EKS-AIM-00376
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00376
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR573.61.7E-172579909331
StatusUnreviewed
Ensembl ProteinENSAMEP00000005444
UniProt AccessionG1LEV7;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000005060ENSAMEP00000005444ENSAMET00000005669
OrganismAiluropoda melanoleuca
Functional Description
Protein Length968
Protein Sequence
(FASTA)
MGPGALLVLL VATTWHVQGV PVIEPSGPEL VVEPGTMVTL RCVGNGSVEW DGPIFPHWNL 60
DTEAPSSILT TNNVTFLHTG TYRCTEPGSP LGGSATIHLY VKDPARPWKV MAQEVTVLEG 120
QDALLPCLLT DPALEAGVSL MRVRGRPVMR QTNYSFSPWY GFTIHKAQFT ETHGYQCSAR 180
VGGGTVTSMS IWLKVQKVIP GPPTLMLEPA ELVRIQGEPA KIVCSASNVD VNFDVFLQHG 240
DTKLTIPQQS DFQGNQYQKV LTLELHHVGF QDAGNYSCVA TNVRGTNSTS MLFRVVESAY 300
LNLTSEQNLL QEVTVGEKVN LQVHVEAYPG LQGFNWTYLG PFSVHQPKLN FVTMKDTYRY 360
TSTLSLPRLK PSEAGRYSFL ARNTGGENSL TFELTLRYPP EVRVTWTVIN GSDALLCEAS 420
GYPQPNVTWL ECRSHMDRCD ETQGLVLEDS HSEVLSREPF HKVIVHSLLA MGTLEHNRTY 480
ECRALNSVGN SSQAFRPISI GAHTQLPDEP LFTPVLVTCM SIMALLLLLL GLLFYKYKQK 540
PKYQVRWKII ESYEGNSYTF IDPTQLPYNE KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG 600
LGKEDAVLKV AVKMLKSTAH ADEREALMSE LKIMSHLGQH ENIVNLLGAC THGGPVLVIT 660
EYCCYGDLLN FLRRKAEAML GPSLSVGQDP QAGAGYKNIH LEKKYVRRDS GFSSQGVDTY 720
VEMRPVSTSS SNDSFSEQAD LDKEDGRPLE LRDLLHFSSQ VAQGMAFLAS KNCIHRDVAA 780
RNVLLTSGRV AKIGDFGLAR DIMNDSNYIV KGNARLPVKW MAPESIFDCV YTVQSDVWSY 840
GILLWEIFSL GLNPYPGILV NSKFYKLVKD GYQMAQPVFA PKNIYSIMQA CWALEPTRRP 900
TFQQICSLLQ EQAQVDRREP DYTNLPSSSS GGGSSSEPEE ESSSEHLACC EQGDIAQPLL 960
QPNNYQFC 968
Nucleotide Sequence
(FASTA)
ATGGGCCCAG GGGCTCTGCT GGTCCTGCTG GTGGCCACAA CTTGGCATGT TCAAGGAGTC 60
CCAGTGATAG AGCCCAGTGG CCCTGAGCTG GTCGTGGAGC CAGGCACAAT GGTGACCCTG 120
AGATGTGTGG GCAACGGCAG CGTGGAATGG GACGGCCCCA TCTTCCCCCA TTGGAACCTG 180
GACACTGAGG CCCCCAGCAG CATCCTGACC ACGAATAACG TCACCTTCCT GCACACCGGG 240
ACCTATCGCT GCACCGAGCC TGGAAGCCCC CTGGGGGGCA GTGCCACCAT CCACCTCTAT 300
GTCAAAGACC CCGCTCGGCC TTGGAAGGTG ATGGCCCAGG AAGTGACGGT GTTGGAGGGT 360
CAGGACGCGC TGCTGCCCTG CCTGCTCACC GACCCCGCGC TGGAGGCAGG CGTCTCGCTG 420
ATGCGGGTGC GGGGCCGGCC TGTCATGCGC CAAACCAACT ATTCCTTCTC GCCCTGGTAT 480
GGCTTCACCA TCCACAAGGC CCAGTTCACT GAGACCCACG GCTACCAGTG CAGTGCTCGA 540
GTGGGTGGCG GCACGGTAAC CTCGATGAGC ATCTGGCTTA AAGTGCAGAA AGTCATCCCA 600
GGGCCCCCGA CCTTGATGCT GGAACCTGCA GAGCTGGTAC GGATTCAGGG AGAGCCTGCC 660
AAGATCGTGT GCTCAGCCAG CAATGTTGAT GTTAACTTTG ACGTCTTCCT CCAACATGGA 720
GACACCAAGC TCACAATCCC TCAACAATCC GACTTCCAAG GTAACCAGTA CCAAAAAGTC 780
CTGACCCTCG AGCTCCATCA TGTAGGCTTC CAAGATGCCG GCAACTACTC CTGTGTGGCC 840
ACCAATGTCC GAGGCACCAA CTCCACCTCC ATGCTCTTCC GGGTGGTAGA GAGTGCCTAC 900
TTGAACTTGA CCTCTGAGCA GAACCTCCTT CAGGAGGTGA CTGTGGGTGA GAAGGTCAAT 960
CTCCAAGTCC ACGTCGAGGC CTACCCGGGC CTGCAAGGTT TTAACTGGAC CTATCTGGGA 1020
CCTTTCTCTG TCCACCAGCC CAAGCTCAAT TTTGTCACGA TGAAGGACAC ATACAGGTAC 1080
ACCTCTACCC TCTCCCTGCC TCGCCTGAAG CCGTCGGAGG CGGGTCGCTA CTCCTTCCTG 1140
GCCAGAAACA CCGGAGGCGA GAATTCTCTG ACCTTTGAGC TCACGCTGAG ATACCCCCCA 1200
GAGGTAAGGG TCACATGGAC CGTCATCAAT GGCTCTGATG CACTGCTCTG TGAAGCCTCA 1260
GGGTACCCCC AGCCCAATGT GACATGGCTG GAGTGCCGGA GCCACATGGA TAGGTGTGAT 1320
GAGACCCAAG GGCTGGTCCT AGAGGACTCA CACTCGGAGG TGCTGAGCCG GGAGCCCTTC 1380
CACAAGGTGA TTGTCCATAG CCTGCTGGCC ATGGGGACCT TGGAACACAA CAGGACTTAC 1440
GAGTGCCGGG CCCTCAACAG CGTGGGGAAC AGCTCCCAGG CCTTCAGGCC CATCTCTATA 1500
GGAGCCCACA CGCAGCTTCC TGACGAGCCA CTCTTCACGC CTGTGCTGGT CACCTGCATG 1560
TCCATCATGG CCCTGTTGCT GCTGCTGCTG GGGCTGCTTT TCTACAAGTA CAAGCAGAAG 1620
CCCAAGTACC AGGTGCGCTG GAAGATCATT GAGAGCTACG AGGGCAACAG TTACACCTTC 1680
ATTGACCCCA CCCAGCTGCC CTACAACGAG AAGTGGGAGT TCCCCCGAAA CAACCTGCAG 1740
TTTGGGAAGA CTCTCGGAGC TGGTGCTTTT GGGAAGGTGG TAGAAGCCAC GGCCTTCGGT 1800
CTGGGCAAGG AAGATGCTGT CCTGAAGGTG GCTGTGAAGA TGCTGAAGTC CACGGCTCAC 1860
GCGGACGAAA GGGAGGCGCT CATGTCGGAA CTGAAGATCA TGAGTCACCT GGGCCAGCAC 1920
GAGAACATAG TCAACCTTCT GGGAGCCTGC ACCCACGGAG GGCCTGTTCT GGTCATCACC 1980
GAGTACTGTT GCTATGGTGA CCTGCTCAAC TTTTTGCGAA GGAAGGCCGA GGCCATGCTG 2040
GGACCCAGCC TGAGTGTGGG CCAAGACCCC CAGGCAGGCG CTGGCTATAA GAACATCCAC 2100
CTGGAGAAGA AATACGTCCG CAGGGACAGC GGCTTCTCCA GCCAGGGTGT AGACACCTAT 2160
GTGGAGATGA GGCCTGTCTC TACTTCTTCT TCAAATGACT CCTTCTCTGA ACAAGCAGAC 2220
CTGGACAAGG AGGATGGGCG ACCGCTGGAA CTGCGGGACC TGCTCCACTT CTCGAGCCAG 2280
GTGGCCCAGG GCATGGCCTT CCTTGCTTCC AAGAACTGCA TCCACCGGGA CGTGGCAGCC 2340
CGAAACGTCC TGCTGACCAG TGGGCGTGTG GCCAAGATTG GGGACTTTGG GCTGGCCAGG 2400
GACATCATGA ATGACTCCAA CTACATCGTC AAGGGCAATG CCCGCCTGCC CGTGAAGTGG 2460
ATGGCTCCAG AGAGCATCTT CGACTGTGTC TACACGGTTC AGAGCGACGT CTGGTCCTAT 2520
GGCATCCTGC TTTGGGAAAT CTTCTCACTC GGGCTGAACC CCTACCCTGG TATCCTGGTG 2580
AACAGCAAGT TCTATAAACT GGTGAAGGAT GGATACCAAA TGGCCCAGCC TGTGTTCGCC 2640
CCAAAGAATA TATACAGCAT CATGCAGGCC TGCTGGGCCC TGGAGCCTAC CCGCAGACCC 2700
ACCTTCCAGC AGATCTGCTC CCTCCTCCAG GAGCAGGCCC AAGTGGACAG GAGAGAGCCG 2760
GACTACACCA ACTTGCCAAG CAGCAGCAGT GGCGGCGGCA GCAGTAGCGA GCCAGAGGAG 2820
GAGAGCTCCA GCGAGCACCT GGCCTGCTGT GAGCAGGGGG ACATCGCCCA GCCCCTGCTG 2880
CAGCCCAACA ACTACCAGTT CTGCTGA 2907
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++e+ealmselki+shlG
Q: 579   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEREALMSELKIMSHLG  638
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl+  +++++ + +k+
Q: 639   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSVGQDPQAGAGYKN  698
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s+++   se+          a l++e
Q: 699   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSSNDSFSEQ----------ADLDKE  744
         *999***********************....7777777666665..........578999
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 745   DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMN  804
         ************************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 805   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  864
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqp +a+++iy+imq+cw+ ep++rp+f+q+++ll
Q: 865   YKLVKDGYQMAQPVFAPKNIYSIMQACWALEPTRRPTFQQICSLL  909
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEREALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSVGQ DPQAGAGYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSSNDSFSEQ ADLDKEDGRP LELRDLLHFS 180
SQVAQGMAFL ASKNCIHRDV AARNVLLTSG RVAKIGDFGL ARDIMNDSNY IVKGNARLPV 240
KWMAPESIFD CVYTVQSDVW SYGILLWEIF SLGLNPYPGI LVNSKFYKLV KDGYQMAQPV 300
FAPKNIYSIM QACWALEPTR RPTFQQICSL L 331
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013