EKS-AIM-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	438.8	7.8E-132	345	599	255

Status

Unreviewed

Ensembl Protein

ENSAMEP00000008436

UniProt Accession

G1LN12;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000007953	ENSAMEP00000008436	ENSAMET00000008788

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

672

Protein Sequence
(FASTA)

MAPFLRIAFT SYELGSLQTA DEASQPFCAV KMKEALSTER GKTLVQKKPT MYPEWKSTFD 60

AHIYEGRVIQ IVLMRAAEEP MSEVTVGVSV LAERCKKNNG KAEFWLDLQP QAKVLMSVQY 120

FLEDVDCKQS MRGEDEAKFP TMNRRGAIKQ AKIHYIKNHE FIATFFRQPT FCSVCKDFVW 180

GLNKQGYKCR QCNAAIHKKC IDKIIGRCTG TAANSRDTIF QKERFNIDMP HRFKVYNYMS 240

PTFCDHCGSL LWGLVKQGLK CEDCGMNVHH KCQKKVANLC GINQKLLAEA LNQVSQRPSR 300

KSETETVGIY QNFERKPGIS GDIVPDNGTY GKIWEGSTRC NIENFTFHKV LGKGSFGKVL 360

LAELKGKKEF FAIKALKKDV VLIDDDVECT MVEKRVLALA WENPFLTHLF CTFQTKDHLF 420

FVMEFLNGGD LMYHIQDKGR FELYRATFYA AEIVCGLQFL HNKGIIYRDL KLDNVMLDQD 480

GHIKIADFGM CKENIFGEKQ ASTFCGTPDY IAPEILQGLK YSFSVDWWSF GVLLYEMLIG 540

QSPFHGDDED ELFESIRVDT PHYPRWITKE SKDILEKLLE RDTTKRLGVN GNMKIHPFFK 600

TINWTLLEKR AVEPPFKPKV KSPGDYSNFD QEFLNEKARL SYTDKNLIDS MDQTAFAGFS 660

FVNPKFERFL EK 672

Nucleotide Sequence
(FASTA)

ATGGCGCCGT TCCTGCGCAT TGCCTTCACC TCCTATGAGC TGGGCTCCCT GCAGACTGCC 60

GATGAGGCCA GCCAGCCCTT CTGTGCCGTG AAGATGAAGG AGGCGCTCAG CACAGAGCGC 120

GGGAAGACGC TGGTGCAGAA GAAGCCCACC ATGTACCCCG AGTGGAAGTC CACATTCGAC 180

GCCCACATCT ACGAGGGCCG TGTCATCCAG ATCGTGCTGA TGCGGGCCGC CGAAGAGCCG 240

ATGTCCGAGG TGACAGTGGG CGTATCGGTG CTGGCTGAAC GCTGCAAGAA GAACAACGGC 300

AAGGCGGAGT TCTGGCTGGA CCTGCAACCC CAAGCCAAGG TGTTGATGTC TGTGCAGTAT 360

TTCCTGGAAG ATGTAGATTG CAAACAGTCT ATGCGCGGTG AAGACGAGGC CAAGTTCCCA 420

ACAATGAACC GCCGTGGAGC CATCAAACAG GCCAAAATCC ACTACATCAA GAACCACGAG 480

TTTATTGCCA CCTTCTTCAG ACAGCCCACT TTCTGTTCTG TGTGCAAAGA CTTTGTTTGG 540

GGTCTCAACA AGCAAGGCTA CAAATGCAGG CAATGCAACG CTGCAATCCA CAAGAAATGC 600

ATCGACAAGA TCATCGGCCG GTGCACGGGC ACCGCGGCCA ACAGCCGGGA CACCATATTC 660

CAGAAAGAAC GTTTCAACAT TGACATGCCG CACCGATTCA AGGTTTACAA CTATATGAGC 720

CCCACCTTCT GTGACCACTG CGGCAGCCTG CTCTGGGGGC TGGTGAAGCA GGGCTTAAAA 780

TGTGAAGACT GTGGCATGAA CGTACATCAT AAGTGCCAGA AGAAGGTGGC CAACCTCTGT 840

GGCATTAACC AGAAGCTCCT GGCTGAGGCG TTGAACCAAG TGAGCCAGAG ACCCTCCCGG 900

AAGTCAGAAA CAGAGACTGT TGGAATCTAC CAGAATTTTG AGAGGAAGCC AGGAATCTCT 960

GGAGATATTG TCCCAGACAA CGGGACCTAC GGCAAGATCT GGGAGGGCAG CACCAGGTGC 1020

AACATTGAGA ACTTCACCTT CCACAAGGTC CTGGGCAAAG GCAGCTTTGG GAAGGTGCTG 1080

CTTGCAGAGC TGAAGGGCAA GAAGGAGTTC TTCGCCATCA AGGCCCTCAA GAAGGACGTG 1140

GTTCTGATTG ATGACGATGT GGAGTGCACC ATGGTGGAGA AGCGGGTGCT GGCACTCGCC 1200

TGGGAGAATC CCTTTCTCAC CCACCTCTTC TGCACGTTCC AGACCAAGGA CCACCTGTTC 1260

TTCGTGATGG AGTTCCTCAA TGGGGGGGAC CTGATGTACC ACATCCAGGA CAAAGGCCGC 1320

TTCGAGCTCT ACCGTGCCAC GTTTTATGCA GCCGAGATAG TCTGTGGACT ACAGTTTCTG 1380

CACAACAAAG GGATCATTTA CAGGGACCTC AAGCTGGACA ACGTGATGCT GGACCAGGAT 1440

GGCCACATCA AGATTGCTGA CTTTGGGATG TGCAAGGAGA ACATATTTGG GGAGAAGCAG 1500

GCTAGCACCT TCTGTGGCAC CCCTGACTAT ATCGCCCCCG AGATCCTGCA GGGCCTGAAG 1560

TACTCATTCT CCGTGGACTG GTGGTCCTTT GGAGTCCTTC TCTACGAGAT GCTCATCGGT 1620

CAGTCCCCCT TCCATGGTGA CGATGAGGAC GAGCTCTTTG AGTCCATCCG TGTGGACACA 1680

CCACATTATC CCCGCTGGAT CACCAAGGAG TCCAAGGACA TCCTGGAGAA GCTGCTTGAA 1740

AGGGATACAA CCAAGAGGCT GGGAGTGAAC GGGAACATGA AAATCCACCC CTTCTTCAAG 1800

ACCATCAACT GGACTCTGCT GGAGAAACGG GCTGTGGAGC CGCCCTTCAA GCCCAAAGTG 1860

AAGTCCCCTG GAGACTACAG CAACTTCGAC CAGGAGTTCC TGAACGAGAA GGCACGCCTC 1920

TCCTACACCG ACAAGAACCT CATCGACTCC ATGGACCAAA CGGCATTCGC TGGCTTCTCC 1980

TTCGTGAACC CCAAATTTGA GAGATTCCTG GAAAAGTGA 2019

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkvllaelk+++e++aik lkkdvvl dddve+t+vekrvlala+++p

Q: 345   FTFHKVLGKGSFGKVLLAELKGKKEFFAIKALKKDVVLIDDDVECTMVEKRVLALAWENP  404

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++lf++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaei+++l+flh+kg

Q: 405   FLTHLFCTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIVCGLQFLHNKG  464

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnv+ld++Ghik+adfG+cke+i+ +k++stfcGtPdyiaPeil++ +y++s

Q: 465   IIYRDLKLDNVMLDQDGHIKIADFGMCKENIFGEKQASTFCGTPDYIAPEILQGLKYSFS  524

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++ll++d++

Q: 525   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLLERDTT  584

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  ++k h+ff

Q: 585   KRLGV--NG--NMKIHPFF  599

         *****..55..67888887

Domain Sequence
(FASTA)

FTFHKVLGKG SFGKVLLAEL KGKKEFFAIK ALKKDVVLID DDVECTMVEK RVLALAWENP 60

FLTHLFCTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEIV CGLQFLHNKG 120

IIYRDLKLDN VMLDQDGHIK IADFGMCKEN IFGEKQASTF CGTPDYIAPE ILQGLKYSFS 180

VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLLERDTT 240

KRLGVNGNMK IHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005783	; C:endoplasmic reticulum
GO:0016363	; C:nuclear matrix
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0008047	; F:enzyme activator activity
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0006915	; P:apoptotic process
GO:0042100	; P:B cell proliferation
GO:0090398	; P:cellular senescence
GO:0016064	; P:immunoglobulin mediated immune response
GO:0032613	; P:interleukin-10 production
GO:0032615	; P:interleukin-12 production
GO:0035556	; P:intracellular signal transduction
GO:0030837	; P:negative regulation of actin filament polymerization
GO:0051490	; P:negative regulation of filopodium assembly
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0050732	; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331	; P:negative regulation of platelet aggregation
GO:0042119	; P:neutrophil activation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:2000304	; P:positive regulation of ceramide biosynthetic process
GO:2000753	; P:positive regulation of glucosylceramide catabolic process
GO:1900163	; P:positive regulation of phospholipid scramblase activity
GO:0035307	; P:positive regulation of protein dephosphorylation
GO:2001022	; P:positive regulation of response to DNA damage stimulus
GO:2000755	; P:positive regulation of sphingomyelin catabolic process
GO:0032930	; P:positive regulation of superoxide anion generation
GO:0023021	; P:termination of signal transduction

KEGG

aml:100481918

;

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013