EKS-AIM-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	374.8	2.0E-112	786	1052	267

Status

Unreviewed

Ensembl Protein

ENSAMEP00000010060

UniProt Accession

G1LSM0;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000009532	ENSAMEP00000010060	ENSAMET00000010499

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

1084

Protein Sequence
(FASTA)

MDNPENVFQM FEAHMQSYKG DDPLGEWESY VQWVEENFPE NKEYLTTLLE HLMKEFLDKK 60

KYHNDPRFIN YCLKFAQYNS DLHQFFEFLY NHGIGTMSSP LYVAWAGHLE GQGELQHASA 120

VFRRGLQNQA EPRELLQQHY RLFQARLTET HLPSQARTSE PLHDAQILNQ MMTSKSNPGN 180

NSACISKNQG SEVSGVVSSA CDKESKKEQR VIMISKSEYS ARAPSAARAD VQQVVMYCKE 240

KLLREESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL 300

HQVVETSQEN LPVFQERSEV NPAYMGPSVG SQQEMRAPSL PAINHQTSKN MGEKPGETNP 360

IVPLPTANTV TAALVSPAIS QSVSPRVPLA AQPVTDSMFT VARKDDRCVT KSTHEFKPQS 420

GAEIKEGSET HKVVNTGSFH TTPNTSLGTV QATPSRVQPS PTVHTKEALG FIMNMFQAPT 480

LPDISDDKDE WPSLDQNEDA FEAQFQKNAR SSGAWGVNKI ISSLSSAFPV FEDGNKENYG 540

LPQPKNKPAG ARTFGERSVS RFPSKPNKEV PHAEEFLDDS TVWGVRCNRT LAPSPKSPGH 600

FTAAAQLAST PFIKPPADAG PALEDKENVV TKECTLDSRE ENMAGPSKDR KFSPIQEKSL 660

EPAFPADVSS APLLRGSQPV AGGVLASEVA QSLEACKLTD TNLVIAEDPL DASAGRRAER 720

MQTSSLENVG ASNLTVENPW DDALILELLS GLSKPVRSYP NTYEWQCKLP AIKPKTEFQL 780

GSLLVYVDHL LGEGAFAQVY EVTHGEVNDT KNKQKFVLKV QKPGNPWEFY IGTQLMERLK 840

PSMRHMFIKF YSAHFFQNGS VLVGDLYSYG TLLNAINLYK NTPEKVMPQA LVLSFAVRML 900

FMMEQVHDCE IIHGDIKPDN FILGNRFLEQ DGDDDDVSAG LALIDLGQSI DMKLFPKGTT 960

FTGKCETSGF QCIEMLSNKP WNYQIDYFGV AATVYCMLFG TYMKVKNEGG VWKPEGLFRR 1020

LPHLDMWSEF FHIMLNIPDC QHLPSLDLLR QKLNKVLQQH YTNKIKTLRN RLIVLLLEYK 1080

RSRK 1084

Nucleotide Sequence
(FASTA)

ATGGATAACC CGGAAAATGT CTTTCAAATG TTTGAAGCCC ATATGCAGAG CTACAAGGGC 60

GATGATCCAC TTGGTGAATG GGAAAGTTAC GTGCAGTGGG TAGAAGAGAA CTTTCCTGAG 120

AATAAGGAAT ACTTGACAAC TTTATTAGAA CATTTGATGA AGGAATTTTT GGATAAGAAG 180

AAATACCACA ATGACCCAAG ATTCATCAAT TATTGTTTAA AATTTGCTCA GTACAACAGT 240

GATCTTCATC AGTTCTTTGA GTTTCTGTAC AACCACGGGA TCGGGACCAT GTCATCTCCT 300

CTGTACGTAG CCTGGGCAGG GCATCTGGAA GGCCAGGGAG AGCTGCAGCA TGCCAGTGCT 360

GTTTTTCGGA GGGGACTTCA AAACCAGGCT GAGCCAAGAG AGCTGCTGCA ACAACACTAC 420

AGGTTATTTC AGGCACGCCT CACCGAAACG CATTTGCCAT CTCAAGCTAG AACCTCAGAA 480

CCTCTCCATG ATGCTCAGAT TTTAAACCAA ATGATGACAT CAAAATCAAA TCCAGGAAAT 540

AACTCAGCCT GCATTTCTAA GAATCAGGGT TCAGAAGTTT CTGGGGTAGT ATCTTCAGCT 600

TGTGATAAAG AGTCGAAAAA GGAACAGAGG GTGATCATGA TTTCTAAATC AGAATACTCT 660

GCACGAGCAC CTTCAGCAGC CAGAGCTGAC GTGCAGCAGG TTGTTATGTA TTGCAAGGAG 720

AAGCTTCTTC GTGAAGAATC AGAATTTTCC TTTGAAGAGC TGAGAGCCCA GAAATACAAT 780

CAACGGAGAA AGCATGAACA ATGGGTAAAT GAAGATAGAC ATTATATGAA AAGAAAAGAG 840

GCAAATGCTT TCGAAGAACA ACTATTAAAA CAGAAAATGG ATGAACTTCA TAAAAAGTTG 900

CACCAGGTGG TGGAGACGTC CCAGGAGAAC TTGCCCGTTT TCCAGGAAAG GTCTGAGGTT 960

AATCCAGCAT ATATGGGGCC AAGTGTAGGC TCCCAGCAGG AAATGAGAGC TCCGTCTCTT 1020

CCAGCCATCA ATCATCAGAC CTCAAAGAAC ATGGGAGAGA AACCCGGAGA GACAAATCCT 1080

ATTGTTCCTC TTCCTACGGC AAACACCGTC ACTGCTGCCT TGGTGTCCCC GGCCATCAGC 1140

CAGAGTGTAT CTCCTCGTGT TCCTTTGGCA GCCCAGCCAG TGACAGACTC CATGTTTACA 1200

GTGGCCAGAA AAGATGACAG GTGTGTGACT AAAAGCACTC ATGAATTCAA GCCCCAGAGT 1260

GGAGCCGAGA TAAAAGAAGG GTCTGAAACA CATAAGGTTG TTAACACAGG TTCTTTTCAC 1320

ACAACTCCAA ACACATCGCT GGGAACGGTT CAGGCGACCC CATCCAGGGT GCAGCCGTCA 1380

CCCACCGTGC ACACAAAGGA AGCATTAGGC TTCATCATGA ATATGTTTCA GGCTCCTACG 1440

CTTCCTGATA TTTCTGATGA CAAAGATGAA TGGCCATCTC TCGATCAAAA TGAAGATGCA 1500

TTTGAGGCCC AGTTTCAAAA AAATGCAAGG TCTTCTGGGG CTTGGGGAGT CAATAAGATC 1560

ATCTCTTCTT TGTCATCTGC TTTTCCTGTG TTCGAAGATG GAAACAAAGA AAATTATGGA 1620

TTACCACAGC CTAAAAATAA ACCTGCAGGA GCCAGGACCT TTGGAGAACG CTCTGTAAGC 1680

AGATTTCCTT CAAAACCCAA TAAAGAAGTA CCTCACGCCG AAGAGTTTTT GGATGACTCC 1740

ACAGTCTGGG GTGTCCGCTG CAACAGGACC CTGGCGCCCA GTCCGAAGAG CCCCGGACAC 1800

TTCACGGCTG CCGCACAGCT CGCGTCCACG CCTTTCATCA AACCACCCGC GGATGCAGGG 1860

CCTGCTCTGG AGGATAAAGA AAATGTGGTT ACAAAAGAGT GCACTCTGGA TTCTCGTGAA 1920

GAAAACATGG CGGGACCCTC AAAAGACAGA AAGTTCAGTC CAATTCAAGA GAAAAGCCTA 1980

GAACCAGCGT TCCCTGCAGA TGTATCTTCG GCACCCTTGC TCCGTGGGAG CCAGCCTGTC 2040

GCAGGTGGCG TGCTGGCCAG CGAGGTAGCA CAGAGCCTCG AGGCTTGTAA ACTCACAGAC 2100

ACCAACCTCG TCATTGCAGA AGATCCGCTG GACGCCAGCG CTGGGCGCCG AGCAGAACGG 2160

ATGCAGACTA GTTCACTTGA GAATGTCGGT GCTTCAAACT TGACTGTTGA GAATCCATGG 2220

GATGATGCAT TGATTCTCGA ACTTTTATCT GGGCTTTCTA AACCAGTGAG ATCCTATCCA 2280

AATACTTACG AATGGCAGTG TAAACTTCCA GCCATCAAGC CCAAGACTGA GTTCCAACTG 2340

GGTTCCTTGC TGGTCTATGT CGATCACCTT CTTGGAGAAG GGGCCTTTGC CCAGGTCTAT 2400

GAAGTTACCC ACGGAGAAGT GAATGATACC AAAAATAAAC AGAAATTTGT TTTAAAGGTC 2460

CAGAAGCCTG GCAACCCCTG GGAGTTCTAC ATCGGGACCC AGCTGATGGA GAGACTAAAG 2520

CCAAGCATGC GACACATGTT CATCAAATTC TATTCTGCCC ACTTCTTCCA GAATGGCAGT 2580

GTGTTAGTAG GAGATCTCTA CAGCTACGGC ACGCTGCTAA ATGCTATTAA CCTGTATAAA 2640

AACACCCCGG AAAAAGTGAT GCCTCAGGCG CTAGTGCTGT CCTTTGCGGT CAGGATGCTC 2700

TTCATGATGG AGCAAGTGCA CGACTGTGAA ATCATTCATG GTGACATCAA GCCAGACAAT 2760

TTCATCCTTG GAAACAGATT TTTGGAACAG GACGGTGACG ATGATGATGT ATCTGCTGGC 2820

CTGGCACTGA TTGACCTGGG TCAGAGTATA GATATGAAAC TTTTCCCAAA AGGAACTACA 2880

TTTACAGGCA AGTGTGAGAC ATCTGGTTTC CAGTGTATTG AGATGCTCAG CAACAAACCA 2940

TGGAACTACC AGATTGATTA CTTCGGGGTC GCTGCAACGG TGTACTGCAT GCTCTTTGGC 3000

ACTTACATGA AAGTGAAAAA TGAAGGAGGG GTCTGGAAGC CCGAAGGTCT TTTTAGGAGA 3060

CTTCCTCATC TGGATATGTG GAGTGAATTC TTTCACATCA TGTTGAATAT TCCAGACTGT 3120

CAACATCTTC CATCTTTGGA CTTGTTAAGG CAGAAGCTGA ATAAAGTACT TCAACAACAC 3180

TATACAAACA AGATCAAGAC CCTACGTAAT AGGCTAATTG TACTGCTCTT GGAATATAAG 3240

CGTTCTCGAA AATAA 3255

Domain Profile

S: 2     eiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeell  57

         ++++++geGa+a+vy+ +h    d+k++++++lKv+kp n+WefYI +ql+eRlk +++

Q: 786   YVDHLLGEGAFAQVYEVTHgevnDTKNKQKFVLKVQKPGNPWEFYIGTQLMERLK-PSMR  844

         799****************************************************.77**

S: 58    ksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkive  117

         +++i+++sa+ fq++s+lv +++sygtll++in++k++ +kvm+++lv++++v++l ++e

Q: 845   HMFIKFYSAHFFQNGSVLVGDLYSYGTLLNAINLYKNTPEKVMPQALVLSFAVRMLFMME  904

         ************************************************************

S: 118   klHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkgk  176

         ++H++eIiHgD+kPdnf+lgnr+ ++   +d+ ++gl+liD+g+siDmkl+p+gt+f+gk

Q: 905   QVHDCEIIHGDIKPDNFILGNRFLEQDGdDDDVSAGLALIDLGQSIDMKLFPKGTTFTGK  964

         ************************998725556778************************

S: 177   aktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkk  236

         ++t++f+cieml++k+w+Yq+D+fg+aa+++++lfg+y++v++egg wk++  ++rl++

Q: 965   CETSGFQCIEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGVWKPEGLFRRLPHL  1024

         ************************************************************

S: 237   elwekiferlLNisdastlpsleelveek  265

         ++w ++f+ +LNi+d+++lpsl+ l++ k

Q: 1025  DMWSEFFHIMLNIPDCQHLPSLDLLRQ-K  1052

         *************************95.4

Domain Sequence
(FASTA)

YVDHLLGEGA FAQVYEVTHG EVNDTKNKQK FVLKVQKPGN PWEFYIGTQL MERLKPSMRH 60

MFIKFYSAHF FQNGSVLVGD LYSYGTLLNA INLYKNTPEK VMPQALVLSF AVRMLFMMEQ 120

VHDCEIIHGD IKPDNFILGN RFLEQDGDDD DVSAGLALID LGQSIDMKLF PKGTTFTGKC 180

ETSGFQCIEM LSNKPWNYQI DYFGVAATVY CMLFGTYMKV KNEGGVWKPE GLFRRLPHLD 240

MWSEFFHIML NIPDCQHLPS LDLLRQK 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013