EPS-AIM-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP1	413.2	1.5E-124	57	250	194

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005425

UniProt Accession

G1LET8;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP1CB

Gene Synonyms/Alias

PPP1CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005127	ENSAMEP00000005429	ENSAMET00000005654
ENSAMEG00000005127	ENSAMEP00000005425	ENSAMET00000005650

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

327

Protein Sequence
(FASTA)

MADGELNVDS LITRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI 60

CGDIHGQYTD LLRLFEYGGF PPEANYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 120

RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIVDEKIFC CHGGLSPDLQ 180

SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL 240

DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDETLMC SFQILKPSEK 300

KAKYQYGGLN SGRPVTPPRT ANPPKKR 327

Nucleotide Sequence
(FASTA)

ATGGCGGACG GGGAGCTGAA CGTGGACAGT CTCATCACCC GACTGCTGGA GGTACGAGGA 60

TGTCGCCCAG GAAAGATTGT GCAGATGACT GAAGCAGAAG TTCGGGGCTT ATGTATCAAG 120

TCTCGGGAGA TCTTTCTTAG CCAGCCTATT CTTTTGGAGT TGGAAGCACC GCTGAAAATT 180

TGTGGAGATA TTCACGGACA GTATACAGAT TTACTGCGAT TATTTGAATA TGGAGGTTTC 240

CCACCAGAAG CCAACTATCT TTTCTTAGGA GATTATGTGG ACAGAGGAAA GCAGTCTTTG 300

GAAACCATTT GTTTGCTATT GGCTTATAAA ATCAAATATC CAGAGAACTT CTTTCTGTTA 360

AGAGGAAACC ATGAGTGTGC TAGCATCAAT CGCATTTATG GGTTCTATGA TGAATGCAAA 420

CGAAGGTTTA ATATTAAATT GTGGAAGACC TTCACCGATT GTTTTAATTG TCTGCCTATA 480

GCTGCCATTG TGGATGAGAA GATCTTCTGT TGTCATGGAG GACTATCACC AGACCTGCAA 540

TCTATGGAGC AGATTCGAAG AATTATGAGA CCCACTGATG TCCCTGATAC AGGTTTGCTC 600

TGTGATTTGC TGTGGTCTGA CCCAGATAAG GATGTGCAAG GCTGGGGAGA AAATGATCGT 660

GGTGTTTCCT TCACTTTTGG AGCTGATGTA GTCAGTAAAT TTCTGAATCG TCATGATTTA 720

GACTTGATTT GTCGAGCTCA TCAGGTGGTA GAAGATGGAT ATGAATTTTT TGCTAAACGA 780

CAATTGGTAA CCCTATTTTC AGCCCCAAAT TACTGTGGCG AGTTTGATAA TGCTGGTGGA 840

ATGATGAGTG TGGATGAAAC TTTGATGTGT TCATTTCAGA TATTGAAACC ATCTGAAAAG 900

AAAGCTAAGT ACCAGTATGG TGGACTGAAT TCAGGACGTC CTGTCACTCC ACCTCGAACA 960

GCTAATCCAC CGAAGAAAAG G 981

Domain Profile

S: 1     pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen  60

         p+kicgdihgqy+dllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen

Q: 57    PLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPEN  116

         89**********************************************************

S: 61    ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls  120

         ffllrgnhe+asinriygfydeckrr+n+klwktftdcfnclp+aai+deki+c+hggls

Q: 117   FFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS  176

         ************************************************************

S: 121   pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk  180

         pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfgadvv+kfl+

Q: 177   PDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLN  236

         ************************************************************

S: 181   khdldlicrahqvv  194

         +hdldlicrahqvv

Q: 237   RHDLDLICRAHQVV  250

         *************8

Domain Sequence
(FASTA)

PLKICGDIHG QYTDLLRLFE YGGFPPEANY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60

FFLLRGNHEC ASINRIYGFY DECKRRFNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120

PDLQSMEQIR RIMRPTDVPD TGLLCDLLWS DPDKDVQGWG ENDRGVSFTF GADVVSKFLN 180

RHDLDLICRA HQVV 194

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0072357	; C:PTW/PP1 phosphatase complex
GO:0050115	; F:myosin-light-chain-phosphatase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation
GO:0030155	; P:regulation of cell adhesion

KEGG

aml:100471456

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013