EKS-AIM-00158

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00158

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.8	1.1E-149	453	711	259

Status

Unreviewed

Ensembl Protein

ENSAMEP00000005519

UniProt Accession

G1LF32;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005199	ENSAMEP00000005519	ENSAMET00000005745

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

762

Protein Sequence
(FASTA)

MGNGSVKPKH PKHPDGHPGN LSTHALRSKV TELERELRRK DAEIQEREYH LKELREQLSK 60

QTVAIAELTE ELQSKCMQLN KLQDVVHLQG GSPLPASPEK VPLEVHRKAS GLVSLHSRRG 120

AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 180

VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK FLSSIPMWTT FGELAILYNC 240

TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEEKLTKIID 300

CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 360

ISEDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS 420

MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA 480

MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 540

ILRDRGSFDE STSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK 600

IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 660

LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 720

ARNLPSPLQR ELSGPTDHSY FDKYPPEKGV PPDELSGWDK DF 762

Nucleotide Sequence
(FASTA)

ATGGGAAATG GTTCGGTGAA ACCCAAACAT CCCAAGCATC CGGATGGTCA CCCCGGGAAC 60

CTCAGCACCC ATGCCCTGCG GAGCAAGGTG ACAGAGCTGG AGAGAGAGCT GAGGAGGAAG 120

GATGCCGAGA TCCAGGAGCG GGAGTACCAC CTGAAGGAGC TGCGGGAACA ACTGTCCAAG 180

CAGACCGTGG CCATTGCCGA GCTCACGGAG GAACTCCAGA GCAAGTGCAT GCAGCTCAAC 240

AAGCTTCAGG ATGTGGTGCA CCTGCAGGGA GGAAGCCCGC TGCCCGCCTC TCCAGAGAAA 300

GTGCCTCTTG AGGTCCACCG CAAGGCCTCG GGCCTGGTCT CCCTCCACAG CAGGAGGGGG 360

GCAAAAGCCG GGGTGTCTGC TGAGCCAACA ACCCGCACCT ATGACCTCAA TAAGCCCCCA 420

GAATTTTCTT TCGAGAAAGC AAGAGTCAGG AAGGACTCCA GTGAGAAGAA GCTCATTACA 480

GACGCCCTTA ATAAAAATCA ATTTCTAAAG AGACTGGATC CTCAGCAGAT CAAAGACATG 540

GTGGAATGCA TGTATGGGAG AAACTACCAG CAAGGGAGTT ACATTATTAA GCAAGGAGAA 600

CCAGGAAACC ATATTTTTGT GCTAGCAGAG GGCCGACTAG AGGTGTTCCA AGGGGAGAAA 660

TTTCTATCAT CCATCCCTAT GTGGACCACG TTTGGGGAAC TAGCCATTTT ATACAACTGT 720

ACAAGAACTG CCTCCGTGAA AGCTATTACC AATGTTAAAA CTTGGGCTCT AGATCGAGAG 780

GTATTCCAGA ATATAATGAG GAGGACAGCT CAAGCTAGAG ATGAACAGTA CAGAAACTTC 840

CTCAGAAGTG TATCCTTGCT GAAGAATTTA CCTGAAGAAA AACTAACCAA GATCATTGAC 900

TGCTTGGAAG TGGAATACTA TGACAAAGGA GATTACATTA TTAGAGAGGG CGAGGAAGGA 960

AGTACCTTCT TCATCTTAGC AAAAGGAAAG GTAAAAGTCA CCCAGAGCAC AGAGGGCCAT 1020

GATCAACCCC AACTGATAAA AACATTGCAG AAAGGAGAAT ACTTTGGAGA AAAAGCTCTT 1080

ATCAGTGAGG ATGTCAGATC AGCTAACATT ATTGCTGAAG AAAATGATGT GGCATGCCTA 1140

GTTATAGACC GAGAAACATT CAACCAAACA GTCGGGACTT TTGAAGAGCT CCAAAAATAT 1200

CTTGAAGGGT ATGTGGCAAA CCTGAACCGT GATGATGAGA AAAGACATGC GAAGAGATCC 1260

ATGTCTAATT GGAAGCTGTC CAAAGCACTC TCTCTGGAGA TGATTCAGCT GAAGGAGAAG 1320

GTGGCCAGAT TTTCCTCATC ATCCCCATTC CAGAACCTTG AGATTATCGC AACACTGGGC 1380

GTTGGTGGGT TCGGAAGAGT TGAGCTTGTT AAAGTGAAAA ATGAGAATGT TGCTTTTGCT 1440

ATGAAGTGTA TAAGGAAGAA GCACATAGTT GACACAAAAC AACAGGAGCA TGTCTACTCA 1500

GAAAAGAGGA TTCTAGAAGA GTTGTGCTCT CCCTTCATTG TGAAATTATA TCGTACTTTC 1560

AAGGACAATA AGTATGTATA CATGCTTCTG GAGGCCTGCT TAGGTGGGGA GCTGTGGAGC 1620

ATATTAAGGG ACAGAGGCAG CTTCGATGAA TCCACCTCCA AGTTCTGCGT CGCTTGTGTG 1680

ACAGAAGCGT TTGATTACCT GCATCGACTA GGTATAATCT ACAGAGACCT GAAACCAGAA 1740

AACTTAATTC TAGATGCTGA AGGTTATCTT AAATTGGTTG ACTTTGGATT TGCGAAGAAA 1800

ATAGGATCTG GACAGAAAAC GTGGACATTC TGTGGAACTC CAGAGTATGT AGCTCCCGAG 1860

GTCATTCTCA ACAAAGGACA TGACTTCAGC GTGGATTTTT GGTCTCTGGG AATTCTGGTG 1920

TATGAACTCC TAACCGGCAA CCCTCCCTTT TCTGGGATTG ACCAAATGAT GACCTACAAT 1980

CTGATTCTCA AAGGAATTGA AAAAATGGAT TTTCCCAGAA AGATCACAAG ACGACCTGAG 2040

GATTTGATTC GGAGGCTTTG CAGGCAAAAT CCAACAGAAA GACTTGGAAA TCTGAAAAAT 2100

GGAATCAATG ACATTAAGAA ACACAGGTGG TTAAATGGTT TTAATTGGGA GGGACTGAAA 2160

GCACGGAACC TTCCATCACC TTTACAGAGA GAGCTCAGTG GACCCACAGA CCACAGCTAC 2220

TTCGACAAGT ATCCCCCGGA AAAGGGAGTG CCTCCAGATG AGCTGTCAGG CTGGGATAAA 2280

GACTTTTGA 2289

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l++iatlgvggfgrvelvkvk+ e+ afa+k+++kkhivdtkqqehv+sekrilee++s+

Q: 453   LEIIATLGVGGFGRVELVKVKN-ENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSP  511

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw+ilrdrgsfd++t+kf+vacv+ea++ylh+ +

Q: 512   FIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDESTSKFCVACVTEAFDYLHRLG  571

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egylklvdfgfakk++sg+ktwtfcgtpeyvape+ilnkghd+sv

Q: 572   IIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSV  631

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+k+++prkit+++edli++lcr+np

Q: 632   DFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNP  691

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+lk+gi+dikkh+w+

Q: 692   TERLGNLKNGINDIKKHRWL  711

         *******************7

Domain Sequence
(FASTA)

LEIIATLGVG GFGRVELVKV KNENVAFAMK CIRKKHIVDT KQQEHVYSEK RILEELCSPF 60

IVKLYRTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEST SKFCVACVTE AFDYLHRLGI 120

IYRDLKPENL ILDAEGYLKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LNKGHDFSVD 180

FWSLGILVYE LLTGNPPFSG IDQMMTYNLI LKGIEKMDFP RKITRRPEDL IRRLCRQNPT 240

ERLGNLKNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

aml:100467892

;

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013