EKS-AIM-00181

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00181

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	421.3	1.5E-126	57	311	255

Status

Unreviewed

Ensembl Protein

ENSAMEP00000009940

UniProt Accession

G1LSA2;

Protein Name

Protein Synonyms/Alias

Gene Name

TESK1

Gene Synonyms/Alias

TESK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000009438	ENSAMEP00000009940	ENSAMET00000010376

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

628

Protein Sequence
(FASTA)

EAGKRPPLRG PGPGPGEAPG EGPPGPGGTG GGPGRGRPSS YRALRSAVSS LARVDDFHCA 60

EKIGAGFFSE VYKVRHRQSG QVMVLKMNRL PSNRGNTLRE VQLMNRLRHP NILRFMGVCV 120

HQGQLHALTE YMNGGTLEQL LSSPEHLSWP VRLRLALDIA RGLRYLHAKG VFHRDLTSKN 180

CLIRREDRGF TAVVGDFGLA EKIPVYREGA RKEPLAVVGS PYWMAPEVLR GELYDEKADV 240

FAFGIVLCEL IARVPADPDY LPRTEDFGLD VPAFRTLVGD DCPLPFLLLA IHCCSMEPST 300

RAPFTEITQH LEWILEQLPE PAPLTRAPLT HNQRSVSRGG PSATLPRPDP RLSRSRSDLF 360

LPPSPESPPT WGDSLTRVNP FSLREDLRGG KIKLLDTPSK PVTPLPLVPP SPLPSTQLPL 420

VTTPETLVQP GTPARRCRSL PSSPELPRRM ETALPGPGPP SVGPSAEERM ECEGSSPEPE 480

PPGPAPQLPL AVATDNFIST CSSASQPWSP RSGPALNNNP PAVVVNSPQG WAGEPWNRAQ 540

HSLPRAAALE RTEPSPPPSA PRESDEGLPC PGCCLGPFSF GFLSMCPRPT PAVARYRNLN 600

CEAGSLLCHR GHHAKPPTPG LQLPGARS 628

Nucleotide Sequence
(FASTA)

GAGGCCGGGA AGCGGCCCCC ACTGCGGGGC CCTGGGCCAG GGCCGGGAGA GGCGCCGGGG 60

GAGGGGCCCC CGGGACCGGG GGGCACGGGT GGAGGCCCGG GCCGGGGCCG CCCCTCCTCC 120

TACCGGGCTC TCCGCAGCGC CGTGTCCAGC CTGGCGCGCG TGGACGATTT CCACTGCGCC 180

GAGAAGATCG GGGCCGGCTT CTTCTCTGAG GTCTACAAGG TTAGGCACCG ACAGTCAGGG 240

CAAGTCATGG TGCTGAAAAT GAACAGACTC CCCAGTAACC GGGGAAACAC GCTACGGGAA 300

GTGCAGCTGA TGAACCGGCT CCGACACCCC AACATCCTAA GGTTCATGGG GGTGTGTGTG 360

CACCAGGGGC AGCTGCACGC TCTTACAGAG TATATGAATG GGGGGACCCT GGAACAGCTC 420

CTCAGCTCCC CGGAACACCT GTCCTGGCCT GTCAGGCTCC GCCTGGCTCT GGACATTGCC 480

CGTGGCCTGC GGTACCTGCA TGCCAAAGGT GTATTCCACC GAGACCTGAC ATCCAAGAAC 540

TGTCTCATCC GACGGGAAGA CCGAGGCTTC ACGGCTGTTG TGGGTGACTT CGGGCTGGCT 600

GAAAAGATTC CTGTGTATAG GGAAGGGGCA AGAAAGGAGC CATTGGCCGT GGTAGGTTCC 660

CCATACTGGA TGGCTCCAGA AGTGTTGCGG GGTGAGCTGT ATGATGAGAA GGCCGATGTC 720

TTTGCATTTG GGATTGTCCT CTGTGAGCTC ATTGCGCGAG TACCTGCAGA CCCAGATTAC 780

CTACCCCGAA CTGAGGACTT TGGCCTGGAT GTGCCTGCTT TCCGGACCCT GGTAGGGGAT 840

GACTGCCCAC TGCCCTTCCT GCTCCTGGCC ATCCACTGCT GCAGTATGGA ACCTAGCACT 900

CGTGCTCCCT TCACTGAAAT CACCCAGCAC CTGGAATGGA TCCTGGAGCA GCTGCCTGAG 960

CCAGCCCCCC TCACCAGAGC TCCACTGACA CACAATCAGA GGTCTGTTTC AAGAGGGGGT 1020

CCCTCTGCCA CACTTCCTAG GCCAGACCCC CGGCTTTCCC GAAGCCGGTC AGACCTCTTC 1080

CTGCCCCCAT CACCAGAATC CCCCCCGACT TGGGGGGACA GTCTGACTCG AGTCAACCCC 1140

TTCTCACTCC GGGAAGACCT CCGGGGAGGC AAGATCAAGC TGTTGGACAC ACCCAGCAAG 1200

CCGGTCACCC CCCTGCCCCT TGTTCCACCA TCACCACTGC CCTCCACGCA GTTGCCCTTG 1260

GTGACCACTC CAGAGACCCT GGTCCAGCCT GGGACACCTG CCCGTCGCTG CCGCTCGCTC 1320

CCATCATCCC CTGAGCTCCC CCGACGTATG GAGACAGCAC TGCCAGGTCC TGGCCCTCCC 1380

AGTGTGGGCC CCTCGGCTGA AGAAAGAATG GAGTGTGAGG GCAGTAGCCC TGAGCCAGAA 1440

CCCCCAGGAC CGGCTCCCCA GCTGCCCCTG GCTGTGGCCA CAGACAACTT CATCAGCACT 1500

TGTTCCTCGG CCTCCCAGCC CTGGTCCCCT AGATCAGGAC CTGCTCTTAA CAACAACCCC 1560

CCAGCTGTGG TGGTGAACTC CCCACAAGGC TGGGCTGGGG AGCCGTGGAA CCGGGCCCAG 1620

CATAGCCTGC CCCGGGCAGC AGCCCTGGAG CGGACAGAAC CCTCGCCACC CCCTTCAGCT 1680

CCCCGGGAGT CTGATGAGGG GCTGCCCTGC CCTGGCTGCT GTCTTGGCCC TTTTAGCTTT 1740

GGCTTCCTAT CCATGTGCCC CCGCCCCACA CCAGCTGTTG CCCGCTACCG CAACCTGAAC 1800

TGTGAGGCGG GCAGTCTGCT CTGCCACCGA GGGCACCATG CCAAGCCTCC CACACCCGGC 1860

CTGCAGCTGC CCGGGGCACG CTCTTAG 1887

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         ++++ek+G+Gffsev+kv+hr+sG+vmvlk  ++ + +nr n+l+ev+l+++l+hpn+l+

Q: 57    FHCAEKIGAGFFSEVYKVRHRQSGQVMVLK--MNRLPSNRGNTLREVQLMNRLRHPNILR  114

         689***************************..****************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         f+Gv+v++++lh+ltey++gGtl++ll+s+e+l+w++r+rla dia+Gl+ylh+kg++hr

Q: 115   FMGVCVHQGQLHALTEYMNGGTLEQLLSSPEHLSWPVRLRLALDIARGLRYLHAKGVFHR  174

         ************************************************************

S: 121   dlnsknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywm  177

         dl+skncl+r+   ++++vv+dfGla          ek++++++++rk+ l+vvGsPywm

Q: 175   DLTSKNCLIRRedrGFTAVVGDFGLA----------EKIPVYREGARKEPLAVVGSPYWM  224

         **********988889**********..........9***********************

S: 178   aPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcP  237

         aPevl+g+ ydek+dvf+fGivlce+iarv adPdylPrtedfgldv afr+ lv++dcP

Q: 225   APEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRT-LVGDDCP  283

         ****************************************************.*******

S: 238   eaflklavvccdldpesrpsfeelekkl  265

          +fl la++cc+++p++r++f+e++++l

Q: 284   LPFLLLAIHCCSMEPSTRAPFTEITQHL  311

         *************************987

Domain Sequence
(FASTA)

FHCAEKIGAG FFSEVYKVRH RQSGQVMVLK MNRLPSNRGN TLREVQLMNR LRHPNILRFM 60

GVCVHQGQLH ALTEYMNGGT LEQLLSSPEH LSWPVRLRLA LDIARGLRYL HAKGVFHRDL 120

TSKNCLIRRE DRGFTAVVGD FGLAEKIPVY REGARKEPLA VVGSPYWMAP EVLRGELYDE 180

KADVFAFGIV LCELIARVPA DPDYLPRTED FGLDVPAFRT LVGDDCPLPF LLLAIHCCSM 240

EPSTRAPFTE ITQHL 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR015782	; Testis-specific_kinase_1.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013