EKS-AIM-00002
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00002
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph518.52.3E-156578835258
StatusUnreviewed
Ensembl ProteinENSAMEP00000008960
UniProt AccessionG1LPI5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA3
Gene Synonyms/Alias EPHA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000008476ENSAMEP00000008960ENSAMET00000009343
ENSAMEG00000008476ENSAMEP00000008965ENSAMET00000009348
OrganismAiluropoda melanoleuca
Functional Description
Protein Length940
Protein Sequence
(FASTA)
WEEISGVDEH YTPIRTYQVC NVMDHSQNNW LRTNWVPRNS AQKIYVELKF TLRDCNSIPL 60
VLGTCKETFN LYYMESDDDH GVKFREHQFT KIDTIAADES FTQMDLGDRI LKLNTEVREV 120
GPVNKKGFYL AFQDVGACVA LVSVRVYFKK CPFMVKNLAM FPDTVPMDSQ SLVEVRGSCV 180
NNSKEEDPPR MYCSTEGEWL VPIGKCSCNA GYEEGGFMCQ ACRPGFYKAS DGNMKCAKCP 240
PHSSTHEDGS VNCRCENNYF RADKDPPSMA CTRPPSAPRN VISNINETSV ILDWSWPLDT 300
GGRKDVTFNI ICKKCGWNIK QCEPCSPNVR FLPRQFGLTN TTVTVTDLLA HTNYTFEIDA 360
INGVSELSSP PRQFAAVSIT TNQAAPSPVM TIKKDRTSRN SISLSWQEPE HPNGIILDYE 420
VKYYEKQEQE TSYTILRARG TNVTISSLKP DTTYVFQIRA RTAAGYGTNS RKFEFETSPD 480
YNVKTFQTFS ISGENSQVVM IAISAAVAII LLTVVTYVLI GRFCGYNKSK HSADEKRLHF 540
GNGHLKLPGL RTYVDPHTYE DPTQAVHEFA KELDATNISI DKVVGAGEFG EVCSGRLKLP 600
SKKEISVAIK TLKVGYTEKQ RRDFLGEASI MGQFDHPNII RLEGVVTKSK PVMIVTEYME 660
NGSLDSFLRK HDAQFTVIQL VGMLRGIASG MKYLSDMGYV HRDLAARNIL INSNLVCKVS 720
DFGLSRVLED DPEAAYTTRG GKIPIRWTSP EAIAYRKFTS ASDVWSYGIV LWEVMSYGER 780
PYWEMSNQDV IKAVDEGYRL PPPMDCPAAL YQLMLDCWQK DRNNRPKFEQ IVSILDKLIR 840
NPGSLKIVTS TAARPSNLLL DQSNVDITTF RTTGDWLNGV RTAQCKEIFT GVEYSSCDTI 900
AKISTDDMKK VGVTVVGPQK KIISSIKALE TQSKNSPVPV 940
Nucleotide Sequence
(FASTA)
TGGGAAGAGA TCAGTGGTGT TGATGAACAT TACACACCTA TCAGGACTTA CCAGGTGTGC 60
AATGTCATGG ATCATAGTCA AAATAATTGG CTGAGGACAA ACTGGGTCCC CAGGAACTCA 120
GCTCAGAAGA TCTACGTGGA GCTCAAGTTC ACTCTACGGG ACTGCAATAG CATTCCATTG 180
GTTTTGGGAA CTTGCAAGGA GACTTTCAAT TTGTACTACA TGGAGTCTGA TGACGATCAT 240
GGGGTCAAAT TTCGAGAACA TCAGTTTACG AAGATTGACA CCATTGCGGC TGATGAAAGT 300
TTCACCCAAA TGGATCTTGG GGACCGTATT CTGAAACTCA ACACTGAGGT TAGAGAAGTA 360
GGTCCTGTCA ACAAAAAGGG ATTTTATTTG GCATTTCAAG ATGTCGGCGC TTGTGTTGCC 420
TTGGTGTCTG TGAGAGTGTA CTTCAAAAAG TGCCCATTTA TGGTAAAGAA TCTGGCTATG 480
TTTCCAGACA CAGTACCCAT GGATTCCCAA TCCCTGGTGG AGGTTAGAGG ATCTTGTGTT 540
AACAATTCTA AGGAGGAAGA TCCTCCCAGG ATGTACTGCA GTACAGAAGG CGAATGGCTT 600
GTACCCATTG GCAAGTGCTC GTGCAATGCT GGCTATGAAG AAGGAGGTTT TATGTGCCAA 660
GCTTGCCGAC CAGGTTTCTA CAAGGCTTCG GATGGTAATA TGAAATGCGC CAAGTGCCCA 720
CCCCACAGTT CTACTCACGA AGATGGTTCA GTGAACTGCA GGTGTGAGAA TAATTACTTC 780
CGAGCAGACA AAGACCCTCC ATCCATGGCT TGTACCCGAC CTCCATCTGC ACCAAGAAAT 840
GTTATCTCTA ATATAAACGA GACCTCGGTC ATCCTGGACT GGAGTTGGCC CCTAGACACA 900
GGAGGCCGGA AAGATGTTAC CTTCAACATC ATATGTAAAA AATGTGGGTG GAATATAAAA 960
CAGTGTGAGC CATGCAGCCC CAATGTCCGC TTCCTCCCTC GACAGTTTGG ACTCACCAAC 1020
ACTACAGTGA CAGTGACAGA CCTCCTGGCA CATACTAACT ACACCTTTGA GATTGATGCC 1080
ATTAATGGGG TGTCAGAGCT GAGCTCGCCA CCAAGACAGT TCGCTGCAGT CAGCATCACA 1140
ACCAACCAGG CTGCTCCATC GCCTGTCATG ACGATTAAGA AGGATCGAAC GTCCAGAAAC 1200
AGCATCTCTT TATCTTGGCA GGAACCTGAA CACCCTAATG GGATCATATT GGACTACGAG 1260
GTCAAATACT ATGAAAAGCA GGAGCAAGAG ACAAGTTATA CCATTCTGAG GGCAAGAGGC 1320
ACGAATGTTA CCATCAGTAG CCTCAAGCCT GACACTACTT ATGTATTCCA AATCCGAGCC 1380
CGAACAGCAG CTGGATACGG GACCAACAGT CGCAAGTTTG AGTTTGAAAC TAGCCCGGAC 1440
TATAATGTGA AGACCTTCCA AACTTTCTCC ATCTCTGGGG AAAACAGCCA AGTGGTGATG 1500
ATTGCCATTT CAGCGGCCGT GGCGATTATC CTGCTCACGG TCGTTACCTA CGTCTTGATA 1560
GGGAGGTTCT GTGGCTATAA CAAGTCAAAA CACAGTGCAG ATGAAAAAAG GCTTCATTTC 1620
GGGAATGGAC ATTTAAAACT TCCAGGTCTC AGGACTTATG TTGACCCACA CACATACGAA 1680
GACCCTACCC AAGCAGTTCA TGAGTTTGCT AAGGAATTGG ATGCCACCAA CATATCCATT 1740
GACAAAGTTG TTGGAGCAGG CGAATTTGGA GAAGTGTGCA GTGGTCGCTT AAAACTTCCT 1800
TCAAAAAAAG AGATTTCAGT GGCCATCAAA ACCCTGAAAG TGGGCTACAC AGAAAAGCAG 1860
AGGAGAGACT TCCTAGGAGA AGCAAGCATT ATGGGACAAT TTGACCACCC CAACATCATC 1920
CGACTGGAGG GAGTTGTTAC TAAAAGTAAA CCCGTTATGA TTGTCACAGA ATACATGGAG 1980
AATGGTTCCT TGGACAGTTT CTTACGTAAA CACGATGCCC AGTTTACGGT CATCCAGCTA 2040
GTGGGGATGC TTCGAGGGAT AGCATCTGGC ATGAAGTACC TCTCAGATAT GGGTTATGTT 2100
CACCGGGACC TTGCTGCTCG TAACATTTTG ATCAACAGTA ATTTGGTGTG TAAGGTTTCT 2160
GATTTTGGAC TTTCACGTGT TCTAGAGGAT GATCCAGAAG CTGCTTATAC AACAAGAGGA 2220
GGGAAGATCC CAATCCGATG GACATCACCA GAAGCTATTG CTTACCGCAA GTTCACGTCA 2280
GCCAGCGATG TATGGAGTTA CGGGATTGTT CTCTGGGAGG TGATGTCCTA TGGAGAGAGA 2340
CCATACTGGG AGATGTCCAA TCAGGATGTG ATTAAAGCTG TGGATGAAGG CTATCGGCTG 2400
CCGCCCCCCA TGGACTGCCC AGCTGCGTTG TATCAGCTGA TGCTGGACTG CTGGCAGAAA 2460
GACAGGAACA ACAGACCCAA GTTTGAGCAG ATCGTCAGCA TCCTGGACAA GCTTATCCGG 2520
AACCCAGGCA GCCTGAAGAT CGTCACCAGT ACGGCAGCAA GGCCATCAAA CCTTCTTCTG 2580
GACCAAAGCA ATGTCGACAT CACTACCTTC CGCACAACAG GTGACTGGCT TAATGGTGTC 2640
CGGACAGCGC AGTGCAAGGA AATCTTCACA GGCGTGGAGT ACAGTTCTTG TGACACCATA 2700
GCCAAGATTT CCACAGATGA CATGAAAAAG GTTGGCGTCA CTGTGGTTGG TCCACAGAAG 2760
AAAATCATCA GTAGCATTAA AGCTCTAGAA ACGCAATCAA AAAATAGTCC AGTTCCAGTG 2820
TAA 2823
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++i+kv+GaGefGevcsGrlklp+k+ei+vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 578   ISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  637
         689*********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtkskpvmivteymeng+ldsflrk+d qftviqlvgmlrGiasgmkylsdm
Q: 638   NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDM  697
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwt+peaiayrk
Q: 698   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRK  757
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGivlwev+syGerpyw+msnqdvika++egyrlpppmdcpaalyqlmldc
Q: 758   FTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDC  817
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkfeqivsil
Q: 818   WQKDRNNRPKFEQIVSIL  835
         ***************986
Domain Sequence
(FASTA)
ISIDKVVGAG EFGEVCSGRL KLPSKKEISV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIRLEGVVT KSKPVMIVTE YMENGSLDSF LRKHDAQFTV IQLVGMLRGI ASGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TSPEAIAYRK 180
FTSASDVWSY GIVLWEVMSY GERPYWEMSN QDVIKAVDEG YRLPPPMDCP AALYQLMLDC 240
WQKDRNNRPK FEQIVSIL 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00002
EKS-BOT-00002
EKS-CAE-00001
EKS-CAJ-00002
EKS-CAF-00003
EKS-EQC-00003
EKS-FEC-00004
EKS-GAM-00003
EKS-GAG-00003
EKS-GAA-00003
EKS-GOG-00002
EKS-HOS-00003
EKS-ICT-00002
EKS-LOA-00002
EKS-MAM-00002
EKS-MEG-00002
EKS-MOD-00002
EKS-MUM-00002
EKS-MUP-00002
EKS-MYL-00003
EKS-NOL-00002
EKS-ORN-00002
EKS-ORA-00003
EKS-ORC-00002
EKS-ORL-00003
EKS-OTG-00001
EKS-PAT-00002
EKS-PES-00003
EKS-POA-00002
EKS-PRC-00002
EKS-RAN-00003
EKS-SUS-00002
EKS-TAG-00004
EKS-TAR-00003
EKS-TAS-00002
EKS-TEN-00001
EKS-TUT-00001
EKS-XET-00001
Gene Ontology
GO:0005769; C:early endosome
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0071300; P:cellular response to retinoic acid
GO:0010976; P:positive regulation of neuron projection development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0051893; P:regulation of focal adhesion assembly
GO:0070507; P:regulation of microtubule cytoskeleton organization
GO:0032319; P:regulation of Rho GTPase activity
KEGG
aml:100470218;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013