EKS-AIM-00101

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00101

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	472.0	4.0E-142	363	613	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006401

UniProt Accession

G1LHK5;

Protein Name

Protein Synonyms/Alias

Gene Name

ITK

Gene Synonyms/Alias

ITK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000005998	ENSAMEP00000006401	ENSAMET00000006666

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

620

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKTSLAY FENRHGKKRT LKGSIELSRI 60

KCVEIVKSDI CIPCHYKYPF QVVHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPMY 120

HPNFWMDGRW RCCAQLEKLA VGCAQYDPTK NASKKPLPPT PEDNRRSLRE PEETIVIALY 180

DYQTNDPQEL MIQRNEEYYL LDSSEIHWWR VQDKNGHEGY VPSSYLVEKS PNSLETYEWY 240

NKSISRDKAE KLLLDTGKEG AFMVRDSRTP GTYTVSVFTK AIVSENNPCI KHYHIKETNE 300

NPKRYYVAEK YVFDSIPLLI NYHQHNGGGL VTRLRYPVCS WSQKAPVTAG LRYGKWVIDP 360

TELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIQEGAMSE EDFIEEAEVM MKLSHPKLVQ 420

LYGVCLEQAP ICLVFEFMEH GCLSDYLRSQ RGLFASETLL GMCLDVCEGM AYLEEACVIH 480

RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540

VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASANIYQI MSHCWKEKPE 600

DRPPFCRLLS QLAEIAESGL 620

Nucleotide Sequence
(FASTA)

ATGAACAACT TTATCCTCCT GGAAGAACAG CTCATCAAGA AATCACAACA GAAGAGAAGA 60

ACTTCTCCCT CAAACTTCAA AGTCCGCTTC TTTGTTTTAA CCAAAACCAG CCTGGCGTAC 120

TTTGAGAACC GTCATGGGAA AAAGCGCACA TTGAAGGGCT CCATTGAACT CTCCCGAATC 180

AAATGTGTCG AGATTGTGAA AAGTGACATT TGCATCCCAT GCCACTATAA ATACCCATTT 240

CAGGTTGTGC ATGACAACTA CCTCCTGTAT GTGTTTGCTC CAGACCGCGA GAGCCGGCAG 300

CGTTGGGTTC TGGCCCTTAA AGAAGAAACA AGGAATAATA ACAGTTTGGT ACCCATGTAT 360

CATCCTAACT TCTGGATGGA CGGAAGGTGG AGATGCTGTG CTCAGCTAGA GAAGCTCGCA 420

GTGGGCTGTG CCCAGTATGA TCCAACCAAA AATGCTTCAA AGAAGCCTCT TCCTCCTACT 480

CCTGAAGACA ACAGGCGATC ACTTCGGGAA CCTGAAGAAA CCATTGTCAT TGCCTTGTAT 540

GACTACCAAA CAAATGATCC ACAGGAACTC ATGATACAAC GCAATGAGGA GTACTACCTG 600

CTGGACAGTT CTGAGATTCA CTGGTGGAGA GTGCAGGACA AGAATGGGCA TGAAGGATAC 660

GTACCCAGCA GTTATCTGGT GGAAAAATCT CCAAATAGCC TGGAAACCTA TGAGTGGTAC 720

AATAAAAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT TGGACACAGG CAAAGAAGGA 780

GCCTTCATGG TACGAGATTC CAGGACTCCA GGAACATACA CGGTGTCTGT TTTCACCAAA 840

GCCATTGTAA GTGAGAACAA CCCCTGTATA AAGCACTATC ACATCAAAGA AACAAATGAG 900

AACCCCAAGC GATATTATGT GGCTGAGAAG TATGTGTTTG ACTCCATCCC TCTCCTCATC 960

AATTATCACC AACATAATGG AGGAGGTCTG GTCACTAGAC TCCGGTATCC AGTTTGTTCC 1020

TGGAGTCAGA AAGCCCCGGT CACAGCAGGA CTGAGATACG GGAAATGGGT GATTGATCCC 1080

ACAGAGCTCA CTTTTGTGCA GGAGATTGGC AGTGGGCAGT TTGGCTTGGT ACATCTTGGC 1140

TACTGGCTCA ACAAGGACAA AGTGGCCATC AAAACCATTC AAGAAGGGGC TATGTCAGAA 1200

GAGGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTCT CTCACCCCAA ACTGGTCCAG 1260

CTGTACGGGG TGTGCCTAGA GCAGGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320

GGCTGCCTGT CAGATTACCT GCGCAGCCAG CGGGGGCTCT TTGCCTCAGA AACCCTGCTG 1380

GGCATGTGCC TGGATGTGTG TGAGGGCATG GCGTACCTGG AAGAGGCATG TGTCATCCAC 1440

AGAGACCTGG CTGCCAGAAA TTGTTTAGTG GGAGAAAACC AAGTCATCAA GGTGTCCGAC 1500

TTTGGGATGA CAAGGTTCGT CCTTGATGAT CAGTACACCA GTTCCACAGG CACCAAGTTC 1560

CCGGTGAAGT GGGCATCCCC GGAAGTCTTC TCCTTCAGTC GCTATAGCAG CAAGTCAGAC 1620

GTGTGGTCAT TCGGTGTGCT GATGTGGGAA GTCTTCAGTG AAGGCAAAAT CCCATATGAA 1680

AACCGAAGCA ACTCAGAAGT GGTAGAAGAC ATCAGTACCG GATTTCGCTT ATACAAGCCC 1740

CGGCTGGCCT CTGCGAATAT CTACCAGATC ATGAGTCATT GCTGGAAAGA GAAACCAGAA 1800

GACCGGCCAC CTTTCTGCAG ACTCTTGAGT CAACTGGCTG AAATTGCAGA ATCGGGACTT 1860

TAG 1863

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  422

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd

Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFASETLLGMCLDVCEGMAYLEEACVIHRD  482

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las ++y++m +cwkekpe+r

Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASANIYQIMSHCWKEKPEDR  602

         ************************************************************

S: 241   ptfkellsale  251

         p f +lls+l+

Q: 603   PPFCRLLSQLA  613

         ********986

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFASETLLGM CLDVCEGMAY LEEACVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASANIYQIMS HCWKEKPEDR 240

PPFCRLLSQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

aml:100475688

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013