EKS-AIM-00377
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00377
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR555.74.9E-167601961361
StatusUnreviewed
Ensembl ProteinENSAMEP00000005339
UniProt AccessionG1LEK2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000004961ENSAMEP00000005339ENSAMET00000005560
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1102
Protein Sequence
(FASTA)
MQLPSAMPAP VLKEGQVLLL PLLLLLGPQA SWGLVITPPG PELILNVSSN FVLTCSGPAP 60
VVWERMSQEP LQKMAKTQDG TFSSTLTLTN VSGIDTGEYF CTYKGSHGLE PGERKRLYIF 120
VPDPSMGFLP VDPEELFIFL TEITEITIPC RVTDPRLVVT LHEKKVDIPL PIPYDHQRGF 180
SGTFEDKTYV CKTTIGDKEV DSEAYYVYSL QVSSINVSVN AVQTVVRQGE NITIMCIVTG 240
NEVVNFEWTY PRMESGRLVE PVTDFLFNMP SHIRSILHIP SAELGDSGTY ICNVSESVNE 300
HRDEKSINVT VVESGYVRLL GELDAIQFAE LHRSRTLQVM FEAYPPPTVM WFKDNRTLGD 360
SSAGEISLST RNVSETRYVS ELTLVRVKVA EAGCYTMRAF HEDAEAQLSF QLQVNVPVRV 420
LELSESHPAS GEQTVRCRGR GMPQPHLTWS TCSDLKRCPR ELPPTPLGNS SEEESQLETN 480
VTYWPEEQEF EVVSTLRLRR VDQPLSVRCT LHNLLGHDMQ EVTVVPHSLP FKVVVISAIL 540
ALVVLTVISL IILVMLWQKK PRYEIRWKVI ESVSSDGHEY IYVDPMQLPY DSTWELPRDQ 600
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 660
PHLNVVNLLG ACTKGASGPP ALRPCLSLSG DLVDYLHRNK HTFLQRCPDK RRPPSAELYS 720
NALPGGLPLP SHVSLPGESD GGYMDMSKDE SVDYVPMLAM KGGVKYADIE SSSYMAPYDN 780
YVPTAPERTC RATLINESPV LSYTDLVGFS YQVANGMEFL ASKNCVHRDL AARNVLICEG 840
KLVKICDFGL ARDIMRDSNY ISKGSTFLPL KWMAPESIFN SLYTTLSDVW SFGILLWEIF 900
TLGGTPYPEL PMNDQFYNAI KRGYRMAQPA HASDEIYEIM QKCWEEKFEI RPPFSQLVLL 960
LERLLGEGYK KKYQQVDEEF LRSDHPAVLR SQARLPGFHG LRSPLDTSSV LYTAVQPNEG 1020
DNDYIIPLPD PKPEVADEGP LESSPSLASS TLNEVNTPST ISCDSPLEPQ EEPEPQPEPQ 1080
GEPEPPLSSC PGLRAEAEDS FL 1102
Nucleotide Sequence
(FASTA)
ATGCAGCTTC CGAGCGCCAT GCCAGCTCCT GTCCTCAAAG AAGGCCAGGT GCTACTGCTG 60
CCCCTGCTGT TGCTGCTGGG CCCACAGGCC TCCTGGGGCC TGGTCATCAC ACCCCCGGGG 120
CCAGAGCTTA TCCTCAATGT CTCCAGCAAC TTCGTGCTGA CCTGCTCAGG TCCAGCTCCG 180
GTGGTGTGGG AACGGATGTC CCAGGAGCCC CTGCAGAAAA TGGCCAAGAC CCAGGATGGC 240
ACCTTCTCCA GCACACTGAC ACTGACCAAT GTCTCTGGGA TAGACACGGG AGAATACTTC 300
TGCACCTACA AAGGCTCCCA TGGGCTGGAG CCTGGGGAGC GGAAACGGCT CTACATCTTT 360
GTGCCAGATC CCTCGATGGG CTTTCTCCCA GTCGACCCCG AGGAACTATT CATCTTCCTC 420
ACGGAAATAA CTGAGATCAC AATTCCATGC CGAGTGACGG ATCCGAGACT GGTGGTGACA 480
CTGCACGAGA AGAAAGTGGA TATCCCACTG CCCATCCCCT ATGACCACCA ACGTGGCTTC 540
TCTGGTACCT TCGAGGACAA GACCTATGTC TGTAAAACCA CCATCGGGGA CAAGGAAGTT 600
GATTCTGAAG CCTACTATGT CTACAGCCTC CAGGTGTCAT CCATCAATGT CTCAGTGAAT 660
GCAGTGCAGA CTGTGGTCCG TCAGGGTGAG AATATCACCA TCATGTGCAT TGTGACTGGA 720
AATGAGGTGG TCAACTTTGA ATGGACATAC CCACGCATGG AGAGCGGGCG TCTGGTGGAG 780
CCAGTGACTG ACTTCCTCTT CAATATGCCC TCCCACATAC GCTCCATCCT GCACATCCCC 840
AGTGCTGAGC TTGGCGATTC AGGGACCTAC ATCTGCAATG TATCAGAGAG TGTGAATGAG 900
CATCGAGATG AAAAGTCCAT CAATGTCACT GTGGTTGAGA GTGGCTACGT GCGGCTGCTG 960
GGAGAGCTGG ACGCCATACA ATTCGCGGAG CTGCACCGCA GCAGGACTCT GCAGGTCATG 1020
TTCGAGGCCT ACCCGCCGCC TACTGTCATG TGGTTCAAGG ACAACCGCAC GCTAGGCGAC 1080
TCCAGCGCAG GCGAGATCTC CCTGTCCACA CGCAATGTGT CTGAGACCCG GTACGTGTCA 1140
GAACTGACGT TGGTACGGGT GAAGGTGGCC GAGGCGGGCT GCTACACCAT GCGGGCCTTC 1200
CATGAGGACG CGGAGGCCCA GCTCTCCTTC CAGCTGCAGG TCAACGTGCC TGTCCGTGTA 1260
CTGGAGCTGA GTGAAAGCCA CCCTGCCAGC GGGGAGCAGA CAGTCCGCTG TCGTGGCAGG 1320
GGCATGCCCC AGCCACACCT CACCTGGTCT ACCTGCAGCG ACCTCAAAAG ATGTCCGCGC 1380
GAGCTGCCGC CCACGCCGCT GGGGAACAGT TCGGAGGAGG AGAGCCAGCT GGAGACTAAC 1440
GTGACGTACT GGCCCGAGGA GCAGGAGTTC GAGGTGGTGA GCACACTGCG CCTGCGCCGT 1500
GTCGATCAGC CGCTGTCCGT GCGCTGCACT CTGCACAACC TGCTGGGACA CGACATGCAG 1560
GAGGTCACCG TGGTGCCGCA TTCTCTGCCC TTCAAGGTGG TGGTGATCTC AGCCATCCTG 1620
GCCTTGGTGG TCCTCACAGT CATCTCCCTC ATCATCCTCG TCATGCTCTG GCAGAAGAAG 1680
CCACGTTACG AGATCCGATG GAAGGTGATT GAATCCGTGA GCTCCGACGG CCATGAGTAC 1740
ATCTACGTGG ATCCTATGCA GCTGCCCTAC GACTCCACCT GGGAGCTGCC GCGGGACCAG 1800
CTCGTGCTTG GACGCACCCT CGGCTCTGGG GCCTTTGGCC AGGTGGTGGA GGCCACGGCT 1860
CATGGCCTGA GCCATTCGCA GGCCACGATG AAAGTGGCAG TCAAGATGCT GAAATCCACA 1920
GCCCGCAGCA GTGAGAAGCA GGCCCTCATG TCTGAGCTGA AGATCATGAG TCACCTCGGG 1980
CCCCATCTGA ACGTGGTCAA CTTGCTGGGG GCCTGCACCA AAGGAGCCTC GGGGCCGCCT 2040
GCCCTGAGGC CGTGCCTGAG CCTGTCTGGC GACCTGGTTG ACTACCTGCA CCGCAACAAG 2100
CACACCTTCC TGCAGCGCTG CCCCGACAAG CGCCGCCCGC CCAGCGCCGA GCTCTACAGC 2160
AACGCGCTGC CCGGCGGGCT CCCGCTGCCC AGCCACGTGT CTCTGCCCGG GGAGAGCGAC 2220
GGCGGCTACA TGGACATGAG CAAGGACGAG TCCGTGGACT ACGTGCCCAT GCTGGCCATG 2280
AAAGGAGGCG TCAAATACGC AGACATCGAG TCCTCCAGCT ACATGGCCCC TTATGACAAC 2340
TACGTCCCCA CCGCTCCTGA GAGGACCTGT CGGGCAACTC TGATCAACGA GTCCCCAGTG 2400
CTTAGCTACA CGGATCTCGT GGGCTTCAGC TACCAGGTGG CCAACGGCAT GGAGTTCCTG 2460
GCCTCCAAGA ACTGTGTCCA CCGAGATCTG GCAGCCAGAA ATGTGCTCAT CTGTGAGGGC 2520
AAGCTGGTCA AGATCTGTGA CTTTGGCCTG GCTCGTGACA TCATGCGAGA CTCAAACTAT 2580
ATCTCCAAAG GCAGCACCTT CCTGCCTCTG AAGTGGATGG CTCCTGAGAG CATCTTCAAC 2640
AGCCTCTATA CCACCCTGAG CGACGTGTGG TCCTTCGGGA TCCTCCTCTG GGAGATCTTC 2700
ACCCTGGGTG GCACCCCTTA CCCAGAGCTG CCCATGAACG ACCAGTTCTA TAACGCCATC 2760
AAGCGAGGGT ACCGCATGGC CCAGCCTGCC CACGCCTCCG ACGAGATTTA CGAGATCATG 2820
CAGAAGTGCT GGGAAGAGAA ATTCGAGATC CGGCCTCCTT TCTCGCAGCT GGTGCTGCTC 2880
CTTGAGAGGC TGCTGGGCGA GGGATACAAA AAGAAGTACC AGCAGGTGGA TGAGGAGTTT 2940
CTGAGGAGCG ACCACCCAGC CGTCCTTCGG TCCCAAGCCC GCTTGCCTGG CTTCCATGGC 3000
CTCCGATCCC CCCTGGACAC CAGCTCTGTC CTCTACACTG CTGTGCAGCC CAACGAGGGT 3060
GACAACGACT ACATCATCCC CCTGCCTGAC CCCAAACCTG AGGTTGCTGA TGAGGGCCCA 3120
CTGGAGAGTT CTCCCAGCCT TGCCAGCTCC ACCCTGAATG AAGTCAACAC CCCCTCTACC 3180
ATCTCCTGCG ACAGCCCCCT GGAGCCCCAA GAGGAGCCAG AGCCCCAGCC CGAGCCCCAG 3240
GGGGAGCCGG AGCCGCCACT GTCAAGCTGC CCTGGGCTTC GGGCCGAGGC GGAGGACAGC 3300
TTCCTGTAG 3309
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG
Q: 601   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  660
         78**********************************************************
S: 61    ehenivnllGactk..gGpiyviteyccyGdllnylrrkresflkkslekkkekeeelds  118
         +h+n+vnllGactk  +Gp  +       Gdl++yl+r++++fl++  +k++++++el+s
Q: 661   PHLNVVNLLGACTKgaSGPPALRPCLSLSGDLVDYLHRNKHTFLQRCPDKRRPPSAELYS  720
         *************844599999999999********************************
S: 119   kalladkslrsksslssesseeyvdlkkd................vsdvssskadklase  162
         +al+ +  l s++sl  es++ y+d++kd                ++d++ss++++++++
Q: 721   NALPGGLPLPSHVSLPGESDGGYMDMSKDesvdyvpmlamkggvkYADIESSSYMAPYDN  780
         ************************************************************
S: 163   kkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllte  222
         ++  a er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++e
Q: 781   YVPTAPERTCRATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE  839
         ****************9.9*****************************************
S: 223   GkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillwei  282
         Gk+vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillwei
Q: 840   GKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEI  899
         ************************************************************
S: 283   fslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         f+lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv 
Q: 900   FTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVL  959
         **********************************************************99
S: 343   ll  344
         ll
Q: 960   LL  961
         86
Domain Sequence
(FASTA)
LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNVVNLLG ACTKGASGPP ALRPCLSLSG DLVDYLHRNK HTFLQRCPDK RRPPSAELYS 120
NALPGGLPLP SHVSLPGESD GGYMDMSKDE SVDYVPMLAM KGGVKYADIE SSSYMAPYDN 180
YVPTAPERTC RATLINESPV LSYTDLVGFS YQVANGMEFL ASKNCVHRDL AARNVLICEG 240
KLVKICDFGL ARDIMRDSNY ISKGSTFLPL KWMAPESIFN SLYTTLSDVW SFGILLWEIF 300
TLGGTPYPEL PMNDQFYNAI KRGYRMAQPA HASDEIYEIM QKCWEEKFEI RPPFSQLVLL 360
L 361
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0030325; P:adrenal gland development
GO:0060326; P:cell chemotaxis
GO:0001701; P:in utero embryonic development
GO:0001822; P:kidney development
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705; P:skeletal system morphogenesis
GO:0048745; P:smooth muscle tissue development
GO:0001894; P:tissue homeostasis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR00109; TYRKINASE.
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013