EPS-AIM-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/Myotubularins	542.9	4.5E-163	206	580	375

Status

Unreviewed

Ensembl Protein

ENSAMEP00000008431

UniProt Accession

G1LN07;

Protein Name

Protein Synonyms/Alias

Gene Name

MTMR2

Gene Synonyms/Alias

MTMR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000007994	ENSAMEP00000008431	ENSAMET00000008783

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

643

Protein Sequence
(FASTA)

MEKSSSCESL GSQPAAARPP SVDSLSSAST SHSENSVHTK SASVVSSDSI STSADNFSPD 60

LRVLRESNKL AEMEEPPLLP GENIKDMAKD VTYICPFTGA VRGTLTVTNY RLYFKSMERD 120

PPFVLDASLG VISRVEKIGG ASSRGENSYG LETVCKDIRN LRFAHKPEGR TRRSIFENLM 180

KYAFPVSNNL PLFAFEYKEV FPENGWKLYD SLLEYRRQGI PNESWRITKI NERYELCDTY 240

PALLVVPANI PDEELKRVAS FRSRGRIPVL SWIHPESQAT ITRCSQPMVG VSGKRSKEDE 300

KYLQAIMDSN AQSHKIFIFD ARPSVNAVAN KAKGGGYESE DAYQNAELVF LDIHNIHVMR 360

ESLRKLKEIV YPNIEETHWL SNLESTHWLE HIKLILAGAL RIADKVESGK TSVVVHCSDG 420

WDRTAQLTSL AMLMLDGYYR SVRGFEVLVE KEWLSFGHRF QLRLGHGDKN HADADRSPVF 480

LQFIDCVWQM TRQFPTAFEF NEYFLITILD HLYSCLFGTF LCNSEHQRGK ENLPKRTVSL 540

WSYINSQLED FTNPLYGSYA NHVLYPVASM RHLELWVGYY VRWNPRMKPQ EPIHNRYKEL 600

LAKRAELQKK VEELQREISN RSTSSSERAS SPAQCVTPVQ TVV 643

Nucleotide Sequence
(FASTA)

ATGGAGAAGA GCTCGAGCTG CGAGAGTCTT GGCTCTCAGC CGGCCGCCGC ACGGCCGCCC 60

AGCGTGGACT CCCTGTCCAG TGCTTCCACT TCTCACTCAG AGAATTCAGT GCATACAAAA 120

TCAGCTTCTG TGGTATCATC GGACTCCATT TCAACTTCTG CGGACAACTT TTCTCCTGAT 180

TTGAGGGTGC TGAGGGAATC TAACAAATTA GCAGAAATGG AAGAACCACC CTTGCTTCCG 240

GGAGAAAATA TTAAAGACAT GGCCAAAGAT GTAACTTATA TATGTCCATT CACTGGTGCT 300

GTACGAGGAA CTCTGACTGT CACGAATTAC AGGTTATATT TTAAAAGCAT GGAACGGGAT 360

CCCCCATTTG TTTTAGATGC CTCTCTTGGT GTGATAAGTA GAGTAGAAAA AATTGGTGGT 420

GCTTCTAGTA GAGGTGAAAA TTCTTATGGA CTAGAAACTG TGTGTAAGGA TATTCGGAAT 480

TTACGGTTTG CTCATAAACC TGAGGGGCGA ACAAGAAGAT CCATTTTTGA GAATCTAATG 540

AAATATGCAT TTCCTGTCTC AAATAACCTG CCTCTTTTTG CTTTTGAATA CAAAGAAGTA 600

TTTCCTGAAA ATGGGTGGAA GCTATATGAC TCTCTTTTAG AGTATAGAAG ACAGGGAATT 660

CCGAATGAGA GCTGGAGAAT AACAAAGATA AACGAACGCT ATGAGCTCTG TGATACATAT 720

CCTGCCCTCT TGGTTGTGCC AGCAAATATT CCTGATGAAG AATTAAAGAG AGTGGCATCC 780

TTCAGATCAA GGGGCCGTAT CCCAGTTTTA TCATGGATTC ATCCTGAAAG TCAAGCCACT 840

ATCACTCGGT GTAGCCAGCC AATGGTAGGA GTGAGTGGAA AGCGAAGCAA AGAAGATGAA 900

AAATACCTTC AAGCTATCAT GGACTCCAAT GCCCAGTCTC ATAAAATCTT TATATTTGAT 960

GCCCGGCCAA GTGTCAATGC TGTTGCCAAT AAGGCGAAGG GTGGAGGTTA TGAGAGTGAA 1020

GATGCCTATC AAAATGCAGA ACTAGTTTTT CTGGATATCC ACAATATTCA CGTTATGAGA 1080

GAATCATTAC GAAAACTTAA GGAGATTGTG TACCCTAACA TTGAGGAGAC TCACTGGCTG 1140

TCTAACTTGG AATCTACTCA CTGGCTCGAA CATATTAAGC TTATTCTTGC GGGGGCTCTT 1200

CGGATTGCTG ACAAGGTGGA GTCCGGGAAG ACGTCCGTGG TAGTGCACTG CAGCGATGGC 1260

TGGGACCGCA CAGCTCAGCT CACTTCCCTT GCCATGCTTA TGTTGGACGG CTACTATCGG 1320

AGCGTCCGAG GCTTTGAAGT CCTTGTGGAA AAAGAATGGC TAAGCTTTGG ACATCGATTT 1380

CAGCTTAGGC TCGGCCATGG AGATAAGAAC CACGCAGATG CAGACAGATC GCCTGTGTTT 1440

CTTCAGTTTA TTGACTGTGT CTGGCAAATG ACAAGACAGT TTCCTACAGC ATTTGAATTC 1500

AATGAATATT TTCTCATAAC CATTTTGGAC CATCTATATA GCTGTTTATT TGGAACATTC 1560

CTCTGTAACA GTGAACATCA GAGAGGAAAA GAGAATCTCC CTAAAAGGAC TGTGTCACTG 1620

TGGTCTTACA TAAATAGCCA GCTGGAAGAC TTCACTAATC CTCTCTATGG GAGCTACGCC 1680

AATCATGTCC TTTATCCGGT AGCCAGCATG CGCCACCTAG AGCTCTGGGT GGGTTATTAC 1740

GTCAGGTGGA ATCCACGGAT GAAACCGCAG GAACCCATTC ACAACAGATA TAAAGAACTT 1800

CTTGCTAAAC GGGCAGAGCT TCAGAAGAAA GTAGAGGAAC TACAGAGAGA GATTTCCAAC 1860

CGATCCACCT CATCCTCTGA GAGAGCCAGT TCTCCTGCAC AGTGTGTCAC TCCTGTCCAA 1920

ACTGTTGTG 1929

Domain Profile

S: 2     etlkdleeelkrlglanekwrissvNeeykvcesyPallvVPksvqdeelkrvskffskk  61

         ++l+d   e++r+g++ne+wri+++Ne+y++c++yPallvVP+++ deelkrv++f+s++

Q: 206   WKLYDSLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRG  265

         78899999****************************************************

S: 62    riPvlswshkengaallrssqplssledrrskedekllqailkavagrskllivdtrkal  121

         riPvlsw h+e++a+++r+sqp+++++++rskedek+lqai++++a+++k++i+d+r+++

Q: 266   RIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSV  325

         ************************************************************

S: 122   aavankakgkgvese.aysnielvfvelenihevrasfkklkelclpdsvseekwlsaLe  180

         +avankakg+g+ese ay+n+elvf++++nih++r+s++klke+++p +++e++wls+Le

Q: 326   NAVANKAKGGGYESEdAYQNAELVFLDIHNIHVMRESLRKLKEIVYP-NIEETHWLSNLE  384

         **********************************************9.9***********

S: 181   sseWLehikallkkavevaelvesekasvlvheedgwDltaqvtsLvqllldpyyRtleG  240

         s++WLehik +l+ a+++a++ves+k+sv+vh++dgwD+taq+tsL++l+ld yyR+++G

Q: 385   STHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRSVRG  444

         ************************************************************

S: 241   fqvLvekeWlsfGhkFsdRlghleasekea.esPvflqFldcvwqlleQfPaaFEFneaf  299

         f+vLvekeWlsfGh+F+ Rlgh ++++++a +sPvflqF+dcvwq+++QfP+aFEFne+f

Q: 445   FEVLVEKEWLSFGHRFQLRLGHGDKNHADAdRSPVFLQFIDCVWQMTRQFPTAFEFNEYF  504

         ***************************9999*****************************

S: 300   LlvlldhlysslfgtFLlnsekervkqsgekklkektlsvWdllqreskrkklfkNplYs  359

         L+++ldhlys+lfgtFL+nse++r    g+++l ++t+s+W++++  s+ ++ f+NplY

Q: 505   LITILDHLYSCLFGTFLCNSEHQR----GKENLPKRTVSLWSYIN--SQLED-FTNPLYG  557

         ************************....*****************..77777.*******

S: 360   eeskevllPvvsvselklWkavy  382

         +  ++vl+Pv+s+++l+lW  +y

Q: 558   SYANHVLYPVASMRHLELWVGYY  580

         *******************9998

Domain Sequence
(FASTA)

WKLYDSLLEY RRQGIPNESW RITKINERYE LCDTYPALLV VPANIPDEEL KRVASFRSRG 60

RIPVLSWIHP ESQATITRCS QPMVGVSGKR SKEDEKYLQA IMDSNAQSHK IFIFDARPSV 120

NAVANKAKGG GYESEDAYQN AELVFLDIHN IHVMRESLRK LKEIVYPNIE ETHWLSNLES 180

THWLEHIKLI LAGALRIADK VESGKTSVVV HCSDGWDRTA QLTSLAMLML DGYYRSVRGF 240

EVLVEKEWLS FGHRFQLRLG HGDKNHADAD RSPVFLQFID CVWQMTRQFP TAFEFNEYFL 300

ITILDHLYSC LFGTFLCNSE HQRGKENLPK RTVSLWSYIN SQLEDFTNPL YGSYANHVLY 360

PVASMRHLEL WVGYY 375

Keyword

Complete proteome; Hydrolase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005774	; C:vacuolar membrane
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0046855	; P:inositol phosphate dephosphorylation
GO:0035335	; P:peptidyl-tyrosine dephosphorylation
GO:0046856	; P:phosphatidylinositol dephosphorylation
GO:0051262	; P:protein tetramerization

KEGG

aml:100473901

;

InterPros

IPR004182	; GRAM.
IPR010569	; Myotub-related.
IPR017906	; Myotubularin_phosphatase_dom.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF02893	; GRAM; 1.
PF06602	; Myotub-related; 1.

SMARTs

SM00568

; GRAM; 1.

Prosites

PS51339	; PPASE_MYOTUBULARIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.

Prints

Created Date

20-Feb-2013