EKS-AIM-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	449.5	4.8E-135	236	523	288

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006278

UniProt Accession

G1LH84;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR1B

Gene Synonyms/Alias

BMPR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005926	ENSAMEP00000006278	ENSAMET00000006534

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

534

Protein Sequence
(FASTA)

YGWIKINNWV LHIKHLNSYS FFFSANLLDN MLLRSSGKLN VGTKKEDGES TAPTPRPKIL 60

HCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR 120

RSIECCTERN ECNKDLHPTL PPLKNRVSDF VDGPIHHKAL LISVTVCSLL LVLIILFCYF 180

RYKRQETRPR YSIGLEQDET YIPPGESLRD LIEQSQSSGS GSGLPLLVQR TIAKQIQMVK 240

QIGKGRYGEV WMGKWRGEKV AVKVFFTTEE ASWFRETEIY QTVLMRHENI LGFIAADIKG 300

TGSWTQLYLI TDYHENGSLY DYLKSTTLDT KSMLKLAYSS VSGLCHLHTE IFSTQGKPAI 360

AHRDLKSKNI LVKKNGTCCI ADLGLAVKFI SDTNEVDIPP NTRVGTKRYM PPEVLDESLN 420

RNHFQSYIMA DMYSFGLILW EVARRCVSGG IVEEYQLPYH DLVPSDPSYE DMREIVCIKK 480

LRPSFPNRWS SDECLRQMGK LMMECWAHSP ASRLTALRVK KTLAKMSESQ DIKL 534

Nucleotide Sequence
(FASTA)

TATGGTTGGA TTAAAATTAA TAATTGGGTT TTGCATATTA AACACTTAAA CTCTTATTCT 60

TTTTTCTTTT CAGCAAACTT ACTTGATAAC ATGCTTTTGC GAAGTTCAGG AAAATTAAAT 120

GTGGGGACCA AGAAAGAGGA TGGTGAGAGT ACAGCCCCCA CCCCTCGTCC AAAGATCTTG 180

CATTGCAAAT GCCACCACCA TTGTCCAGAA GACTCAGTCA ACAATATTTG CAGCACAGAT 240

GGATATTGTT TCACAATGAT AGAAGAAGAT GATTCTGGGA TGCCTGTGGT CACTTCTGGA 300

TGTCTAGGAC TAGAAGGCTC AGATTTTCAG TGTCGGGATA CCCCCATTCC TCATCAAAGA 360

AGATCAATTG AGTGCTGCAC AGAGCGGAAT GAATGTAATA AAGATCTGCA CCCTACACTG 420

CCTCCACTGA AAAACAGAGT TTCAGATTTT GTTGATGGAC CTATACACCA CAAGGCCTTA 480

CTTATATCTG TAACTGTCTG TAGTTTGCTA TTGGTCCTTA TTATTTTATT CTGTTACTTC 540

AGGTATAAAA GACAAGAAAC CAGACCTCGG TACAGCATTG GGTTAGAACA GGATGAGACG 600

TACATTCCTC CTGGAGAATC CCTTAGAGAC TTAATTGAGC AGTCTCAAAG CTCAGGAAGT 660

GGATCAGGCC TCCCTCTGCT GGTCCAAAGG ACTATAGCTA AGCAGATTCA GATGGTGAAA 720

CAGATTGGAA AAGGTCGCTA TGGGGAAGTT TGGATGGGAA AGTGGCGTGG CGAGAAGGTA 780

GCTGTGAAAG TGTTCTTCAC CACAGAGGAA GCCAGCTGGT TCCGAGAGAC AGAGATATAT 840

CAGACAGTGT TGATGAGGCA TGAAAACATT CTGGGGTTCA TTGCTGCAGA TATCAAAGGG 900

ACAGGGTCCT GGACCCAGTT GTACCTAATC ACAGACTATC ATGAAAATGG TTCCCTCTAT 960

GATTACCTGA AGTCCACCAC CCTAGACACA AAATCGATGC TGAAACTAGC CTACTCTTCT 1020

GTCAGTGGCT TATGTCATTT ACACACAGAA ATCTTTAGTA CCCAAGGCAA ACCAGCAATC 1080

GCCCACCGAG ATCTGAAAAG TAAGAACATC CTGGTGAAGA AAAATGGAAC TTGTTGTATA 1140

GCTGACCTGG GCCTGGCTGT TAAATTCATT AGTGATACCA ATGAAGTTGA CATCCCGCCC 1200

AACACCCGCG TTGGCACCAA ACGCTACATG CCTCCAGAAG TGTTGGACGA GAGCTTAAAT 1260

AGAAATCACT TTCAGTCGTA CATTATGGCC GACATGTACA GTTTCGGACT CATCCTCTGG 1320

GAGGTTGCTA GGAGATGTGT ATCGGGAGGT ATAGTGGAAG AATACCAGCT TCCGTATCAT 1380

GATCTCGTGC CCAGTGACCC TTCTTACGAG GACATGCGAG AGATTGTTTG CATCAAAAAG 1440

CTCCGTCCCT CATTCCCCAA CCGGTGGAGT AGTGATGAGT GTCTAAGGCA GATGGGCAAG 1500

CTCATGATGG AGTGCTGGGC TCACAGCCCT GCGTCAAGAC TGACAGCCCT GCGTGTTAAG 1560

AAAACACTAG CCAAAATGTC AGAGTCCCAG GACATTAAAC TCTGA 1605

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 236   IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  295

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 296   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  355

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 356   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  413

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 414   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  472

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl+ ecW++ p++Rltalrvkk+l

Q: 473   REIVCIKKLRPSFPNRWSSDECLRQMGKLMMECWAHSPASRLTALRVKKTL  523

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMMEC WAHSPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0030509	; P:BMP signaling pathway
GO:0001502	; P:cartilage condensation
GO:0009953	; P:dorsal/ventral pattern formation
GO:0006954	; P:inflammatory response
GO:0035108	; P:limb morphogenesis
GO:0001550	; P:ovarian cumulus expansion
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0060041	; P:retina development in camera-type eye
GO:0031290	; P:retinal ganglion cell axon guidance
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013