EKS-AIM-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	346.7	6.8E-104	16	259	244

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009107

UniProt Accession

G1LPX7;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000008635	ENSAMEP00000009107	ENSAMET00000009495

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1305

Protein Sequence
(FASTA)

LAMFCRYAGL ERIVKKFTFA RVKKVLHLSF CFKVAIKIID KTQLDEENLK KIFREVQIMK 60

MLCHPHIIRL YQVMETERMI YLVTEYASGG EIFDHLVAHG RMAEKEARRK FKQIVAAVYF 120

CHCRNIVHRD LKAENLLLDA NLNIKIADFG FSNLFTPGQL LKTWCGSPPY AAPELFEGKE 180

YDGPKVDIWS LGVVLYVLVC GALPFDGSTL QNLRARVLSG KFRIPFFMST ECEHLIRHML 240

VLDPNKRLSM EQICKHKWMK LGDADPNFDR LIAECQQLKE ERQIDPLNED VLLAMEDMGL 300

DKERTLQSLR SDAYDHYSAI YSLLCDRQKR HKTLRVGAPP SMPRAMAFQA PVNVQAEQAG 360

TTMNISVPQV QLINPENQIV EPDGTVNLDS DEGEEPSPEA LVRYLSMRRH TVGVADPRTE 420

VLEDLQKLLP GFPGVSPQAA FLQVAPNVNF MHNLLPMQNL QPTGQLEYKE QSLLQPPTLQ 480

LLNGMGPLGR RASDGGANIQ LHAQQLLKRP RGPSPLVTMT PAVPAVTPVD EESSDGEPDQ 540

EAVQRYLANR SKRHTLAMTN PTAEIPPDLQ RQLGQQPFRS RVWPPHLVPE QHRSTYKDSN 600

TLHLPTERFS PVRRFSDGAA SIQAFKAHLE KLANSSSIKQ LQQECEQLQK MYGGQIDERA 660

LEKTQQQHVL YQQEQHHQIL QQQIQDSICP PQPSPPLQAA CENQPALLTH QLQRLRIQPS 720

SPPPNHPNNH LFRPPSNSPP PMSSAMIQSH GAASPSQFPG LPSRGAVYQP QPESCSPPPT 780

VALTCLGLQQ PPPSQQVTIQ VQEPVDMLSS MPGTAAGSAG RGLAISPSAS QIQMQHRTNL 840

MAALSYGHRP LSKQLSADSA EAHSSNVNRF SPANYDQAHL HPHLFSDQSR GSPSSYSPST 900

GVGFPPTQAL KVPPLDQFPT FPPSTHQQPA HYTASALQQA LLSPTPPDYT RHQQVPHILQ 960

GLLSPRHSLS GHSDIRLPPA EFAQLVKRQR QQQQQQDYHD LFRHMNQGDA GSLAPGLGGQ 1020

NMTERQALPY QNADSYHHHH TSPQHLLQIR AQECLSQAAS PSPAQGYAQQ PALLRSESME 1080

EECSCEAAKD GFPDRKSSNT VTKGCHDSPL LLSTGGPGDP ESLLGTVSHA RELGIHPYRH 1140

QPTAAFSRNK VSSRESVIGN CMDRSSPGQA MELPDHNGLG YPTRPSVSEH HRPRTLQRHH 1200

TIQNSDDAYV QLDNLPGMSL VAGKALSSAR MSDAVISQSS LMGSQQFQDG ENEECRESLV 1260

GHEHADLTGG GQHLNSSCYP PTCITDILLS YKHPEVPFSM EQAGV 1305

Nucleotide Sequence
(FASTA)

CTTGCCATGT TCTGTCGTTA CGCAGGGCTT GAACGAATAG TGAAGAAATT TACATTTGCT 60

AGAGTAAAAA AAGTTCTTCA TCTTTCATTC TGTTTTAAAG TTGCTATCAA GATCATAGAC 120

AAGACCCAGC TGGATGAAGA AAACTTGAAA AAGATTTTCC GGGAAGTTCA AATTATGAAA 180

ATGCTTTGCC ACCCCCACAT CATCAGGCTC TACCAGGTTA TGGAGACAGA ACGGATGATT 240

TATCTGGTGA CAGAATATGC TAGTGGAGGG GAAATATTTG ACCACCTGGT AGCCCACGGC 300

AGAATGGCGG AGAAGGAGGC CCGTCGGAAG TTCAAACAGA TTGTGGCAGC CGTCTATTTT 360

TGTCACTGTC GGAACATTGT TCATCGTGAT CTAAAAGCTG AAAATTTGCT TCTGGATGCC 420

AATCTGAATA TTAAAATAGC AGATTTTGGC TTCAGTAACC TGTTCACTCC CGGGCAGCTG 480

CTGAAGACGT GGTGCGGCAG CCCCCCCTAT GCTGCGCCTG AGCTCTTTGA GGGAAAGGAA 540

TACGATGGGC CCAAAGTGGA CATCTGGAGC CTTGGAGTCG TCCTCTATGT GCTTGTGTGT 600

GGTGCCCTGC CATTTGATGG GAGCACACTG CAGAATCTGC GGGCCCGGGT GTTGAGTGGA 660

AAGTTCCGCA TCCCATTTTT TATGTCCACA GAGTGTGAGC ACCTGATCCG CCACATGCTG 720

GTGTTAGACC CGAACAAGCG CCTGTCGATG GAGCAGATCT GCAAGCACAA GTGGATGAAG 780

CTAGGGGACG CGGACCCCAA CTTTGACCGG TTAATAGCTG AATGCCAGCA GCTGAAAGAA 840

GAAAGACAGA TAGACCCCCT GAATGAGGAT GTCCTCTTGG CCATGGAGGA CATGGGCCTG 900

GACAAAGAGC GGACGCTACA GTCATTAAGA TCAGATGCCT ACGATCACTA TAGTGCAATC 960

TACAGCCTGC TGTGTGATCG ACAGAAGAGA CACAAAACCC TGCGTGTTGG AGCACCTCCT 1020

AGCATGCCCC GAGCCATGGC CTTTCAAGCA CCAGTCAATG TCCAGGCGGA GCAGGCTGGT 1080

ACCACTATGA ACATCAGCGT TCCCCAGGTG CAGCTGATCA ACCCAGAGAA CCAGATTGTG 1140

GAGCCGGATG GGACAGTGAA CTTGGACAGT GACGAGGGTG AAGAGCCCTC CCCTGAAGCC 1200

TTGGTCCGCT ATCTGTCCAT GAGGAGACAC ACAGTGGGTG TGGCTGACCC ACGCACGGAA 1260

GTTCTGGAAG ATCTGCAGAA GCTCCTGCCC GGCTTTCCTG GAGTCAGCCC GCAGGCTGCG 1320

TTCCTGCAGG TGGCCCCTAA CGTGAACTTC ATGCACAACC TGCTGCCCAT GCAAAATTTG 1380

CAACCGACCG GGCAGCTTGA GTACAAGGAG CAGTCCCTCT TACAGCCGCC CACCCTACAG 1440

CTGCTGAATG GAATGGGACC CCTCGGCCGG AGGGCGTCAG ATGGAGGAGC CAACATCCAG 1500

CTACATGCCC AGCAGCTGCT GAAGCGCCCA CGGGGACCCT CACCACTTGT CACCATGACA 1560

CCAGCGGTGC CGGCAGTTAC GCCTGTGGAC GAGGAGAGCT CGGATGGGGA GCCAGATCAG 1620

GAGGCTGTGC AGAGGTACTT GGCAAATAGG TCCAAAAGAC ATACACTGGC CATGACCAAC 1680

CCTACAGCTG AGATCCCACC GGACCTACAA CGGCAGCTAG GACAGCAGCC TTTCCGTTCC 1740

CGGGTCTGGC CCCCTCACCT GGTACCTGAG CAGCATCGCT CTACCTACAA GGACTCCAAC 1800

ACCCTGCACC TCCCCACGGA GCGTTTCTCC CCCGTGCGCC GGTTCTCAGA CGGGGCTGCA 1860

AGCATTCAGG CCTTCAAAGC TCACCTGGAA AAGCTGGCCA ACAGCAGCAG CATCAAACAG 1920

CTGCAGCAGG AGTGTGAGCA GCTGCAGAAG ATGTACGGGG GGCAGATTGA TGAGCGGGCC 1980

CTGGAGAAGA CCCAGCAGCA GCACGTGTTG TACCAGCAGG AGCAGCACCA TCAAATTCTC 2040

CAGCAGCAGA TTCAAGATTC TATCTGTCCT CCTCAGCCTT CTCCACCTCT TCAGGCTGCA 2100

TGTGAAAATC AGCCAGCCCT CCTTACCCAC CAGCTCCAGA GGTTAAGGAT TCAGCCTTCA 2160

AGCCCACCCC CCAACCACCC CAACAATCAT CTCTTCAGAC CACCCAGTAA TAGTCCTCCC 2220

CCCATGAGCA GTGCCATGAT CCAGTCTCAC GGCGCTGCCT CGCCCTCCCA ATTTCCAGGC 2280

TTACCGTCCC GCGGTGCAGT CTACCAGCCG CAGCCCGAGA GCTGCTCCCC GCCTCCCACC 2340

GTGGCCCTAA CCTGCCTGGG CCTTCAGCAG CCTCCGCCGT CCCAGCAGGT GACCATCCAA 2400

GTACAGGAGC CCGTGGACAT GCTCAGCAGC ATGCCAGGGA CAGCTGCAGG CTCTGCGGGG 2460

CGAGGCCTGG CCATCAGCCC CAGCGCCAGT CAGATTCAGA TGCAGCACCG CACCAACCTG 2520

ATGGCCGCCC TCAGCTACGG GCACCGGCCC TTGTCCAAGC AGCTGAGTGC CGACAGCGCG 2580

GAGGCCCACA GCTCGAACGT GAATCGGTTC TCCCCTGCTA ACTACGACCA GGCGCATTTA 2640

CACCCCCATC TGTTTTCGGA CCAGTCCCGG GGTTCCCCCA GCAGCTACAG CCCTTCAACA 2700

GGAGTGGGGT TCCCTCCAAC CCAAGCCCTG AAAGTCCCTC CACTTGACCA ATTCCCCACC 2760

TTCCCTCCCA GCACCCATCA GCAGCCAGCG CACTATACGG CGTCGGCCCT GCAGCAGGCC 2820

CTGCTGTCCC CCACGCCGCC AGACTATACG AGACACCAGC AGGTGCCGCA CATCCTCCAG 2880

GGACTGCTCT CCCCCCGGCA TTCGCTCAGC GGCCACTCGG ACATCCGGCT GCCCCCGGCG 2940

GAGTTCGCCC AGCTCGTGAA GAGGCAGCGG CAGCAGCAGC AGCAGCAGGA CTACCACGAC 3000

TTGTTCCGGC ACATGAACCA GGGGGACGCA GGGAGCCTGG CTCCCGGTCT CGGGGGACAG 3060

AACATGACAG AGCGCCAGGC TTTACCGTAT CAAAATGCTG ACTCGTATCA CCACCACCAC 3120

ACCAGCCCCC AGCATCTCCT CCAGATCAGG GCCCAGGAAT GCCTGTCGCA GGCTGCGTCC 3180

CCCAGCCCAG CGCAAGGGTA CGCCCAGCAG CCGGCCCTCC TGCGCTCGGA GAGCATGGAA 3240

GAGGAGTGCT CCTGTGAGGC GGCCAAGGAC GGCTTTCCAG ACAGGAAGAG CTCAAACACA 3300

GTGACCAAAG GTTGCCATGA CAGCCCCCTG CTCTTGAGTA CTGGCGGCCC TGGGGACCCC 3360

GAATCTTTAC TGGGAACTGT GAGCCACGCG CGGGAGTTGG GGATACATCC CTACCGACAC 3420

CAGCCGACTG CTGCATTCAG TAGGAATAAG GTGTCCAGCC GAGAGTCGGT CATAGGGAAC 3480

TGCATGGATA GAAGTTCTCC AGGACAAGCA ATGGAGCTGC CAGATCACAA CGGACTCGGG 3540

TACCCAACAC GCCCCTCTGT CAGTGAGCAC CACAGGCCCC GGACCCTCCA GAGACACCAC 3600

ACGATCCAGA ACAGTGATGA TGCTTATGTG CAGCTGGATA ACTTGCCGGG AATGAGTCTC 3660

GTGGCTGGGA AAGCACTCAG TTCTGCCCGT ATGTCGGACG CGGTTATCAG TCAGTCCTCA 3720

CTCATGGGGA GCCAGCAGTT TCAAGATGGG GAAAATGAGG AATGCAGGGA GAGCCTAGTT 3780

GGTCACGAGC ACGCAGACCT GACTGGTGGC GGCCAGCATT TAAACTCCTC TTGCTACCCA 3840

CCCACGTGCA TCACCGACAT CCTGCTCAGC TACAAGCACC CCGAGGTCCC CTTCAGCATG 3900

GAGCAGGCGG GCGTGTAA 3918

Domain Profile

S: 9     egsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpniikllevie  68

         + +f++Vk++ h +   kva+Kii+k++l+ee+l+ki+rE++i+k+l hp+ii+l++v+e

Q: 16    KFTFARVKKVLHLSFCFKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVME  75

         5689********************************************************

S: 69    tkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeN  128

         t++++ylv+eyasgge+fd+++++gr+ ekear+ fkq+v+av ++h ++ivHrDlK+eN

Q: 76    TERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVAAVYFCHCRNIVHRDLKAEN  135

         ************************************************************

S: 129   llldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvL  188

         llld++ nikiaDFG++nlf++g+ll+t+cGsppYaaPel++gk+Y+gpkvD+WslGvvL

Q: 136   LLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVL  195

         ************************************************************

S: 189   yalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilk  248

         y+lv+g+lPfd+++l++l++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR+++e+i k

Q: 196   YVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICK  255

         ************************************************************

S: 249   hewl  252

         h+w+

Q: 256   HKWM  259

         ***8

Domain Sequence
(FASTA)

KFTFARVKKV LHLSFCFKVA IKIIDKTQLD EENLKKIFRE VQIMKMLCHP HIIRLYQVME 60

TERMIYLVTE YASGGEIFDH LVAHGRMAEK EARRKFKQIV AAVYFCHCRN IVHRDLKAEN 120

LLLDANLNIK IADFGFSNLF TPGQLLKTWC GSPPYAAPEL FEGKEYDGPK VDIWSLGVVL 180

YVLVCGALPF DGSTLQNLRA RVLSGKFRIP FFMSTECEHL IRHMLVLDPN KRLSMEQICK 240

HKWM 244

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013