EKS-AIM-00313

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00313

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	300.7	9.0E-90	3	222	220

Status

Unreviewed

Ensembl Protein

ENSAMEP00000010455

UniProt Accession

G1LTR4;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

MAP4K5

Gene Synonyms/Alias

MAP4K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000009856	ENSAMEP00000010461	ENSAMET00000010916
ENSAMEG00000009856	ENSAMEP00000010455	ENSAMET00000010910

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

790

Protein Sequence
(FASTA)

GDDFSLIQQE IFMVKECKHC NIVAYFGSYL SREKLWICME YCGGGSLQDI YHVTGPLSEL 60

QIAYVCRETL QGLAYLHTKG KMHRDIKGAN ILLTDHGDVK LADFGVAAKI TATIAKRKSF 120

IGTPYWMAPE VAAVEKNGGY NQLCDIWAVG ITAIELGELQ PPMFDLHPMR ALFLMSKSNF 180

QPPKLKDKTK WSSTFHNFVK VALTKNPKKR PTAERLLTHT FVGQPGLSRA LAVELLDKVN 240

NPDNHAHYTE GDDDDFEPHA IIRHTIRSTN RNARAERTAS EINFDKLQFE PPLRKETEAR 300

DEMGVSSDPN FVLQWNPFVD GANTGKSTSK RAPPPLPPKP RINSYPEDSL LDEEKSSTVK 360

RCPDTENRAP QFLRRQSSPS CGPVAETSSI GNGDGISKLM SENTEGSAQA PQLPRKKDKR 420

DFPKPAINGL PPTPKVLMGA CFSKVFDGCP LKINCATSWI HPDTKDQYII FGTEDGIYTL 480

NLNELHEATM EQLFPRKCTW LYVINNTLMS LSEGKTFQLY SHNLIALFEQ AKKPGLAAHI 540

QTHRFPDRIL PRKFALTTKI PDTKGCHKCC IVRNPYTGHK YLCGALQSGI VLLQWYEPMQ 600

KFMLIKHFDF PLPSPLNVFE MLVIPEQEYP MVCVAISKGT ESHQVVQFET INLNSASSWF 660

TEIGAGSQQL DSIHVTQLER DTVLVCLDKF VKIVNLQGKL KSSKKLASEL SFDFRIESVV 720

CLQDSVLAFW KHGMQGKSFK SDEVTQEISD ETRVFRLLGS DRVVVLESRP TENPTAHSNL 780

YILAGHENSY 790

Nucleotide Sequence
(FASTA)

GGAGATGATT TTTCTTTGAT TCAACAAGAA ATATTTATGG TTAAAGAATG TAAACATTGC 60

AACATCGTTG CCTACTTTGG GAGCTATCTC AGTCGAGAAA AACTGTGGAT TTGTATGGAA 120

TACTGTGGTG GTGGATCACT TCAAGATATT TACCATGTTA CTGGACCATT ATCAGAATTG 180

CAAATAGCCT ATGTATGCAG AGAAACTTTA CAGGGTCTTG CCTATTTGCA TACTAAAGGC 240

AAAATGCATA GAGATATCAA AGGTGCAAAT ATTTTATTGA CAGATCATGG TGATGTAAAA 300

TTAGCTGACT TTGGCGTGGC TGCGAAAATA ACAGCCACCA TTGCAAAGAG AAAATCTTTC 360

ATTGGCACTC CCTACTGGAT GGCCCCAGAA GTTGCAGCAG TAGAAAAGAA TGGCGGCTAC 420

AACCAGCTCT GTGATATCTG GGCAGTGGGA ATAACGGCGA TTGAACTTGG AGAACTTCAG 480

CCGCCCATGT TTGATCTTCA TCCAATGAGG GCCCTGTTCT TAATGTCAAA AAGTAATTTT 540

CAGCCTCCAA AACTAAAGGA CAAAACAAAA TGGTCATCAA CATTCCATAA TTTTGTCAAA 600

GTAGCACTAA CCAAAAACCC CAAAAAAAGA CCAACCGCTG AAAGACTTCT GACTCATACG 660

TTTGTAGGGC AGCCAGGTCT CTCTAGGGCC CTTGCAGTTG AGCTGTTGGA CAAAGTGAAT 720

AATCCAGACA ACCATGCACA TTACACTGAG GGAGATGACG ATGACTTTGA GCCCCATGCA 780

ATCATTCGTC ATACCATTAG ATCTACAAAC AGGAATGCCA GAGCTGAACG GACAGCTTCA 840

GAAATAAATT TTGACAAATT ACAATTCGAA CCTCCTCTGA GAAAAGAAAC AGAAGCACGG 900

GATGAAATGG GAGTGTCATC AGACCCAAAC TTTGTATTAC AGTGGAATCC TTTTGTTGAT 960

GGTGCAAATA CTGGGAAATC AACCTCAAAG CGCGCACCTC CGCCCCTACC TCCTAAGCCA 1020

AGGATAAACA GCTACCCTGA AGACAGCCTC CTAGATGAAG AAAAGTCATC AACTGTAAAA 1080

CGTTGTCCTG ATACAGAGAA CAGAGCTCCC CAATTTCTCA GAAGACAGAG TAGCCCCAGT 1140

TGTGGTCCTG TAGCCGAGAC TTCCTCTATT GGAAATGGTG ATGGTATTTC AAAACTGATG 1200

AGTGAAAATA CAGAAGGATC AGCACAAGCA CCACAGTTAC CACGGAAAAA GGACAAGCGA 1260

GATTTCCCAA AACCAGCCAT CAATGGCCTT CCACCCACCC CGAAAGTGCT GATGGGAGCA 1320

TGTTTTTCCA AAGTTTTTGA TGGATGCCCT TTGAAAATTA ATTGTGCAAC ATCCTGGATA 1380

CATCCTGATA CAAAAGATCA GTACATTATT TTTGGAACTG AAGATGGTAT TTACACGTTG 1440

AATCTCAATG AGCTACATGA GGCAACGATG GAACAGTTAT TTCCTCGGAA ATGTACTTGG 1500

CTCTATGTTA TCAATAATAC TTTAATGTCG TTATCAGAAG GAAAAACCTT TCAACTCTAC 1560

TCTCATAACC TGATAGCTTT GTTTGAACAA GCCAAAAAGC CAGGATTAGC TGCCCATATT 1620

CAAACTCATA GGTTTCCAGA CCGCATACTA CCAAGAAAGT TCGCTTTAAC AACAAAGATT 1680

CCTGATACAA AAGGCTGCCA CAAATGTTGC ATAGTCAGAA ACCCTTACAC AGGACATAAA 1740

TACCTCTGTG GAGCTTTACA GTCTGGAATT GTTTTACTTC AGTGGTATGA GCCAATGCAG 1800

AAATTCATGT TGATAAAGCA CTTTGATTTT CCTTTGCCAA GTCCTCTGAA TGTTTTTGAA 1860

ATGCTGGTAA TACCAGAACA GGAATACCCG ATGGTCTGTG TAGCTATTAG CAAAGGCACC 1920

GAATCCCATC AGGTGGTTCA GTTTGAGACA ATCAACCTGA ACTCTGCATC TTCATGGTTC 1980

ACAGAGATTG GTGCAGGTAG CCAACAGTTG GATTCCATTC ACGTAACACA GTTGGAGAGA 2040

GATACCGTTT TAGTGTGTTT AGATAAATTT GTAAAAATTG TAAATCTACA AGGAAAACTA 2100

AAATCAAGTA AGAAACTGGC TTCTGAGCTA AGTTTTGATT TTCGCATTGA ATCTGTAGTA 2160

TGCCTTCAAG ATAGCGTGTT GGCTTTCTGG AAACATGGAA TGCAGGGTAA AAGCTTCAAA 2220

TCAGATGAGG TTACCCAGGA GATTTCAGAT GAAACAAGAG TTTTCCGCTT GTTGGGATCA 2280

GACAGGGTTG TCGTTCTGGA AAGTAGGCCA ACAGAAAATC CTACTGCACA CAGCAATCTT 2340

TACATCTTGG CTGGACATGA AAATAGTTAC TAA 2373

Domain Profile

S: 39    kleelqkeisvlkklkhpniveylesflkeeelwlvmeylagGslsdlvkeelkselkEe  98

         + +++q+ei ++k++kh niv+y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E

Q: 3     DFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSEL  60

         6789**********************************************..********

S: 99    qiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktv  158

         qiay++re+l++L+ylH+k+++Hrdik++niLlt++g+VkL+dfgvaa++++t +krk++

Q: 61    QIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSF  120

         ************************************************************

S: 159   vgtpywmAPEviaqe.ekgYdekaDiwslGItaielaegepPfkdleplkallkilkne.  216

         +gtpywmAPEv a+e + gY++ +Diw++GItaiel e +pP++dl+p++al++++k++

Q: 121   IGTPYWMAPEVAAVEkNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNf  180

         **************98889***********************************999998

S: 217   .ppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

          ppklk+k+k+s++f++fv+ +l+knp+kRp+a++ll+h+F+

Q: 181   qPPKLKDKTKWSSTFHNFVKVALTKNPKKRPTAERLLTHTFV  222

         8****************************************7

Domain Sequence
(FASTA)

DFSLIQQEIF MVKECKHCNI VAYFGSYLSR EKLWICMEYC GGGSLQDIYH VTGPLSELQI 60

AYVCRETLQG LAYLHTKGKM HRDIKGANIL LTDHGDVKLA DFGVAAKITA TIAKRKSFIG 120

TPYWMAPEVA AVEKNGGYNQ LCDIWAVGIT AIELGELQPP MFDLHPMRAL FLMSKSNFQP 180

PKLKDKTKWS STFHNFVKVA LTKNPKKRPT AERLLTHTFV 220

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013