EKS-AIM-00347
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00347
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src367.63.0E-110288522235
StatusUnreviewed
Ensembl ProteinENSAMEP00000008129
UniProt AccessionG1LMD8;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000007672ENSAMEP00000008129ENSAMET00000008467
ENSAMEG00000007672ENSAMEP00000008151ENSAMET00000008491
OrganismAiluropoda melanoleuca
Functional Description
Protein Length537
Protein Sequence
(FASTA)
NGGWGHDNLR YFWKFPGQGP RMSDVGEVDL GGAPSAPSIP PGTMGCSCSS NPEDDWMENI 60
DVCENCHYPI VPLDGKATLP IRNGSDVRDP LVTYEGSNPP ASPLQDNLVI ALHSYEPSHD 120
GDLGFEKGEQ LRILEQSGEW WKAQSLTTGQ EGFIPFNFVA KANSLEPEPW FFKNLSRKDA 180
ERQLLAPGNT HGSFLIRESE STAGSFSLSV RDFDQNQGEV VKHYKIRNLD NGGFYISPRI 240
TFPGLHELVR HYTNASDGLC TRLSRPCQTQ KPQKPWWEDE WEVPRETLKL VERLGAGQFG 300
EVWMGYYNGH TKVAVKSLKQ GSMSPDAFLA EANLMKQLQH QRLVRLYAVV TQEPIYIITE 360
YMENGSLVDF LKTPPGIKLT INKLLDMAAQ IAEGMAFIEE RNYIHRDLRA ANILVSDTLS 420
CKIADFGLAR LIEDNEYTAR EGAKFPIKWT APEAINYGTF TINHGRIPYP GMTNPEVIQN 480
LERGYRMVRP DNCPEELYHL MMLCWKERPE ERPTFDYLRS VLEDFFTATE GQYQPQP 537
Nucleotide Sequence
(FASTA)
AATGGGGGAT GGGGACATGA CAATCTCAGG TACTTTTGGA AATTCCCAGG GCAAGGCCCT 60
AGGATGTCTG ATGTTGGGGA AGTAGATCTT GGGGGAGCCC CTTCAGCCCC CTCTATTCCC 120
CCAGGGACCA TGGGCTGTAG CTGCAGCTCA AACCCCGAAG ATGACTGGAT GGAAAACATC 180
GATGTTTGTG AGAACTGCCA TTACCCCATA GTCCCACTGG ATGGCAAGGC CACGCTGCCC 240
ATCCGGAATG GCTCTGATGT GCGGGATCCA CTGGTTACCT ACGAAGGCTC CAACCCCCCG 300
GCCTCACCCT TGCAAGACAA CCTGGTTATC GCTCTGCACA GCTATGAGCC CTCTCACGAT 360
GGAGACTTGG GCTTCGAGAA GGGTGAACAG CTCCGCATCC TGGAGCAGAG CGGCGAGTGG 420
TGGAAGGCAC AGTCCCTGAC CACGGGCCAG GAAGGTTTCA TTCCCTTCAA CTTCGTGGCC 480
AAAGCGAACA GCCTAGAGCC CGAACCCTGG TTCTTCAAGA ACCTGAGCCG CAAGGACGCT 540
GAGCGGCAGC TCCTGGCGCC CGGGAACACG CACGGCTCCT TCCTGATCCG GGAAAGCGAG 600
AGCACCGCGG GATCGTTTTC ACTGTCCGTG CGGGACTTCG ACCAGAACCA GGGAGAGGTG 660
GTAAAACATT ACAAAATCCG TAACCTGGAC AACGGCGGCT TCTACATCTC CCCTCGCATC 720
ACTTTTCCTG GCCTGCACGA GCTGGTCCGC CATTACACCA ATGCTTCGGA CGGGCTGTGC 780
ACGCGGTTGA GTCGCCCCTG CCAGACCCAG AAGCCCCAGA AGCCTTGGTG GGAGGACGAG 840
TGGGAGGTTC CCAGGGAGAC GCTGAAGCTG GTGGAGCGGC TGGGAGCTGG CCAGTTCGGG 900
GAGGTGTGGA TGGGGTACTA CAACGGGCAC ACAAAGGTGG CAGTGAAGAG CCTGAAGCAG 960
GGCAGCATGT CCCCCGACGC CTTCCTGGCG GAGGCCAACC TCATGAAGCA GCTGCAACAC 1020
CAGAGACTGG TCCGGCTCTA CGCGGTGGTC ACCCAGGAGC CCATCTACAT CATCACGGAA 1080
TACATGGAGA ACGGGAGCCT GGTGGATTTC CTCAAGACCC CCCCGGGCAT CAAGCTGACC 1140
ATCAACAAAC TCTTGGATAT GGCAGCCCAA ATTGCAGAGG GCATGGCATT CATTGAAGAG 1200
CGGAATTATA TCCACCGTGA CCTGAGGGCT GCCAACATCC TGGTGTCTGA CACCCTGAGC 1260
TGCAAGATCG CAGACTTTGG CCTAGCACGC CTCATCGAGG ACAACGAGTA CACAGCCAGG 1320
GAGGGAGCCA AGTTTCCCAT TAAGTGGACA GCACCAGAAG CCATTAACTA TGGGACGTTC 1380
ACCATCAACC ATGGCCGCAT CCCTTACCCA GGGATGACCA ATCCCGAGGT GATCCAGAAC 1440
CTGGAGCGAG GCTACCGCAT GGTGCGACCT GACAACTGTC CGGAGGAGTT GTACCATCTC 1500
ATGATGTTGT GCTGGAAGGA GCGCCCCGAG GAACGGCCCA CCTTCGACTA CCTGCGCAGT 1560
GTGCTGGAGG ACTTCTTCAC AGCCACGGAG GGCCAGTACC AGCCCCAGCC CTGA 1614
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 288   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  347
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+  g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 348   AVVTQ-EPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  406
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+fti    
Q: 407   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTI----  462
         ******************************************************97....
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
                     +G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pee
Q: 463   -----------NHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKERPEE  511
         ...........58***********************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 512   RPTFDYLRSVL  522
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTPPGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTINHGRI 180
PYPGMTNPEV IQNLERGYRM VRPDNCPEEL YHLMMLCWKE RPEERPTFDY LRSVL 235
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013