EKS-AIM-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	387.9	2.5E-116	53	314	262

Status

Unreviewed

Ensembl Protein

ENSAMEP00000007820

UniProt Accession

G1LLJ8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K6

Gene Synonyms/Alias

MAP2K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000007357	ENSAMEP00000007820	ENSAMET00000008147

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

334

Protein Sequence
(FASTA)

MSLPIGRKRN PGLKIPKEAF EQPQPSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG 60

RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF 120

REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 180

KPSNVLINTL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI 240

WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSEEFVDF TSQCLKKNSK 300

ERPTYPELMQ HPFFTLHESK ATDVASFVKL ILGD 334

Nucleotide Sequence
(FASTA)

ATGTCTCTCC CCATAGGCAG GAAGCGAAAC CCTGGCCTTA AGATTCCAAA GGAAGCATTT 60

GAACAACCTC AGCCCAGTTC CACGCCACCT CGAGACTTAG ACTCTAAAGC TTGCATTTCT 120

ATTGGAAATC AGAACTTTGA GGTGAAGGCC GATGACCTGG AGCCCATAAT GGAACTGGGG 180

CGAGGTGCGT ACGGGGTGGT GGAGAAGATG CGACACGTGC CCAGCGGGCA GATCATGGCG 240

GTGAAGCGGA TCCGGGCCAC AGTAAATAGC CAGGAGCAGA AAAGGCTACT GATGGATTTG 300

GATATTTCCA TGAGGACAGT GGACTGTCCT TTCACCGTCA CCTTTTATGG TGCCCTCTTC 360

CGGGAGGGTG ACGTTTGGAT CTGTATGGAG CTCATGGATA CGTCGCTAGA TAAATTCTAC 420

AAACAAGTGA TTGATAAAGG CCAAACAATT CCAGAGGACA TCTTAGGGAA AATAGCAGTT 480

TCTATTGTAA AAGCGTTAGA ACACTTACAC AGTAAGCTCT CTGTCATTCA TCGAGACGTC 540

AAGCCTTCCA ACGTGCTGAT CAACACTCTG GGCCAAGTGA AGATGTGCGA TTTTGGAATC 600

AGTGGCTACC TTGTGGACTC TGTGGCTAAA ACTATTGATG CAGGATGCAA ACCGTACATG 660

GCTCCTGAAA GAATAAACCC AGAGCTCAAT CAGAAGGGCT ACAGTGTGAA GTCTGACATT 720

TGGAGTCTGG GCATCACAAT GATTGAGTTG GCAATCCTTC GGTTTCCCTA CGACTCTTGG 780

GGAACTCCCT TCCAGCAGCT CAAACAGGTG GTGGAGGAAC CCTCGCCACA ACTCCCAGCG 840

GACAAATTCT CCGAAGAGTT TGTTGACTTT ACCTCACAGT GCTTGAAGAA GAATTCCAAA 900

GAACGGCCAA CATATCCAGA ACTTATGCAA CATCCATTTT TCACCCTACA CGAATCCAAA 960

GCAACAGACG TGGCATCTTT TGTAAAACTG ATTCTTGGAG ACTAA 1005

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le + elG+G++gvVek++h +sg+i+avK+ir++++++eqk++l++l++ +++ ++p++

Q: 53    LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT  112

         57789*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++k+v++k ++ipe++lgkiav++vkale+l++

Q: 113   VTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS  171

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n+ G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 172   KLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIdAGCKPYMAPERINPelnQ  231

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Ysvksd+WslG+t++ela+ r+py+++ +++++lk++v+e++p+lp+++fseef++f

Q: 232   KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSEEFVDFT  291

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         s+Clkk++keRp++ el++h+f+

Q: 292   SQCLKKNSKERPTYPELMQHPFF  314

         *********************96

Domain Sequence
(FASTA)

LEPIMELGRG AYGVVEKMRH VPSGQIMAVK RIRATVNSQE QKRLLMDLDI SMRTVDCPFT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKQ VIDKGQTIPE DILGKIAVSI VKALEHLHSK 120

LSVIHRDVKP SNVLINTLGQ VKMCDFGISG YLVDSVAKTI DAGCKPYMAP ERINPELNQK 180

GYSVKSDIWS LGITMIELAI LRFPYDSWGT PFQQLKQVVE EPSPQLPADK FSEEFVDFTS 240

QCLKKNSKER PTYPELMQHP FF 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0060048	; P:cardiac muscle contraction
GO:0000165	; P:MAPK cascade

KEGG

aml:100469111

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013