EKS-AIM-00213

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00213

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	335.6	2.2E-100	168	419	252

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005313

UniProt Accession

G1LEH7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005013	ENSAMEP00000005313	ENSAMET00000005534
ENSAMEG00000005013	ENSAMEP00000005315	ENSAMET00000005536

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

448

Protein Sequence
(FASTA)

MLWLALGPFH AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 60

EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120

KVNTRAGPSQ HGSPAVSDSL PSNSLKKSSA ELKKILANGQ MNEQDIRYRD TLGHGNGGTV 180

YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240

TEFMDGGSLD VYRKIPEHVL GRIAIAVVKG LTYLWSLKIL HRDVKPSNML VNTRGQVKLC 300

DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360

KNQGSLMPLQ LLQCIVDEDS PVLPVGEFSE PFVHFITQCM RKQPKERPAP EDLMGHPFIM 420

QFNDGNATVV SMWVCRALEE RRSQQGPP 448

Nucleotide Sequence
(FASTA)

ATGCTGTGGC TGGCCCTTGG CCCCTTCCAT GCCATGGAGA ACCAGGTGCT GGTGATTCGT 60

ATCAAGATTC CAAATAGTGG CGCAGTGGAC TGGACAGTGC ACTCCGGACC GCAGTTACTC 120

TTCAGGGATG TGCTGGATGT GATAGGCCAG GTTCTGCCTG AAGCAACAAC CACAGCATTT 180

GAATATGAAG ATGAAGATGG TGACCGAATT ACAGTGAGGA GCGATGAAGA AATGAAGGCC 240

ATGCTGTCCT ATTATTATTC CACAGTAATG GAACAGCAAG TAAATGGACA GTTAATAGAG 300

CCTCTGCAGA TATTTCCAAG AGCCTGCAAG CCTCCTGGGG AACGGAACAT ACATGGCCTG 360

AAGGTGAATA CCCGGGCTGG ACCCTCTCAA CACGGCAGCC CAGCGGTCTC CGACTCACTT 420

CCAAGCAATA GCTTAAAGAA GTCTTCTGCC GAACTGAAAA AAATATTAGC CAATGGCCAG 480

ATGAATGAAC AAGACATACG GTATCGAGAC ACTCTTGGCC ATGGCAACGG AGGCACAGTC 540

TACAAAGCAT ATCATGTCCC GAGTGGGAAA ATATTAGCTG TAAAGGTCAT ACTACTAGAT 600

ATTACACTGG AACTTCAGAA GCAAATTATG TCTGAATTGG AAATTCTTTA TAAGTGTGAT 660

TCATCATATA TCATAGGGTT TTATGGTGCA TTTTTCGTAG AAAACAGGAT TTCAATATGT 720

ACAGAATTCA TGGATGGGGG ATCCTTGGAT GTATATAGAA AAATTCCAGA GCATGTCCTT 780

GGAAGAATTG CAATAGCAGT TGTTAAAGGT CTTACCTATT TGTGGAGTTT AAAGATTTTA 840

CATAGAGATG TGAAGCCCTC CAATATGCTA GTAAACACAA GAGGACAGGT CAAGCTGTGC 900

GATTTTGGAG TTAGCACTCA GCTGGTGAAT TCTATAGCCA AGACGTATGT TGGAACAAAT 960

GCTTATATGG CGCCTGAAAG AATTTCAGGG GAGCAGTATG GAATCCATTC TGATGTCTGG 1020

AGTTTAGGAA TCTCTTTCAT GGAGCTTGCT CTTGGGAGGT TTCCATATCC TCAGATTCAG 1080

AAAAACCAGG GATCTTTAAT GCCTCTCCAG CTTCTGCAGT GCATTGTTGA TGAGGATTCG 1140

CCCGTCCTTC CGGTTGGAGA GTTCTCCGAG CCATTTGTAC ATTTCATCAC TCAGTGCATG 1200

CGAAAACAAC CAAAAGAAAG ACCAGCACCT GAGGACCTGA TGGGCCACCC GTTCATCATG 1260

CAGTTCAATG ACGGAAACGC CACCGTGGTG TCCATGTGGG TGTGCAGGGC GCTGGAGGAG 1320

AGGCGCAGCC AGCAGGGGCC TCCG 1344

Domain Profile

S: 3     kleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivk  62

           ++lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++

Q: 168   YRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIG  226

         5679************************************************.*******

S: 63    fyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkekl  122

         fyGaf+ e+++sic+e+mdg+sld v++k       ipe+vlg+ia+avvk+l+yl+ +l

Q: 227   FYGAFFVENRISICTEFMDGGSLD-VYRK-------IPEHVLGRIAIAVVKGLTYLW-SL  277

         ************************.6876.......9********************.78

S: 123   kiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvk  182

         ki+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++

Q: 278   KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIH  336

         *****************************************************.******

S: 183   sdvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefv  236

         sdvWslG++++ela gr+py++ ++      +l+ll++iv+e++p+lp  efse f++f+

Q: 337   SDVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEDSPVLPVGEFSEPFVHFI  396

         ***********************9999*********************************

S: 237   skClkkdekeRpklkellkhafi  259

         ++C++k++keRp  ++l+ h+fi

Q: 397   TQCMRKQPKERPAPEDLMGHPFI  419

         **********************7

Domain Sequence
(FASTA)

YRDTLGHGNG GTVYKAYHVP SGKILAVKVI LLDITLELQK QIMSELEILY KCDSSYIIGF 60

YGAFFVENRI SICTEFMDGG SLDVYRKIPE HVLGRIAIAV VKGLTYLWSL KILHRDVKPS 120

NMLVNTRGQV KLCDFGVSTQ LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM 180

ELALGRFPYP QIQKNQGSLM PLQLLQCIVD EDSPVLPVGE FSEPFVHFIT QCMRKQPKER 240

PAPEDLMGHP FI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007507	; P:heart development
GO:0000165	; P:MAPK cascade

KEGG

aml:100468286

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013