EKS-AIM-00301
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-AIM-00301
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20321.34.7E-9617273257
StatusUnreviewed
Ensembl ProteinENSAMEP00000010789
UniProt AccessionG1LUP0;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K1
Gene Synonyms/Alias MAP4K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSAMEG00000010182ENSAMEP00000010789ENSAMET00000011252
OrganismAiluropoda melanoleuca
Functional Description
Protein Length829
Protein Sequence
(FASTA)
MELVDPDIFN RDPRDHYDLL QRLGGGTYGE VFKARDKVTG DLVAVKMVKT EPDDDVSTLQ 60
KEILILKTCR HANIVAYHGS YLWWLQKFWI CMEFCGAGSL QDIYQVTGAL SELQISYVCR 120
EVLQGLAYLH SQKKIHRDIK GANILINDAG EVRLADFGIS AQIGATLARR LSFIGTPYWM 180
APEVAAVALK GGYNELCDIW SLGITAIELA ELQPPLFDVH PLRVLFLMTK SGYQPPRLKE 240
KGKWSAAFHN FVKVTLTKNP KKRPGATKML SHQLVSQPRL NRGLILDLLD KLRNPGKGAP 300
VVEIEDEEPE VPPAVPRRIR STHRSSSLGI PDADCCRRHM EFRKLRAMES RPIPHTAHLK 360
PPGDFRSSSP RRHLSESDDD YDDVDIPTPA EDTPPPLPPK PKFRSPSDEG PGGTGDEGQL 420
SPGVLVRCAS GPPPRTPHLG PPLASRSPHL TAHSEPSLWN PTPREPDQPP LLPPKKEKMK 480
RKVEVPERDG CALLVKLFNG CPLRIHSTAA WTHPSTKDQH LLLGAEEGIF ILNRNDQEAT 540
LEMLFPSRTT WVYSINNVLM SLSGKTPHLY SHSILGLLER KEARAGSPIA HISPHRLLAR 600
KNMVSTKIQD TKGCRACCVA EGASSGGPFL CGALETSVVL LQWYQPMNKF LLVRALCPTP 660
RGSKTASLQT EGPGNTWEAP CCIGVSPGQP AKSVLFHTVR FGALSCWLGE MSTEHRGPVQ 720
VTQVEEDKVM VLMDGSLKLV TPEGAPVRGL RTPEIPMTEA VEAVAMVGGR LQAFWKHGVQ 780
VWAPGSDQLL QELRDPTLTF RLLGSPRPVV VETRPADDPT APSNLYIQE 829
Nucleotide Sequence
(FASTA)
ATGGAGCTCG TGGACCCCGA CATCTTTAAC AGGGACCCCC GGGATCACTA TGACCTGCTG 60
CAGCGGCTGG GTGGCGGCAC CTATGGAGAA GTCTTCAAGG CTCGCGACAA GGTGACGGGG 120
GACCTGGTGG CAGTGAAGAT GGTGAAGACG GAGCCTGACG ACGATGTTTC CACACTTCAG 180
AAGGAAATCC TCATCTTGAA AACTTGCCGG CATGCCAACA TCGTGGCCTA CCATGGGAGT 240
TATCTCTGGT GGCTTCAGAA GTTCTGGATA TGCATGGAAT TCTGTGGGGC TGGTTCTCTC 300
CAGGACATCT ACCAAGTGAC AGGCGCCCTG TCGGAGCTCC AGATTAGCTA TGTCTGTCGG 360
GAAGTGCTCC AGGGACTTGC CTATCTGCAC TCACAGAAGA AGATACACCG GGACATTAAG 420
GGAGCCAACA TCCTCATCAA TGATGCTGGG GAGGTCAGAC TGGCTGACTT TGGTATCTCA 480
GCCCAGATTG GGGCCACGCT GGCTCGACGC CTCTCTTTCA TTGGGACGCC CTACTGGATG 540
GCTCCAGAAG TGGCGGCCGT GGCCCTGAAG GGGGGATACA ACGAGCTGTG TGACATCTGG 600
TCCCTGGGCA TCACCGCCAT CGAACTAGCC GAGCTGCAAC CACCGCTATT TGACGTGCAT 660
CCTCTCCGAG TTCTCTTCCT CATGACGAAG AGTGGCTACC AGCCCCCCAG GCTAAAAGAA 720
AAAGGCAAAT GGTCGGCTGC TTTCCACAAT TTTGTCAAAG TCACCCTCAC TAAGAACCCC 780
AAGAAACGAC CTGGTGCCAC CAAGATGCTC AGTCACCAGC TGGTGTCCCA GCCCAGGCTG 840
AATAGAGGCC TGATCCTAGA TCTTCTTGAC AAGCTGAGGA ATCCAGGGAA GGGGGCCCCT 900
GTGGTGGAGA TTGAAGATGA GGAGCCTGAG GTGCCCCCTG CTGTCCCCCG GCGGATCCGG 960
TCCACCCACC GATCCAGCTC TCTAGGGATC CCAGATGCTG ACTGCTGTCG GCGGCACATG 1020
GAGTTCCGGA AGCTCAGAGC GATGGAGTCC AGACCCATAC CCCACACGGC CCACTTAAAG 1080
CCCCCTGGAG ACTTCAGGAG CAGCAGTCCT AGGAGGCACC TGTCGGAGTC TGACGATGAC 1140
TATGACGACG TGGACATCCC CACCCCTGCC GAGGACACCC CCCCTCCACT GCCTCCCAAG 1200
CCCAAGTTCC GTTCTCCATC AGACGAGGGG CCCGGGGGCA CTGGGGATGA GGGACAGCTG 1260
AGCCCGGGGG TGCTGGTCCG GTGTGCCAGT GGGCCTCCCC CCCGAACCCC CCATCTTGGG 1320
CCTCCCCTGG CCAGCCGCAG CCCCCACCTA ACTGCCCATT CAGAACCCTC ACTCTGGAAC 1380
CCAACCCCCC GGGAGCCCGA TCAGCCCCCA TTGTTACCCC CCAAGAAGGA AAAGATGAAG 1440
AGAAAGGTAG AGGTCCCAGA GAGAGACGGA TGTGCCCTTC TCGTGAAGTT GTTCAACGGC 1500
TGCCCCCTCC GAATCCACAG CACGGCTGCC TGGACACACC CCTCCACCAA GGACCAGCAC 1560
CTGCTCCTGG GGGCAGAGGA AGGCATTTTC ATCTTGAACC GAAATGACCA GGAGGCCACG 1620
CTGGAGATGC TCTTTCCCAG CCGGACTACC TGGGTGTACT CCATCAACAA TGTCCTCATG 1680
TCTCTCTCAG GGAAGACCCC CCACCTGTAT TCTCATAGCA TCCTGGGCCT GCTGGAACGG 1740
AAGGAGGCCA GAGCGGGGAG CCCCATCGCC CACATTAGCC CCCATCGGCT ACTGGCAAGG 1800
AAGAACATGG TCTCCACCAA GATCCAGGAC ACCAAAGGGT GCCGAGCTTG CTGCGTGGCG 1860
GAGGGTGCGA GCTCGGGGGG CCCGTTCCTG TGCGGGGCAT TGGAGACGTC CGTGGTCCTG 1920
CTTCAGTGGT ACCAGCCCAT GAACAAGTTC CTGCTGGTCC GGGCCCTATG TCCCACCCCC 1980
CGGGGCTCCA AGACGGCATC CCTCCAAACC GAGGGCCCAG GAAATACTTG GGAAGCCCCC 2040
TGCTGCATCG GCGTGAGCCC GGGGCAGCCG GCGAAGTCGG TGCTCTTCCA CACCGTGCGC 2100
TTCGGCGCGC TCTCCTGCTG GCTGGGCGAG ATGAGCACAG AGCACAGGGG ACCGGTACAG 2160
GTGACCCAGG TAGAGGAAGA CAAGGTGATG GTGTTGATGG ACGGGTCCCT GAAGCTGGTG 2220
ACCCCGGAGG GAGCCCCAGT CCGGGGGCTT CGAACTCCGG AGATCCCCAT GACTGAAGCG 2280
GTGGAAGCCG TGGCTATGGT CGGGGGTCGG CTCCAGGCCT TTTGGAAGCA TGGAGTGCAG 2340
GTGTGGGCTC CCGGCTCAGA CCAGCTATTG CAGGAGCTGA GAGACCCCAC CCTCACCTTC 2400
CGTCTGCTTG GCTCCCCCAG GCCTGTGGTG GTGGAGACAC GCCCAGCAGA TGATCCTACT 2460
GCCCCCAGCA ACCTCTACAT CCAGGAATGA 2490
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         y+ll+++g G++g+v++ar+k tg+lva+k++++e  +++++lqkei +lk+++h niv+
Q: 17    YDLLQRLGGGTYGEVFKARDKVTGDLVAVKMVKTEPDDDVSTLQKEILILKTCRHANIVA  76
         899*********************************************************
S: 61    ylesflk.eeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119
         y++s+l   ++ w++me++ +Gsl+d+++  ++  l+E qi+y++revl++L+ylHs+k+
Q: 77    YHGSYLWwLQKFWICMEFCGAGSLQDIYQ--VTGALSELQISYVCREVLQGLAYLHSQKK  134
         ******989********************..9****************************
S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYd  178
         iHrdik++niL+++ geV+L+dfg++aq+ +t ++r +++gtpywmAPEv a+  + gY+
Q: 135   IHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVAlKGGYN  194
         ****************************************************998999**
S: 179   ekaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvek  236
         e +DiwslGItaielae +pP++d++pl++l++++k+   pp+lk+k k+s +f++fv+ 
Q: 195   ELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGyqPPRLKEKGKWSAAFHNFVKV  254
         ***********************************998889*******************
S: 237   clqknpekRpsasellkhk  255
          l+knp+kRp a+++l+h+
Q: 255   TLTKNPKKRPGATKMLSHQ  273
         ******************8
Domain Sequence
(FASTA)
YDLLQRLGGG TYGEVFKARD KVTGDLVAVK MVKTEPDDDV STLQKEILIL KTCRHANIVA 60
YHGSYLWWLQ KFWICMEFCG AGSLQDIYQV TGALSELQIS YVCREVLQGL AYLHSQKKIH 120
RDIKGANILI NDAGEVRLAD FGISAQIGAT LARRLSFIGT PYWMAPEVAA VALKGGYNEL 180
CDIWSLGITA IELAELQPPL FDVHPLRVLF LMTKSGYQPP RLKEKGKWSA AFHNFVKVTL 240
TKNPKKRPGA TKMLSHQ 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>
EKS-ANC-00309
EKS-BOT-00322
EKS-CAF-00326
EKS-CAP-00354
EKS-DAR-00678
EKS-EQC-00312
EKS-FEC-00307
EKS-GOG-00323
EKS-HOS-00332
EKS-ICT-00303
EKS-LOA-00343
EKS-MAM-00336
EKS-MOD-00314
EKS-MUM-00357
EKS-MUP-00315
EKS-MYL-00318
EKS-NOL-00300
EKS-ORN-00413
EKS-OTG-00330
EKS-PAT-00308
EKS-POA-00325
EKS-RAN-00337
EKS-SAH-00298
EKS-SUS-00281
EKS-TAR-00417
Gene Ontology
GO:0005524; F:ATP binding
GO:0008349; F:MAP kinase kinase kinase kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0000185; P:activation of MAPKKK activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0006950; P:response to stress
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013