EKS-AIM-00098

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00098

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	489.2	2.1E-147	402	652	251

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009855

UniProt Accession

G1LS18;

Protein Name

Protein Synonyms/Alias

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000009289	ENSAMEP00000009855	ENSAMET00000010284

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

MATVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 60

ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180

HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSASELKKVV ALYDYMPMNA NDLQLRKGDE 240

YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300

EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360

YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420

WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480

CLLNYLREMR NRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540

GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600

FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKAEE RPTFKILLSN ILDVMDEES 659

Nucleotide Sequence
(FASTA)

ATGGCTACAG TAATCCTGGA GAGCATCTTT CTGAAGCGAT CCCAGCAGAA AAAGAAGACA 60

TCACCTTTAA ACTTCAAGAA GCGCCTCTTT CTCTTGACTG TGCACAAACT TTCCTACTAT 120

GAGTATGACT TTGAACGTGG GAGAAGAGGC AGTAAGAAGG GTTCCATAGA CGTTGAGAAG 180

ATCACCTGCG TTGAAACAGT GGTTCCTGAA AAAAATCCTC CCCCTGAAAG ACAGATTCCA 240

AGAAGGGGTG AAGAGTCCAG TGAAATGGAG CAGATTTCAA TCATTGAAAG GTTCCCTTAC 300

CCCTTCCAGG TTGTGTATGA CGAAGGGCCT CTTTATGTCT TCTCCCCAAC TGAAGAACTG 360

AGAAAGCGTT GGATTCACCA GCTCAAAAAT GTAATCCGGT ACAACAGTGA CCTGGTACAG 420

AAATACCACC CTTGCTTCTG GATCGATGGG CAGTATCTCT GCTGTTCTCA GACAGCCAAA 480

AATGCGATGG GCTGCCAAAT TTTGGAGAAC AGGAATGGAA GTTTAAAACC TGGGAGTTCT 540

CACAGAAAGA CAAAAAAGCC CCTTCCTCCC ACACCCGAGG AGGACCAGAT CTTGAAAAAG 600

CCACTGCCCC CTGAGCCAAC AGCAGCACCT GTCTCTGCAA GTGAGCTGAA AAAGGTTGTA 660

GCCCTTTATG ATTACATGCC AATGAACGCA AATGATCTAC AGCTACGAAA GGGCGACGAG 720

TATTTTATCC TGGAGGAGAG CAACTTACCC TGGTGGAGAG CACGGGATAA AAATGGGCAG 780

GAAGGCTACA TCCCTAGTAA CTATGTCACC GAAGCAGAAG ACTCTATAGA AATGTATGAG 840

TGGTATTCCA AACACATGAC CCGGAGTCAA GCTGAGCAAC TGCTCAAGCA AGAGGGGAAA 900

GAAGGAGGTT TCATTGTCAG AGACTCCAGC AAAGCTGGAA AATATACTGT GTCTGTGTTT 960

GCTAAATCTA CAGGGGACCC TCAAGGGGTG ATACGCCATT ATGTTGTGTG TTCCACACCG 1020

CAGAGCCAGT ATTACCTGGC AGAGAAGCAC CTTTTCAGCA CCATCCCTGA GCTCATCAAC 1080

TACCATCAGC ATAACTCTGC AGGGCTCATA TCTAGGCTCA AATATCCAGT GTCTCAACAA 1140

AACAAGAATG CACCTTCCAC TGCGGGCCTG GGCTATGGAT CATGGGAAAT TGATCCAAAG 1200

GACCTGACCT TCTTGAAGGA GCTGGGGACT GGACAGTTTG GGGTAGTGAA GTATGGGAAA 1260

TGGAGAGGCC AGTATGACGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCCGAGGAT 1320

GAGTTCATTG AAGAAGCCAA AGTCATGATG AATCTGTCCC ATGAAAAGCT GGTACAGTTG 1380

TACGGCGTCT GCACCAAACA GCGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440

TGCCTCCTGA ACTACCTGAG GGAAATGCGC AACCGCTTCC AGACCCAGCA GCTGCTGGAG 1500

ATGTGCAAGG ATGTCTGCGA GGCCATGGAA TACCTGGAGT CAAAGCAATT CCTTCACCGA 1560

GACCTGGCGG CTCGAAACTG TTTGGTAAAT GATCAAGGAG TTGTTAAAGT ATCTGACTTC 1620

GGCCTCTCCA GGTATGTCCT GGATGATGAA TATACAAGCT CAGTAGGCTC CAAATTTCCA 1680

GTCCGGTGGT CTCCACCAGA AGTCCTTATG TATAGCAAGT TCAGCAGCAA ATCTGACATC 1740

TGGGCTTTTG GGGTTTTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC TTATGAAAGA 1800

TTTACTAACA GTGAAACCGC CGAACACATT GCCCAAGGCC TACGTCTCTA TAGGCCTCAT 1860

CTAGCTTCAG AGAGGGTATA TACCATCATG TACAGCTGCT GGCATGAGAA AGCAGAGGAA 1920

CGTCCCACTT TCAAAATTCT GCTGAGCAAC ATCCTAGATG TCATGGATGA AGAATCCTGA 1980

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly

Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd

Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRNRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w

Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek+eer

Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKAEER  641

         ************************************************************

S: 241   ptfkellsale  251

         ptfk lls++

Q: 642   PTFKILLSNIL  652

         ********996

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNYLREMRN RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180

AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYTIMY SCWHEKAEER 240

PTFKILLSNI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031410	; C:cytoplasmic vesicle
GO:0005829	; C:cytosol
GO:0045121	; C:membrane raft
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005547	; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0048469	; P:cell maturation
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

aml:100472303

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013