EPS-AIM-00077

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00077

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	435.9	2.0E-131	84	284	201

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009260

UniProt Accession

G1LQC9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CA

Gene Synonyms/Alias

PPP3CA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000008779	ENSAMEP00000009260	ENSAMET00000009659

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

521

Protein Sequence
(FASTA)

MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 60

ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 120

DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 180

AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 240

NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 300

SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 360

VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 420

LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN 480

ERMPPRRDAM PSDANLNSIN KALASETNGT DSNGSNSSNI Q 521

Nucleotide Sequence
(FASTA)

ATGTCCGAGC CCAAGGCAAT TGATCCCAAG TTGTCGACGA CCGACAGGGT GGTGAAAGCT 60

GTCCCATTTC CTCCAAGTCA TCGGCTTACA GCAAAAGAAG TGTTTGATAA TGATGGAAAA 120

CCTCGTGTGG ATATCTTAAA GGCACATCTC ATGAAGGAGG GCAGGCTGGA AGAGAGCGTT 180

GCATTGAGAA TAATAACAGA GGGGGCTTCC ATTCTTCGAC AGGAAAAGAA TTTGCTGGAT 240

ATTGATGCAC CAGTCACAGT TTGTGGGGAC ATCCATGGAC AATTCTTTGA CTTGATGAAG 300

CTTTTTGAAG TGGGGGGATC TCCTGCCAAC ACTCGCTACC TCTTCTTAGG GGACTATGTT 360

GACAGAGGGT ACTTCAGTAT CGAATGTGTG CTGTATTTGT GGGCCTTGAA AATTCTTTAC 420

CCCAAAACAC TGTTTTTACT TCGTGGAAAT CATGAATGTA GACATCTAAC AGAGTATTTC 480

ACGTTTAAAC AAGAATGTAA AATAAAGTAT TCAGAACGCG TATATGACGC CTGTATGGAT 540

GCCTTTGACT GCCTGCCTCT GGCTGCTCTG ATGAACCAGC AGTTCCTGTG TGTCCACGGG 600

GGTTTATCTC CAGAGATTAA CACTTTAGAT GACATCAGGA AATTAGACCG ATTCAAAGAA 660

CCACCTGCTT ATGGACCTAT GTGTGATATC CTGTGGTCAG ACCCGCTGGA GGATTTTGGA 720

AACGAGAAGA CTCAGGAACA TTTCACTCAC AACACAGTCA GGGGGTGTTC GTACTTCTAC 780

AGTTACCCGG CTGTGTGTGA ATTCTTACAG CACAATAATT TGTTATCTAT ACTCCGAGCC 840

CATGAAGCCC AGGATGCAGG GTATCGCATG TACAGGAAAA GCCAAACGAC AGGCTTCCCT 900

TCTCTAATTA CAATTTTCTC AGCACCAAAT TACTTAGATG TATACAATAA CAAAGCTGCA 960

GTATTGAAGT ATGAGAACAA CGTCATGAAT ATCAGGCAAT TCAACTGTTC TCCTCACCCC 1020

TACTGGCTTC CAAATTTCAT GGATGTTTTC ACTTGGTCCC TGCCATTTGT TGGGGAAAAA 1080

GTGACCGAGA TGCTGGTAAA TGTCCTCAAC ATCTGCTCAG ATGATGAACT GGGGTCAGAA 1140

GAAGATGGAT TTGATGGAGC AACAGCCGCA GCCCGGAAGG AGGTGATAAG GAACAAGATC 1200

CGAGCAATAG GCAAAATGGC CCGAGTGTTC TCGGTTCTCA GAGAAGAGAG CGAGAGTGTG 1260

CTGACACTGA AAGGCTTGAC CCCCACGGGT ATGCTCCCCA GCGGAGTGCT TTCTGGAGGG 1320

AAGCAGACAC TGCAAAGCGC TACTGTTGAG GCTATTGAGG CTGATGAAGC TATCAAAGGA 1380

TTTTCACCAC AACATAAGAT CACTAGCTTC GAGGAGGCCA AGGGCTTAGA CCGAATTAAC 1440

GAGAGGATGC CACCTCGCAG AGATGCCATG CCCTCTGACG CCAACCTTAA CTCCATCAAC 1500

AAGGCTCTCG CCTCAGAGAC TAACGGCACG GACAGCAATG GCAGTAATAG CAGCAATATC 1560

CAG 1563

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         pvtvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl+alkilypkt

Q: 84    PVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKT  143

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservydac++afd+lplaal+nqqflcvhggls

Q: 144   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLS  203

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++tlddirkldrfkeppayg+mcd+lwsdpledfgnek++e+f+hn+vrgcsyfysy+

Q: 204   PEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYP  263

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+nnllsi+raheaq

Q: 264   AVCEFLQHNNLLSILRAHEAQ  284

         ********************8

Domain Sequence
(FASTA)

PVTVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WALKILYPKT 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYDACMDAFD CLPLAALMNQ QFLCVHGGLS 120

PEINTLDDIR KLDRFKEPPA YGPMCDILWS DPLEDFGNEK TQEHFTHNTV RGCSYFYSYP 180

AVCEFLQHNN LLSILRAHEA Q 201

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0030018	; C:Z disc
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0008144	; F:drug binding
GO:0033173	; P:calcineurin-NFAT signaling cascade
GO:0006816	; P:calcium ion transport
GO:0035690	; P:cellular response to drug
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006470	; P:protein dephosphorylation
GO:0006606	; P:protein import into nucleus
GO:0060079	; P:regulation of excitatory postsynaptic membrane potential
GO:0050804	; P:regulation of synaptic transmission
GO:0051592	; P:response to calcium ion
GO:0006950	; P:response to stress
GO:0048741	; P:skeletal muscle fiber development
GO:0014883	; P:transition between fast and slow fiber

KEGG

aml:100467653

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013