EKS-AIM-00154
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00154
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb493.01.9E-148423680258
StatusUnreviewed
Ensembl ProteinENSAMEP00000009835
UniProt AccessionG1LRZ8;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000009322ENSAMEP00000009846ENSAMET00000010273
ENSAMEG00000009322ENSAMEP00000009835ENSAMET00000010262
OrganismAiluropoda melanoleuca
Functional Description
Protein Length741
Protein Sequence
(FASTA)
MPIAQLLELW KKIEVEPMEI ETTEEDLNLD SEPTVEDTVE EEEGTVKEID ISHHVKEGFE 60
KADPSQFELL KVLGQGSYGK VFLVRKTKGS DAGQLYAMKV LKKATLKVRD RVRSKMERDI 120
LAEVNHPFIV KLHYAFQTEG KLYLILDFLR GGDLFSRLSK EVMFTEEDVK FYLAELALAL 180
DHLHGLGIIY RDLKPENILL DEEGHIKITD FGLSKEAIDH DKRAYSFCGT IEYMAPEVVN 240
RRGHTQSADW WSFGVLMFEM LTGSLPFQGK DRKETMALIL KAKLGMPQFL SMEAQSLLRA 300
LFKRNPCNRL GAGIDGVEEI KRHPFFVTID WNKLYRKEIK PPFKPAVGRP EDTFHFDPEF 360
TARTPTDSPG VPPSANAHHL FRGFSFVASS LVQEPSQQDL HKATVHPIVQ QLHGNNIHFT 420
DGYEIKEDIG VGSYSVCKRC VHKATEAEYA VKIIDKSKRD PSEEIEILLR YGQHPNIITL 480
KDVYDDGKFV YLVMELMRGG ELLDRILRQR CFSEREASDV LCTITKTMDY LHSQGVVHRD 540
LKPSNILYMD ESGNPESIRI CDFGFAKQLR AENGLLMTPC YTANFVAPEV LKRQGYDAAC 600
DIWSLGTLLY TMLAGFTPFA NGPDDTPEEI LARIGSGKYA LSGGNWDSIS DAAKDVVSKM 660
LHVDPHQRLT AVQVLKHPWI VNREYLSQNQ LSRQDVHLVK GAMAATYFAL NRTPQAPRLE 720
PVLSSSLAQR RGMKRLTSTR L 741
Nucleotide Sequence
(FASTA)
ATGCCGATTG CACAGTTGCT GGAGCTATGG AAAAAGATCG AGGTGGAGCC CATGGAAATA 60
GAGACCACCG AGGAGGATCT TAACCTGGAC TCGGAGCCCA CCGTCGAAGA TACCGTGGAA 120
GAAGAGGAAG GCACTGTCAA GGAGATCGAC ATCAGCCACC ATGTGAAAGA AGGCTTTGAG 180
AAGGCCGACC CTTCCCAGTT TGAACTGTTG AAAGTGTTAG GACAAGGCTC CTATGGAAAG 240
GTGTTCCTTG TGAGGAAGAC CAAGGGATCC GACGCTGGGC AGCTGTACGC CATGAAAGTG 300
CTTAAGAAAG CTACCTTGAA AGTTCGGGAC CGAGTCAGAT CGAAAATGGA GAGAGACATT 360
TTGGCAGAAG TGAATCACCC TTTCATTGTA AAGCTTCATT ATGCCTTTCA GACGGAAGGA 420
AAGCTCTACC TGATCCTGGA CTTTCTGCGT GGAGGGGACC TCTTCAGCCG GCTCTCCAAA 480
GAGGTGATGT TCACGGAGGA GGATGTCAAG TTCTACCTGG CTGAGCTGGC CTTGGCTCTA 540
GACCACCTCC ACGGTCTGGG GATCATCTAT AGAGACCTGA AGCCTGAGAA CATCCTGCTG 600
GACGAAGAGG GACACATTAA GATCACAGAT TTCGGGCTGA GTAAGGAGGC CATTGACCAC 660
GACAAGAGAG CTTACTCGTT CTGCGGGACG ATCGAGTACA TGGCGCCCGA GGTGGTGAAC 720
CGGCGGGGAC ACACGCAGAG TGCCGACTGG TGGTCCTTCG GTGTGCTCAT GTTTGAGATG 780
CTCACGGGAT CTCTGCCATT CCAGGGGAAG GACAGGAAGG AGACCATGGC CCTCATCCTC 840
AAGGCCAAGC TGGGCATGCC GCAGTTCCTC AGCATGGAAG CCCAGAGTCT GCTGAGAGCC 900
CTATTCAAAC GGAACCCGTG CAACCGACTG GGTGCTGGCA TCGACGGAGT GGAGGAGATC 960
AAGCGGCATC CTTTCTTTGT GACCATAGAC TGGAATAAGC TGTACAGGAA GGAGATCAAG 1020
CCACCATTCA AACCAGCGGT GGGCAGGCCC GAGGATACCT TCCACTTCGA CCCCGAGTTC 1080
ACAGCACGAA CGCCCACAGA CTCACCTGGC GTCCCCCCCA GCGCCAACGC ACATCATCTA 1140
TTCAGAGGAT TCAGCTTTGT GGCTTCAAGT CTGGTCCAGG AGCCCTCGCA GCAAGATCTG 1200
CACAAAGCCA CGGTTCATCC CATCGTGCAG CAGTTACACG GGAACAACAT ACACTTCACC 1260
GATGGCTATG AGATCAAGGA GGACATCGGG GTGGGCTCCT ACTCCGTGTG CAAGCGATGT 1320
GTGCATAAAG CTACTGAGGC AGAGTATGCC GTGAAGATCA TCGACAAGAG TAAGAGAGAC 1380
CCCTCGGAAG AGATCGAGAT CCTGCTGAGG TACGGGCAGC ACCCGAACAT CATCACGCTC 1440
AAGGACGTCT ATGACGACGG GAAGTTCGTG TACCTGGTGA TGGAGCTGAT GCGCGGCGGG 1500
GAGCTGCTGG ACCGCATTCT CCGGCAGCGC TGCTTCTCGG AGCGGGAGGC CAGCGACGTG 1560
CTGTGCACGA TCACCAAAAC CATGGACTAC CTCCACTCAC AAGGGGTGGT TCATCGAGAT 1620
CTGAAGCCCA GTAATATACT GTACATGGAC GAGTCTGGAA ACCCTGAGTC CATCCGAATC 1680
TGTGACTTTG GGTTTGCCAA GCAGCTTCGA GCCGAGAACG GGCTGTTGAT GACACCCTGC 1740
TACACGGCAA ACTTCGTTGC CCCGGAGGTC CTGAAGCGGC AAGGCTACGA TGCAGCATGT 1800
GACATCTGGA GTTTGGGGAC CCTGTTATAC ACCATGCTGG CAGGATTTAC CCCCTTTGCA 1860
AACGGCCCGG ATGATACTCC CGAGGAGATT CTGGCAAGGA TTGGCAGTGG GAAGTACGCC 1920
CTTTCTGGGG GGAACTGGGA CTCGATCTCC GATGCCGCGA AGGACGTTGT GTCCAAGATG 1980
CTCCATGTGG ACCCTCATCA GCGCCTGACG GCAGTTCAAG TCCTGAAACA CCCATGGATC 2040
GTGAACAGAG AGTACCTGTC CCAAAACCAG CTCAGCAGAC AAGACGTCCA CCTGGTGAAG 2100
GGTGCCATGG CCGCCACCTA CTTCGCTCTG AACAGAACTC CCCAGGCCCC GCGGCTGGAG 2160
CCGGTGCTGT CGTCCAGCCT GGCTCAGCGC AGGGGCATGA AGAGACTCAC GTCCACGAGG 2220
CTA 2223
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+GvGsysvckrcvhkat+ e+avkiidkskrd+seeieillry+qhpni+tlkd
Q: 423   YEIKEDIGVGSYSVCKRCVHKATEAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  482
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgk+vylv+el++GGelldri+++++fsereas++l+t++k+++ylh+qGvvhrdlk
Q: 483   VYDDGKFVYLVMELMRGGELLDRILRQRCFSEREASDVLCTITKTMDYLHSQGVVHRDLK  542
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 543   PSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  602
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG llytmlaG++pfangp+dt+eeila+i++Gk++lsG++wds+s++akd+vsk+l+
Q: 603   WSLGTLLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLH  662
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+lkh+w+
Q: 663   VDPHQRLTAVQVLKHPWI  680
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGVG SYSVCKRCVH KATEAEYAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKFVYL VMELMRGGEL LDRILRQRCF SEREASDVLC TITKTMDYLH SQGVVHRDLK 120
PSNILYMDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGTLLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALS GGNWDSISDA AKDVVSKMLH 240
VDPHQRLTAV QVLKHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MEG-00128
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0002035; P:brain renin-angiotensin system
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0060047; P:heart contraction
GO:0007507; P:heart development
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0001556; P:oocyte maturation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
aml:100483843;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013