EKS-AIM-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	321.6	2.4E-96	1602	1820	219

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009542

UniProt Accession

G1LR58;

Protein Name

Protein Synonyms/Alias

Gene Name

TRPM7

Gene Synonyms/Alias

TRPM7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000009020	ENSAMEP00000009542	ENSAMET00000009954

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1869

Protein Sequence
(FASTA)

QSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM 60

KYSDVKLGDH FNQTLEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEVI 120

LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGT 180

GVAKHVGDAL KEHASRSSRK ICTIGIAPWG VIENRNDLVG RDVVAPYQTL LNPLSKLNVL 240

NNLHSHFILV DDGTVGKYGA EVRLRRELEK TINQQRIHAR IGQGVPVVAL IFEGGPNVIL 300

TVLEYLQESP PVPVVVCEGT GRAADLLAYI HKQTEEGGSL PDAAEPDIIS TIKKTFNFGQ 360

SEAVHLFQTL MECMKRKELI TVFHIGSDEH QDIDVAILTA LLKGTNASAF DQLILTLAWD 420

RVDIAKNHVF VYGQQWLVGS LEQAMLDALV MDRVAFVKLL IENGVSMHKF LTIPRLEELY 480

NTKQGPTNPM LFHLVRDVKQ GNLPPGYKIT LIDIGLVIEY LMGGTYRCTY TRKRFRLIYN 540

SLGGNNRRSG RNTSSSTPQL RKSHESFGNR ADKKEKMRHN HFIKTAQPYR PKIDTAVEEG 600

KKKRAKDEIV DIDDPETKRF PYPLNELLIW ACLMKRQVMA RFLWQHGEES MAKALVACKI 660

YRSMAYEAKQ SDLVDDTSEE LKQYSNDFGQ LAVELLEQSF RQDETMAMKL LTYELKNWSN 720

STCLKLAVSS RLRPFVAHTC TQMLLSDMWM GRLNMRKNSW YKVILSILVP PAILMLEYKT 780

KAEMSHIPQS QDAHQMTMED SENNFQNIAE EIPMEVFKEV RILDSNEGKN EMEIQIKSKK 840

LPITRKFYAF YHAPIVKFWF NTLAYLGFLM LYTFVVLVQM ERLPSVQEWI VIAYIFTYAI 900

EKVREIFMSE AGKISQKIKV WFSDYFNISD TIAIISFFIG FGLRFGAKWN FENAYDNHVF 960

VAGRLIYCLN IIFWYVRLLD FLAVNQQAGP YVMMIGKMVA NMFYIVVIMA LVLLSFGVPR 1020

KAILYPREAP SWTLAKDIVF HPYWMIFGEV YAYEIDVCAN DSTISQICGP GTWLTPFLQA 1080

VYLFVQYIIM VNLLIAFFNN VYLQVKAISN IVWKYQRYHF IMAYHEKPVL PPPLIILSHI 1140

VSLFCCICKR RKKDKTSDGP KLFLTEEDQK KLHDFEEQCV EMYFNEKDDK FHSGSEERIR 1200

VTFERVEQMC IQIKEVGDRV NYIKRSLQSL DSQIGHLQDL SALTVDTLKT LTAQKASEAS 1260

KVHNEITREL SISKHLAQNL IDDGPVRPSV WKKHSVVNTL SSSLPQGGLE STNPFLCNIF 1320

MKDEKDPPCN IFSQDLPVIP QRKEFSFPEA GSSCGALFPS AVSPPELRQR IHGVEMLKIF 1380

SKNQKLGSSS NSIPHLSSPP TKFFVSTPSQ PSCKSHLETV TKDQEIVCSK AAEGDNVEFG 1440

AFVGHRDSID YLQKFKETSN KIKEILSSDA PSENTLKHVS SHAGFTECRK TSIPLHSEQV 1500

ESSGRRPSTE ETHEVDSKAA LLPDWLQDRP SNRDMPSEEG TLNGLASPFK PVLDTNYYYS 1560

AVERNNLMRL SQSIPFTPVP PRGEPVTVYR LEESSPSILN NSMSSWSQLG LCAKIEFLSK 1620

EEMGGGLRRA VKVQCTWSEH DILKSGHLYI IKSFLPEVVN TWSSIYKEDT VLHLCLREIQ 1680

QQRAAQKLTF AFNQMKPKSI PYSPRFLEVF LLYCHSAGQW FAVEECMTGE FRKYNNNNGD 1740

EIIPTNTLEE IMLAFSHWTY EYTRGELLVL DLQGVGENLT DPSVIKAEEK RSCDMVFGPA 1800

NLGEDAIKNF RAKHHCNSCC RKLKLPDLKR NDYTPDKILF PQDEPSDLTL QPGNSTKESE 1860

STNSIRLML 1869

Nucleotide Sequence
(FASTA)

CAGTCCCAGA AATCCTGGAT AGAAAGCACT TTGACCAAGA GGGAATGTGT ATATATTATA 60

CCAAGTTCCA AAGACCCTCA CAGATGCCTT CCAGGATGTC AAATTTGTCA GCAACTTGTC 120

AGGTGTTTTT GTGGTCGCTT GGTCAAGCAA CATGCTTGTT TTACTGCAAG TCTTGCCATG 180

AAATACTCAG ATGTGAAATT GGGTGACCAT TTTAATCAGA CATTAGAAGA GTGGTCTGTG 240

GAAAAGCATA CAGAACAGAG CCCAACGGAT GCTTATGGAG TCATAAATTT TCAAGGGGGT 300

TCTCATTCCT ACAGAGCTAA GTATGTGAGA CTATCATATG ACACCAAACC TGAAGTCATT 360

CTGCAACTTC TGCTTAAAGA ATGGCAAATG GAATTACCCA AACTTGTTAT CTCTGTGCAT 420

GGGGGCATGC AGAAATTTGA ACTTCACCCA CGAATCAAGC AGCTGCTTGG AAAGGGTCTT 480

ATTAAAGCTG CAGTTACAAC CGGAGCCTGG ATTTTAACTG GAGGAGTAAA CACAGGAACA 540

GGTGTGGCAA AACATGTTGG TGATGCCCTC AAAGAACACG CTTCCAGATC ATCTCGAAAG 600

ATTTGCACTA TTGGAATAGC ACCCTGGGGA GTGATTGAAA ACAGAAATGA TCTTGTTGGG 660

AGAGATGTGG TTGCTCCTTA TCAAACCTTG TTGAACCCTC TGAGCAAATT GAATGTTCTG 720

AATAATCTAC ATTCCCATTT CATATTGGTG GATGATGGCA CTGTTGGAAA GTATGGGGCA 780

GAAGTGAGAT TGAGAAGAGA ACTTGAAAAA ACTATTAATC AGCAAAGAAT TCATGCTAGA 840

ATTGGACAAG GCGTCCCTGT GGTGGCACTT ATATTTGAGG GCGGGCCAAA TGTTATCCTC 900

ACGGTTTTAG AATATCTTCA AGAAAGTCCT CCTGTTCCAG TCGTCGTTTG TGAAGGAACA 960

GGCAGAGCTG CAGATCTACT AGCATATATT CATAAGCAAA CGGAAGAGGG AGGCAGTCTT 1020

CCTGATGCAG CAGAGCCTGA TATTATTTCA ACCATCAAAA AAACATTTAA CTTTGGCCAG 1080

AGCGAAGCAG TTCATTTATT TCAAACACTG ATGGAGTGCA TGAAAAGAAA GGAGCTTATC 1140

ACGGTTTTCC ACATTGGATC AGATGAGCAT CAAGATATAG ATGTAGCAAT ACTTACTGCA 1200

CTGCTTAAAG GCACTAATGC ATCTGCATTT GACCAGCTCA TCCTTACGTT GGCTTGGGAT 1260

AGAGTTGACA TTGCCAAAAA TCATGTGTTT GTTTATGGAC AGCAGTGGCT GGTTGGGTCC 1320

TTGGAACAAG CTATGCTTGA TGCTCTTGTA ATGGATAGAG TTGCATTTGT GAAACTTCTT 1380

ATTGAAAATG GAGTAAGCAT GCATAAATTC CTTACCATTC CTAGACTGGA AGAACTTTAT 1440

AACACAAAAC AAGGTCCAAC TAATCCAATG CTATTTCATC TTGTTCGGGA TGTCAAACAG 1500

GGAAATCTTC CTCCAGGATA TAAGATCACC CTAATCGACA TAGGACTTGT TATTGAGTAT 1560

CTTATGGGAG GAACCTATAG ATGCACCTAC ACTCGGAAGC GTTTTCGATT AATATATAAT 1620

AGTCTTGGTG GAAATAATCG GAGGTCTGGC CGAAATACGT CCAGCAGTAC TCCTCAGTTG 1680

CGCAAGAGTC ATGAATCTTT TGGGAATAGG GCAGATAAAA AGGAAAAAAT GAGGCACAAT 1740

CATTTCATTA AAACAGCACA GCCCTATCGA CCAAAGATTG ATACAGCTGT GGAAGAAGGA 1800

AAGAAGAAGA GAGCCAAAGA TGAAATTGTA GATATTGATG ATCCAGAAAC CAAGCGCTTT 1860

CCTTATCCAC TTAATGAACT ATTAATTTGG GCTTGCCTTA TGAAGAGACA GGTCATGGCC 1920

CGTTTTTTAT GGCAGCATGG TGAAGAATCA ATGGCTAAAG CATTAGTTGC CTGTAAGATC 1980

TATCGTTCAA TGGCATATGA AGCAAAGCAG AGTGACCTTG TAGATGATAC TTCAGAAGAA 2040

TTGAAACAGT ATTCTAATGA TTTTGGTCAG CTAGCAGTTG AATTACTAGA ACAGTCCTTC 2100

AGACAAGATG AAACCATGGC TATGAAATTG CTCACTTACG AACTGAAAAA CTGGAGTAAC 2160

TCCACCTGCC TCAAGTTAGC AGTTTCTTCA AGACTTAGAC CTTTTGTAGC TCACACCTGT 2220

ACACAAATGT TGTTATCTGA TATGTGGATG GGAAGGCTGA ATATGAGGAA AAATTCCTGG 2280

TACAAGGTCA TACTAAGCAT TTTAGTTCCA CCTGCCATAT TAATGCTAGA GTATAAGACA 2340

AAGGCTGAGA TGTCTCATAT TCCACAATCT CAAGACGCCC ACCAAATGAC AATGGAAGAT 2400

AGCGAAAACA ACTTTCAAAA CATAGCAGAA GAGATTCCCA TGGAAGTGTT TAAAGAAGTA 2460

AGAATATTGG ACAGTAATGA AGGAAAGAAT GAAATGGAGA TACAAATAAA ATCAAAAAAG 2520

CTTCCCATTA CAAGAAAGTT TTACGCCTTT TATCATGCAC CAATTGTAAA ATTCTGGTTT 2580

AATACGTTGG CATACTTAGG ATTTCTGATG CTTTATACAT TTGTGGTTCT TGTACAAATG 2640

GAACGATTGC CTTCAGTTCA AGAATGGATT GTTATTGCTT ATATTTTTAC CTATGCTATT 2700

GAGAAAGTCC GTGAGATCTT TATGTCTGAA GCTGGAAAAA TAAGCCAGAA GATTAAAGTG 2760

TGGTTTAGTG ATTACTTCAA TATCAGTGAT ACAATTGCCA TAATTTCTTT CTTCATTGGA 2820

TTTGGACTAA GATTTGGAGC AAAATGGAAC TTTGAAAATG CATATGATAA TCATGTTTTT 2880

GTTGCTGGAA GATTAATTTA CTGTCTTAAC ATAATATTTT GGTATGTGCG TTTGCTAGAT 2940

TTTCTAGCTG TAAATCAACA GGCAGGACCT TATGTAATGA TGATTGGAAA AATGGTAGCC 3000

AATATGTTCT ACATTGTAGT GATTATGGCT CTTGTATTAC TTAGTTTTGG TGTTCCCAGA 3060

AAAGCAATAC TTTATCCTCG TGAAGCACCA TCTTGGACTC TTGCTAAAGA TATAGTTTTT 3120

CATCCATACT GGATGATTTT TGGTGAAGTT TACGCATATG AAATTGACGT GTGTGCAAAT 3180

GATTCCACTA TCTCTCAAAT CTGTGGTCCT GGAACATGGT TGACTCCATT TCTTCAAGCA 3240

GTCTACCTCT TTGTACAGTA TATCATTATG GTCAATCTTC TTATTGCATT TTTCAACAAT 3300

GTGTATTTAC AAGTGAAGGC AATTTCCAAT ATTGTATGGA AGTACCAACG TTATCATTTT 3360

ATTATGGCTT ATCATGAGAA ACCTGTTCTG CCTCCACCAC TTATCATTCT CAGCCATATA 3420

GTTTCTCTGT TTTGCTGCAT ATGTAAAAGA AGAAAAAAAG ATAAGACTTC AGATGGACCA 3480

AAACTTTTTT TAACAGAAGA AGATCAAAAG AAACTACATG ACTTTGAAGA ACAGTGTGTT 3540

GAGATGTATT TTAATGAAAA AGATGACAAA TTCCATTCTG GGAGTGAAGA GAGAATTCGT 3600

GTCACTTTTG AAAGGGTGGA GCAGATGTGC ATTCAGATTA AAGAAGTTGG AGATCGCGTC 3660

AACTATATAA AAAGATCATT ACAGTCATTA GATTCTCAAA TTGGCCATTT GCAAGATCTT 3720

TCAGCCCTGA CTGTAGATAC ATTAAAAACA CTCACTGCTC AGAAAGCTTC GGAAGCTAGC 3780

AAAGTTCACA ATGAAATCAC ACGAGAGTTG AGCATTTCCA AACATTTGGC TCAAAACCTT 3840

ATTGACGACG GTCCCGTAAG ACCTTCTGTA TGGAAAAAGC ACAGTGTTGT AAATACACTT 3900

AGTTCCTCTC TTCCTCAAGG TGGTCTTGAA AGTACTAATC CTTTTCTTTG TAATATTTTT 3960

ATGAAAGATG AAAAAGATCC CCCGTGTAAC ATATTTAGTC AGGATTTACC TGTAATACCC 4020

CAGAGAAAAG AATTCAGTTT CCCAGAGGCT GGTTCCTCTT GTGGTGCCTT ATTCCCAAGT 4080

GCTGTTTCTC CTCCAGAACT GCGACAAAGA ATACATGGGG TAGAAATGTT AAAAATCTTC 4140

AGTAAAAATC AAAAATTAGG CAGTTCTTCT AATAGCATAC CACACCTGTC ATCCCCACCA 4200

ACCAAATTTT TTGTTAGTAC ACCTTCCCAG CCAAGTTGTA AAAGCCACTT AGAAACTGTA 4260

ACCAAAGATC AAGAAATTGT TTGCTCTAAA GCTGCAGAAG GAGATAATGT AGAATTCGGA 4320

GCATTTGTAG GACACAGAGA TAGCATAGAT TATTTGCAGA AGTTTAAAGA AACATCAAAC 4380

AAGATAAAAG AAATATTATC CAGTGATGCT CCTTCTGAAA ACACGTTGAA ACATGTGAGT 4440

TCTCATGCTG GATTTACTGA ATGTCGCAAA ACTTCCATTC CTCTTCATTC AGAGCAAGTG 4500

GAAAGTAGCG GTAGAAGGCC ATCTACAGAA GAAACTCATG AAGTAGATTC CAAAGCAGCT 4560

TTACTACCGG ATTGGTTACA AGATAGACCA TCAAACAGAG ACATGCCATC TGAAGAAGGA 4620

ACATTAAATG GTCTTGCTTC TCCATTTAAA CCAGTTCTGG ATACAAATTA CTACTACTCA 4680

GCTGTGGAAA GAAATAATTT GATGAGATTA TCCCAGAGCA TTCCGTTTAC ACCTGTGCCT 4740

CCAAGAGGTG AGCCTGTCAC GGTGTATCGC TTGGAAGAGA GTTCACCCAG TATACTGAAT 4800

AACAGCATGT CTTCTTGGTC ACAGCTTGGC CTCTGTGCCA AAATAGAGTT TTTAAGTAAA 4860

GAGGAGATGG GAGGCGGTTT GCGGAGAGCT GTCAAAGTAC AGTGTACCTG GTCAGAACAT 4920

GATATCCTCA AATCAGGTCA TCTTTATATT ATCAAATCTT TTCTTCCTGA GGTGGTTAAC 4980

ACATGGTCTA GTATTTATAA AGAAGATACA GTTCTGCATC TCTGTCTCAG AGAAATTCAA 5040

CAACAGAGAG CAGCACAGAA ACTCACGTTT GCCTTCAACC AAATGAAACC CAAATCCATA 5100

CCATATTCTC CGAGGTTCCT TGAAGTTTTC CTGCTGTATT GCCATTCAGC AGGACAGTGG 5160

TTTGCTGTGG AAGAATGTAT GACTGGAGAA TTCAGAAAAT ACAACAATAA TAACGGTGAT 5220

GAGATTATTC CGACTAATAC ACTGGAAGAG ATCATGCTAG CCTTTAGCCA CTGGACTTAT 5280

GAATATACAA GAGGGGAGTT ACTGGTACTT GATTTACAAG GTGTGGGTGA AAATTTGACC 5340

GACCCATCTG TGATTAAAGC AGAAGAAAAG AGATCCTGTG ATATGGTTTT TGGCCCAGCA 5400

AATCTAGGTG AAGATGCAAT AAAAAACTTC AGAGCAAAAC ATCACTGTAA TTCATGTTGT 5460

AGAAAGCTTA AACTTCCAGA TCTGAAGAGG AATGACTATA CACCTGATAA AATTCTGTTT 5520

CCTCAGGATG AGCCTTCAGA TTTGACTCTT CAGCCTGGAA ATTCCACCAA AGAATCAGAA 5580

TCAACTAATT CTATTCGTCT TATGTTATAA 5610

Domain Profile

S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50

         s++sWsq +++++i++lskee+ G+lR+a++v          k+g+l+++k++l+evv++

Q: 1602  SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVqctwsehdilKSGHLYIIKSFLPEVVNT  1661

         699*********************************************************

S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110

         +++iyke++vlhl+lr++++qraaqkl+++fnq+kPk+i+y+pr++evfL +++s++q++

Q: 1662  WSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWF  1721

         ************************************************************

S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170

         +vEe+++Gef+Kynnnngdei+++n+lee+mlafsH+tyeyt+gellV+DlqGvge+lTD

Q: 1722  AVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1781

         ************************************************************

S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205

         p++++    +s++++fg+anlge+aiknF+akhhCN++C

Q: 1782  PSVIKaeekRSCDMVFGPANLGEDAIKNFRAKHHCNSCC  1820

         *****99999*****************************

Domain Sequence
(FASTA)

SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV KVQCTWSEHD ILKSGHLYII KSFLPEVVNT 60

WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF 120

AVEECMTGEF RKYNNNNGDE IIPTNTLEEI MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180

PSVIKAEEKR SCDMVFGPAN LGEDAIKNFR AKHHCNSCC 219

Keyword

Complete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0005262	; F:calcium channel activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031032	; P:actomyosin structure organization
GO:0016340	; P:calcium-dependent cell-matrix adhesion
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR005821	; Ion_trans_dom.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.

Pfam

PF02816	; Alpha_kinase; 1.
PF00520	; Ion_trans; 1.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013