EKS-AIM-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph432.83.2E-130621875255
StatusUnreviewed
Ensembl ProteinENSAMEP00000007226
UniProt AccessionG1LJW7;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000006731ENSAMEP00000007226ENSAMET00000007531
OrganismAiluropoda melanoleuca
Functional Description
Protein Length972
Protein Sequence
(FASTA)
MERRWPLGLG LLLLLCAPLP PGARAKEVTL MDTTTAQGEL GWLLDPPEDG WSEVQQILNG 60
TPLYMYQDCP VQAGGDTDHW LRSNWIYRGE EASRVHVELQ FTVRDCKSFP GGAGPLGCKE 120
TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLA SGAVKLNVER CSLGRLTRRG 180
LYLAFHNPGA CVALVSVRVF YQRCPEVVHS LARFPDTLPG PGGLVEVAGT CLPRAQASPG 240
PSAAPRMHCS PDGEWLVPVG RCHCEPGYEE DGSGEACLAC PSGSYRADTG APHCLKCPGH 300
STTESEGATI CTCESGHFRA PGEGPQVLCT RPPSVPRNLS FSILGTQLSL RWEPPADMGG 360
RQDVRYIVGC SQCRGAVVDG GPCQPCGGSV RFSPGASGLI APAVRVNGLE PYANYTFNVV 420
AQNGVSGLGT STHAGASLSI SMGHAGLSLR LVKKEPRQLE LTWAGSRPRS PGGNLSYELH 480
VLNQDEERHQ MVLEPRVLLT ELQPDTTYIV RVRMLTPLGP GPFSPDHEFR TSPPVSRRLT 540
GGEIVAIIFG LLLAVALLLG MLFFRSRKAE RRQQQRQRDR VTDVNREDKL WLKPYVDLQA 600
YEDPAQGALD FTQELDPGWL IVDTVIGEGE FGEVYRGTLR IPSQDCKTVA IKTLKDTSPD 660
GQWWNFLREA TIMGQFNHPH ILHLEGVVTK RKPIMIITEF MQNGALDAFL REREDQLVPG 720
QLVAMLQGIA SGMNYLSDHN YVHRDLAARN ILVSQNLCCK VSDFGLTRLL DNFDGTYETQ 780
GGKIPIRWTA PEAIAHRTFT TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR 840
LPPPVDCPAP LYELMKNCWA YDRARRPSFH QLKAHLEQLL ANPHSLRTIA NFDPRVTLRL 900
PSLSGSDGIP YRSVPEWLES IRMKRYILHF RSAGLDTMEC VLELTAEDLA QMGITLPGHQ 960
KRILCSIQGF KD 972
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GCTGGCCCCT GGGGCTCGGG CTGCTGCTGC TGCTCTGCGC CCCGCTGCCC 60
CCGGGGGCGC GCGCCAAGGA AGTCACTCTG ATGGACACGA CCACAGCACA GGGAGAGCTG 120
GGCTGGCTGC TGGATCCCCC AGAGGATGGG TGGAGTGAGG TGCAGCAGAT ACTGAATGGG 180
ACGCCCCTCT ACATGTACCA GGATTGCCCA GTGCAAGCAG GCGGGGACAC CGACCATTGG 240
CTGCGCTCCA ACTGGATTTA CCGGGGGGAG GAAGCTTCTC GGGTCCATGT GGAGCTGCAG 300
TTCACCGTGA GGGACTGCAA GAGTTTCCCC GGGGGAGCCG GGCCTCTGGG CTGCAAGGAG 360
ACCTTCAACC TCCTCTACAT GGAGAGTGAC CAGGACGTGG GCATCCAGCT CCGAAGGCCC 420
TTGTTCCAGA AGGTGACTAC TGTGGCTGCA GACCAGAGCT TCACCATCCG AGACCTGGCA 480
TCTGGCGCCG TGAAACTGAA CGTGGAGCGC TGCTCCCTGG GCCGCCTGAC CCGCCGAGGC 540
CTCTACCTCG CTTTCCACAA CCCAGGTGCC TGCGTGGCCC TGGTGTCCGT GAGGGTGTTC 600
TACCAGCGCT GTCCCGAAGT TGTGCACAGC TTGGCCCGGT TCCCCGACAC TCTGCCTGGC 660
CCTGGCGGCT TGGTGGAAGT GGCAGGGACC TGCTTGCCCC GTGCCCAGGC CAGCCCCGGC 720
CCCTCAGCCG CGCCCCGCAT GCACTGCAGC CCCGACGGTG AGTGGTTGGT GCCCGTGGGG 780
CGGTGCCACT GTGAGCCTGG CTATGAGGAA GACGGCAGCG GGGAAGCGTG CCTGGCCTGC 840
CCTAGCGGCT CCTACCGGGC GGACACAGGT GCACCCCATT GTCTCAAGTG CCCGGGACAC 900
AGCACAACGG AGTCTGAGGG GGCCACCATC TGCACCTGTG AGAGCGGCCA TTTCCGAGCC 960
CCTGGGGAGG GCCCCCAGGT GTTATGCACA CGGCCCCCCT CAGTTCCCCG AAACCTGAGC 1020
TTCTCTATTT TGGGGACTCA GCTCTCCCTG CGATGGGAAC CCCCGGCAGA TATGGGGGGT 1080
CGCCAGGATG TGAGGTACAT TGTGGGGTGT TCTCAGTGTC GGGGAGCAGT GGTGGATGGA 1140
GGACCCTGCC AGCCCTGTGG GGGAAGCGTG CGCTTTTCCC CGGGAGCCAG TGGGCTCATA 1200
GCACCAGCTG TGCGTGTCAA CGGCCTTGAA CCCTACGCCA ACTACACCTT TAACGTTGTG 1260
GCCCAGAATG GAGTGTCAGG GCTGGGCACC TCCACACATG CCGGCGCCTC CCTGAGCATC 1320
AGCATGGGGC ATGCAGGCCT GTCCCTGAGG CTGGTGAAGA AGGAACCCCG GCAGCTGGAA 1380
CTGACCTGGG CAGGGTCCCG GCCCCGCAGC CCCGGGGGGA ACTTGAGCTA TGAGCTGCAT 1440
GTGCTGAATC AGGATGAAGA ACGGCACCAG ATGGTTCTAG AACCCAGGGT CTTGCTGACT 1500
GAACTGCAGC CAGACACTAC GTACATTGTC AGAGTTCGAA TGTTGACCCC TCTAGGGCCT 1560
GGCCCTTTCT CCCCTGACCA TGAGTTTCGG ACAAGCCCAC CAGTTTCCAG GCGCCTGACC 1620
GGAGGCGAGA TCGTAGCCAT CATCTTCGGG CTGCTGCTGG CTGTAGCTCT GCTGCTCGGG 1680
ATGCTCTTCT TCCGCTCAAG GAAAGCTGAG CGGCGACAGC AGCAGAGGCA ACGTGATCGC 1740
GTCACCGATG TGAACCGAGA GGACAAGCTG TGGCTGAAGC CTTATGTGGA CCTCCAAGCG 1800
TATGAGGACC CTGCCCAGGG AGCCCTGGAC TTCACCCAGG AGCTTGACCC AGGCTGGCTG 1860
ATTGTGGACA CTGTCATAGG GGAAGGAGAG TTTGGGGAAG TATATCGAGG GACCCTGAGA 1920
ATCCCTAGCC AGGACTGCAA GACTGTGGCC ATTAAGACCT TGAAAGACAC CTCTCCAGAC 1980
GGCCAGTGGT GGAACTTCCT TCGAGAGGCA ACTATCATGG GCCAGTTCAA CCACCCACAC 2040
ATTTTGCACC TGGAAGGCGT TGTCACAAAG AGAAAGCCCA TCATGATAAT CACAGAGTTT 2100
ATGCAGAACG GAGCCCTGGA TGCCTTCCTG AGGGAGCGGG AGGACCAGCT GGTCCCTGGG 2160
CAGCTGGTGG CCATGCTGCA GGGCATTGCC TCTGGCATGA ACTACCTTAG TGACCACAAT 2220
TACGTCCACC GGGACCTTGC TGCCAGGAAC ATCTTAGTGA GTCAGAACCT GTGCTGCAAG 2280
GTGTCTGACT TTGGCCTGAC CCGCCTCCTG GACAACTTTG ATGGCACATA TGAAACCCAG 2340
GGAGGAAAGA TCCCCATCCG TTGGACAGCC CCAGAAGCCA TTGCCCATCG CACCTTCACC 2400
ACGGCCAGCG ATGTGTGGAG CTTTGGGATT GTGATGTGGG AGGTGTTGAG CTTTGGAGAC 2460
AAGCCCTACG GGGAGATGAG CAATCAGGAG GTAATGAAGA GCATTGAGGA TGGGTACCGG 2520
CTGCCGCCTC CTGTGGACTG CCCTGCTCCT CTCTATGAAC TCATGAAGAA CTGCTGGGCC 2580
TATGACCGTG CCCGTCGGCC CTCCTTCCAC CAGCTGAAGG CGCATCTGGA ACAACTGCTT 2640
GCCAACCCGC ACTCCCTGCG GACCATTGCC AACTTTGATC CCAGGGTGAC TCTTCGCCTG 2700
CCCAGCTTGA GTGGCTCGGA TGGGATCCCC TATCGGAGCG TCCCCGAGTG GCTGGAGTCA 2760
ATCCGCATGA AACGCTACAT CCTGCACTTC CGCTCAGCAG GGCTGGACAC CATGGAGTGT 2820
GTTCTGGAGC TGACGGCCGA AGACCTGGCA CAGATGGGGA TCACGCTACC AGGACACCAG 2880
AAGCGCATTC TTTGCAGTAT TCAGGGATTC AAGGACTGA 2919
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
          +++viG+GefGev++G+l++p++   +vaiktlk++s + q+++fl+ea+i+Gqf+hp+
Q: 621   IVDTVIGEGEFGEVYRGTLRIPSQDCKTVAIKTLKDTSPDGQWWNFLREATIMGQFNHPH  680
         5899******************999999********************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i++leGvvtk+kp+mi+te+m+ngald+flr++++q++  qlv+ml+Giasgm+ylsd++
Q: 681   ILHLEGVVTKRKPIMIITEFMQNGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSDHN  740
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilv++nl+ckvsdfGl+r l d+ + +y+t+ggkipirwtapeaia+r+f
Q: 741   YVHRDLAARNILVSQNLCCKVSDFGLTRLL-DNFDGTYETQGGKIPIRWTAPEAIAHRTF  799
         ****************************98.7789*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 800   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  859
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dra+rp f+q++++
Q: 860   AYDRARRPSFHQLKAH  875
         ************9986
Domain Sequence
(FASTA)
IVDTVIGEGE FGEVYRGTLR IPSQDCKTVA IKTLKDTSPD GQWWNFLREA TIMGQFNHPH 60
ILHLEGVVTK RKPIMIITEF MQNGALDAFL REREDQLVPG QLVAMLQGIA SGMNYLSDHN 120
YVHRDLAARN ILVSQNLCCK VSDFGLTRLL DNFDGTYETQ GGKIPIRWTA PEAIAHRTFT 180
TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YDRARRPSFH QLKAH 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013