EKS-AIM-00361
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00361
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11364.44.2E-109636892257
StatusUnreviewed
Ensembl ProteinENSAMEP00000010579
UniProt AccessionG1LU31;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K5
Gene Synonyms/Alias MAP3K5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000010066ENSAMEP00000010579ENSAMET00000011037
ENSAMEG00000010066ENSAMEP00000010581ENSAMET00000011039
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1283
Protein Sequence
(FASTA)
PPPPPGSFWN VETAAAPGTG CPAATSGSSA TRCRGNSSSG GGRRTTVAYV INEASQGQLV 60
VAESEALQSL REACETVGAT LETLHFGKLD FGETTVLDRF YNADIAVVEM SDAFRQPSLF 120
YHLGVRESFS MANNIILYCD NNSDSLQSLK EIICQKNTMC TGNYTFVPYM ITPHNKVYCC 180
DSSFMKGLTE LMQPNFELLL GPICLPLVDR FIQLLKVAQA SSSQYFRESI LNDIRKARNL 240
YTGKELAAEL ARIRQRVDNI EVLTADIVIT LLLSYRDIQD YDSIVKLVET LEKLPTFDLA 300
SHHHVKFHYA FALNRRNLPG DRAKALDVMI PLVQSEGQVA SDMYCLVGRI YKDMFLDSNF 360
LDTESRDHGA SWFKKAFESE PSLQSGINYA VLLLAAGHQF ESSFELRKVG VKLSSLLGKK 420
GNLEKLQSYW EVGFFLGASV LANDHMRVIQ ASEKLFKLKT PAWYLKSIVE TILIYKHFVK 480
LTTEQPVAKQ ELVDFWMDFL VEATKTDVTV VRFPVLILEP TKIYQPSYLS INNEVEEKTI 540
SIWHVLPDDK KGIHEWNFSA SSVRGVSISK FEERCCFLYV LHNSDDFQIY FCTELHCKKF 600
FEMVNTITEE KGRSTEEGDC ESDSLEYDYE YDENGDRVVL GKGTYGIVYA GRDLSNQVRI 660
AIKEIPERDS RYSQPLHEEI ALHKHLKHKN IVQYLGSFSE NGFIKIFMEQ VPGGSLSALL 720
RSKWGPLKDN EQTIGFYTKQ ILEGLKYLHD NQIVHRDIKG DNVLINTYSG VLKISDFGTS 780
KRLAGINPCT ETFTGTLQYM APEIIDKGPR GYGKAADIWS LGCTIIEMAT GKPPFYELGE 840
PQAAMFKVGM FKVHPEIPES MSAEAKAFIL KCFEPDPDKR ACANDLLIDE FLKVSSKKKK 900
TQPKLSALSA GSNEYLRSIS LPVPVLVEDT SSSSEYGSVS PDTELKVDPF SFKTRAKSCG 960
EKDVKGIRTL FLGIPDENFE DHSAPPSPEE KDSGFFMLRK DSERRATLHR ILTEDQDKVV 1020
RNLMESLAQG AEEPKLKWEH ITTLIASLRE FVRTTDRKII ATTLSKLKLE LDFDSHGISQ 1080
VQVVLFGFQD AVNKVLRNHN IKPHWMFALD SIIRKAVQTA ITILVPELRP HFSLASESDT 1140
ADQEDLDAED DHEERPSNQT VQRPHAVIED AVATSGVSTL SSTVSHDSQN AHRSLNVQLG 1200
RMKIETNRLL EELVQKEKEL QALLHQAIEE KDQEIKHLKL KSQPIDIPGL PECPRDSPGT 1260
NTEESELTEW LREKGADEDT ISR 1283
Nucleotide Sequence
(FASTA)
CCGCCGCCGC CGCCGGGCAG CTTCTGGAAC GTGGAGACTG CTGCCGCCCC TGGCACCGGT 60
TGTCCCGCTG CCACCTCTGG GAGCAGCGCC ACCCGGTGCC GGGGCAACTC TAGTAGCGGA 120
GGCGGCCGAC GGACCACGGT GGCATATGTG ATCAACGAAG CGAGCCAGGG GCAGCTCGTG 180
GTGGCCGAGA GCGAGGCCCT GCAGAGCCTG CGGGAGGCGT GCGAGACGGT GGGCGCCACC 240
CTGGAGACCC TGCATTTTGG TAAACTGGAC TTCGGGGAAA CCACGGTGCT GGACCGCTTT 300
TACAATGCAG ATATTGCTGT GGTGGAGATG AGCGATGCCT TCCGCCAGCC GTCCTTGTTT 360
TACCACCTCG GAGTGAGAGA AAGTTTCAGC ATGGCCAACA ACATCATCCT CTACTGTGAT 420
AATAATTCAG ACTCTCTGCA GTCACTGAAG GAAATCATTT GCCAGAAGAA TACTATGTGC 480
ACTGGGAACT ACACATTCGT CCCTTACATG ATCACTCCAC ATAACAAGGT CTACTGCTGT 540
GATAGCAGCT TCATGAAGGG GTTGACGGAG CTCATGCAAC CGAACTTCGA GCTGCTTCTT 600
GGACCCATTT GCTTACCTCT TGTGGACCGT TTCATTCAGC TTCTGAAGGT GGCACAAGCA 660
AGTTCGAGCC AGTATTTCCG GGAATCTATA CTCAATGATA TCAGGAAAGC TCGAAATTTA 720
TACACTGGTA AAGAATTGGC AGCTGAATTG GCAAGAATTC GGCAACGAGT AGATAATATT 780
GAAGTCTTGA CAGCGGATAT TGTCATAACC CTCTTACTTT CCTACAGAGA CATCCAGGAC 840
TATGATTCTA TTGTGAAGCT GGTAGAGACA TTAGAAAAGC TGCCAACCTT TGATTTGGCT 900
TCCCATCACC ATGTGAAGTT TCATTATGCA TTTGCACTGA ATAGGAGAAA TCTCCCTGGA 960
GATAGAGCAA AAGCTCTTGA TGTTATGATC CCGCTGGTGC AAAGTGAAGG GCAGGTTGCT 1020
TCAGATATGT ATTGCCTCGT TGGTCGAATT TACAAAGACA TGTTTTTGGA CTCTAATTTC 1080
CTGGACACTG AGAGTCGAGA CCATGGAGCT TCTTGGTTCA AAAAGGCATT TGAATCTGAG 1140
CCATCACTAC AGTCAGGAAT TAATTACGCA GTCCTTCTCC TGGCGGCTGG ACATCAGTTT 1200
GAGTCTTCAT TTGAGCTCCG GAAAGTTGGG GTGAAGCTGA GTAGCCTCCT TGGTAAAAAG 1260
GGAAACTTAG AAAAACTCCA GAGCTACTGG GAAGTTGGAT TTTTTCTGGG TGCCAGTGTC 1320
CTGGCCAATG ACCACATGAG AGTCATCCAA GCATCGGAAA AGCTTTTTAA ACTGAAAACA 1380
CCGGCATGGT ACCTCAAGTC GATTGTAGAG ACAATTTTGA TATATAAGCA TTTTGTGAAA 1440
CTGACTACAG AGCAGCCTGT GGCCAAACAG GAGCTCGTGG ACTTCTGGAT GGATTTCCTG 1500
GTCGAGGCCA CAAAGACAGA TGTTACCGTA GTTCGGTTTC CAGTATTAAT ATTAGAGCCC 1560
ACCAAAATCT ATCAGCCTTC GTATTTGTCT ATCAACAATG AAGTTGAGGA AAAGACGATA 1620
TCTATTTGGC ACGTGCTTCC TGATGACAAG AAAGGTATAC ATGAGTGGAA TTTTAGTGCT 1680
TCTTCTGTCA GGGGAGTGAG TATTTCTAAA TTTGAAGAAC GATGCTGTTT TCTTTATGTG 1740
CTTCATAATT CTGACGATTT CCAAATCTAT TTCTGTACAG AACTGCATTG TAAAAAGTTT 1800
TTTGAGATGG TGAACACCAT CACTGAAGAG AAGGGGAGAA GCACGGAGGA AGGTGATTGT 1860
GAAAGTGACT CCCTAGAGTA TGACTATGAA TATGACGAGA ACGGTGACAG AGTCGTTTTA 1920
GGGAAAGGCA CTTATGGGAT CGTCTACGCA GGCCGAGACC TGAGCAACCA AGTCCGAATC 1980
GCTATAAAGG AAATCCCAGA GAGAGATAGC AGATACTCCC AGCCCCTACA TGAAGAAATA 2040
GCATTGCATA AGCATCTAAA GCACAAAAAT ATTGTCCAGT ATCTGGGCTC TTTCAGTGAG 2100
AATGGTTTCA TCAAAATCTT CATGGAGCAG GTCCCAGGAG GAAGCCTTTC TGCTCTCCTT 2160
CGTTCCAAAT GGGGCCCATT GAAGGACAAT GAGCAAACCA TCGGCTTTTA TACGAAGCAG 2220
ATACTTGAAG GATTAAAATA CCTCCATGAC AATCAGATAG TCCACCGGGA TATAAAGGGC 2280
GACAACGTGT TGATTAATAC CTATAGTGGT GTTCTCAAGA TCTCGGACTT CGGGACATCA 2340
AAGAGGCTCG CTGGCATAAA CCCATGTACT GAAACTTTTA CTGGCACCCT TCAGTATATG 2400
GCACCAGAAA TCATAGACAA AGGACCGCGA GGCTACGGGA AAGCAGCGGA CATCTGGTCT 2460
TTGGGCTGCA CCATCATCGA AATGGCCACA GGGAAACCAC CTTTTTATGA ACTGGGAGAA 2520
CCACAAGCAG CTATGTTCAA GGTGGGGATG TTTAAAGTCC ACCCAGAGAT CCCAGAGTCC 2580
ATGTCAGCCG AGGCCAAGGC ATTCATCCTG AAGTGTTTCG AACCAGACCC TGACAAGAGA 2640
GCCTGTGCGA ACGACTTGCT TATTGATGAG TTCTTAAAAG TTTCCAGCAA AAAGAAAAAG 2700
ACACAACCCA AGCTTTCAGC CCTTTCAGCT GGATCAAATG AGTATCTTCG AAGCATATCC 2760
TTGCCTGTGC CTGTCCTGGT GGAGGATACG AGCAGCAGCA GCGAGTACGG CTCAGTTTCT 2820
CCCGACACCG AGTTAAAGGT GGACCCCTTC TCTTTCAAAA CGAGAGCCAA ATCCTGCGGA 2880
GAAAAAGATG TAAAGGGAAT ACGGACACTC TTCTTGGGCA TCCCGGATGA AAATTTTGAA 2940
GACCACAGCG CTCCGCCTTC CCCTGAAGAA AAAGATTCTG GGTTCTTTAT GCTGAGGAAG 3000
GACAGCGAGA GACGGGCCAC TCTTCACAGG ATCCTGACAG AAGACCAAGA CAAAGTTGTG 3060
AGAAACTTAA TGGAATCTTT GGCTCAGGGG GCCGAAGAAC CTAAACTCAA ATGGGAACAT 3120
ATCACAACCC TCATCGCAAG CCTCAGAGAA TTTGTGAGAA CCACAGACCG AAAAATCATT 3180
GCCACCACAC TGTCCAAGCT GAAGCTGGAA CTCGACTTCG ACAGCCACGG CATTAGCCAA 3240
GTCCAGGTGG TGCTCTTCGG TTTTCAGGAT GCTGTCAATA AAGTTCTTCG GAATCATAAT 3300
ATCAAGCCAC ACTGGATGTT TGCCTTAGAC AGTATCATCC GAAAGGCGGT GCAGACGGCT 3360
ATTACCATTC TGGTTCCAGA ACTGAGGCCA CATTTCAGCC TCGCATCGGA GAGTGATACC 3420
GCTGATCAGG AAGACTTGGA TGCAGAAGAT GACCATGAGG AACGGCCTTC GAACCAAACT 3480
GTCCAAAGAC CTCATGCTGT CATTGAAGAT GCTGTGGCTA CCTCAGGGGT GAGCACACTC 3540
AGTTCTACTG TATCCCACGA CTCCCAAAAT GCTCACCGGT CCCTCAATGT GCAACTTGGA 3600
AGGATGAAAA TAGAAACTAA TAGATTACTG GAAGAATTGG TTCAGAAAGA GAAAGAATTA 3660
CAAGCACTCC TTCATCAAGC TATTGAAGAA AAAGACCAAG AAATTAAACA CCTGAAGCTT 3720
AAGTCCCAAC CAATAGATAT TCCTGGATTG CCTGAATGCC CCCGGGATTC TCCTGGCACA 3780
AATACTGAAG AGTCTGAACT TACTGAGTGG CTCAGAGAAA AGGGAGCTGA TGAAGACACT 3840
ATAAGTCGG 3849
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n
Q: 636   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  690
         5789**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+
Q: 691   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  750
         *******************************9*****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k
Q: 751   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  807
         ***************************************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+
Q: 808   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  867
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         f+ kc+e dp+kr++a++LL +efl
Q: 868   FILKCFEPDPDKRACANDLLIDEFL  892
         *********************9996
Domain Sequence
(FASTA)
DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60
GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120
RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180
ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240
DPDKRACAND LLIDEFL 257
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00378
EKS-BOT-00387
EKS-CAF-00390
EKS-CAP-00418
EKS-DAR-00769
EKS-EQC-00380
EKS-FEC-00376
EKS-GAG-00327
EKS-GAA-00475
EKS-GOG-00384
EKS-HOS-00395
EKS-LAC-00401
EKS-LOA-00395
EKS-MAM-00386
EKS-MEG-00320
EKS-MOD-00376
EKS-MUM-00421
EKS-MUP-00382
EKS-MYL-00386
EKS-NOL-00355
EKS-ORN-00500
EKS-ORA-00336
EKS-ORC-00364
EKS-ORL-00460
EKS-OTG-00390
EKS-PES-00346
EKS-POA-00379
EKS-RAN-00402
EKS-SAH-00359
EKS-TAG-00460
EKS-TAR-00496
EKS-TEN-00496
EKS-XET-00502
Gene Ontology
GO:0005524; F:ATP binding
GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0000186; P:activation of MAPKK activity
GO:0070301; P:cellular response to hydrogen peroxide
GO:0010421; P:hydrogen peroxide-mediated programmed cell death
GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254; P:JNK cascade
GO:0043065; P:positive regulation of apoptotic process
KEGG
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013