EKS-AIM-00026
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00026
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak344.25.8E-1037741045272
StatusUnreviewed
Ensembl ProteinENSAMEP00000010263
UniProt AccessionD2HMR9;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK2
Gene Synonyms/Alias JAK2; PANDA_012908;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000009661ENSAMEP00000010263ENSAMET00000010711
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1057
Protein Sequence
(FASTA)
GITPVYHSMF ALMSETERIW YPPNHVFHID ESTRQNVLYR IRFYFPYWYC NGSNRTYRHG 60
ISRGAEAPLL DDFVMAYLFA QWRHDFLHGW IKIPVTHETQ EECLGMAVLD MMRLAKEKDQ 120
TPLDIYSSIS YKTFLPKCVR AKIQDYHILT RKRIRYRFRR FIEQFSHCKA TARNLKLKYL 180
INLETLQSAF YTEQFEVKEP GSGPSGEEIF ATIIITGNGG IQWSRGKHKE SETLTEQDLQ 240
LYCDFPDIID VTIKQASQEG SNESRIVTIH KQDGKNLEIE LSSLREALSF VSLIDGYYRL 300
TADAHHYLCK EVAPPMVLEN IQSNCHGPIL MDFAISKLKK AGNQTGLYVL RCSPKDFNKY 360
FLTFAVEREN VIEYKHCLIT KNENGEYNLS GTKKNFSNLK DLLNCYQMET VRSDSIIFQF 420
TKCCPPKLKD KSNLLVFRTN GISDVPTSPT LQRHNNVNQM VFHKIRNEDL MFNESLGQGT 480
FTKIFKGIRR EVGDYGQLHE TEVLLKVLDK AHRNYSESFF EAASMMSQLS HKHLVLNYGV 540
CVCGEENILV QEFVKFGSLD TYLKKNKNSI NILWKLEVAK QLAWAMHFLE EKALIHGNVC 600
AKNILLIREE DRKTGNPPFI KLSDPGISIT VLPKDILQER IPWVPPECIE NPKNLNLATD 660
KWSFGTTLWE ICSGGDKPLS ALDSQRKLQF YEDRHQLPAP KWTELANLIN NCMDYEPDFR 720
PSFRAIIRDL NSLFTPDYEL LTENDMLPNM RIGALGFSGA FEDRDPTQFE ERHLKFLQQL 780
GKGNFGSVEM CRYDPLQDNT GEVVAVKKLQ HSTEEHLRDF EREIEILKSL QHDNIVKYKG 840
VCYSAGRRNL RLIMEYLPYG SLRDYLQKHK ERIDHKKLLQ YTSQICKGME YLGTKRYIHR 900
DLATRNILVE NENRVKIGDF GLTKVLPQDK EYYKVKEPGE SPIFWYAPES LTESKFSVAS 960
DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP 1020
DEIYLIMTEC WNNNVNQRPS FRDLALRVDQ IRDNMAG 1057
Nucleotide Sequence
(FASTA)
GGAATCACAC CTGTGTATCA TAGTATGTTT GCTTTAATGA GTGAAACAGA AAGGATCTGG 60
TATCCACCCA ACCATGTCTT CCATATAGAT GAATCAACCA GACAAAATGT ACTCTACAGA 120
ATAAGATTTT ACTTTCCTTA CTGGTATTGT AATGGCAGCA ACAGAACCTA TCGGCATGGA 180
ATATCTCGAG GTGCTGAAGC TCCTCTTCTT GACGACTTTG TCATGGCTTA CCTTTTTGCT 240
CAGTGGCGGC ATGATTTTTT ACATGGATGG ATAAAAATAC CTGTGACCCA TGAAACACAG 300
GAAGAATGTC TTGGAATGGC TGTGTTAGAT ATGATGAGAC TAGCCAAAGA GAAGGATCAA 360
ACCCCACTGG ACATCTATAG TTCTATCAGC TACAAGACAT TCTTACCAAA ATGTGTTCGA 420
GCAAAGATCC AAGACTATCA TATTTTGACA AGGAAACGAA TAAGGTACAG GTTTCGCAGA 480
TTTATTGAGC AATTCAGCCA TTGCAAAGCC ACTGCCAGAA ACTTGAAACT TAAGTATCTT 540
ATAAATCTGG AAACTCTTCA GTCTGCCTTC TACACAGAGC AGTTTGAAGT AAAAGAACCT 600
GGAAGTGGTC CTTCAGGTGA GGAGATTTTT GCAACCATTA TAATAACTGG AAACGGTGGA 660
ATTCAGTGGT CAAGAGGGAA ACATAAAGAA AGTGAGACAC TGACAGAACA GGATTTACAG 720
TTATATTGTG ACTTTCCTGA TATTATTGAT GTTACTATTA AGCAAGCAAG CCAAGAAGGC 780
TCAAATGAAA GTAGAATTGT AACTATCCAT AAGCAAGATG GTAAAAACCT GGAAATTGAA 840
CTTAGCTCAT TAAGAGAAGC TTTGTCCTTT GTGTCATTAA TTGATGGCTA TTATAGATTA 900
ACCGCAGATG CACATCATTA CCTCTGTAAA GAAGTAGCAC CTCCAATGGT CCTTGAAAAT 960
ATACAAAGCA ACTGTCATGG CCCAATTTTA ATGGATTTCG CCATCAGTAA ACTAAAGAAA 1020
GCAGGTAATC AGACTGGACT CTATGTACTT CGATGCAGTC CTAAGGACTT TAATAAGTAT 1080
TTTCTGACTT TTGCTGTCGA GCGAGAAAAT GTCATTGAAT ATAAGCACTG TTTGATTACA 1140
AAAAATGAGA ATGGAGAATA CAACCTCAGT GGGACCAAGA AGAACTTCAG TAATCTTAAA 1200
GATCTTTTGA ATTGCTACCA AATGGAAACT GTTCGCTCAG ACAGTATAAT TTTCCAGTTT 1260
ACTAAATGCT GTCCCCCAAA GTTGAAAGAT AAATCAAACC TTCTAGTCTT CAGAACCAAT 1320
GGTATTTCTG ATGTTCCAAC ATCACCGACA TTACAGAGGC ATAATAATGT GAACCAAATG 1380
GTGTTTCACA AAATCAGAAA TGAAGATTTG ATGTTTAATG AAAGCCTTGG TCAAGGCACT 1440
TTTACAAAAA TTTTTAAAGG TATAAGAAGA GAAGTAGGAG ACTATGGTCA ACTCCATGAA 1500
ACAGAAGTTC TTTTAAAAGT TCTGGATAAA GCACACAGAA ACTACTCAGA GTCTTTCTTT 1560
GAAGCAGCAA GCATGATGAG CCAGCTTTCT CACAAGCATC TGGTTTTAAA TTATGGAGTA 1620
TGTGTCTGTG GGGAGGAGAA TATTCTGGTT CAAGAGTTTG TAAAATTTGG ATCATTAGAT 1680
ACATATCTGA AAAAGAATAA AAATTCTATA AATATATTAT GGAAACTTGA AGTGGCTAAA 1740
CAGTTGGCAT GGGCCATGCA TTTTCTAGAA GAAAAAGCAC TTATTCATGG AAATGTGTGT 1800
GCCAAAAATA TTCTGCTTAT CAGAGAAGAA GACAGGAAGA CAGGAAATCC TCCTTTCATC 1860
AAACTTAGTG ATCCTGGCAT TAGTATTACA GTTTTGCCAA AGGACATTCT TCAGGAGAGA 1920
ATACCATGGG TACCACCTGA ATGCATCGAA AATCCTAAAA ATCTAAATTT GGCAACAGAC 1980
AAATGGAGTT TTGGTACCAC TTTGTGGGAA ATCTGCAGTG GAGGAGATAA GCCTCTGAGT 2040
GCTTTGGATT CTCAAAGAAA GCTACAGTTT TATGAAGATA GGCACCAGCT TCCTGCACCA 2100
AAGTGGACAG AATTAGCAAA TCTTATTAAT AATTGTATGG ATTATGAACC AGATTTTAGA 2160
CCTTCTTTCA GAGCCATCAT ACGAGATCTT AATAGTTTGT TTACTCCAGA TTATGAACTA 2220
TTAACAGAAA ATGACATGTT ACCAAATATG AGAATAGGTG CCCTAGGGTT TTCTGGTGCT 2280
TTTGAAGACC GAGACCCTAC ACAGTTTGAA GAGAGACACT TGAAATTTCT ACAGCAACTT 2340
GGCAAGGGTA ATTTTGGCAG TGTGGAGATG TGCCGGTATG ACCCTCTGCA AGACAACACT 2400
GGGGAGGTGG TGGCTGTGAA GAAGCTCCAG CACAGTACTG AAGAGCACCT GCGAGACTTT 2460
GAAAGGGAAA TTGAAATCCT CAAATCGCTG CAGCATGACA ACATTGTGAA GTACAAGGGA 2520
GTGTGCTACA GTGCTGGTCG GCGTAATCTA AGATTAATTA TGGAATATTT ACCATATGGA 2580
AGTTTACGAG ACTATCTCCA AAAACATAAA GAACGGATAG ATCATAAAAA ACTTCTGCAG 2640
TATACATCTC AGATATGCAA GGGCATGGAG TATCTTGGTA CAAAAAGGTA TATCCACAGG 2700
GATCTGGCAA CAAGGAATAT ATTGGTGGAA AACGAAAACA GAGTTAAAAT TGGAGATTTT 2760
GGGTTAACCA AAGTCTTGCC ACAAGACAAA GAATACTACA AAGTAAAAGA ACCTGGTGAA 2820
AGTCCCATAT TCTGGTATGC TCCAGAATCA CTGACGGAGA GCAAGTTTTC TGTGGCTTCA 2880
GATGTCTGGA GCTTTGGAGT GGTTCTGTAT GAACTTTTCA CGTATATTGA GAAGAGTAAA 2940
AGTCCCCCAG CGGAATTTAT GCGTATGATT GGCAATGACA AACAAGGACA GATGATTGTG 3000
TTTCATTTGA TAGAACTCCT AAAGAATAAT GGAAGATTAC CAAGACCAGA TGGATGCCCA 3060
GATGAGATTT ATTTGATCAT GACAGAATGC TGGAACAATA ATGTCAATCA ACGCCCCTCT 3120
TTTAGAGACC TAGCTCTTCG AGTTGATCAA ATAAGGGACA ACATGGCTGG ATGA 3174
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk++++Lgkg+f++v+++r+d+ +d+t+e va+k L++s+e++ rdf+re+eil++l+h+
Q: 774   LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD  833
         6899********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk+kgvc++ g++  rl+mey+++GsL++yL+k+ke++++++ll++++q++k+meYL+
Q: 834   NIVKYKGVCYSAGRRnlRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLG  893
         **********999888********************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         +k+++hrd+a+rn+Lve+e++      vk++d+gl+k+++qd eYy v+e+++s+i+w+a
Q: 894   TKRYIHRDLATRNILVENENR------VKIGDFGLTKVLPQDkEYYKVKEPGESPIFWYA  947
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle........rklel  224
         pe+l+e+k +s+asdvWsFgv+lyel+t ++k++sp    +r+++++        +++el
Q: 948   PESLTESK-FSVASDVWSFGVVLYELFTyIEKSKSPpaefMRMIGNDkqgqmivfHLIEL  1006
         ********.*******************************999999999***********
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFrail  262
         l+++ rlp+p+ cp+e++ +mt+c++++ +qrpsFr+++
Q: 1007  LKNNGRLPRPDgCPDEIYLIMTECWNNNVNQRPSFRDLA  1045
         ************************************995
Domain Sequence
(FASTA)
LKFLQQLGKG NFGSVEMCRY DPLQDNTGEV VAVKKLQHST EEHLRDFERE IEILKSLQHD 60
NIVKYKGVCY SAGRRNLRLI MEYLPYGSLR DYLQKHKERI DHKKLLQYTS QICKGMEYLG 120
TKRYIHRDLA TRNILVENEN RVKIGDFGLT KVLPQDKEYY KVKEPGESPI FWYAPESLTE 180
SKFSVASDVW SFGVVLYELF TYIEKSKSPP AEFMRMIGND KQGQMIVFHL IELLKNNGRL 240
PRPDGCPDEI YLIMTECWNN NVNQRPSFRD LA 272
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00025
EKS-BOT-00031
EKS-CAJ-00030
EKS-CAF-00031
EKS-CAP-00032
EKS-CII-00224
EKS-DAR-00042
EKS-DRM-00011
EKS-EQC-00028
EKS-FEC-00028
EKS-GAM-00013
EKS-GAG-00025
EKS-GAA-00046
EKS-GOG-00030
EKS-HOS-00032
EKS-LAC-00033
EKS-LOA-00030
EKS-MAM-00031
EKS-MEG-00027
EKS-MOD-00030
EKS-MUM-00032
EKS-MUP-00032
EKS-MYL-00032
EKS-NOL-00029
EKS-ORN-00046
EKS-ORA-00025
EKS-ORC-00031
EKS-ORL-00043
EKS-OTG-00031
EKS-PAT-00029
EKS-PES-00027
EKS-POA-00028
EKS-PTV-00030
EKS-RAN-00032
EKS-SAH-00029
EKS-SUS-00028
EKS-TAG-00028
EKS-TAR-00046
EKS-TEN-00050
EKS-XET-00030
EKS-XIM-00044
Gene Ontology
GO:0005901; C:caveola
GO:0005737; C:cytoplasm
GO:0005856; C:cytoskeleton
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0035401; F:histone kinase activity (H3-Y41 specific)
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0060396; P:growth hormone receptor signaling pathway
GO:0035722; P:interleukin-12-mediated signaling pathway
GO:0061180; P:mammary gland epithelium development
GO:0030099; P:myeloid cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0043392; P:negative regulation of DNA binding
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:0050727; P:regulation of inflammatory response
GO:0046677; P:response to antibiotic
GO:0007262; P:STAT protein import into nucleus
GO:0033209; P:tumor necrosis factor-mediated signaling pathway
GO:0007260; P:tyrosine phosphorylation of STAT protein
KEGG
InterPros
IPR019749; Band_41_domain.
IPR019748; FERM_central.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693; Tyr_kinase_non-rcpt_Jak2.
Pfam
PF07714; Pkinase_Tyr; 2.
PF00017; SH2; 1.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR01823; JANUSKINASE.
PR01825; JANUSKINASE2.
PR00109; TYRKINASE.
Created Date20-Feb-2013