EKS-AIM-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	425.6	6.1E-128	236	485	250

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006502

UniProt Accession

G1LHV4;

Protein Name

Protein Synonyms/Alias

Gene Name

BLK

Gene Synonyms/Alias

BLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000006136	ENSAMEP00000006502	ENSAMET00000006772

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MGVVSSKKQV KEKSKGRWSP VKVSTQSKDP PPLPPLVLFN HLAPAPPDTC PDKEEHFVVA 60

LYDYSSVNDR DLQMLKGEKL QILKEVGDWW LARSLITGRE GYVPSNFVAR VETLEVEKWF 120

FRSISRKDAE RQLLAPINKA GSFLIRESET NKGAFSLTVK DVTTQGEMIK HYKIRSLDEG 180

GYYISPRITF PTLQALVQHY SQKGDGLCQR LTQPCVSLAP QNPWAQDEWE IPRQSLKLVR 240

KLGSGQFGEV WMGYFKNNVK VAIKTLKEGT MSPEAFLAEA NLMKTLQHER LVRLYAVVTK 300

EPIYIVTEYM ARGCLLDFLK TDEGSRLSLP RLIDMSAQIA EGMAYIEQMN SIHRDLRAAN 360

ILVSETLCCK IADFGLARII DNEYTAQEGA KFPIKWTAPE AIHFGVFTIK ADVWSFGILL 420

MEIVTYGRVP YPGMSNPEVI RSLERGYRMP RPDSCPPELY RGVIAECWRS RPEDRPTFEF 480

LQSVLEDFHT ATEEQYELQP 500

Nucleotide Sequence
(FASTA)

ATGGGAGTGG TGAGCAGCAA AAAGCAAGTG AAGGAGAAGA GTAAGGGCCG ATGGAGTCCT 60

GTGAAGGTCA GCACCCAGAG CAAAGACCCC CCACCACTGC CACCCCTGGT CCTGTTTAAC 120

CACCTGGCCC CTGCACCTCC GGACACATGC CCAGACAAAG AGGAGCATTT CGTGGTGGCC 180

CTGTACGACT ACAGCTCAGT GAATGACAGG GACCTGCAGA TGCTGAAGGG GGAGAAGCTG 240

CAGATACTGA AGGAAGTTGG AGACTGGTGG TTGGCCAGGT CTCTCATAAC CGGAAGAGAA 300

GGCTACGTGC CCAGCAACTT TGTGGCCCGA GTGGAGACCC TGGAAGTGGA AAAATGGTTC 360

TTTAGATCAA TTAGCCGGAA GGATGCTGAG AGGCAGCTTC TGGCTCCAAT CAATAAGGCG 420

GGCTCCTTTC TTATCAGAGA GAGTGAAACC AACAAAGGTG CCTTTTCCTT GACTGTGAAG 480

GATGTGACCA CCCAGGGAGA GATGATCAAA CACTACAAGA TCCGCTCCCT GGATGAAGGG 540

GGCTATTACA TCTCCCCCCG CATCACCTTC CCTACTCTCC AAGCTCTGGT GCAGCATTAT 600

TCTCAGAAAG GGGATGGTTT ATGCCAGAGG CTGACCCAAC CCTGTGTGAG CCTGGCTCCT 660

CAAAACCCCT GGGCCCAGGA TGAGTGGGAA ATCCCCCGGC AGTCTCTCAA GCTGGTCAGG 720

AAACTCGGGT CTGGGCAGTT TGGTGAAGTC TGGATGGGTT ATTTCAAGAA CAACGTGAAA 780

GTGGCCATCA AGACCTTAAA GGAGGGAACC ATGTCTCCAG AGGCCTTCCT GGCAGAGGCC 840

AACCTGATGA AAACTCTCCA GCATGAGAGG CTAGTTCGTC TCTATGCCGT GGTCACCAAG 900

GAACCCATTT ACATCGTGAC CGAGTACATG GCCAGAGGAT GCTTACTGGA TTTCCTGAAG 960

ACAGATGAAG GTAGCAGATT GTCCCTCCCA CGACTGATCG ACATGTCAGC CCAGATTGCC 1020

GAAGGAATGG CGTATATCGA GCAAATGAAT TCAATCCACC GTGACCTGAG GGCGGCCAAC 1080

ATCCTGGTGT CTGAGACCCT GTGCTGCAAG ATCGCTGACT TCGGCTTGGC CCGCATCATT 1140

GACAATGAAT ACACTGCCCA AGAAGGGGCC AAGTTCCCCA TCAAGTGGAC TGCCCCAGAG 1200

GCCATCCATT TTGGGGTGTT CACCATCAAA GCAGACGTGT GGTCATTTGG AATCCTCCTG 1260

ATGGAAATCG TCACTTATGG GCGTGTACCC TACCCAGGAA TGAGCAACCC CGAGGTCATC 1320

CGCAGCCTGG AGCGGGGCTA CCGCATGCCA CGCCCCGACT CGTGCCCGCC CGAGCTGTAC 1380

CGCGGTGTCA TCGCCGAGTG CTGGCGGAGC CGGCCGGAGG ACCGGCCCAC CTTCGAGTTC 1440

CTGCAGTCTG TGCTCGAGGA CTTCCACACG GCCACCGAGG AGCAGTATGA GCTGCAGCCC 1500

TAG 1503

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k++vkva+ktlkegt+speafl+ea+++k+l+he+lv+ly

Q: 236   LKLVRKLGSGQFGEVWMGYFKNNVKVAIKTLKEGTMSPEAFLAEANLMKTLQHERLVRLY  295

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aq+aeGmay+e++n ihr

Q: 296   AVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIEQMNSIHR  354

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 355   DLRAANILVSETLCCKIADFGLARII-DNEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  413

         *************************9.89*******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfGill+eivt+G+vPypGm+n ev++++ergyr+prp++cp ely+ +++ecw+++pe

Q: 414   WSFGILLMEIVTYGRVPYPGMSNPEVIRSLERGYRMPRPDSCPPELYRgVIAECWRSRPE  473

         ************************************************9***********

S: 240   erPtfetlqevl  251

         +rPtfe+lq+vl

Q: 474   DRPTFEFLQSVL  485

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYF KNNVKVAIKT LKEGTMSPEA FLAEANLMKT LQHERLVRLY 60

AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY IEQMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDNEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGILLMEIVT YGRVPYPGMS NPEVIRSLER GYRMPRPDSC PPELYRGVIA ECWRSRPEDR 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

aml:100479355

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013