EKS-AIM-00317
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00317
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK397.24.3E-1195441027484
StatusUnreviewed
Ensembl ProteinENSAMEP00000010644
UniProt AccessionG1LU96;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000010091ENSAMEP00000010644ENSAMET00000011104
OrganismAiluropoda melanoleuca
Functional Description
Protein Length1066
Protein Sequence
(FASTA)
LGAAAAPTSA ARVPAAGAVA TAEVTVEDAE AAAVDQEPRD PEPDDEADLR PRGRSLVIIS 60
TLDGRIAALD PENHGKKQWD LDVGSGSLVS SSLSKPEVFG NKMIIPSLDG DLFQWDRDRE 120
SMETVPFTVE SLLESSYKFG DDVVLVGGKS LTTYGLSAYT GKVRYICSAL GCRQWDNDDM 180
EQEDILLLQR SQKTVRAVGP RSGNEKWNFS VGHFELRYIP DMETRAGFIE STLKPSGNKE 240
GSKIISDVEE QEAAMMDTVI KVSVADWKVM AFSKKGGHLE WEYQFCTPIA SAWLVKDGKV 300
IPISLFDDTS YASSNEVLED EEDIVEAARG ATENSVYLGM YRGQLYLQSS VRISEKFPTS 360
PKALESVNNE YELMPLPTIK WKPLIHSPSR TPVLVGSDEF DKCLSNDKFS HEEYSNGALS 420
ILQYPYEDNG YYLPYYKRER SKRSTQITVR FLDNPNYSKN IRKKDPVLLL HWWKEIVGTI 480
LFCIIATTFI VRRLFHPHPH RQRKESETQC QTETKYDSVS GEAKDNSWND IKNSGYVSRY 540
LTDFEPVQCM GRGGFGVVFE ARNKVDDCNY AIKRIRLPNR ELAREKVMRE VKALAKLDHP 600
GIVRYFNAWL EAPPEKWQEK MDEIWLKDES TDWPLSSPSP MDAPSVKIRR MDPFSTKEHI 660
EIIAPSSQRR SFSVGISCGQ TSSSESQFSP LEFSGTDHAD TSESVDAACN LRDSCLTDCD 720
VEDGTMDGND EGHSFELSPS GASPYERSRE RTSSSIVFED SGCDNASSKE ELKTKRLHMG 780
NHCANKLSAF KHSSSESSSE PSISVSPPRP TTLSLDLTKN TAEKLQPSSP KVYLYIQMQL 840
CRKENLKDWM NSRCTIAERE RSVCLHIFLQ IAEAVEFLHS KGLMHRDLKP SNIFFTVDDV 900
VKVGDFGLVT EMDQDEEEEM VLTPMPAYAR HTGQVGTKLY MSPEQIHGNN YSHKVDIFSL 960
GLILFELLYP FGTQMERVRV LTDVRNLKFP PLFTQKYPRE YVMVQDMLSP SPMERPEATT 1020
IIENAVFEDL ELPGKTVLRQ RSRSLSSSGT KHSRQSSNSR SPLPSN 1066
Nucleotide Sequence
(FASTA)
CTGGGGGCAG CGGCCGCTCC CACTTCTGCA GCGCGGGTGC CGGCTGCAGG GGCCGTGGCT 60
ACGGCAGAAG TGACGGTGGA GGACGCCGAA GCTGCCGCTG TGGACCAGGA GCCGCGGGAC 120
CCGGAACCCG ATGACGAGGC CGACCTAAGG CCGCGCGGCA GATCATTAGT GATTATCAGT 180
ACTTTAGATG GGCGAATTGC TGCCTTGGAT CCTGAGAATC ATGGTAAAAA GCAGTGGGAT 240
TTGGACGTGG GATCCGGTTC TTTGGTTTCA TCCAGCCTCA GCAAACCAGA GGTATTTGGG 300
AATAAGATGA TCATTCCTTC TCTGGATGGA GACCTCTTCC AGTGGGACCG GGACCGTGAG 360
AGCATGGAAA CAGTTCCTTT TACAGTTGAA TCACTTCTTG AATCTTCTTA TAAATTTGGA 420
GATGATGTTG TTTTGGTTGG AGGAAAGTCT CTCACTACAT ATGGACTCAG TGCATATACT 480
GGAAAGGTGA GGTATATCTG TTCAGCTTTG GGTTGTCGCC AGTGGGATAA TGATGACATG 540
GAACAAGAAG ACATCCTGCT TCTGCAGCGC TCCCAGAAAA CTGTTAGAGC TGTCGGACCT 600
CGCAGTGGCA ACGAGAAGTG GAATTTCAGT GTTGGCCACT TTGAACTTCG GTATATTCCA 660
GACATGGAAA CTAGAGCCGG ATTTATTGAA AGCACCTTAA AGCCCAGTGG GAACAAAGAA 720
GGGTCTAAAA TTATTTCAGA TGTGGAAGAA CAGGAAGCTG CCATGATGGA CACAGTGATA 780
AAGGTCTCAG TTGCTGACTG GAAGGTTATG GCGTTTAGCA AGAAGGGAGG ACATCTGGAA 840
TGGGAATACC AGTTTTGTAC TCCCATTGCA TCCGCTTGGT TAGTTAAGGA TGGAAAAGTC 900
ATTCCCATAA GTCTTTTTGA TGATACAAGT TATGCATCTA GCAATGAAGT TTTAGAAGAT 960
GAAGAAGACA TTGTAGAAGC TGCCCGAGGA GCCACAGAAA ACAGCGTTTA CCTGGGAATG 1020
TACAGAGGTC AGCTGTATCT GCAGTCATCA GTCAGAATTT CAGAAAAGTT TCCTACAAGT 1080
CCCAAGGCCT TGGAATCTGT CAATAATGAA TATGAACTTA TGCCTTTGCC AACAATCAAA 1140
TGGAAACCCT TAATTCATTC TCCTTCCAGA ACTCCTGTCT TGGTGGGGTC TGATGAATTT 1200
GACAAATGTC TCAGTAACGA TAAGTTTTCT CATGAAGAGT ACAGTAATGG CGCGCTTTCA 1260
ATCTTGCAAT ACCCATATGA AGATAATGGT TATTATCTAC CATACTACAA GAGGGAGAGG 1320
AGCAAACGGA GCACACAGAT CACAGTCCGA TTTCTCGATA ACCCAAATTA CAGCAAGAAC 1380
ATTCGGAAAA AGGATCCTGT TCTCCTCTTA CACTGGTGGA AAGAAATAGT TGGAACTATT 1440
TTGTTTTGTA TCATAGCCAC AACTTTTATT GTGCGTAGAC TTTTCCATCC TCATCCTCAC 1500
AGACAAAGGA AGGAATCTGA AACTCAGTGT CAAACTGAAA CTAAATATGA TTCTGTCAGT 1560
GGAGAAGCTA AGGACAATAG CTGGAATGAC ATAAAAAATT CTGGATATGT ATCACGCTAT 1620
CTAACAGACT TTGAACCAGT TCAGTGCATG GGTCGTGGTG GGTTTGGAGT CGTCTTTGAA 1680
GCCAGAAACA AAGTAGATGA CTGCAATTAT GCTATCAAGA GAATACGCCT CCCCAACAGG 1740
GAGTTGGCTC GGGAAAAGGT AATGCGAGAA GTTAAAGCCT TAGCCAAGCT TGACCATCCA 1800
GGGATTGTTA GATATTTCAA TGCGTGGTTA GAAGCACCAC CAGAGAAGTG GCAAGAAAAA 1860
ATGGATGAAA TTTGGCTGAA AGATGAAAGC ACAGATTGGC CGCTCAGCTC TCCTAGTCCC 1920
ATGGATGCAC CGTCAGTTAA AATACGCAGA ATGGATCCTT TCTCTACAAA GGAACATATT 1980
GAAATCATAG CTCCTTCTTC ACAAAGGAGG TCTTTTTCAG TAGGGATTTC CTGTGGCCAG 2040
ACGAGTTCAT CTGAGAGCCA GTTCTCTCCG CTGGAATTTT CGGGAACAGA CCATGCAGAT 2100
ACCAGTGAGT CCGTGGATGC AGCGTGCAAC CTCCGGGATA GCTGCCTCAC GGACTGCGAT 2160
GTGGAAGATG GTACTATGGA TGGCAATGAC GAGGGACACT CCTTTGAACT TAGTCCTTCT 2220
GGAGCTTCTC CTTACGAAAG GTCAAGGGAG AGAACATCCT CTTCTATAGT ATTTGAAGAT 2280
TCTGGCTGTG ATAACGCGTC CAGTAAAGAA GAGCTCAAAA CGAAGCGACT GCATATGGGC 2340
AACCATTGTG CGAATAAACT AAGTGCTTTC AAGCATTCCA GTAGCGAGTC TTCTTCCGAA 2400
CCAAGTATCT CTGTCTCTCC TCCAAGACCG ACCACTTTAA GTCTAGATCT CACCAAAAAC 2460
ACTGCAGAGA AACTCCAGCC CAGCTCCCCG AAGGTGTATC TTTACATTCA GATGCAGCTG 2520
TGCAGAAAGG AAAACCTCAA AGACTGGATG AACAGCCGCT GCACCATAGC GGAGAGAGAG 2580
AGGAGCGTGT GTCTGCACAT CTTCCTGCAG ATCGCAGAGG CCGTTGAGTT TCTGCACAGT 2640
AAAGGCCTCA TGCACAGGGA CCTCAAGCCT TCCAACATAT TCTTTACAGT GGACGATGTG 2700
GTCAAGGTTG GAGACTTTGG ATTAGTGACC GAAATGGACC AGGATGAGGA AGAGGAGATG 2760
GTTCTGACCC CGATGCCAGC CTATGCCAGA CACACAGGAC AAGTGGGGAC CAAACTGTAT 2820
ATGAGCCCAG AGCAGATTCA TGGAAACAAC TACTCTCATA AAGTGGACAT CTTTTCTTTA 2880
GGCCTCATTC TGTTTGAATT GCTATACCCA TTCGGCACTC AGATGGAGAG AGTCAGGGTC 2940
TTAACGGATG TAAGAAATCT CAAATTTCCA CCACTGTTTA CTCAGAAATA TCCCCGTGAG 3000
TATGTGATGG TTCAAGACAT GCTCTCTCCA TCCCCCATGG AACGCCCAGA AGCTACCACC 3060
ATCATTGAAA ATGCTGTATT TGAAGACCTG GAGCTTCCAG GAAAAACAGT ACTCAGACAG 3120
AGGTCTCGCT CCCTGAGTTC ATCGGGAACA AAACATTCAA GACAGTCCAG CAACTCCCGG 3180
AGCCCTTTGC CAAGCAATTA G 3201
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe ++++G+GgfgvV++a+nk+d+++yaikri+l++++ ++ekv+revkaLakl+hp+iv
Q: 544   FEPVQCMGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLDHPGIV  603
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++e++                                              
Q: 604   RYFNAWLEAPPEKWqekmdeiwlkdestdwplsspspmdapsvkirrmdpfstkehieii  663
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 664   apssqrrsfsvgiscgqtsssesqfsplefsgtdhadtsesvdaacnlrdscltdcdved  723
         ********************************************************9999
S: 75    ...tdsseveaeaeleesesseesdtk.................................  98
            + ++++ +++el++s +s++++++                                 
Q: 724   gtmD-GNDEGHSFELSPSGASPYERSRertsssivfedsgcdnasskeelktkrlhmgnh  782
         9640.555555555555555555555555666666666666666666666666*******
S: 99    ..................................................llyiqmelce  108
                                                           +lyiqm+lc+
Q: 783   canklsafkhsssesssepsisvspprpttlsldltkntaeklqpsspkvYLYIQMQLCR  842
         ************************************************************
S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167
         ke+Lkdw+++r+++ +r++ v+ ++f q++e++e+lHskgl+HrdLkpsniF++ dd vK
Q: 843   KENLKDWMNSRCTIAERERSVClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTVDDVVK  902
         ************************************************************
S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227
         +gDFgL+t+++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl
Q: 903   VGDFGLVTEMDQDEEEEMVLTPMPAYARHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGL  962
         ************************************************************
S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287
         ilfeLlypf t+merv++lt++r++k+p  f++k+p e+ ++q++ls +p+eRp+a++++
Q: 963   ILFELLYPFGTQMERVRVLTDVRNLKFPPLFTQKYPREYVMVQDMLSPSPMERPEATTII  1022
         ************************************************************
S: 288   ksell  292
         +++++
Q: 1023  ENAVF  1027
         99875
Domain Sequence
(FASTA)
FEPVQCMGRG GFGVVFEARN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLDHPGIV 60
RYFNAWLEAP PEKWQEKMDE IWLKDESTDW PLSSPSPMDA PSVKIRRMDP FSTKEHIEII 120
APSSQRRSFS VGISCGQTSS SESQFSPLEF SGTDHADTSE SVDAACNLRD SCLTDCDVED 180
GTMDGNDEGH SFELSPSGAS PYERSRERTS SSIVFEDSGC DNASSKEELK TKRLHMGNHC 240
ANKLSAFKHS SSESSSEPSI SVSPPRPTTL SLDLTKNTAE KLQPSSPKVY LYIQMQLCRK 300
ENLKDWMNSR CTIAERERSV CLHIFLQIAE AVEFLHSKGL MHRDLKPSNI FFTVDDVVKV 360
GDFGLVTEMD QDEEEEMVLT PMPAYARHTG QVGTKLYMSP EQIHGNNYSH KVDIFSLGLI 420
LFELLYPFGT QMERVRVLTD VRNLKFPPLF TQKYPREYVM VQDMLSPSPM ERPEATTIIE 480
NAVF 484
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
EKS-SCP-00084
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013