO:0046777	; P:protein autophosphorylation
GO:0048814	; P:regulation of dendrite morphogenesis

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013