EKS-AIM-00279
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00279
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.91.7E-151512769258
StatusUnreviewed
Ensembl ProteinENSAMEP00000007761
UniProt AccessionG1LLD3;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000007301ENSAMEP00000007761ENSAMET00000008086
ENSAMEG00000007301ENSAMEP00000007755ENSAMET00000008080
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1086
Protein Sequence
(FASTA)
TVTRTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG ACVTQCPQTF 60
VYNPTTFQLE HNFNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE ENGIKMCKPC 120
TDICPKACDG IGTGSLMSAQ TVDSSNIDRF INCTKINGNL IFLVTGIHGD PYNAIEAIDP 180
EKLNVFRTVR EITGFLNIQS WPPNMTDFSV FSNLVTIGGR VLYSGLSLLI LKQQGITSLQ 240
FQSLKEISAG NIYITDNSNL CYYHTINWTT LFSTINQRIV IRDNRKAENC TAEGMVCNHL 300
CSNDGCWGPG PDQCLSCRRF SRGRSCIESC NLYDGEFREF ENGSICVECD PQCEKMEDGI 360
LTCHGPGPDN CTKCSHFKDG PNCVEKCPDG LQGANSFIFK YADQDRECHP CHPNCTQGCS 420
GPTSHDCIYY PWTGHSTLPQ HARTPLIAAG VIGGLFILVI VGLTFAVYVR RKSIKKKRAL 480
RRFLETELVE PLTPSGTAPN QAQLRILKET ELKRVKVLGS GAFGTVYKGI WVPEGETVKI 540
PVAIKILNET TGPKANVEFM DEALIMASMD HPHLVRLLGV CLSPTIQLVT QLMPHGCLLD 600
YVHEHKDNIG SQLLLNWCVQ IAKGMMYLEE RRLVHRDLAA RNVLVKSPNH VKITDFGLAR 660
LLEGDEKEYN ADGGKMPIKW MALECIHYRK FTHQSDVWSY GVTIWELMTF GGKPYDGIPT 720
REIPDLLEKG ERLPQPPICT IDVYMVMVKC WMIDADSRPK FKELAAEFSR MARDPQRYLV 780
IQGDDRMKLP SPNDSKFFQN LLDEEDLEDM MDAEEYLVPQ AFNIPPPIYT SRARIDSNRN 840
QFVYRDGGFA AEQGVPVPYR ATTSTIPEAP VAQGATADMF DDSCCNGTLR KPVAPHVQED 900
SSTQRYSADP TVFAPERSPR GELDEEGYMT PMRDKPKQEY LNPVEENPFV SRRKNGDLQA 960
LDNPEYHNAS NGPPKTEDEY VNEPLYLNTF ANALGNAEYL KNHVLSVPEK AKKAFDNPDY 1020
WNHSLPPRST LQHPDYLQEY STNYFYKQNG RIRPIVAENP EYLSEFSLKP GTVLPPPPYR 1080
HRNTVV 1086
Nucleotide Sequence
(FASTA)
ACAGTGACAA GGACGGTGTG TGCAGAGCAG TGTGATGGCA GGTGCTATGG GCCCTATGTC 60
AGTGACTGCT GTCATAGAGA ATGTGCTGGG GGCTGCTCAG GACCTAAGGA CACAGACTGC 120
TTTGCCTGCA TGAATTTCAA TGACAGTGGA GCATGTGTTA CTCAGTGTCC CCAAACTTTT 180
GTCTACAATC CAACCACCTT TCAACTGGAG CATAACTTCA ATGCAAAGTA TACATATGGA 240
GCATTTTGTG TCAAGAAATG CCCACATAAC TTTGTGGTGG ATTCCAGTTC CTGTGTGCGT 300
GCCTGCCCCA GTTCCAAGAT GGAAGTAGAA GAAAATGGGA TTAAAATGTG TAAACCTTGC 360
ACGGATATTT GCCCCAAAGC TTGTGATGGT ATTGGCACAG GATCACTGAT GTCAGCTCAG 420
ACCGTGGATT CCAGTAACAT TGACAGATTC ATAAACTGCA CCAAAATCAA TGGGAATTTG 480
ATCTTCCTTG TCACTGGTAT TCATGGGGAC CCTTACAACG CAATTGAAGC CATAGACCCA 540
GAGAAACTGA ATGTTTTCCG GACAGTTCGA GAGATAACGG GTTTCTTAAA CATACAGTCA 600
TGGCCCCCAA ACATGACTGA CTTCAGTGTT TTCTCTAACC TGGTGACCAT CGGTGGAAGA 660
GTCCTCTATA GTGGCCTCTC CTTGCTTATC CTTAAGCAAC AGGGCATCAC TTCTCTACAA 720
TTCCAATCTC TGAAGGAAAT CAGTGCAGGA AACATCTATA TTACTGACAA CAGCAACCTA 780
TGTTATTATC ATACCATTAA TTGGACAACA CTCTTCAGCA CTATCAACCA AAGAATAGTG 840
ATCCGGGACA ATAGGAAAGC TGAAAACTGT ACTGCTGAAG GAATGGTGTG CAACCATCTG 900
TGTTCAAACG ATGGCTGTTG GGGACCTGGC CCCGACCAGT GCCTGTCATG CCGTCGTTTC 960
AGCAGAGGAA GGAGCTGCAT CGAGTCTTGT AACCTCTATG ATGGTGAATT TCGAGAGTTT 1020
GAGAATGGCT CCATCTGTGT GGAGTGTGAC CCCCAGTGTG AGAAGATGGA AGATGGCATC 1080
CTCACCTGCC ATGGACCGGG ACCTGACAAC TGCACAAAGT GCTCCCATTT TAAAGATGGT 1140
CCGAACTGTG TGGAAAAATG TCCAGATGGC CTACAGGGGG CAAACAGTTT CATTTTCAAG 1200
TATGCTGATC AGGATCGGGA GTGCCACCCA TGCCATCCAA ACTGCACCCA AGGGTGTAGC 1260
GGTCCCACTA GTCATGACTG CATTTATTAT CCTTGGACGG GCCATTCCAC TTTACCACAA 1320
CATGCTAGAA CTCCGCTAAT TGCAGCGGGA GTTATCGGCG GGCTCTTCAT CTTGGTCATC 1380
GTGGGTCTAA CATTTGCAGT TTATGTTAGA AGGAAGAGCA TCAAAAAGAA AAGAGCCTTA 1440
AGAAGATTTC TGGAAACAGA GTTAGTAGAA CCCTTAACTC CCAGTGGTAC GGCACCCAAT 1500
CAAGCTCAAC TTCGTATTTT AAAAGAAACT GAGCTCAAAA GAGTGAAAGT ACTCGGCTCA 1560
GGTGCTTTTG GAACAGTTTA TAAGGGTATT TGGGTACCTG AAGGAGAAAC AGTAAAGATT 1620
CCTGTGGCTA TTAAGATTCT TAATGAAACA ACTGGTCCCA AAGCCAATGT AGAGTTCATG 1680
GATGAAGCTT TGATCATGGC AAGTATGGAT CATCCACACT TAGTCCGGTT ATTGGGTGTG 1740
TGTCTGAGCC CAACCATTCA GCTGGTTACA CAGCTTATGC CCCATGGCTG CCTGTTGGAT 1800
TATGTCCACG AACACAAGGA CAACATTGGA TCCCAGCTGC TGCTTAACTG GTGTGTCCAG 1860
ATAGCTAAGG GAATGATGTA CTTGGAAGAA AGACGGCTTG TTCATCGGGA TTTGGCAGCC 1920
CGAAATGTCT TAGTGAAATC TCCAAACCAT GTGAAAATCA CAGATTTTGG ACTAGCCAGA 1980
CTCTTAGAAG GAGATGAAAA AGAGTATAAT GCTGATGGAG GAAAGATGCC AATTAAATGG 2040
ATGGCTCTGG AGTGTATACA CTACAGGAAA TTCACCCATC AGAGTGATGT TTGGAGCTAC 2100
GGAGTCACTA TATGGGAACT GATGACCTTT GGAGGAAAAC CCTACGATGG AATTCCAACC 2160
CGAGAAATCC CGGATTTATT AGAGAAAGGA GAACGTTTGC CCCAGCCTCC AATCTGCACT 2220
ATTGACGTTT ACATGGTCAT GGTCAAATGT TGGATGATTG ATGCTGACAG TAGGCCTAAA 2280
TTTAAGGAAC TGGCTGCTGA ATTTTCAAGG ATGGCACGAG ACCCTCAAAG ATATCTCGTT 2340
ATTCAGGGTG ATGATCGCAT GAAGCTTCCC AGTCCAAACG ACAGCAAGTT CTTTCAGAAT 2400
CTCTTGGATG AAGAGGATTT GGAAGACATG ATGGATGCTG AGGAATACCT GGTCCCTCAG 2460
GCTTTCAACA TCCCACCTCC CATCTATACT TCCAGAGCGA GAATTGACTC AAATAGGAAC 2520
CAGTTTGTAT ACCGAGATGG AGGTTTTGCT GCAGAGCAAG GAGTACCTGT GCCCTACAGA 2580
GCCACGACCA GCACGATCCC AGAAGCTCCA GTTGCTCAGG GGGCTACAGC CGATATGTTT 2640
GATGACTCCT GTTGTAACGG CACCCTGCGC AAGCCAGTGG CACCCCACGT GCAGGAGGAC 2700
AGCAGCACCC AGAGGTACAG CGCGGACCCC ACCGTCTTTG CGCCGGAACG GAGCCCACGA 2760
GGAGAGCTGG ATGAAGAAGG TTACATGACC CCTATGCGAG ATAAACCTAA ACAAGAATAC 2820
CTGAACCCTG TGGAGGAGAA CCCTTTCGTT TCGCGGAGGA AAAACGGAGA CCTTCAAGCT 2880
TTGGATAATC CCGAATATCA CAATGCTTCC AATGGTCCAC CCAAGACAGA GGATGAGTAT 2940
GTGAATGAGC CACTGTACCT CAACACCTTT GCCAACGCGT TGGGGAATGC CGAGTACCTG 3000
AAGAACCATG TACTGTCTGT GCCAGAGAAG GCCAAGAAAG CATTCGACAA CCCTGACTAC 3060
TGGAACCACA GCCTGCCACC TCGGAGCACC CTTCAGCACC CAGACTACCT GCAGGAGTAC 3120
AGCACAAACT ATTTTTATAA ACAAAATGGA CGGATCCGGC CTATTGTGGC AGAGAATCCT 3180
GAATACCTCT CTGAGTTCTC GCTGAAGCCG GGCACTGTGC TGCCTCCTCC ACCCTACAGA 3240
CACCGAAATA CTGTGGTGTA A 3261
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 512   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  571
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 572   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  631
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 632   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  691
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 692   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  751
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 752   MIDADSRPKFKELAAEFS  769
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00650
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00377
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013