EKS-AIM-00032
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00032
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RAD53427.32.1E-128222488267
StatusUnreviewed
Ensembl ProteinENSAMEP00000008952
UniProt AccessionG1LPH2;
Protein Name
Protein Synonyms/Alias
Gene NameCHEK2
Gene Synonyms/Alias CHEK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000008484ENSAMEP00000008952ENSAMET00000009335
OrganismAiluropoda melanoleuca
Functional Description
Protein Length545
Protein Sequence
(FASTA)
VMSRETDGEC QQSHGSSACS QPQGGFSQSQ GISSQTHGSS SQSQGTSSST STAPTSSQSS 60
HSSSGTLSSL DTVSTQELCS IPEDQEPEEP VPAPWARLWA LQDGFPNLEC VNDNYWFGRD 120
RSCDYCFDEP LLKRTDKYRT YSKKHFRIFR EMGPKNSYIA YIEDHSGNGT FVNRELVGKG 180
RRLPLNNNSE IALSVWSNKV FVFFDLTVDD QSVYPKELRD QYILSKTLGS GACGEVKLAF 240
ERKTCKKVAI KIISKRKFAI GSESGADPPP NVETEIEILK KLDHPCIIKI KDFFDAEDYY 300
IVLELMEGGE LFDRVVGNKR LKEATCKLYF YQMLLAVQYL HENGIIHRDL KPENVLLSSQ 360
KEDCLIKITD FGQSKILGET SLMRTLCGTP TYLAPEVLNS FGTAGYNRAV DCWSLGVILF 420
ICLSGYPPFS EHKTQVSLKD QITSGKFNFI PEVWTEVSEK ALDLVKKLLI VDPKVRFTTE 480
EALRHPWLQD EDMKRKFQKL LFEETKSTAL PQLPAQPSTS RKRRLEGEAE DADTTKRLAV 540
CAAVS 545
Nucleotide Sequence
(FASTA)
GTGATGTCTC GAGAGACGGA TGGGGAGTGT CAGCAGTCCC ATGGCAGTAG CGCCTGTTCA 60
CAGCCCCAAG GCGGCTTCTC ACAGTCTCAA GGCATCTCCT CCCAGACGCA CGGCTCCTCG 120
TCACAATCTC AAGGAACGTC CAGCTCCACC AGCACAGCAC CCACATCCAG CCAGTCCTCT 180
CACTCCAGCT CGGGGACGCT GAGCTCCTTA GACACAGTGT CCACCCAGGA ACTCTGTTCT 240
ATTCCTGAGG ACCAGGAACC CGAGGAGCCT GTCCCTGCCC CTTGGGCTCG ATTATGGGCC 300
CTTCAGGATG GGTTCCCCAA TCTTGAGTGT GTTAATGACA ACTACTGGTT TGGGAGAGAT 360
AGAAGCTGTG ACTACTGCTT TGATGAGCCA CTGCTGAAAA GAACGGATAA ATACCGGACT 420
TACAGCAAGA AGCACTTTCG GATTTTCAGA GAAATGGGTC CTAAAAACTC TTACATCGCA 480
TACATAGAAG ATCACAGTGG GAATGGAACC TTTGTAAATA GAGAGCTGGT AGGGAAAGGA 540
AGACGCCTTC CTTTGAATAA CAATTCTGAA ATTGCACTGT CAGTGTGGAG TAATAAAGTT 600
TTTGTATTTT TTGATCTGAC TGTAGATGAT CAGTCAGTTT ATCCTAAGGA ATTAAGAGAC 660
CAATACATCC TGTCAAAAAC TCTTGGAAGC GGTGCCTGTG GTGAAGTGAA GCTAGCTTTT 720
GAGAGGAAAA CATGTAAGAA AGTAGCCATA AAAATCATCA GCAAAAGGAA GTTCGCTATT 780
GGCTCTGAGA GTGGGGCAGA TCCACCTCCC AATGTTGAAA CAGAAATAGA AATTTTGAAA 840
AAACTAGATC ATCCTTGTAT CATCAAGATT AAAGACTTTT TTGATGCCGA AGATTATTAT 900
ATTGTTTTGG AATTGATGGA AGGAGGAGAG CTTTTCGACA GGGTGGTGGG GAATAAGCGC 960
CTCAAAGAAG CTACGTGTAA ACTCTATTTT TACCAGATGC TCCTGGCTGT ACAGTACCTT 1020
CATGAAAACG GTATTATACA TCGGGACTTA AAACCAGAGA ATGTTCTACT CTCATCTCAA 1080
AAAGAGGACT GTCTTATAAA GATTACTGAT TTTGGGCAGT CTAAGATTTT GGGGGAGACC 1140
TCTCTTATGA GAACTTTATG TGGTACTCCC ACCTACCTGG CTCCTGAGGT TCTTAATTCC 1200
TTTGGGACTG CTGGATATAA CCGAGCTGTG GATTGCTGGA GTTTAGGAGT TATTCTTTTT 1260
ATTTGCCTTA GTGGGTATCC ACCTTTCTCT GAGCATAAGA CTCAGGTGTC TTTGAAGGAT 1320
CAGATCACCA GTGGAAAATT CAATTTCATT CCTGAAGTCT GGACAGAGGT CTCAGAAAAG 1380
GCTCTGGACC TTGTCAAGAA GTTGTTGATA GTGGATCCAA AGGTGCGTTT TACGACAGAA 1440
GAAGCTTTAA GACACCCGTG GCTTCAGGAT GAAGACATGA AGAGAAAATT TCAGAAATTA 1500
CTTTTTGAAG AAACAAAGTC AACGGCTCTA CCCCAACTCC CAGCCCAGCC TTCCACGAGT 1560
CGAAAGCGGC GTCTTGAAGG GGAAGCAGAG GATGCTGACA CCACAAAGCG CCTGGCTGTG 1620
TGTGCTGCTG TGTCGTGA 1638
Domain Profile
S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59
         yilsk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s++ ++   +ve+e+eilkk
Q: 222   YILSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSESGADPPPNVETEIEILKK  281
         89*********************************999**********************
S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119
         l+hP+i+k+kd+f++e++ y+vlel+egGel+d+vv +k+lke+++kl+f+q+l av+yl
Q: 282   LDHPCIIKIKDFFDAEDY-YIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYL  340
         *****************9.*****************************************
S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179
         he+giihrDlkPen+Lls+++ed+l+kitDfG++k+lge+slm+tlCGtp+y+aPevl +
Q: 341   HENGIIHRDLKPENVLLSSQKEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS  400
         ************************************************************
S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239
          g+a+y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gk++fi+e+w+++se+
Q: 401   FGTAGYNRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKFNFIPEVWTEVSEK  460
         ************************************************************
S: 240   akdlikklLvvdPeerlsieealnhpWl  267
         a+dl+kklL+vdP+ r+++eeal+hpWl
Q: 461   ALDLVKKLLIVDPKVRFTTEEALRHPWL  488
         ***************************8
Domain Sequence
(FASTA)
YILSKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SESGADPPPN VETEIEILKK 60
LDHPCIIKIK DFFDAEDYYI VLELMEGGEL FDRVVGNKRL KEATCKLYFY QMLLAVQYLH 120
ENGIIHRDLK PENVLLSSQK EDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLNSF 180
GTAGYNRAVD CWSLGVILFI CLSGYPPFSE HKTQVSLKDQ ITSGKFNFIP EVWTEVSEKA 240
LDLVKKLLIV DPKVRFTTEE ALRHPWL 267
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-BOT-00037
EKS-CAE-00032
EKS-CAJ-00036
EKS-CAF-00037
EKS-CAP-00037
EKS-CII-00014
EKS-CIS-00038
EKS-DAR-00048
EKS-DRM-00013
EKS-EQC-00034
EKS-FEC-00034
EKS-GAG-00030
EKS-GOG-00035
EKS-HOS-00037
EKS-ICT-00032
EKS-LAC-00038
EKS-LOA-00036
EKS-MAM-00036
EKS-MEG-00032
EKS-MOD-00036
EKS-MUM-00038
EKS-MUP-00038
EKS-MYL-00038
EKS-NOL-00035
EKS-ORN-00053
EKS-ORA-00032
EKS-ORC-00035
EKS-ORL-00049
EKS-OTG-00038
EKS-PAT-00034
EKS-PES-00033
EKS-POA-00034
EKS-RAN-00038
EKS-SAH-00035
EKS-TAG-00034
EKS-TAR-00053
EKS-TEN-00057
EKS-XET-00037
EKS-XIM-00051
EKS-SCP-00036
Gene Ontology
GO:0000781; C:chromosome, telomeric region
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0044257; P:cellular protein catabolic process
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0006302; P:double-strand break repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010332; P:response to gamma radiation
GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307; P:spindle assembly involved in mitosis
KEGG
InterPros
IPR000253; FHA_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008984; SMAD_FHA_domain.
Pfam
PF00498; FHA; 1.
PF00069; Pkinase; 1.
SMARTs
SM00240; FHA; 1.
SM00220; S_TKc; 1.
Prosites
PS50006; FHA_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013