EKS-AIM-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	432.5	7.1E-130	15	288	274

Status

Unreviewed

Ensembl Protein

ENSAMEP00000007282

UniProt Accession

G1LK22;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000006839	ENSAMEP00000007282	ENSAMET00000007589

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

747

Protein Sequence
(FASTA)

MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDVK IAIKSCRLEL STKNRERWCH 60

EIQIMKKLNH ANVVKARDVP EELNFLINDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120

ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKIM HKIIDLGYAK DVDQGSLCTS 180

FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240

CIFACEEMTG EVRFSSHLPQ PNSLCSLIVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 300

FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 360

SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI DKVRDSKIQL 420

PIIQLRKVWA EAVHYVSGLK EDYSRLFQGQ RAAMLSLLRY NANLTKMKNT LISASQQLKA 480

KLEFFHKSIQ LDLERYSEQM TYGISSEKML KAWKEMEEKA IHYAEVGVIG YLEDQIMSLH 540

TEIMELQKSP YGRRQGDLME SLEQRAIDLY KQLKHRPSDH SYSDSTEMVK IIVHTVQSQD 600

RVLKELFGHL SKLLGCKQKI IDLLPKVEMA LSNIKEADNT VMFMQGKRQK EIWHLLKIAC 660

TQSSARSLVV SSLEGAVAPQ ASAWLPPTST EREHPLSCVV TPQDGETIAQ MIEENLNCLG 720

HLSTIIREGN EEQGSRMMNL DWSWLTE 747

Nucleotide Sequence
(FASTA)

ATGGAGCGGC CCCCGGGGCT GCGGCCGGGC GCGGGCGGGC CCTGGGAGAT GCGGGAGCGG 60

CTGGGCACCG GCGGCTTTGG GAACGTCTGC CTGTACCAGC ATCGGGAACT TGATGTCAAA 120

ATAGCAATTA AGTCATGTCG CCTAGAACTA AGTACCAAAA ACAGAGAACG GTGGTGCCAT 180

GAAATCCAGA TCATGAAGAA GTTGAACCAC GCCAATGTTG TAAAGGCCCG TGATGTACCT 240

GAGGAATTGA ATTTTTTAAT TAATGATGTG CCTCTTCTAG CAATGGAATA CTGTTCTGGA 300

GGAGATCTCC GGAAGTTACT CAACAAACCA GAAAATTGCT GTGGACTTAA AGAAAGCCAG 360

ATACTTTCTT TACTGAGTGA TATAGGGTCT GGGATCCGAT ATTTGCATGA AAACAAAATT 420

ATACATCGTG ATCTAAAACC TGAAAACATA GTTCTTCAGG ATGTTGGGGG AAAGATTATG 480

CATAAAATAA TTGATCTGGG ATATGCCAAA GATGTTGATC AAGGAAGTCT GTGTACATCT 540

TTTGTGGGAA CACTGCAATA TCTGGCCCCA GAACTCTTTG AGAATAAGCC TTACACAGCC 600

ACTGTTGATT ATTGGAGCTT TGGGACCATG GTATTTGAAT GTATTGCTGG ATATAGGCCT 660

TTTTTGCATC ATCTGCAGCC ATTTACCTGG CATGAGAAGA TTAAGAAGAA GGATCCAAAG 720

TGTATATTTG CATGTGAAGA GATGACAGGA GAAGTTCGGT TTAGTAGTCA TTTACCTCAA 780

CCAAATAGCC TTTGTAGTTT AATAGTAGAA CCCATGGAAA ACTGGCTTCA GTTGATGCTG 840

AATTGGGATC CTCAGCAAAG AGGAGGACCT GTAGATCTTA CTTTGAAGCA GCCAAGATGT 900

TTTGTATTAA TGGATCACAT TCTGAATTTG AAGATAGTAC ACATCCTAAA TATGACTTCT 960

GCAAAGATAA TTTCTTTTTT GTTACCACCT GATGAAAGTC TTCATTCACT ACAGTCTCGT 1020

ATTGAGCGTG AAACTGGAAT AAATACTGGT TCTCAAGAGC TGCTTTCAGA GACAGGAATT 1080

TCTCTGGATC CTCGGAAACC AGCCTCTCAA TGTGTTCTAG ATGGAGTCAG AGGCTGTGAT 1140

AGCTATATGG TGTATTTGTT TGATAAAAGT AAGACTGTAT ATGAAGGACC ATTTGCTTCC 1200

AGAAGTTTAT CTGACTGTGT AAATTATATT GATAAAGTAC GGGACAGCAA AATACAGCTT 1260

CCAATTATAC AGCTGCGTAA AGTATGGGCT GAAGCAGTAC ACTATGTGTC TGGGCTAAAA 1320

GAAGACTACA GCAGGCTCTT TCAGGGACAA AGAGCAGCAA TGTTAAGTCT TCTTCGATAC 1380

AATGCTAACT TGACAAAAAT GAAGAACACT TTGATCTCAG CATCTCAGCA ACTGAAAGCT 1440

AAATTGGAGT TTTTCCACAA AAGCATTCAG CTTGACTTGG AAAGATACAG TGAGCAGATG 1500

ACTTATGGGA TATCCTCAGA AAAAATGTTA AAAGCATGGA AGGAAATGGA AGAAAAGGCT 1560

ATCCACTATG CTGAGGTGGG TGTCATTGGT TACCTGGAGG ATCAGATCAT GTCCCTGCAC 1620

ACTGAAATCA TGGAGCTGCA GAAGAGCCCT TATGGAAGAC GTCAGGGAGA CTTGATGGAA 1680

TCTCTGGAAC AGCGTGCCAT TGATCTGTAT AAGCAGTTAA AGCACAGACC TTCAGATCAC 1740

TCCTACAGCG ACAGCACGGA AATGGTGAAG ATCATTGTGC ATACTGTTCA AAGTCAGGAC 1800

CGGGTTCTCA AGGAGCTGTT TGGTCATCTG AGCAAGTTAC TGGGCTGTAA GCAGAAGATT 1860

ATTGATCTAC TGCCCAAGGT GGAAATGGCC CTCAGTAACA TCAAAGAAGC TGACAATACT 1920

GTCATGTTTA TGCAGGGAAA GAGACAGAAA GAAATATGGC ATCTCCTTAA AATTGCCTGT 1980

ACACAGAGTT CTGCCCGGTC CCTTGTAGTA TCCAGTCTAG AAGGTGCAGT AGCCCCTCAG 2040

GCATCAGCAT GGCTTCCCCC AACTTCAACA GAACGTGAAC ATCCTCTGTC ATGCGTGGTA 2100

ACTCCTCAAG ATGGGGAGAC TATAGCACAA ATGATAGAAG AAAATTTGAA CTGTCTTGGC 2160

CATTTAAGCA CTATTATTCG TGAAGGAAAT GAGGAACAGG GCAGTAGAAT GATGAATCTT 2220

GATTGGAGTT GGTTAACAGA ATGA 2244

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         We++e+LG+G+fgnv+ +++++ + kia+k+++ e+s+++re++++e+++++klnh+n+v

Q: 15    WEMRERLGTGGFGNVCLYQHRELDVKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV  74

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k+ dv+eeln++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++Lsd+ +g+ry

Q: 75    KARDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY  134

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+enki+hRDlkPenivl+++ +gk ++k++DlG+a+++d++++++s+vGt++YlaPel+

Q: 135   LHENKIIHRDLKPENIVLQDV-GGKIMHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF  193

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k ytatvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k+i+++e+++gev+

Q: 194   ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMTGEVR  253

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekrw  275

         fss+lP+++sl+s+++e +e++l+++l++d+++r+

Q: 254   FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRG  288

         ********************************986

Domain Sequence
(FASTA)

WEMRERLGTG GFGNVCLYQH RELDVKIAIK SCRLELSTKN RERWCHEIQI MKKLNHANVV 60

KARDVPEELN FLINDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL LSDIGSGIRY 120

LHENKIIHRD LKPENIVLQD VGGKIMHKII DLGYAKDVDQ GSLCTSFVGT LQYLAPELFE 180

NKPYTATVDY WSFGTMVFEC IAGYRPFLHH LQPFTWHEKI KKKDPKCIFA CEEMTGEVRF 240

SSHLPQPNSL CSLIVEPMEN WLQLMLNWDP QQRG 274

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation
GO:0007595	; P:lactation
GO:0060749	; P:mammary gland alveolus development
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0002011	; P:morphogenesis of an epithelial sheet
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0030316	; P:osteoclast differentiation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013