EKS-AIM-00137
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00137
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk472.42.5E-142195440246
StatusUnreviewed
Ensembl ProteinENSAMEP00000009294
UniProt AccessionD2HKY4;
Protein Name
Protein Synonyms/Alias
Gene NameCSK
Gene Synonyms/Alias CSK; PANDA_012092;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000008812ENSAMEP00000009294ENSAMET00000009693
OrganismAiluropoda melanoleuca
Functional Description
Protein Length450
Protein Sequence
(FASTA)
LPALQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLCPPE TGLFLVREST NYPGDYTLCV 120
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 180
DEFFRSGWAL NMKDLKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420
NCWHLDAATR PSFLQLREQL EHIKTHELHL 450
Nucleotide Sequence
(FASTA)
TTGCCTGCCC TGCAGGCCGC CTGGCCATCC GGTACAGAAT GCATTGCCAA GTACAACTTT 60
CATGGCACTG CCGAGCAGGA CCTTCCCTTC TGCAAAGGAG ACGTGCTCAC CATTGTGGCG 120
GTCACCAAGG ACCCAAACTG GTACAAAGCC AAGAACAAGG TGGGCCGTGA GGGCATCATC 180
CCAGCCAACT ACGTCCAGAA GCGGGAGGGC GTGAAGGCCG GCACCAAGCT CAGCCTCATG 240
CCCTGGTTCC ATGGCAAGAT CACACGGGAG CAGGCCGAGC GGCTTCTGTG CCCACCGGAG 300
ACGGGCCTGT TCCTGGTGCG GGAGAGCACC AACTACCCCG GGGACTACAC GCTGTGCGTG 360
AGCTGCGACG GCAAGGTGGA GCACTACCGT ATCATGTACC ACGCCAGCAA GCTCAGCATC 420
GACGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTAG AGCACTACAC CTCAGACGCT 480
GACGGACTCT GTACTCGGCT CATCAAGCCA AAGGTCATGG AGGGCACGGT GGCAGCCCAG 540
GATGAGTTCT TCCGCAGCGG CTGGGCACTG AACATGAAGG ACCTGAAGCT GCTGCAGACC 600
ATTGGGAAGG GGGAGTTTGG AGATGTGATG CTGGGTGATT ACCGAGGGAA CAAAGTCGCT 660
GTCAAGTGCA TTAAAAATGA TGCCACCGCG CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 720
ACGCAACTTC GGCATAGCAA CCTGGTACAG CTCCTGGGCG TGATCGTGGA AGAGAAGGGC 780
GGGCTCTACA TCGTCACTGA GTACATGGCC AAGGGGAGCC TGGTGGACTA TCTGCGGTCG 840
AGGGGTCGGT CGGTGCTGGG CGGAGACTGT CTCCTCAAGT TCTCACTAGA TGTCTGTGAG 900
GCCATGGAAT ACCTGGAGGG CAATAACTTC GTGCACCGGG ATCTGGCTGC CCGCAACGTG 960
CTGGTGTCTG AGGACAACGT GGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 1020
AGCACCCAGG ACACGGGCAA GCTGCCAGTC AAGTGGACAG CCCCGGAGGC CCTGAGAGAG 1080
AAGAAATTCT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTCCTCTG GGAAATCTAC 1140
TCCTTCGGGC GAGTGCCTTA TCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAG 1200
AAGGGCTACA AGATGGATGC CCCCGACGGC TGCCCGCCTG CGGTCTACGA GGTCATGAAG 1260
AACTGCTGGC ACCTGGACGC CGCCACGCGG CCCTCCTTCC TGCAGCTCCG GGAGCAGCTC 1320
GAGCACATCA AAACCCACGA GCTGCACCTG 1350
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv
Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254
         6899********************************************************
S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119
         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd
Q: 255   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314
         *****99*****************************************************
S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179
         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi
Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374
         ************************************************************
S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239
         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf 
Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFL  434
         ************************************************************
S: 240   klkekl  245
         +l+e+l
Q: 435   QLREQL  440
         ***997
Domain Sequence
(FASTA)
LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60
IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120
LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180
LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAATRPSFL 240
QLREQL 246
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-DRM-00070
EKS-EQC-00143
EKS-FEC-00136
EKS-GAM-00074
EKS-GAG-00123
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAM-00143
EKS-MAE-00056
EKS-MEG-00113
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-ORN-00178
EKS-ORL-00168
EKS-OTG-00150
EKS-PAT-00135
EKS-PES-00130
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAR-00188
EKS-TEN-00180
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005813; C:centrosome
GO:0005794; C:Golgi apparatus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0008285; P:negative regulation of cell proliferation
GO:0042997; P:negative regulation of Golgi to plasma membrane protein transport
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013