EKS-AIM-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	447.4	1.4E-134	277	526	250

Status

Unreviewed

Ensembl Protein

ENSAMEP00000006922

UniProt Accession

G1LJ17;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1

Gene Synonyms/Alias

YES1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000006544	ENSAMEP00000006922	ENSAMET00000007212

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

543

Protein Sequence
(FASTA)

IMGCIKSKEN KSPTIKYRTE NTPEPVSTSV SHYGAEHTAV AASSSTKGAS VNFNSLSMTP 60

FGGSSGVTPF GGASSSFSVV PSSYPAGLTG GVTIFVALYD YEARTTEDLS FKKGERFQII 120

NNTEGDWWEA RSIATGKNGY IPSNYVAPAD SIQAEEWYFG KMGRKDAERL LLNPGNQRGI 180

FLVRESETTK VGAYSLSIRD WDEVRGDNVK HYKIRKLDNG GYYITTRAQF DTLQKLVKHY 240

TEHADGLCHK LTTVCPTVKP QTQGLAKDAW EIPRESLRLE VKLGQGCFGE VWMGTWNGTT 300

KVAIKTLKPG TMMPEAFLQE AQIMKKLRHD KLVPLYAVVS EEPIYIVTEF MSKGSLLDFL 360

KEGDGKYLKL PQLVDMAAQI ADGMAYIERM NYIHRDLRAA NILVGENLVC KIADFGLARL 420

IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LQTELVTKGR VPYPGMVNRE 480

VLEQVERGYR MPCPQGCPES LHELMNLCWK KDPDERPTFE YIQSFLEDYF TATEPQYQPG 540

ENL 543

Nucleotide Sequence
(FASTA)

ATAATGGGCT GCATTAAAAG TAAAGAGAAC AAAAGTCCAA CCATTAAATA TAGAACCGAA 60

AACACTCCAG AACCTGTCAG TACAAGTGTC AGCCATTATG GGGCAGAACA CACGGCAGTG 120

GCAGCATCGT CTTCCACAAA GGGAGCGTCT GTTAATTTTA ACAGTCTTTC CATGACGCCA 180

TTTGGAGGAT CCTCAGGGGT CACACCTTTT GGAGGAGCAT CGTCTTCATT CTCAGTGGTG 240

CCAAGTTCAT ATCCTGCTGG TTTAACAGGT GGTGTTACTA TATTTGTGGC CTTATATGAT 300

TATGAAGCTA GAACTACAGA AGACCTTTCA TTCAAGAAAG GTGAACGGTT TCAAATAATT 360

AACAACACGG AAGGAGACTG GTGGGAAGCA AGATCAATTG CTACAGGAAA GAATGGCTAT 420

ATCCCTAGCA ATTATGTAGC CCCTGCAGAT TCCATTCAGG CAGAAGAATG GTATTTTGGC 480

AAAATGGGGA GAAAAGATGC CGAAAGATTA CTTCTGAATC CTGGGAATCA ACGAGGTATT 540

TTCTTGGTAA GAGAGAGTGA AACTACTAAA GTAGGTGCTT ATTCTCTCTC TATTCGTGAT 600

TGGGATGAGG TAAGAGGTGA CAATGTGAAA CACTATAAAA TTAGGAAACT TGACAACGGT 660

GGATACTATA TCACAACCAG AGCACAATTT GATACTCTGC AGAAGTTGGT AAAACACTAC 720

ACAGAACATG CTGATGGTTT ATGCCATAAG TTAACAACCG TGTGTCCAAC TGTGAAACCC 780

CAGACTCAAG GTCTAGCAAA AGATGCTTGG GAAATCCCTC GAGAATCTTT GCGACTAGAG 840

GTTAAATTAG GACAAGGATG TTTTGGTGAA GTATGGATGG GAACATGGAA TGGAACCACG 900

AAAGTAGCAA TCAAAACACT AAAACCAGGT ACAATGATGC CAGAAGCTTT TCTACAAGAG 960

GCTCAAATAA TGAAAAAATT AAGACATGAT AAACTTGTTC CACTGTATGC TGTTGTTTCT 1020

GAAGAGCCAA TTTACATTGT CACTGAATTT ATGTCAAAAG GGAGTTTATT GGATTTCCTG 1080

AAGGAGGGAG ATGGGAAGTA TTTGAAGCTC CCACAGCTGG TTGATATGGC TGCTCAGATT 1140

GCTGATGGTA TGGCGTATAT TGAAAGAATG AATTATATTC ACCGAGATCT TCGAGCTGCT 1200

AATATTCTTG TAGGGGAAAA TCTTGTGTGC AAAATAGCAG ATTTTGGTTT AGCAAGGTTA 1260

ATTGAAGACA ATGAATATAC AGCAAGACAA GGTGCAAAGT TTCCAATCAA ATGGACAGCT 1320

CCCGAGGCTG CACTATATGG CCGATTTACA ATAAAGTCTG ATGTTTGGTC ATTTGGAATT 1380

CTACAGACAG AACTGGTAAC AAAGGGCAGA GTGCCATATC CAGGTATGGT AAACCGTGAA 1440

GTGCTAGAAC AGGTGGAACG AGGATACAGG ATGCCTTGCC CTCAGGGCTG CCCAGAATCC 1500

CTACATGAAT TGATGAATCT TTGTTGGAAG AAGGACCCTG ATGAAAGACC AACATTTGAA 1560

TATATTCAGT CCTTCTTGGA AGACTACTTC ACTGCTACAG AGCCACAGTA CCAGCCAGGA 1620

GAAAATTTAT AA 1632

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt++peafl+eaqi+kklrh+klv ly

Q: 277   LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY  336

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke +gk+lklp+lvd+aaq+a+Gmay+e++n+ihr

Q: 337   AVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHR  395

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 396   DLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  455

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGil te+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+el++ cwkkdp+e

Q: 456   WSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDE  515

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe++q++l

Q: 516   RPTFEYIQSFL  526

         *******9986

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMMPEA FLQEAQIMKK LRHDKLVPLY 60

AVVSEEPIYI VTEFMSKGSL LDFLKEGDGK YLKLPQLVDM AAQIADGMAY IERMNYIHRD 120

LRAANILVGE NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILQTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHELMN LCWKKDPDER 240

PTFEYIQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0015758	; P:glucose transport

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013