EKS-AIM-00438

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00438

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	364.4	3.9E-109	15	305	291

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006841

UniProt Accession

G1LIT7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000006484	ENSAMEP00000006841	ENSAMET00000007127

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

552

Protein Sequence
(FASTA)

MCAAEVDHHV AQRYLLKRRL GKGAYGIVWK AVDRRTGEVV AIKKIFDAFR DKTDAQRTFR 60

EIMLLQELGD HPNIIRLLDV IRAENDRDIY LVFESMDTDL NAVICKGKLL RDVHKRYIIY 120

QLLRATKFIH SGRVIHRDQK PSNILLDSSC LVKLCDFGLA RSLSGLPEGP EGQALTDYVA 180

TRWYRAPEVL LSSSWYTPGV DMWSLGCILG EMLRGRPLFP GTSTLHQLEL ILETIPPPSK 240

EDLLALGSSY SASILPCLGS RPRQTLDTLL PSDTPPEALD LLRRLLVFAP DKRLSAAQAL 300

QHPYVQRFHC PAREWSRVRL PVLEGVQLSA PEYRSRVYQM VLERRGNSCV PRDKGLGSTA 360

PGAQPSAPWS QAPLLKSRVI PQPAPGSPPQ NSGRSPGHQR AHDMACGAKN LPRQSSAPLL 420

QPPPPGGLGR GERPPGATAE APSAPSWVKP SGKGAAPSLA SQAAAQVAIQ ALIRSDWNPG 480

RGVRATGARR VPRGLPADVR PAPRPGRRMF SASASQGAQG AARAALGGYS QAYGTVCHSA 540

LGRLPLLPGP RA 552

Nucleotide Sequence
(FASTA)

ATGTGCGCCG CGGAGGTGGA CCACCACGTA GCCCAACGAT ACCTGCTTAA GCGGCGGCTG 60

GGGAAGGGGG CCTATGGCAT CGTGTGGAAG GCAGTGGATA GGAGGACTGG CGAGGTCGTG 120

GCCATCAAGA AGATCTTCGA TGCCTTTAGA GATAAGACGG ATGCCCAGAG AACGTTCCGG 180

GAAATCATGC TGCTCCAGGA ACTTGGGGAC CATCCCAACA TCATCCGCCT CCTGGATGTG 240

ATCCGGGCAG AGAATGACAG GGACATTTAC CTGGTGTTTG AGTCTATGGA CACTGACCTG 300

AACGCCGTCA TCTGCAAGGG CAAGCTGCTG AGGGACGTCC ACAAGCGTTA CATCATCTAC 360

CAGCTCCTAC GGGCCACCAA GTTCATCCAC TCAGGACGTG TCATCCACCG AGACCAGAAG 420

CCATCCAACA TCCTCCTGGA CTCCAGCTGC TTGGTGAAGC TCTGTGACTT TGGTCTTGCT 480

CGCTCCCTCA GTGGCCTCCC TGAGGGGCCT GAGGGCCAGG CCCTGACAGA TTACGTGGCC 540

ACACGCTGGT ACCGGGCTCC CGAGGTGCTG CTGTCCTCTA GCTGGTACAC CCCTGGGGTG 600

GACATGTGGA GTCTGGGCTG CATCCTGGGG GAGATGCTTC GGGGGAGGCC CCTGTTCCCC 660

GGCACATCCA CGCTGCACCA GCTGGAGCTG ATCCTAGAGA CCATCCCACC GCCATCCAAG 720

GAGGACCTCC TGGCTCTTGG CTCAAGCTAC AGTGCCTCGA TCCTGCCCTG CCTGGGGTCC 780

CGGCCACGGC AGACGCTGGA CACCCTCCTG CCGTCAGACA CACCCCCGGA GGCCTTGGAT 840

CTCCTCAGGA GGCTCCTGGT ATTTGCCCCG GACAAGCGGC TTAGCGCGGC CCAGGCACTG 900

CAGCACCCCT ACGTGCAGAG GTTCCACTGC CCGGCCCGTG AGTGGAGTCG GGTGCGGCTC 960

CCGGTGCTTG AAGGAGTTCA GCTCTCAGCC CCGGAGTATC GCAGCCGTGT CTATCAGATG 1020

GTCCTGGAGC GCAGGGGCAA CAGCTGCGTC CCCAGAGACA AGGGCCTGGG GAGCACAGCC 1080

CCCGGCGCAC AGCCCAGTGC CCCCTGGTCC CAGGCACCCC TGCTCAAATC CAGAGTCATC 1140

CCGCAGCCGG CCCCGGGCTC GCCCCCGCAG AACTCCGGAC GCAGCCCCGG TCACCAGCGC 1200

GCGCACGACA TGGCCTGCGG AGCCAAGAAC CTTCCGCGGC AGAGCTCGGC CCCCCTGCTC 1260

CAGCCTCCGC CCCCAGGAGG TCTCGGGAGA GGGGAGAGGC CCCCTGGGGC GACGGCGGAG 1320

GCCCCCTCGG CACCCTCGTG GGTGAAGCCC AGCGGGAAGG GGGCGGCGCC CTCCCTGGCT 1380

TCCCAGGCCG CCGCCCAGGT GGCCATCCAG GCCCTCATCC GGAGCGACTG GAATCCGGGC 1440

CGTGGGGTGA GGGCGACCGG CGCGCGACGG GTCCCTCGCG GGCTTCCCGC GGATGTCCGG 1500

CCCGCGCCCC GGCCCGGCCG GAGGATGTTC AGCGCCTCGG CCTCGCAGGG GGCCCAGGGC 1560

GCCGCAAGGG CTGCTCTCGG GGGCTACTCT CAAGCCTACG GGACCGTCTG CCACTCGGCG 1620

CTGGGCCGCC TGCCCCTGCT CCCGGGGCCC CGAGCGTAA 1659

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+el +h+Ni

Q: 15    LLKRRLGKGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREIMLLQELgDHPNI  74

         56789*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         i+lldv+++e+     +d+Ylv+e m+tdL++vi +   l+d h ++++yq+lr++k++H

Q: 75    IRLLDVIRAEN----DRDIYLVFESMDTDLNAVICKGkLLRDVHKRYIIYQLLRATKFIH  130

         ********999....9******************9987899*******************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s +viHrD+KPsN+l+++ c +k++dFGlars +   e      lt+yvatrwYraPe+l

Q: 131   SGRVIHRDQKPSNILLDSSCLVKLCDFGLARSLSGLPEGPegqaLTDYVATRWYRAPEVL  190

         ********************************766555445667****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls++ yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile+++ ps+e+l ++ s+

Q: 191   LSSSWYTPGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILETIPPPSKEDLLALGSSY  250

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

          ++++  l +++++++++l+p+ + +ealdLl++lLv++pdkR+s+++aL+hpY+

Q: 251   SASILPCLGSRPRQTLDTLLPSdTPPEALDLLRRLLVFAPDKRLSAAQALQHPYV  305

         ********************985779****************************7

Domain Sequence
(FASTA)

LLKRRLGKGA YGIVWKAVDR RTGEVVAIKK IFDAFRDKTD AQRTFREIML LQELGDHPNI 60

IRLLDVIRAE NDRDIYLVFE SMDTDLNAVI CKGKLLRDVH KRYIIYQLLR ATKFIHSGRV 120

IHRDQKPSNI LLDSSCLVKL CDFGLARSLS GLPEGPEGQA LTDYVATRWY RAPEVLLSSS 180

WYTPGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILET IPPPSKEDLL ALGSSYSASI 240

LPCLGSRPRQ TLDTLLPSDT PPEALDLLRR LLVFAPDKRL SAAQALQHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013