EKS-AIM-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-AIM-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	317.4	6.0E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSAMEP00000010627

UniProt Accession

G1LU79;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSAMEG00000010058	ENSAMEP00000010627	ENSAMET00000011086

Organism

Ailuropoda melanoleuca

Functional Description

Protein Length

651

Protein Sequence
(FASTA)

MKDYDELLKY YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIEA 60

LKNLRHQHIC QLYHVLETAN KIFIVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKVKLID FGLCAKPKGN KDYQLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSSSSILLL 240

QQMLQVDPKK RISVKNLLSH PWIMHDYNCP VEWQSKNSLI HLDEDCVTEL SVHHRNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV RLRLPSFSCG LANTTPVTNI KSKNLSLEDM 360

TTSDENYVAG LIDPGWCGDS SAAGAATPQT PQFAKRWTES NGLESKSLTP VLCRASANKL 420

KNKENVYTPK SAVKDDNCFV FPEPKTPVNK NQYKREILST PNHDTTPSKA RNQCLKETPV 480

KMPVNSAGTE KLMTGVISPE RRCRSVELDL NQAHVEDTPK RKGIKVFGSL ERGLDKVITV 540

LTRSKRKGSA KDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPEKHVDFI QKGYTLKCQT 600

QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V 651

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGATGAACT TCTCAAATAC TATGAATTAT ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCCTGCCAT ATCCTCACTG GAGAAATGGT AGCTATAAAA 120

ATCATGGATA AAAATGCACT AGGGAGTGAT TTGCCCCGGG TCAAAACGGA GATTGAGGCC 180

TTGAAGAACC TGAGACATCA GCATATATGT CAACTCTACC ATGTGCTAGA GACAGCCAAC 240

AAAATATTCA TTGTTCTTGA GTATTGCCCC GGGGGAGAGC TGTTTGACTA CATAATTTCC 300

CAGGATCGCC TGTCCGAGGA GGAGACCCGA GTTGTCTTCC GGCAGATAGT TTCTGCGGTT 360

GCTTATGTGC ACAGCCAGGG CTATGCTCAC AGGGACCTCA AACCAGAAAA TTTGTTGTTT 420

GATGAATATC ATAAGGTAAA GCTGATTGAC TTTGGTCTCT GTGCGAAACC CAAGGGTAAC 480

AAGGATTACC AACTGCAGAC ATGCTGTGGG AGTCTTGCTT ATGCAGCACC TGAATTAATA 540

CAAGGCAAAT CCTATCTGGG GTCAGAGGCA GATGTTTGGA GTATGGGCAT ACTCTTATAT 600

GTACTTATGT GTGGCTTTCT ACCATTTGAT GATGATAATG TCATGGCTTT GTACAAGAAG 660

ATTATGAGAG GGAAATACGA GGTACCTAAG TGGCTCTCTT CCAGTAGCAT TCTGCTTCTT 720

CAACAAATGC TACAGGTGGA CCCAAAGAAA CGGATTTCTG TGAAAAATCT ATTGAGCCAT 780

CCCTGGATCA TGCACGATTA CAACTGTCCT GTTGAGTGGC AAAGCAAGAA TTCTCTTATT 840

CACCTTGATG AAGATTGTGT AACAGAACTT TCTGTTCACC ACAGAAATAA TCGGCAAACA 900

ATGGAGGATT TAATTTCATT GTGGCAGTAT GATCACCTCA CCGCTACCTA TCTTCTGCTT 960

CTAGCCAAGA AGGCTCGGGG GAAACCAGTT CGTTTAAGGC TTCCTTCTTT TTCCTGTGGA 1020

CTAGCCAATA CCACCCCAGT CACAAACATT AAGTCAAAGA ATCTGAGTCT AGAAGATATG 1080

ACAACAAGTG ATGAAAACTA TGTGGCTGGA TTGATAGACC CTGGCTGGTG TGGAGACAGC 1140

TCAGCAGCAG GTGCGGCCAC TCCTCAGACA CCACAGTTTG CCAAGCGTTG GACAGAATCA 1200

AATGGTCTGG AATCTAAATC ATTAACTCCA GTATTATGCA GAGCATCTGC CAATAAATTA 1260

AAGAACAAAG AGAATGTATA TACGCCTAAA TCTGCTGTAA AGGATGACAA CTGCTTTGTA 1320

TTTCCTGAGC CAAAGACTCC AGTTAATAAG AACCAGTATA AGAGAGAAAT CCTCTCTACA 1380

CCAAATCATG ACACTACACC CTCAAAAGCC AGAAACCAGT GCCTGAAAGA AACCCCAGTT 1440

AAAATGCCAG TAAATTCAGC AGGAACAGAG AAGTTAATGA CAGGTGTCAT TAGCCCTGAG 1500

AGGCGATGTC GCTCAGTGGA ACTGGATCTC AACCAAGCAC ATGTAGAGGA TACTCCAAAG 1560

AGAAAAGGAA TCAAAGTGTT TGGGAGCCTT GAAAGGGGAT TGGATAAGGT TATCACTGTG 1620

CTTACTAGGA GCAAGAGGAA GGGCTCTGCC AAAGATGGCC CAAGAAGACT AAAGCTTCAC 1680

TATAATGTGA CTACAACCAG ATTAGTGAAT CCAGATCAAC TCTTGAATGA AATAATGTCT 1740

ATTCTTCCAG AGAAGCACGT TGACTTTATA CAAAAGGGCT ATACACTGAA GTGTCAAACA 1800

CAGTCAGATT TTGGTAAAGT GACAATGCAG TTTGAACTAG AAGTGTGCCA GCTTCAAAAA 1860

CCCGATGTGG TGGGTATCAG GAGGCAGCGG CTTAAGGGTG ATGCCTGGGT TTACAAGAGA 1920

TTAGTGGAAG ACATCCTGTC TAGCTGCAAG GTATAA 1956

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l ++k+Eie+lk+l+h++i

Q: 11    YELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRVKTEIEALKNLRHQHI  69

         999*******************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +

Q: 70    CQLYHVLETANKIFIVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDEYHKVKLIDFGLCAKPKGNkdYQLQTCCGSLAYAAPELIQGKSYLGSE  189

         *************************9655443399*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki++gk+e+pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSSSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 250   KRISVKNLLSHPWI  263

         *************7

Domain Sequence
(FASTA)

YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIEA LKNLRHQHIC 60

QLYHVLETAN KIFIVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYVHSQGYAH 120

RDLKPENLLF DEYHKVKLID FGLCAKPKGN KDYQLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSSSSILLL QQMLQVDPKK 240

RISVKNLLSH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013