EKS-AIM-00386

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00386

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	480.5	1.2E-144	14	275	262

Status

Unreviewed

Ensembl Protein

ENSAMEP00000007073

UniProt Accession

G1LJG8;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000006710	ENSAMEP00000007075	ENSAMET00000007375
ENSAMEG00000006710	ENSAMEP00000007073	ENSAMET00000007373

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED 60

IEREVSILKE IQHPNVITLH EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL 120

KQILNGVYYL HSLQIAHFDL KPENIMLLDR NVPKPRIKII DFGLAHKIDF GNEFKNIFGT 180

PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYEFEEEY 240

FSNTSALAKD FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA 300

ARTKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 360

QHLLGSLSNY DVNQPNKHGT PPLLIAAGCG NIQILQLLIK RGSRINVQDK GGSNAIYWAS 420

RHGHVDTLKF LNENKCPLDV KDKSGETALH VAARYGHADV VQLLCSFGSN PNFQDKEEET 480

PLHCAAWHGY YSVAKALCEA GCNVNIKNRE GETPLLTASA RGYHDIVECL SEHGADLNAS 540

DKDGHIALHL AVRRCQMEVI QTLISQGCSV DFQDRHGNTP LHVACKDGNV PIVVALCEAS 600

CNLDISNKYG RTPLHLAANN GILDVVRYLC LAGANVEALT SDGKTAEELA KSEQHEHVAG 660

LLARLRKDAH RTLFIQQLRP TQTLQSRIKL KLFGHSGSGK TTLVESLKCG LLRSFFRRRR 720

PRLSSMNSTR FPPSPLASKP 740

Nucleotide Sequence
(FASTA)

ATGACCGTGT TCAGGCAGGA AAACGTGGAT GATTACTACG ACACCGGCGA GGAACTTGGC 60

AGTGGGCAGT TTGCAGTGGT GAAGAAATGC CGGGAGAAAA GCACTGGTCT ACAGTATGCC 120

GCCAAGTTTA TCAAGAAAAG GAGGACGAAA TCGAGCCGGC GGGGCGTGAG CCGCGAGGAC 180

ATCGAGCGGG AGGTCAGCAT CCTGAAGGAG ATCCAGCATC CCAACGTCAT CACCCTGCAT 240

GAAGTTTACG AGAACAAGAC AGACGTCATC CTGATCTTAG AACTAGTTGC AGGTGGCGAG 300

CTGTTTGACT TCTTGGCTGA AAAGGAATCT CTGACTGAAG AGGAAGCAAC CGAGTTTCTC 360

AAACAAATTC TTAATGGTGT TTACTACCTG CACTCCCTTC AGATTGCCCA TTTTGATCTT 420

AAGCCCGAAA ACATAATGCT TTTGGATAGA AATGTCCCTA AACCTCGGAT CAAGATCATT 480

GATTTTGGGT TGGCCCATAA AATTGACTTT GGAAATGAAT TCAAAAACAT ATTTGGGACA 540

CCAGAGTTTG TTGCTCCTGA GATAGTCAAC TACGAACCTC TTGGTCTTGA GGCAGATATG 600

TGGAGTATCG GGGTAATAAC CTATATTCTC CTAAGTGGGG CCTCCCCATT TCTTGGAGAC 660

ACTAAGCAAG AAACGTTAGC AAACGTATCG GCCGTCAACT ACGAATTTGA GGAAGAATAC 720

TTCAGTAATA CCAGTGCCCT AGCCAAAGAT TTCATAAGAA GACTCCTCGT CAAGGATCCA 780

AAGAAGAGAA TGACAATTCA AGATAGTTTG CAGCATCCCT GGATCAAGCC TAAAGATACC 840

CAACAAGCGC TTAGTAGAAA GGCGTCGGCC GTCAACATGG AGAAGTTCAA GAAGTTCGCA 900

GCCCGGACGA AGTGGAAACA ATCCGTTCGC TTGATATCAC TGTGCCAAAG ATTATCCAGG 960

TCGTTCTTGT CCAGGAGTAA CATGAGTGTT GCCAGAAGCG ATGATACTCT GGATGAGGAA 1020

GACTCCTTTG TGATGAAAGC CATCATCCAC GCCATCAACG ATGATAACGT CCCAGGCCTG 1080

CAGCACCTCC TGGGCTCATT GTCCAACTAC GACGTTAACC AGCCCAACAA GCATGGGACA 1140

CCTCCGTTAC TGATCGCTGC TGGCTGTGGG AATATTCAAA TCCTACAGTT GCTCATTAAA 1200

AGAGGCTCAA GAATCAATGT CCAGGATAAG GGTGGATCCA ATGCCATCTA CTGGGCCTCT 1260

CGGCATGGCC ATGTAGACAC CCTGAAATTT CTCAATGAGA ACAAATGCCC TTTGGATGTT 1320

AAAGACAAGT CTGGAGAGAC AGCCCTTCAC GTGGCAGCTC GCTACGGCCA CGCCGACGTG 1380

GTACAGCTGT TGTGCAGCTT TGGCTCTAAC CCCAATTTCC AGGACAAGGA AGAAGAAACC 1440

CCCCTGCACT GCGCTGCCTG GCACGGCTAC TACTCTGTGG CCAAAGCCCT TTGCGAAGCC 1500

GGCTGCAATG TGAACATTAA GAACCGAGAA GGAGAGACAC CCCTCCTGAC AGCCTCTGCC 1560

AGGGGCTACC ACGACATCGT GGAGTGTCTG TCTGAACACG GAGCCGACCT GAATGCCTCC 1620

GACAAGGATG GACACATTGC TCTTCATCTT GCCGTGAGAC GGTGTCAGAT GGAGGTCATC 1680

CAGACTCTCA TCAGCCAGGG ATGTTCTGTC GACTTCCAAG ACAGGCACGG CAACACCCCC 1740

CTCCATGTGG CCTGCAAAGA TGGCAACGTG CCTATCGTGG TGGCCCTCTG TGAAGCCAGC 1800

TGCAATTTGG ATATCTCTAA CAAGTACGGC CGAACGCCTC TGCACCTCGC AGCCAACAAC 1860

GGGATTCTGG ATGTGGTCCG CTACCTCTGT CTGGCAGGCG CCAACGTGGA GGCCCTCACC 1920

TCGGACGGGA AGACAGCAGA AGAGCTTGCT AAATCAGAAC AGCACGAACA CGTAGCAGGT 1980

CTGCTTGCAA GACTCCGAAA GGACGCTCAC CGGACACTCT TCATCCAGCA GCTGCGACCC 2040

ACGCAGACCC TGCAATCCAG AATCAAACTG AAGCTGTTTG GCCACTCGGG CTCTGGGAAG 2100

ACCACGCTGG TGGAATCTCT CAAGTGTGGG CTGCTGAGAA GCTTCTTCAG GAGACGCCGG 2160

CCCAGACTCT CCTCTATGAA CTCCACCCGG TTCCCGCCCT CGCCGCTGGC ATCCAAGCCG 2220

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         +tg+elgsG+favv+kcrekstG +yaakf+kkrr+kssrrgvsre+ierev++lkei+

Q: 14    DTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ-  72

         789********************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         +pnvi+lhevyenk+dvililelvaGGelfd+laekesl+eeeate+lkqil+gv+ylhs

Q: 73    HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHS  132

         ************************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

          +i+h+dlkPeni+lld++vpk++ik+idfGl++ki+ g+e+k+i+GtPefvaPeivnye

Q: 133   LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE  192

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmwsiGvityillsgasPflGdtkqetl+n+savn++f+ee+fs++s lakdfi

Q: 193   PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEEEYFSNTSALAKDFI  252

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

         rrllvkdp+kr+ti+++l+h+w+

Q: 253   RRLLVKDPKKRMTIQDSLQHPWI  275

         **********************8

Domain Sequence
(FASTA)

DTGEELGSGQ FAVVKKCREK STGLQYAAKF IKKRRTKSSR RGVSREDIER EVSILKEIQH 60

PNVITLHEVY ENKTDVILIL ELVAGGELFD FLAEKESLTE EEATEFLKQI LNGVYYLHSL 120

QIAHFDLKPE NIMLLDRNVP KPRIKIIDFG LAHKIDFGNE FKNIFGTPEF VAPEIVNYEP 180

LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANVSAVN YEFEEEYFSN TSALAKDFIR 240

RLLVKDPKKR MTIQDSLQHP WI 262

Keyword

ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000310	; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR020676	; Death-assoc_prot_kinase.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013