EPS-AIM-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-AIM-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.7	1.0E-56	153	409	257

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009377

UniProt Accession

G1LQP3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000008905	ENSAMEP00000009377	ENSAMET00000009777

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

443

Protein Sequence
(FASTA)

MASGAPQQSS RPAEEIPGFL DAFLCDFPAP LSLESPVPWK LPGTVLSQEE VEGELAELAM 60

GFLSSRSAPP PLASSLAHEA VSQLLQTDLS EFRKLPRQEE EEEEDDEEEK APVTLLDAGD 120

LARSFFNRLW EVCSQWQKQV PLTARVPQRQ WLVSVHAIRN TRRKMEDRHV CLPAFNQLFG 180

LSDPVDRAYF AVFDGHGGVD AARFAAVHVH TNVARQPELH EDPARALREA FRRTDEMFLW 240

KAKRERLQSG TTGVCVLIAG KTLHVAWLGD SQVILVQQGQ VVKLMEPHRP ERQDEKERIE 300

ALGGFVSHMD CWRVNGTLAV SRAIDPGDVF QKPYVSGEAD SASRELTGSE DYLLLACDGF 360

FDVVPHQEVA GLVQSHLVRQ QGSGLQVAEE LVAAARERGS HDNITVMVVF LRDPRDLLKG 420

GAQGAGDVPS GLSEPETNTA RRC 443

Nucleotide Sequence
(FASTA)

ATGGCCTCTG GAGCCCCCCA GCAGAGCAGC CGGCCAGCAG AGGAGATCCC AGGCTTCCTG 60

GACGCCTTCC TCTGCGACTT CCCAGCGCCG CTGAGTCTAG AGAGCCCTGT GCCATGGAAG 120

CTCCCGGGGA CAGTGCTGAG CCAGGAGGAG GTGGAGGGAG AGCTGGCCGA GCTGGCGATG 180

GGCTTCCTGA GCAGCAGGAG CGCCCCGCCA CCACTTGCCT CATCTCTGGC CCACGAGGCG 240

GTTTCCCAGC TGCTACAGAC AGACCTTTCC GAATTCAGGA AGTTGCCCAG GCAGGAGGAG 300

GAGGAGGAAG AGGATGACGA GGAAGAGAAG GCCCCTGTGA CCTTGCTGGA TGCCGGGGAC 360

CTGGCACGAA GTTTCTTTAA CCGGCTCTGG GAAGTGTGCA GCCAGTGGCA GAAGCAGGTG 420

CCCTTGACCG CGCGGGTTCC TCAGCGGCAG TGGCTGGTCT CGGTGCATGC CATCCGGAAC 480

ACCCGCCGCA AGATGGAGGA CCGGCACGTG TGCCTGCCCG CCTTCAACCA GCTCTTTGGC 540

CTGTCCGACC CCGTGGACCG AGCCTACTTC GCTGTGTTCG ATGGTCACGG CGGGGTGGAC 600

GCTGCTCGGT TCGCTGCCGT GCACGTGCAC ACCAACGTTG CCCGCCAGCC GGAGCTGCAC 660

GAGGACCCCG CCCGAGCCCT CAGAGAAGCC TTCCGGCGCA CCGATGAGAT GTTTCTCTGG 720

AAAGCCAAGC GAGAGCGGCT GCAGAGCGGC ACCACAGGGG TGTGTGTGCT CATCGCCGGA 780

AAGACCCTGC ACGTCGCCTG GCTCGGGGAC TCCCAGGTCA TCCTGGTGCA GCAGGGACAG 840

GTGGTGAAGC TGATGGAACC GCACAGACCT GAGCGACAGG ACGAGAAGGA GCGCATCGAG 900

GCCCTGGGCG GCTTCGTGTC TCACATGGAC TGCTGGAGAG TCAACGGGAC CCTGGCCGTG 960

TCCAGAGCCA TCGACCCAGG GGACGTCTTC CAGAAGCCCT ACGTGTCAGG GGAGGCGGAC 1020

TCAGCCTCTC GGGAGCTGAC GGGCTCCGAG GACTACCTGC TGCTGGCCTG TGATGGCTTC 1080

TTCGATGTTG TCCCCCACCA GGAGGTCGCT GGCCTCGTCC AGAGCCACTT GGTCAGGCAG 1140

CAGGGCAGCG GGCTGCAGGT TGCCGAGGAG CTGGTGGCTG CAGCCCGGGA GCGGGGCTCC 1200

CACGACAACA TCACAGTCAT GGTGGTCTTC CTCAGGGACC CCCGAGACCT ACTGAAGGGT 1260

GGGGCCCAGG GGGCAGGGGA TGTGCCCTCT GGCCTCTCAG AGCCAGAGAC CAACACAGCT 1320

AGGAGGTGC 1329

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklhei  60

         v+v ++ + r++med++   p f +  + +d    a+f+v+DGhgg ++a+f++ ++h+

Q: 153   VSVHAIRNTRRKMEDRHVCLPAFNQLFGLSDPvdRAYFAVFDGHGGVDAARFAAVHVHTN  212

         6788999****************999888887778*************************

S: 61    laeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyva  120

         +a++ e      ++  +al++aF +tde +  l +++ +  +sG+t v++li +++l+va

Q: 213   VARQPE----LHEDPARALREAFRRTDEMF--LWKAKRERLQSGTTGVCVLIAGKTLHVA  266

         ****77....6677788*************..5555568889******************

S: 121   nvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRal..  178

          +GdS+++L ++g++v+l + H+p+r+dE+eRie+ gg v   d+ Rv+G LavsRa+

Q: 267   WLGDSQVILVQQGQVVKLMEPHRPERQDEKERIEALGGFVSHMDCWRVNGTLAVSRAIdp  326

         ********************************************99**************

S: 179   GdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqe  237

         Gd++ kpyv+ e +  s +lt ++++l La+DG +dvv+ +e+  lv+++l  ++ +  +

Q: 327   GDVFQKPYVSGEADSASRELTGSEDYLLLACDGFFDVVPHQEVAGLVQSHLVrQQGSGLQ  386

         ************************************************99985778899*

S: 238   aakkLvklalargskdnvsaivv  260

         +a++Lv+ a++rgs+dn++++vv

Q: 387   VAEELVAAARERGSHDNITVMVV  409

         *******************9997

Domain Sequence
(FASTA)

VSVHAIRNTR RKMEDRHVCL PAFNQLFGLS DPVDRAYFAV FDGHGGVDAA RFAAVHVHTN 60

VARQPELHED PARALREAFR RTDEMFLWKA KRERLQSGTT GVCVLIAGKT LHVAWLGDSQ 120

VILVQQGQVV KLMEPHRPER QDEKERIEAL GGFVSHMDCW RVNGTLAVSR AIDPGDVFQK 180

PYVSGEADSA SRELTGSEDY LLLACDGFFD VVPHQEVAGL VQSHLVRQQG SGLQVAEELV 240

AAARERGSHD NITVMVV 257

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013