EKS-AIM-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	321.5	4.1E-96	21	287	267

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005218

UniProt Accession

G1LE84;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3A

Gene Synonyms/Alias

MYO3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000004928	ENSAMEP00000005218	ENSAMET00000005433

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1617

Protein Sequence
(FASTA)

MLPLTGKTII FDNFPDPSDT WEITETIGKG TYGKVFKALN KKNGQKAAVK ILDPIHDIDE 60

EIEAEYNILK TLSDHPNVVR FYGMYFKKVK IDGDKLWWVL ELCNGGSVAD LVKGFLKKGK 120

RMSETIIAYI LREALLGLQH LHNNKTIHRD IKGNNILLTT EGGVKLVDFG VSAQLTSTRY 180

RRNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF 240

KIPRNPPPKL RQPEIWSAEF NDFISKCLTK DYEKRPTVSA LLQHKFITQI EGKDVMLQKQ 300

LMEFINIHQG MGGTEKARHE RIHTKKSNFT RSLMSSLKDV DDLATLEVLD ENTVSEQLEK 360

CYSRDQIYIY VGDILIALNP FQSLGLYSTE HSKLYIGAKR TANPPHIFAM ADLGYQSMIT 420

YNSDQCIVIS GESGAGKTES AHLLVQQLTV LGKANNRTLQ EKILQVNNLV EAFGNASTII 480

NDNSSRFGKY LEMKFTSSGA VVGAQISEYL LEKSRVIRQA LGEKNFHIFY YIYAGLAEKK 540

KLAHYKLPEN KPPRYLQNDH LRTVQDMMNN SFYKSQYELI EQCFKVIGFT MEQLGSIYSI 600

LAAILNVGNI EFSSVATEHQ IDKSHISNHA ALENSASLLC IQADELQEAL TSHCVVTRGE 660

TIIRPNTVEK ATDVRDAMAK TLYGHLFSWI VNRINSLLKH GTSLSGNADE LSIGILDIFG 720

FENFKKNSFE QLCINIANEQ IQYYFNQHVF TWEQNEYLNE GVNARMIEYE DNRPLLDMFL 780

QKPMGLLSLL DEESQFPKAT DQTLVEKFEG NLKSQYFWRP KRMELSFGIH HYAGKVLYNA 840

SGFLAKNRDT LPTDIVLLLR SSENNVIRQL VSHPLTKTGN LPHSKTRNII NYQMRTSEKS 900

INLTKDQSGE ATHHAIETTN MKTQTVASYF RYSLMDLLSK MVVGRPHFVR CIKPNNERQA 960

RKYDKEKVLV QLRYTGILET ARIRRLGYSH RILFSNFIKR YHVLCYKWNE EPPGSPDACA 1020

AILEKAGLDN WALGKTKVFL KYYHVEQLNL MRKEAIDKLI LIQACVRGFL DLRRYQKIQE 1080

KRKESAILIQ SAARGHLVRK QRKAVVNTKN TAVTTIQTHD QEFDYKKNFE NKRDSSTKKQ 1140

TENAVATNET AIPAANNTGS TSVVKPSTFK AEDEATLAVE NNNRGYQTQN EINNMFGEET 1200

TREPHLVGDP WAEEHPQKKC MKDLEENSKL RQVEKENTVI ENYYQRYAEE RNFEESKAAY 1260

LERKAIAGRP SYPELWSVEN ETKQPSFKRT LEPSLSQKSV YQNANSKEQE KKTSVVTQKA 1320

PTCGQQRSQL RPGMVRERQA EAAVRAPEED RAAVFIQSKY RGYKRRQQLR KDRMSSFKNQ 1380

KIVATPTEVA RNTQDLYSYP TKHEESCNFR TKNDNDSKAV LEKEACDLAI FSRQISKLSE 1440

EYFILQKKLN EMILSQQLKP LYLGVYPHKP INRRVSSQQC LSGISKEEEP KILRPPRRPR 1500

KPKTLNNSED STYYYLLHKS IQEEKRRPRK DSQGKLLDLE DFYYKEFLPS RSGPKEHKPS 1560

LREGRQQGEH QHRCFNADKR CWAEENQERE EKDSAANPYD YRRLLRKTSQ RQRLVQQ 1617

Nucleotide Sequence
(FASTA)

ATGCTTCCAT TAACTGGAAA AACAATCATC TTTGATAACT TTCCTGATCC TTCTGATACA 60

TGGGAAATCA CCGAAACGAT TGGCAAAGGA ACTTACGGGA AAGTTTTTAA AGCGTTGAAT 120

AAAAAAAATG GCCAAAAAGC AGCAGTGAAA ATTCTGGACC CAATTCATGA TATCGATGAA 180

GAGATCGAAG CAGAGTATAA CATCTTAAAG ACGCTTTCCG ACCACCCCAA TGTGGTCAGA 240

TTCTACGGCA TGTACTTTAA GAAGGTTAAA ATAGATGGAG ACAAGCTGTG GTGGGTTCTT 300

GAGCTGTGCA ATGGAGGATC CGTGGCTGAT CTTGTGAAGG GATTTCTGAA GAAGGGCAAA 360

AGAATGAGTG AAACCATAAT TGCCTATATT TTACGTGAAG CACTATTGGG ACTTCAGCAT 420

TTGCATAACA ACAAAACCAT CCACCGTGAC ATAAAAGGAA ATAACATTCT GTTGACCACT 480

GAGGGTGGAG TCAAACTGGT AGATTTTGGT GTGTCTGCAC AGCTCACCAG TACTCGATAC 540

CGTCGGAATA CATCTGTAGG AACGCCATTT TGGATGGCTC CTGAGGTGAT TGCATGTGAA 600

CAGCAATTGG ATACCACTTA TGATGCCAGG TGTGACACAT GGTCCCTGGG GATCACAGCC 660

ATCGAGCTAG GGGACGGAGA TCCTCCATTA GCCGACCTGC ATCCCATGAG AGCGCTCTTC 720

AAAATACCAA GGAATCCACC CCCCAAACTA AGGCAGCCTG AGATATGGTC AGCAGAATTC 780

AATGACTTCA TTAGCAAGTG CTTGACTAAA GATTATGAAA AGCGTCCAAC AGTGTCAGCT 840

CTTTTACAGC ATAAATTCAT TACTCAAATT GAGGGCAAAG ATGTGATGTT GCAAAAACAA 900

CTCATGGAAT TCATCAACAT TCATCAAGGC ATGGGAGGCA CAGAAAAGGC CAGACATGAA 960

CGTATTCATA CCAAGAAGAG TAACTTCACT AGATCACTAA TGTCCAGTCT GAAGGATGTA 1020

GACGATTTAG CAACCCTAGA AGTTTTGGAT GAGAATACAG TCTCAGAACA ACTTGAGAAG 1080

TGTTATTCCA GAGATCAGAT TTATATCTAT GTGGGAGACA TACTCATTGC TCTTAACCCT 1140

TTTCAGAGTC TGGGTCTTTA TTCCACAGAG CATTCCAAAC TATATATTGG AGCAAAGAGA 1200

ACTGCCAATC CTCCTCACAT TTTTGCAATG GCTGACTTAG GATACCAATC AATGATAACA 1260

TATAATTCAG ATCAGTGCAT TGTTATTTCT GGAGAAAGTG GTGCTGGAAA GACAGAAAGT 1320

GCTCATCTTT TGGTTCAGCA GCTGACGGTG CTTGGAAAGG CTAATAACAG AACCCTGCAA 1380

GAGAAGATTT TACAAGTGAA CAATTTGGTG GAAGCCTTTG GCAATGCCTC CACTATTATA 1440

AATGACAATT CCAGCCGATT TGGAAAATAC TTAGAAATGA AATTTACTTC TTCCGGAGCT 1500

GTTGTGGGAG CACAGATTTC TGAATACCTT CTGGAAAAAT CGCGAGTTAT CCGCCAAGCT 1560

CTTGGAGAAA AAAATTTTCA TATTTTTTAC TACATCTACG CTGGCTTAGC TGAAAAGAAG 1620

AAACTAGCCC ATTACAAGTT GCCTGAAAAT AAGCCCCCCA GATATCTACA AAATGACCAC 1680

CTCAGAACAG TACAGGACAT GATGAATAAT AGTTTCTATA AATCCCAATA TGAATTAATT 1740

GAGCAGTGTT TCAAAGTCAT AGGTTTTACA ATGGAGCAAC TTGGAAGTAT ATACAGTATA 1800

TTGGCTGCAA TCTTGAATGT TGGCAACATT GAATTTTCTT CTGTGGCAAC TGAACACCAG 1860

ATTGACAAGA GCCACATTTC CAATCATGCA GCTCTGGAGA ACTCTGCTTC TCTGCTTTGC 1920

ATTCAGGCAG ATGAGCTACA AGAAGCTCTT ACCTCCCACT GTGTGGTTAC TAGAGGAGAA 1980

ACCATCATAC GGCCCAATAC TGTAGAAAAA GCCACTGATG TCCGAGATGC TATGGCGAAA 2040

ACTTTATATG GGCATCTCTT TAGTTGGATA GTCAATCGTA TTAACAGCTT ACTGAAGCAT 2100

GGCACGTCAC TAAGTGGGAA CGCTGATGAA CTGAGCATTG GCATTCTGGA TATATTTGGC 2160

TTTGAAAATT TCAAGAAAAA TTCCTTTGAG CAGCTGTGCA TTAACATTGC AAATGAACAA 2220

ATTCAGTATT ATTTCAATCA ACACGTGTTC ACATGGGAAC AGAATGAATA TCTAAATGAA 2280

GGTGTTAATG CCAGAATGAT TGAATATGAA GATAACCGTC CCCTCCTAGA TATGTTTCTG 2340

CAGAAGCCAA TGGGTCTGCT ATCCCTGCTC GATGAAGAAA GTCAGTTTCC CAAGGCCACT 2400

GACCAGACTC TCGTGGAAAA ATTTGAAGGT AACCTGAAAT CACAGTATTT CTGGAGGCCC 2460

AAAAGAATGG AACTTAGTTT TGGAATTCAC CACTATGCAG GAAAGGTCCT GTATAATGCA 2520

AGTGGGTTCT TAGCTAAAAA TAGAGACACT CTTCCAACTG ATATTGTGCT GCTTTTGAGG 2580

TCATCAGAAA ACAATGTCAT TCGCCAACTA GTCAGTCACC CTTTGACAAA AACAGGTAAT 2640

CTGCCACATT CTAAAACCAG AAATATAATA AATTATCAAA TGAGGACTTC AGAAAAATCA 2700

ATCAACTTGA CAAAGGATCA AAGTGGAGAA GCCACACATC ATGCCATAGA GACCACCAAC 2760

ATGAAGACAC AAACAGTTGC ATCATATTTT AGATATTCCC TGATGGATTT GTTATCCAAA 2820

ATGGTGGTGG GCCGGCCTCA CTTTGTCCGT TGCATCAAAC CAAATAATGA ACGTCAGGCA 2880

AGAAAATATG ACAAAGAGAA AGTCCTCGTA CAGCTTCGCT ACACAGGAAT TCTGGAAACA 2940

GCGAGAATTC GAAGGCTGGG ATACTCACAT CGGATACTTT TCTCCAACTT CATAAAAAGG 3000

TACCATGTTC TCTGCTACAA GTGGAACGAA GAGCCCCCAG GGAGCCCTGA TGCCTGTGCC 3060

GCCATCTTGG AAAAAGCTGG TCTTGATAAC TGGGCTCTTG GAAAAACAAA AGTGTTCCTG 3120

AAATATTATC ATGTAGAACA GTTAAATTTA ATGCGAAAGG AAGCCATTGA CAAGCTTATT 3180

TTGATTCAAG CCTGTGTCAG AGGATTCTTG GATTTAAGAA GATACCAAAA AATACAGGAG 3240

AAAAGGAAAG AGAGTGCTAT CCTAATACAG TCAGCTGCAA GAGGACATCT AGTCAGGAAA 3300

CAAAGAAAAG CAGTTGTTAA CACAAAAAAC ACAGCAGTAA CAACGATTCA GACCCATGAT 3360

CAGGAATTTG ACTACAAGAA AAACTTTGAA AATAAAAGGG ACTCTTCTAC GAAGAAACAG 3420

ACAGAAAATG CAGTCGCTAC TAATGAAACA GCCATTCCAG CTGCAAACAA TACAGGAAGT 3480

ACATCTGTAG TGAAGCCTTC CACTTTCAAA GCTGAAGACG AAGCCACTCT GGCCGTTGAA 3540

AATAACAACA GAGGATATCA AACTCAGAAC GAAATTAATA ACATGTTTGG AGAAGAGACT 3600

ACGCGTGAAC CACATCTGGT AGGGGACCCT TGGGCAGAAG AACACCCCCA AAAGAAGTGT 3660

ATGAAAGACC TGGAAGAGAA CAGTAAGCTA AGGCAAGTGG AGAAGGAGAA CACTGTGATC 3720

GAGAATTACT ACCAGAGGTA TGCAGAGGAA AGGAATTTTG AAGAATCCAA AGCAGCATAT 3780

CTAGAAAGAA AGGCCATAGC AGGAAGGCCA AGCTACCCAG AACTTTGGTC AGTGGAGAAT 3840

GAGACAAAGC AGCCTTCGTT TAAAAGAACA TTGGAACCGA GCCTTAGCCA AAAGTCAGTC 3900

TATCAAAATG CAAATAGCAA GGAACAGGAA AAGAAGACAT CGGTAGTCAC CCAGAAGGCA 3960

CCGACGTGCG GCCAGCAGAG AAGCCAGCTG AGGCCAGGGA TGGTCCGAGA GAGGCAGGCT 4020

GAAGCAGCAG TCCGAGCCCC GGAAGAAGAT AGAGCGGCAG TGTTCATTCA GAGCAAATAC 4080

CGGGGCTACA AGAGGAGGCA GCAATTAAGG AAGGACAGGA TGTCTTCTTT TAAAAATCAA 4140

AAGATTGTTG CGACACCGAC CGAAGTAGCA AGAAATACTC AAGATCTGTA TTCCTATCCC 4200

ACAAAGCATG AGGAATCCTG TAATTTCAGG ACTAAGAATG ACAACGACTC GAAAGCAGTC 4260

TTAGAGAAAG AAGCATGTGA TTTGGCCATC TTTTCAAGAC AGATATCAAA GTTATCTGAA 4320

GAATATTTCA TTCTGCAGAA AAAACTGAAT GAAATGATTT TGTCACAGCA ACTGAAGCCT 4380

CTTTATCTGG GTGTCTATCC TCATAAGCCA ATTAATAGAC GAGTTTCTTC TCAGCAGTGC 4440

CTCTCAGGTA TCTCTAAAGA AGAAGAGCCA AAAATATTGA GACCCCCAAG ACGGCCCCGG 4500

AAACCCAAAA CATTAAATAA CTCTGAGGAC TCCACATACT ATTATCTGCT ACATAAGTCA 4560

ATCCAAGAAG AAAAACGAAG ACCAAGAAAA GATAGTCAGG GAAAATTATT AGACCTGGAA 4620

GATTTCTATT ATAAGGAATT TTTGCCCAGT CGTTCTGGAC CAAAGGAACA TAAGCCTAGT 4680

TTAAGAGAAG GAAGACAACA GGGAGAACAC CAGCATCGAT GTTTTAATGC TGACAAAAGG 4740

TGCTGGGCGG AGGAGAACCA GGAGCGGGAG GAAAAGGACT CCGCGGCCAA CCCCTACGAC 4800

TACCGGAGGC TCCTGCGCAA AACCTCCCAG CGGCAGCGCC TTGTGCAGCA G 4851

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +e++e+igkG++gkv++a +kk+g+++a+k+++  + +  ee++ e+++lk+l++ pn+v

Q: 21    WEITETIGKGTYGKVFKALNKKNGQKAAVKILDPIH-DIDEEIEAEYNILKTLSDhPNVV  79

         7999*****************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lw v+e+++gGs+ dlvk   ++ ++++E+ iayilre+l +L+

Q: 80    RFYGMYFKkvkidGDKLWWVLELCNGGSVADLVKgfLKKGKRMSETIIAYILREALLGLQ  139

         ********999999********************7778899*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++k+iHrdik++niLlt+eg VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 140   HLHNNKTIHRDIKGNNILLTTEGGVKLVDFGVSAQLTSTRYRRNTSVGTPFWMAPEVIAC  199

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP++dl+p++al+ki++n+ppkl++++ +s e

Q: 200   EqqlDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPEIWSAE  259

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f++kcl+k++ekRp++s ll+hkF+

Q: 260   FNDFISKCLTKDYEKRPTVSALLQHKFI  287

         ***************************7

Domain Sequence
(FASTA)

WEITETIGKG TYGKVFKALN KKNGQKAAVK ILDPIHDIDE EIEAEYNILK TLSDHPNVVR 60

FYGMYFKKVK IDGDKLWWVL ELCNGGSVAD LVKGFLKKGK RMSETIIAYI LREALLGLQH 120

LHNNKTIHRD IKGNNILLTT EGGVKLVDFG VSAQLTSTRY RRNTSVGTPF WMAPEVIACE 180

QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF KIPRNPPPKL RQPEIWSAEF 240

NDFISKCLTK DYEKRPTVSA LLQHKFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031941	; C:filamentous actin
GO:0030175	; C:filopodium
GO:0016459	; C:myosin complex
GO:0030898	; F:actin-dependent ATPase activity
GO:0043531	; F:ADP binding
GO:0005524	; F:ATP binding
GO:0060002	; F:plus-end directed microfilament motor activity
GO:0004672	; F:protein kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007605	; P:sensory perception of sound

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013