EPS-AIM-00039

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00039

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	617.1	4.8E-186	185	496	312

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009058

UniProt Accession

D2HL56;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C; PANDA_012187;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000008577	ENSAMEP00000009058	ENSAMET00000009444

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALADATRAIE IDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTITF MKELMQWYKD QKKLHRKCAY QILVQVKEAL SKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENHL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLRGSDLR PQFHQFTAVP 480

HPDVKPMAYA STLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAGCCCCCG 60

GCTGATGGCG CTCTGAAGCG GGCAGAGGAG CTCAAGACGC AAGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAATGC AATCAAATTC TACAGCCAGG CCATCGAGCT GAACCCCAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTATCTGC GCACCGAGTG CTATGGCTAC 240

GCGCTGGCTG ACGCCACACG GGCCATTGAG ATCGACAAGA AGTACATTAA GGGCTACTAC 300

CGCCGGGCCG CCAGCAACAT GGCACTGGGC AAGTTCCGGG CCGCCTTGCG TGACTACGAG 360

ACGGTGGTGA AGGTGAAGCC CCACGACAAG GACGCCAAAA TGAAGTACCA GGAGTGCAAC 420

AAGATCGTGA AGCAGAAGGC CTTCGAGCGG GCCATTGCAG GCGATGAGCA CAAGCGTTCC 480

GTGGTGGACT CGCTGGACAT CGAGAGCATG ACCATCGAGG ACGAGTACAG CGGGCCCAAA 540

CTCGAGGATG GCAAAGTGAC AATCACCTTC ATGAAGGAGC TCATGCAGTG GTACAAGGAC 600

CAGAAGAAGC TGCACCGGAA ATGCGCCTAC CAGATCCTGG TACAGGTCAA AGAGGCCCTC 660

TCCAAGCTGA GCACGCTCGT GGAGACCACG CTCAAAGAGA CAGAGAAGAT TACGGTGTGC 720

GGGGACACCC ATGGCCAGTT CTATGACCTC CTCAACATAT TTGAGCTCAA TGGTTTACCC 780

TCGGAGACCA ACCCCTACAT ATTTAATGGC GACTTTGTGG ACCGCGGCTC CTTCTCTGTA 840

GAAGTGATCC TCACCCTGTT TGGCTTTAAG CTCCTGTACC CAGATCACTT TCACCTACTT 900

CGAGGCAACC ACGAGACGGA CAACATGAAC CAGATCTATG GCTTCGAGGG CGAGGTGAAG 960

GCCAAATACA CAGCCCAGAT GTACGAACTC TTCAGCGAGG TGTTCGAGTG GCTCCCACTG 1020

GCCCAGTGTA TCAACGGCAA AGTGCTGATC ATGCACGGGG GCTTGTTCAG TGAGGACGGC 1080

GTCACCCTAG ACGATATCCG GAAGATCGAG CGGAACCGGC AGCCCCCAGA TTCAGGTCCC 1140

ATGTGCGACC TGCTCTGGTC AGACCCACAG CCGCAGAACG GACGCTCGGT CAGCAAGCGG 1200

GGCGTGAGCT GCCAGTTTGG CCCTGATGTC ACCAAGGCCT TCCTGGAGGA GAACCACCTG 1260

GACTACATCA TCCGCAGCCA CGAGGTCAAG GCCGAGGGCT ACGAGGTGGC ACACGGCGGC 1320

CGCTGTGTCA CCGTCTTCTC TGCCCCCAAC TACTGTGACC AGATGGGGAA TAAAGCCTCC 1380

TACATCCACC TCCGGGGCTC TGACCTGCGG CCCCAGTTCC ACCAGTTCAC AGCAGTGCCT 1440

CATCCCGACG TCAAGCCCAT GGCCTACGCC AGCACGCTGC TGCAGTTAGG GATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v+++l+kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKELMQWYKDQKKLHRKCAYQILVQVKEALSKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENHLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih+r++dlr+++++f+av+hpdv

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLRGSDLRPQFHQFTAVPHPDV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+ +ll+l

Q: 485   KPMAYASTLLQL  496

         ********9987

Domain Sequence
(FASTA)

KVTITFMKEL MQWYKDQKKL HRKCAYQILV QVKEALSKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENHLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL RGSDLRPQFH QFTAVPHPDV 300

KPMAYASTLL QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0043278	; P:response to morphine

KEGG

aml:100472775

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013