EKS-AIM-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	395.2	1.7E-118	216	509	294

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006262

UniProt Accession

G1LH69;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005925	ENSAMEP00000006262	ENSAMET00000006517

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

539

Protein Sequence
(FASTA)

PSPVNNDMMV TDNNGVIKFP QLCKFCDVRS STCDNQKSCV SNCSITSICE KPHEVCLAVW 60

RKNDENITLE TLCHDPKDTY HGIVLEDSAS PKCIMKEKKV LGETFFMCSC SSDECNDYII 120

FSEEYATNNP DLLLVIFQVT GISLLPPLGI AIAVIVTFYC YRVHRQQKLS PSWETSKPRK 180

LMEFSEHLAI ILEDDRSDIS STCANNINHN TELLPIELDT LVGKGRFAEV YKAKLKQNTS 240

EQFETVAVKI FPYEEYASWK TEKDIFSDIN LKHENVLQFL TAEERKTELG KQYWLITAFH 300

AKGNLQEYLT RHVISWEDLR KLGSSLARGI AHLHSDHTLC GRPKMPIVHR DLKSSNILVK 360

NDLTCCLCDF GLSLRLDPTL SVDDLANSGQ VGTARYMAPE VLESRMNLEN VESFKQTDVY 420

SMALVLWEMT SRCNAVGEVK DYEPPFGSKV REHPCVESMK DNVLRDRGRP EIPSSWLNHQ 480

GIQTVCETLT ECWDHDPEAR LTAQCVAERF SELEHLDRLS GRSCSEEKIP EDGSLNTTK 539

Nucleotide Sequence
(FASTA)

CCCTCCCCAG TTAATAATGA CATGATGGTC ACTGACAACA ATGGTGTCAT CAAATTTCCA 60

CAATTGTGTA AATTTTGCGA TGTGAGATCT TCCACCTGTG ACAATCAGAA ATCCTGCGTG 120

AGCAACTGCA GCATTACATC CATCTGTGAG AAGCCACATG AAGTCTGTCT GGCGGTCTGG 180

AGAAAGAATG ATGAGAACAT AACACTGGAG ACGCTTTGCC ATGACCCCAA GGACACCTAC 240

CACGGAATCG TTCTCGAAGA TTCTGCTTCT CCAAAGTGTA TTATGAAGGA AAAAAAGGTG 300

TTGGGCGAGA CTTTCTTTAT GTGTTCCTGT AGCTCCGACG AGTGCAATGA CTACATCATC 360

TTCTCGGAAG AATATGCCAC CAACAACCCT GACCTGTTGT TAGTCATATT CCAAGTGACA 420

GGCATCAGCC TCCTACCACC ACTGGGAATC GCCATAGCCG TCATCGTCAC CTTCTACTGC 480

TACCGGGTTC ACCGGCAGCA GAAGCTGAGC CCGTCCTGGG AGACCAGCAA GCCGCGGAAG 540

CTCATGGAGT TCAGCGAGCA CCTGGCCATC ATTCTGGAAG ACGACCGCTC CGACATCAGC 600

TCTACCTGCG CCAACAACAT CAACCACAAC ACAGAGCTGC TGCCCATTGA GCTGGACACC 660

CTGGTGGGGA AAGGTCGCTT CGCCGAGGTC TACAAGGCCA AGCTGAAGCA GAACACTTCA 720

GAACAGTTCG AGACCGTGGC GGTCAAGATC TTCCCTTATG AGGAGTACGC CTCCTGGAAG 780

ACAGAGAAGG ACATCTTCTC AGACATCAAC CTGAAGCATG AGAACGTCCT GCAGTTCCTG 840

ACGGCCGAGG AGCGGAAGAC AGAGCTGGGC AAGCAGTACT GGCTGATCAC AGCCTTCCAC 900

GCCAAGGGCA ACCTACAGGA GTACCTCACG CGGCACGTCA TCAGCTGGGA GGACCTGCGC 960

AAGCTGGGCA GCTCCCTCGC CCGGGGCATC GCTCACCTGC ACAGCGACCA TACCCTGTGC 1020

GGGAGGCCCA AGATGCCCAT TGTGCACAGG GACCTCAAGA GCTCCAATAT CCTCGTCAAG 1080

AACGACCTGA CCTGCTGCCT GTGTGACTTT GGGCTTTCCC TGCGCCTCGA CCCGACTCTG 1140

TCTGTGGATG ACCTGGCCAA CAGTGGGCAG GTGGGAACTG CAAGATACAT GGCTCCAGAA 1200

GTCCTAGAGT CCAGGATGAA TCTGGAGAAC GTTGAATCCT TTAAGCAGAC GGATGTCTAC 1260

TCCATGGCTC TGGTACTCTG GGAAATGACA TCGCGCTGCA ATGCGGTGGG AGAAGTGAAA 1320

GATTACGAGC CTCCATTTGG TTCCAAGGTG CGGGAGCATC CTTGTGTTGA GAGCATGAAG 1380

GACAACGTGC TGAGAGACCG AGGGCGACCA GAAATTCCTA GCTCCTGGCT CAACCACCAG 1440

GGCATCCAGA CCGTGTGCGA AACTCTGACC GAGTGCTGGG ACCACGACCC GGAGGCCCGG 1500

CTCACGGCCC AGTGCGTGGC GGAGCGCTTC AGCGAACTGG AGCACCTGGA CAGGCTCTCA 1560

GGGAGGAGCT GCTCCGAGGA GAAGATTCCC GAAGATGGCT CGCTGAACAC TACCAAATAG 1620

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 216   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  275

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         +lqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 276   VLQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  335

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 336   D-HTLCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  394

         *.7888******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 395   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  453

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 454   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQTVCETLTECWDHDPEARLTAQCVAER  509

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

VLQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTLCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQTV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013