EKS-AIM-00280
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00280
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.02.2E-149723980258
StatusUnreviewed
Ensembl ProteinENSAMEP00000010504
UniProt AccessionG1LTV6;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000009949ENSAMEP00000010504ENSAMET00000010960
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1263
Protein Sequence
(FASTA)
VSTMELAAWC RWGLLLALLP SGAAGTQVCT GTDLKLRLPA SPETHLDMLR HLYQACQVVQ 60
GNLELTYLPA NASLSFLQDI QEVQGYVLIA HSQVRQVPLQ RLRIVRGTQL FEDNYALAVL 120
DNGELPEGDT SVAGATPGGL RELQLRSLTE ILKGGVLIQR NPQLCHQDTI LWKDIFHKNN 180
QLALTLIDTN RSRACQPCSP ACKDPHCWGA SSGDCQSLTR TVCAGGCARC KGPKPTDCCH 240
EQCAAGCTGP KHSDCLACLH FNHSGICELH CPALVTYNTD TFESMPNPEG RYTFGASCVT 300
ACPYNYLSTD VGSCTLVCPL NNQEVTAEDG TQRCEKCSRP CARVCYGLGM EHLREAKAVT 360
SANIQEFAGC KKIFGSLAFL PESFEGDPAS NTAPLQPEQL RVFEALEEIT GYLYISAWPD 420
SLPNLSVFQN LRVIRGRVLH DGAYSLTLQG LRISWLGLRS LRELGSGLAL IHRNARLCFI 480
HTVPWEQLFR NPHQALLHSA NRPEAECVGK GLACYPLCAH GHCWGPGPTQ CVNCSQFLRG 540
QECVEECREL QGLPREYVKD RYCLPCHPEC RPQNGSVTCF GSEADQCVAC AHYKDPPSCV 600
ARCPSGVKPD LSFMPIWKFA DEEGTCQPCP INCTHSCGDL DERGCPAEQR ASPVTSIIAA 660
VVGILLAVVM GLVFGILIKR RRQKIRKYTM RRLLQETELV EPLTPSGAMP NQAQMRILKE 720
TELRKVKVLG SGAFGTVYKG IWIPDGENVK IPVAIKVLRE NTSPKANKEI LDEAYVMAGV 780
GSPYVSRLLG ICLTSTVQLV TQLMPYGCLL DHVREHRGRL GSQDLLNWCV QIAKGMSYLE 840
DVRLVHRDLA ARNVLVKSPN HVKITDFGLA RLLDIDETEY HADGGKVPIK WMALESILRR 900
RFTHQSDVWS YGVTVWELMT FGAKPYDGIP AREIPDLLEK GERLPQPPIC TIDVYMIMVK 960
CWMIDSECRP RFRELVAEFS RMARDPQRFV VIQNEDLGPA SPLDSTFYRS LLEDDDMGDL 1020
VDAEEYLVPQ QGFFCPDPAP GAGGPAHRRH RSSSTRSGGG ELTLGLEPSE EEPPKSPLAP 1080
SEGAGSDVFD GDLGMGAAKG LHSLPPQDLS PLQRYSEDPT VPLPPETDGY VAPLTCSPQP 1140
EYVNQPEVWP QPPSPLEGPL PPPRPAGATL ERPKTLSPKT LSPGKNGVVK DVFAFGSAVE 1200
NPEYLAPRGR AAPQPHPPPA FSPAFDNLYY WDQDPSERGS PPSTFEGTPT AENPEYLGLD 1260
VPV 1263
Nucleotide Sequence
(FASTA)
GTGAGCACCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGC TCCTCCTCGC CCTCCTGCCC 60
TCCGGAGCCG CGGGCACCCA AGTGTGCACC GGCACAGACC TGAAGCTGCG TCTCCCCGCC 120
AGTCCCGAGA CCCACCTGGA TATGCTCCGC CACCTCTACC AGGCCTGTCA AGTGGTACAG 180
GGTAACTTGG AGCTCACCTA CCTGCCTGCC AACGCCAGCC TGTCCTTCCT GCAGGATATC 240
CAGGAGGTGC AGGGCTACGT GCTCATTGCT CACAGCCAAG TGAGACAGGT CCCGCTGCAG 300
AGGCTCCGAA TCGTGCGAGG CACCCAGCTC TTTGAGGACA ACTACGCCCT GGCCGTGCTG 360
GACAATGGAG AGCTGCCCGA GGGGGACACC TCTGTGGCAG GGGCTACCCC AGGAGGGCTG 420
CGGGAGCTGC AGCTTCGAAG CCTCACAGAG ATCCTGAAGG GAGGGGTCTT GATTCAGCGG 480
AACCCACAGC TGTGCCACCA GGACACGATT TTGTGGAAGG ACATCTTCCA CAAGAACAAC 540
CAGCTGGCCC TCACGCTGAT AGACACCAAC CGCTCTCGGG CCTGCCAACC CTGTTCTCCA 600
GCCTGTAAAG ACCCCCACTG CTGGGGAGCA AGTTCTGGGG ACTGTCAGAG CTTGACACGA 660
ACCGTCTGTG CCGGCGGCTG TGCCCGCTGC AAGGGCCCAA AACCCACTGA CTGCTGCCAC 720
GAGCAGTGCG CAGCTGGCTG CACGGGCCCC AAGCACTCGG ACTGCCTGGC CTGCCTTCAC 780
TTCAACCACA GTGGCATCTG TGAGCTGCAC TGCCCAGCCC TGGTCACCTA CAACACGGAC 840
ACGTTCGAAT CCATGCCCAA CCCTGAGGGC CGATACACCT TCGGTGCCAG CTGTGTGACC 900
GCCTGTCCCT ACAACTACCT GTCCACGGAC GTGGGGTCCT GCACCCTGGT CTGTCCCCTG 960
AACAACCAAG AGGTGACGGC TGAGGATGGC ACCCAGCGGT GTGAGAAATG CAGCAGACCC 1020
TGTGCCCGAG TGTGCTACGG TCTGGGCATG GAGCACCTGC GGGAGGCGAA GGCGGTCACC 1080
AGCGCCAACA TCCAAGAGTT CGCCGGCTGC AAGAAGATCT TTGGGAGCCT GGCGTTTCTG 1140
CCAGAGAGCT TCGAGGGAGA CCCAGCCTCC AACACTGCCC CCCTACAGCC TGAGCAGCTC 1200
AGAGTGTTCG AGGCCCTGGA GGAGATCACA GGTTACCTGT ATATCTCAGC GTGGCCGGAC 1260
AGCTTGCCTA ACCTCAGTGT CTTCCAGAAC CTGCGAGTAA TCCGGGGACG AGTTCTGCAT 1320
GATGGTGCCT ACTCGCTGAC CCTGCAAGGG CTGCGCATCA GCTGGCTGGG GCTGCGCTCA 1380
CTGCGGGAAC TGGGCAGCGG GCTGGCCCTC ATCCACCGCA ACGCCCGCCT CTGCTTCATC 1440
CACACGGTGC CCTGGGAGCA GCTCTTCCGG AACCCCCACC AAGCCCTGCT GCACAGTGCC 1500
AACCGGCCGG AGGCCGAGTG CGTGGGCAAG GGCCTGGCCT GCTACCCGCT GTGCGCCCAT 1560
GGGCACTGCT GGGGTCCGGG GCCCACCCAG TGCGTCAACT GCAGCCAATT CCTTCGGGGC 1620
CAGGAGTGTG TGGAGGAATG CCGAGAACTG CAGGGGCTAC CCCGGGAATA TGTGAAGGAC 1680
AGATACTGTC TGCCATGCCA CCCTGAGTGT CGGCCCCAGA ATGGCTCAGT GACCTGCTTT 1740
GGGTCGGAGG CTGACCAGTG TGTGGCCTGC GCCCACTACA AGGACCCTCC CTCCTGCGTG 1800
GCTCGCTGCC CCAGTGGTGT GAAACCCGAC CTCTCTTTCA TGCCCATTTG GAAGTTTGCA 1860
GATGAGGAGG GCACATGCCA GCCGTGCCCC ATCAACTGCA CCCACTCCTG TGGGGACCTG 1920
GACGAGAGGG GCTGCCCCGC CGAGCAGAGA GCCAGCCCTG TGACATCCAT CATTGCCGCT 1980
GTGGTGGGCA TTCTGCTGGC CGTGGTCATG GGGCTGGTCT TCGGCATTCT GATCAAGCGA 2040
AGGCGACAGA AGATCCGCAA GTACACGATG CGGAGGCTGC TGCAGGAAAC TGAGCTGGTG 2100
GAGCCGCTGA CGCCTAGCGG AGCAATGCCC AACCAGGCTC AGATGCGGAT CCTGAAAGAG 2160
ACAGAGCTGA GGAAGGTGAA GGTGCTTGGA TCCGGAGCTT TTGGCACCGT CTACAAGGGC 2220
ATCTGGATCC CTGATGGGGA AAATGTGAAA ATCCCAGTGG CCATCAAAGT GTTGAGGGAA 2280
AACACATCTC CCAAAGCCAA CAAAGAAATC TTGGACGAAG CATACGTGAT GGCTGGAGTG 2340
GGCTCCCCAT ATGTGTCCCG CCTTCTGGGC ATCTGCCTGA CGTCCACAGT GCAGCTGGTG 2400
ACACAGCTTA TGCCCTATGG CTGCCTCTTA GACCACGTCC GAGAGCATCG TGGGCGTCTG 2460
GGCTCCCAGG ACCTCCTGAA CTGGTGTGTG CAGATCGCTA AGGGGATGAG CTACTTGGAG 2520
GACGTCCGGC TCGTGCACAG GGACCTGGCT GCCCGGAACG TGCTGGTCAA GAGTCCCAAC 2580
CATGTCAAGA TTACAGACTT CGGGCTGGCT CGGTTGCTGG ACATTGATGA GACCGAGTAC 2640
CACGCGGATG GGGGCAAGGT GCCCATCAAG TGGATGGCGC TGGAGTCCAT TCTCCGTCGG 2700
CGGTTCACCC ACCAGAGTGA TGTGTGGAGC TATGGTGTGA CTGTGTGGGA ACTGATGACT 2760
TTTGGGGCCA AACCTTACGA TGGGATCCCA GCCCGAGAGA TCCCTGACCT GCTGGAGAAG 2820
GGGGAACGGC TGCCCCAGCC CCCCATCTGC ACCATCGACG TCTACATGAT CATGGTTAAA 2880
TGTTGGATGA TAGACTCTGA ATGTCGACCA CGGTTCCGGG AGCTGGTGGC CGAATTCTCC 2940
CGCATGGCCA GGGACCCCCA GCGCTTTGTG GTCATCCAGA ACGAAGACCT GGGCCCCGCC 3000
AGCCCGTTGG ACAGCACCTT CTACCGTTCG CTGCTGGAAG ATGACGACAT GGGGGACCTG 3060
GTGGATGCCG AGGAGTACCT GGTGCCCCAG CAGGGGTTCT TCTGCCCAGA CCCTGCCCCT 3120
GGAGCGGGGG GCCCGGCCCA CCGCAGGCAC CGCAGCTCAT CCACCAGGAG TGGCGGTGGC 3180
GAGCTGACAC TGGGACTGGA GCCCTCCGAG GAAGAGCCCC CCAAGTCTCC ACTGGCCCCG 3240
TCAGAGGGGG CTGGCTCTGA CGTGTTTGAT GGTGACTTGG GAATGGGGGC GGCCAAGGGG 3300
CTGCACAGCC TTCCCCCCCA GGACCTGAGC CCTCTACAGC GGTACAGCGA GGACCCTACA 3360
GTACCCCTGC CCCCTGAGAC TGATGGCTAC GTTGCCCCTC TGACCTGCAG CCCCCAGCCT 3420
GAATACGTGA ACCAGCCTGA GGTTTGGCCG CAGCCCCCCT CACCCCTAGA AGGCCCTCTG 3480
CCTCCTCCTC GACCTGCTGG TGCCACCCTG GAAAGGCCCA AGACTCTGTC CCCCAAGACC 3540
CTCTCCCCTG GCAAGAATGG AGTCGTCAAA GACGTTTTTG CCTTTGGGAG TGCGGTGGAG 3600
AACCCTGAGT ACTTGGCACC CCGGGGCAGG GCTGCCCCTC AGCCCCACCC TCCTCCAGCC 3660
TTCAGCCCAG CCTTTGACAA CCTCTATTAC TGGGACCAGG ACCCATCAGA GCGGGGCTCT 3720
CCACCCAGTA CCTTTGAAGG GACCCCTACA GCAGAGAACC CTGAGTACCT GGGCCTGGAC 3780
GTGCCAGTGT GA 3792
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 723   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  782
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 783   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  842
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 843   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  902
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 903   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  962
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 963   MIDSECRPRFRELVAEFS  980
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MEG-00239
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORA-00262
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAG-00314
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013